Dentin Matrix Protein 1 (DMP1): New and important roles for biomineralization and phosphate homeostasis

Journal of Dental Research

Volumn 86, Issue 12, 2007, Pages 1134-1141

  Qin, C ^a   D'Souza, R ^a   Feng, J Q ^a  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

Author keywords

Dentin matrix protein 1; Dentinogenesis; Hypophosphatemic rickets; Osteogenesis; Phosphate homeostasis; SIBLING family

Indexed keywords

DMP1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 23; PHOSPHATE; PHOSPHOPROTEIN; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ANIMAL; BONE; BONE DEVELOPMENT; BONE MINERALIZATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW; TOOTH DEVELOPMENT; X LINKED HYPOPHOSPHATEMIC RICKETS;

ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; DENTINOGENESIS; EXTRACELLULAR MATRIX PROTEINS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HUMANS; HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; MICE; OSTEOGENESIS; PHOSPHATES; PHOSPHOPROTEINS;

EID: 37549059576     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910708601202     Document Type: Review

References (67)

1. About I, Laurent-Maquin D, Lendahl U, Mitsiadis TA (2000). Nestin expression in embryonic and adult human teeth under normal and pathological conditions. Am J Pathol 157:287-295.
2. Baba O, Qin C, Brunn JC, Jones JE, Wygant JN, McIntyre BW, et al. (2004). Detection of dentin sialoprotein in rat periodontium. Eur J Oral Sci 112:163-170.
3. Bonewald LF (2006). Mechanosensation and transduction in osteocytes. Bonekey Osteovision 3(10):7-15.
4. Bresler D, Bruder J, Mohnike K, Fraser WD, Rowe PS (2004). Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets. J Endocrinol 183:R1-R9.
5. Butler WT, Brunn JC, Qin C, McKee MD (2002). Extracellular matrix proteins and the dynamics of dentin formation. Connect Tissue Res 43:301-307.
6. Chaplet M, De Leval L, Waltregny D, Detry C, Fornaciari G, Bevilacqua G, et al. (2003). Dentin matrix protein 1 is expressed in human lung cancer. J Bone Miner Res 18:1506-1512.
7. Chen S, Inozentseva-Clayton N, Dong J, Gu TT, MacDougall M (2004). Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression. J Cell Biochem 92:332-349.
8. D'Souza RN, Cavender A, Sunavala G, Alvarez J, Ohshima T, Kulkarni AB, et al. (1997). Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. J Bone Miner Res 12:2040-2049.
9. Feng JQ, Luan X, Wallace J, Jing D, Ohshima T, Kulkarni AB, et al. (1998). Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein. J Biol Chem 273:9457-9464.
10. Feng JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, et al. (2002). Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res 17:1822-1831.
11. Feng JQ, Huang H, Lu Y, Ye L, Xie Y, Tsutsui TW, et al. (2003). The dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res 82:776-780.
12. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, et al. (2006). Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 38:1310-1315.
13. Fisher LW, Fedarko NS (2003). Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res 44(Suppl 1):33-40.
14. Fisher LW, Torchia DA, Fohr B, Young MF, Fedarko NS (2001). Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. Biochem Biophys Res Commun 280:460-465.
15. Fisher LW, Jain A, Tayback M, Fedarko NS (2004). Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers. Clin Cancer Res 10:8501-8511.
16. Foster BL, Nociti FH Jr, Swanson EC, Matsa-Dunn D, Berry JE, Cupp CJ, et al. (2006). Regulation of cementoblast gene expression by inorganic phosphate in vitro. Calcif Tissue Int 78:103-112.
17. Franceschi RT (1999). The developmental control of osteoblast-specific gene expression: role of specific transcription factors and the extracellular matrix environment. Crit Rev Oral Biol Med 10:40-57.
18. Gajjeraman S, Narayanan K, Hao J, Qin C, George A (2007). Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem 282:1193-1204.
