A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme - Simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains

FEBS Journal

Volumn 278, Issue 21, 2011, Pages 4055-4069

  Haque, Mohammad M ^a   Kenney, Claire ^a   Tejero, Jesús ^a   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

conformational equilibrium; electron transfer; flavoprotein; kinetic model; nitric oxide

Indexed keywords

CYTOCHROME C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLAVINE MONONUCLEOTIDE; FLAVOPROTEIN; NEURONAL NITRIC OXIDE SYNTHASE;

ARTICLE; CATALYSIS; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME KINETICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; STEADY STATE;

ELECTRON TRANSPORT; FLAVINS; FLAVOPROTEINS; KINETICS; MODELS, CHEMICAL; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN CONFORMATION; PROTEINS;

EID: 80255129738     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08310.x     Document Type: Article

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