Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2

Journal of Dental Research

Volumn 83, Issue 8, 2004, Pages 590-595

  Iohara, K ^a   Nakashima, M ^a   Ito, M ^b   Ishikawa, M ^a   Nakasima, A ^a   Akamine, A ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

BMP2; Dental pulp capping; Dentin regeneration; Pellet culture; Stem cell therapy

Indexed keywords

BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CULTURE TECHNIQUE; CYTOLOGY; DENTIN; DOG; DRUG EFFECT; ENDODONTICS; HUMAN; METHODOLOGY; ODONTOBLAST; PHYSIOLOGY; REGENERATION; STEM CELL; STEM CELL TRANSPLANTATION; SWINE; TOOTH DEVELOPMENT; TOOTH PULP; VALIDATION STUDY;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE TECHNIQUES; DENTAL PULP; DENTAL PULP CAPPING; DENTAL PULP CAVITY; DENTIN; DENTINOGENESIS; DOGS; HUMANS; ODONTOBLASTS; RECOMBINANT PROTEINS; REGENERATION; STEM CELL TRANSPLANTATION; STEM CELLS; SWINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 4444361765     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910408300802     Document Type: Article

References (27)

1. Ballock RT, Reddi AH (1994). Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. J Cell Biol 126:1311-1318.
2. Bègue-Kirn C, Krebsbach PH, Bartlett JD, Butler WT (1998). Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation. Enr J Oral Sci 106:963-970.
3. Buurma B, Gu K, Rutherford RB (1999). Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffolds. Eur J Oral Sci 107:282-289.
4. Chiba K, Andersson GB, Masuda K, Momohara S, Williams JM, Thonar EJ (1998). A new culture system to study the metabolism of the intervertebral disc in vitro. Spine 23:1821-1828.
5. Couble ML, Farges JC, Bleicher F, Perrat-Mabillon B, Boudeulle M, Magloire H (2000). Odontoblast differentiation of human dental pulp cells in explant cultures. Calcif Tissue Int 66:129-138.
6. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000). Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630.
7. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. (2002). Stem cell properties of human dental pulp stem cells. J Dent Res 81:531-535.
8. Junqueira LC, Bignolas G, Brentani RR (1979). Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11:447-455.
9. Kato Y, Iwamoto M, Koike T, Suzuki F, Takano Y (1988). Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors. Proc Natl Acad Sci USA 85:9552-9556.
10. Lee JY, Hall R, Pelinkovic D, Cassinelli E, Usas A, Gilbertson L, et al. (2001). New use of a three-dimensional pellet culture system for human intervertebral disc cells: initial characterization and potential use for tissue engineering. Spine 26:2316-2322.
11. Lowry OH, Roberts NR, Wu ML, Hixon WS, Crawford EJ (1954). The quantitative histochemistry of brain. II. Enzyme measurement. J Biol Chem 207:19-37.
12. Mooney DJ, Powell C, Piana J, Rutherford B (1996). Engineering dental pulp-like tissue in vitro. Biotechnol Prog 12:865-868.
13. Nakashima M (1991). Establishment of primary cultures of pulp cells from bovine permanent incisors. Arch Oral Biol 36:655-663.
14. Nakashima M (1994a). Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic protein (BMP)-2 and -4. J Dent Res 73:1515-1522.
15. Nakashima M (1994b). Induction of dentine in amputated pulp of the dogs by recombinant human bone morphogenetic proteins-2 and - 4 with collagen matrix. Arch Oral Biol 39:1085-1089.
16. Nakashima M, Reddi AH (2003). The application of bone morphogenetic protein to dental tissue engineering . Nat Biotech 21:1025-1031.
17. Nakashima M, Nagasawa H, Yamada Y, Reddi AH (1994). Regulatory role of transforming growth factor-β, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells. Dev Biol 162:18-28.
18. Nakashima M, Tachibana K, Iohara K, Ito M, Ishikawa M, Akamine A (2003). Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11. Human Gene Therapy 14:591-597.
19. Putnam AJ, Mooney DJ (1996). Tissue engineering using synthetic extracellular matrices. Nat Med 2:824-826.
20. Ruchon AF, Marcinkiewicz M, Siegfried G, Tenenhouse HS, DesGroseillers L, Crine P, et al. (1998). Pex mRNA is localized in developing mouse osteoblasts and odontoblasts. J Histochem Cytochem 46:459-468.
21. Rutherford RB (2001). BMP-7 gene transfer to inflamed ferret dental pulps. Eur J Oral Sci 109:422-424.
22. Rutherford RB, Wahle J, Tucker M, Rueger D, Charette M (1993). Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 38:571-576.
23. Rutherford RB, Spangberg L, Tucker M, Rueger D, Charette M (1994). The time-course of the induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 39:833-838.
24. Tziafas D, Smith AJ, Lesot H (2000). Designing new treatment strategies in vital pulp therapy. J Dent 28:77-92.
25. Yamashiro T, Aberg T, Levanon D, Groner Y, Thesleff I (2002). Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Gene Exp Patterns 2:109-112.
26. Yokose S, Kadokura H, Tajima Y, Fujieda K, Katayama I, Matsuoka T, et al. (2000). Establishment and characterization of a culture system for enzymatically released rat dental pulp cells. Calcif Tissue Int 66:139-144.
27. Yoo JU, Barthel TS, Nishimura K, Solchaga L, Caplan AI, Goldberg VM, et al. (1998). The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Jt Surg Am 80:1745-1757.