Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30105-30116

  Haque, Mohammad Mahfuzul ^a   Fadlalla, Mohammed A ^a   Aulak, Kulwant S ^a   Ghosh, Arnab ^a   Durra, Deborah ^a   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; DOMAIN-DOMAIN INTERACTIONS; ELECTRON FLUX; ELECTRON TRANSFER; FLAVIN FLUORESCENCE; FLEXIBLE HINGES; NEURONAL NITRIC-OXIDE SYNTHASE (NNOS); NITRIC OXIDE SYNTHASES; PRE-REDUCTION; REDUCTION RATE; STOPPED-FLOW KINETICS; WILD TYPES;

CALMODULIN; CAMS; CATALYSIS; ELECTRON TRANSITIONS; ENZYMES; PORPHYRINS;

REDUCTION;

CALMODULIN; CYTOCHROME C; FLAVINE ADENINE NUCLEOTIDE REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; FLAVINE MONONUCLEOTIDE; HEME; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOFLAVIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ELECTRON TRANSPORT; FLOW KINETICS; FLUORESCENCE; HINGE REGION; MOLECULAR INTERACTION; MUTANT; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN; REDUCTION; SYNTHESIS; WILD TYPE;

ANIMALS; CALMODULIN; CYTOCHROMES C; ELECTRON TRANSPORT; FLAVIN MONONUCLEOTIDE; FLAVIN-ADENINE DINUCLEOTIDE; KINETICS; NADP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; RATS;

RATTUS;

EID: 84865756786     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.339697     Document Type: Article

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