19. George A, Sabsay B, Simonian PA, Veis A (1993). Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. J Biol Chem 268:12624-12630.
20. Gluhak-Heinrich J, Ye L, Bonewald LF, Feng JQ, MacDougall M, Harris SE, et al. (2003). Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. J Bone Miner Res 18:807-817.
21. He G, Dahl T, Veis A, George A (2003a). Nucleation of apatite crystals in vitro by self-assembled dentin matrix protein 1. Nat Mater 2:552-558.
22. He G, Dahl T, Veis A, George A (2003b). Dentin matrix protein 1 initiates hydroxyapatite formation in vitro. Connect Tissue Res 44(Suppl 1):240-245.
23. Hirst KL, Ibaraki-O'Connor K, Young MF, Dixon MJ (1997). Cloning and expression analysis of the bovine dentin matrix acidic phosphoprotein gene. J Dent Res 76:754-760.
24. Karadag A, Fedarko NS, Fisher LW (2005). Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44. Cancer Res 65:11545-11552.
25. Karsenty G, Ducy P, Starbuck M, Priemel M, Shen J, Geoffroy V, et al. (1999). Cbfa1 as a regulator of osteoblast differentiation and function. Bone 25:107-108.
26. Kim JW, Yamakoshi Y, Iwata T, Hu YY, Zhang H, Hu JC, et al. (2006). Porcine dentin matrix protein 1: gene structure, cDNA sequence, and expression in teeth. Eur J Oral Sci 114:33-41.
27. Kulkarni GV, Chen B, Malone JP, Narayanan AS, George A (2000). Promotion of selective cell attachment by the RGD sequence in dentine matrix protein 1. Arch Oral Biol 45:475-484.
28. Ling Y, Rios HF, Myers ER, Lu Y, Feng JQ, Boskey AL (2005). DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res 20:2169-2177.
29. Liu S, Gupta A, Quarles LD (2007). Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization. Curr Opin Nephrol Hypertens 16:329-335.
30. Lorenz-Depiereux B, Bastepe M, Benet-Pages A, Amyere M, Wagenstaller J, Muller-Barth U, et al. (2006). DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet 38:1248-1250.
31. Lu Y, Zhang S, Xie Y, Pi Y, Feng JQ (2005). Differential regulation of dentin matrix protein 1 expression during odontogenesis. Cells Tissues Organs 181:241-247.
32. Lu Y, Xie Y, Zhang S, Dusevich V, Bonewald LF, Feng JQ (2007a). DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res 86:320-325.
33. Lu Y, Ye L, Yu S, Zhang S, Xie Y, McKee MD, et al. (2007b). Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Dev Biol 303:191-201.
34. MacDougall M, Simmons D, Luan X, Nydegger J, Feng J, Gu TT (1997). Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination. J Biol Chem 272:835-842.
35. MacDougall M, Gu TT, Luan X, Simmons D, Chen J (1998). Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. J Bone Miner Res 13:422-431.
36. Nakasone N, Yoshie H, Ohshima H (2006). An immunohistochemical study of the expression of heat-shock protein-25 and cell proliferation in the dental pulp and enamel organ during odontogenesis in rat molars. Arch Oral Biol 51:378-386.
37. Narayanan K, Srinivas R, Ramachandran A, Hao J, Quinn B, George A (2001). Differentiation of embryonic mesenchymal cells to odontoblast-like cells by overexpression of dentin matrix protein 1. Proc Natl Acad Sci USA 98:4516-4521.
38. Narayanan K, Ramachandran A, Hao J, George A (2002). Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors. Connect Tissue Res 43:365-371.
39. Narayanan K, Ramachandran A, Hao J, He G, Park KW, Cho M, et al. (2003). Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem 278:17500-17508.
40. Narayanan K, Gajjeraman S, Ramachandran A, Hao J, George A (2006). Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. J Biol Chem 281:19064-19071.
41. Ogbureke KU, Fisher LW (2004). Expression of SIBLINGS and their partner MMPs in salivary glands. J Dent Res 83:664-670.
42. Ogbureke KU, Fisher LW (2005). Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Kidney Int 68:155-166.
