Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11374-11384

  Hamdane, Djemel ^a   Xia, Chuanwu ^b   Im, Sang Choul ^a   Zhang, Haoming ^a   Kim, Jung Ja P ^b   Waskell, Lucy ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CYTOCHROME P450; CYTOCHROMES P450; OPEN CONFORMATION; OXIDOREDUCTASE; REDOX PARTNERS; STRUCTURAL REARRANGEMENT; TRANSFER ELECTRONS; WILD TYPES; WILD-TYPE ENZYMES;

AMINES; AMINO ACIDS; CONFORMATIONS; ENZYMES; ORGANIC ACIDS;

ELECTRONS;

CYTOCHROME P450; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; BENZPHETAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; RIBOFLAVIN DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLIZATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; HINGE REGION; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE; ANIMAL; CHEMISTRY; CONFORMATION; ELECTRON; GENE DELETION; KINETICS; METABOLISM; MUTAGENESIS; MUTATION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RAT;

ANIMALS; BENZPHETAMINE; ELECTRONS; FLAVIN MONONUCLEOTIDE; FLAVINS; GENE DELETION; KINETICS; MOLECULAR CONFORMATION; MUTAGENESIS; MUTATION; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS;

EID: 66449111327     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807868200     Document Type: Article

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