43. Ogbureke KU, Fisher LW (2007). SIBLING expression patterns in duct epithelia reflect the degree of metabolic activity. J Histochem Cytochem 55:403-409.
44. Ogbureke KU, Nikitakis NG, Warburton G, Ord RA, Sauk JJ, Waller JL, et al. (2007). Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer. Oral Oncol 43:920-932.
45. Oka S, Oka K, Xu X, Sasaki T, Bringas P Jr, Chai Y (2007). Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev 124:409-415.
46. Qin C, Brunn JC, Cook RG, Orkiszewski RS, Malone JP, Veis A, et al. (2003). Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites. J Biol Chem 278:34700-34708.
47. Qin C, Baba O, Butler WT (2004). Post-translational modifications of SIBLING proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med 15:126-136.
48. Qin C, Huang B, Wygant JN, McIntyre BW, McDonald CH, Cook RG, et al. (2006). A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment. J Biol Chem 281:8034-8040.
49. Rios HF, Ye L, Dusevich V, Eick D, Bonewald LF, Feng JQ (2005). DMP1 is essential for osteocyte formation and function. J Musculoskelet Neuronal Interact 5:325-327.
50. Rowe PS (2004). The wrickkened pathways of FGF23, MEPE and PHEX. Crit Rev Oral Biol Med 15:264-281.
51. Rowe PS, Kumagai Y, Gutierrez G, Garrett IR, Blacher R, Rosen D, et al. (2004). MEPE has the properties of an osteoblastic phosphatonin and minhibin. Bone 34:303-319.
52. Rowe PS, Garrett IR, Schwarz PM, Carnes DL, Lafer EM, Mundy GR, et al. (2005). Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). Bone 36:33-46.
53. Rowe PS, Matsumoto N, Jo OD, Shih RN, Oconnor J, Roudier MP, et al. (2006). Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin. Bone 39:773-786.
54. Schiavi SC (2006). Bone talk. Nat Genet 38:1230-1231.
55. Sreenath T, Thyagarajan T, Hall B, Longenecker G, D'Souza R, Hong S, et al. (2003). Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem 278:24874-24880.
56. Steiglitz BM, Ayala M, Narayanan K, George A, Greenspan DS (2004). Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J Biol Chem 279:980-986.
57. Tartaix PH, Doulaverakis M, George A, Fisher LW, Butler WT, Qin C, et al. (2004). in vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem 279:18115-18120.
58. Terasawa M, Shimokawa R, Terashima T, Ohya K, Takagi Y, Shimokawa H (2004). Expression of dentin matrix protein 1 (DMP1) in nonmineralized tissues. J Bone Miner Metab 22:430-438.
59. Thotakura SR, Karthikeyan N, Smith T, Liu K, George A (2000). Cloning and characterization of rat dentin matrix protein 1 (DMP1) gene and its 5′-upstream region. J Biol Chem 275:10272-10277.
60. Toyosawa S, O'hUigin C, Tichy H, Klein J (1999). Characterization of dentin matrix protein 1 gene in Crocodilia. Gene 234:307-314.
61. Toyosawa S, Sato A, O'hUigin C, Tichy H, Klein J (2000). Expression of the dentin matrix protein 1 gene in birds. J Mol Evol 50:31-38.
62. Toyosawa S, Shintani S, Fujiwara T, Ooshima T, Sato A, Ijuhin N, et al. (2001). Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts. J Bone Miner Res 16:2017-2026.
63. Toyosawa S, Tomita Y, Kishino M, Hashimoto J, Ueda T, Tsujimura T, et al. (2004). Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia. Mod Pathol 17:573-578.
64. Yang W, Kalajzic I, Lu Y, Guo D, Harris MA, Gluhak-Heinrich J, et al. (2004). in vitro and in vivo study on osteocyte-specific mechanical signaling pathways. J Musculoskelet Neuronal Interact 4:386-387.
65. Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, et al. (2005). Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J Biol Chem 280:20680-20690.
66. Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, et al. (2004). Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem 279:19141-19148.
67. Ye L, Mishina Y, Chen D, Huang H, Dallas SL, Dallas MR, et al. (2005). Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem 280:6197-203.