Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27232-27240

  Tejero, Jesús ^a   Hannibal, Luciana ^a   Mustovich, Anthony ^a   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGE REVERSAL; COMPLEX PATTERN; ELECTRON TRANSFER; ELECTROSTATIC INTERACTIONS; GLOBAL MODELS; MODULAR ENZYMES; MOLECULAR BASIS; NITRIC OXIDE SYNTHASES; NITRIC-OXIDE SYNTHASE; POSITIVE CHARGES; POSITIVELY CHARGED; REDUCTION RATE; STOPPED FLOW; SUBDOMAIN; THERMODYNAMIC DRIVING FORCES;

CATALYSIS; COMPUTER SIMULATION; ELECTRON TRANSITIONS; ELECTROSTATICS; NITRIC OXIDE; PORPHYRINS;

REDUCTION;

FLAVINE MONONUCLEOTIDE; HEME; LYSINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME METABOLISM; GENE MUTATION; MOLECULAR DOCKING; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; STATIC ELECTRICITY; STEADY STATE; SURFACE CHARGE; THERMODYNAMICS;

ANIMALS; CATALYSIS; ELECTRON TRANSPORT; FLAVIN MONONUCLEOTIDE; HEME; MICE; MODELS, CHEMICAL; MUTATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; OXYGEN; PROTEIN STRUCTURE, TERTIARY; RATS; SURFACE PROPERTIES;

EID: 77956070332     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.138842     Document Type: Article

References (60)

1. Pfeiffer, S., Mayer, B., and Hemmens, B. (1999) Angew. Chem. Int. Ed. 38, 1714-1731
2. Stuehr, D. J., Santolini, J., Wang, Z. Q., Wei, C. C., and Adak, S. (2004) J. Biol. Chem. 279, 36167-36170
3. Lancaster, J. R., Jr. (1997) Nitric Oxide 1, 18-30
4. Alderton, W. K., Cooper, C. E., and Knowles, R. G. (2001) Biochem. J. 357, 593-615
5. Stuehr, D. J. (1999) Biochim. Biophys. Acta 1411, 217-230
6. Gorren, A. C., and Mayer, B. (2007) Biochim. Biophys. Acta 1770, 432-445
7. Fischmann, T. O., Hruza, A., Niu, X. D., Fossetta, J. D., Lunn, C. A., Dolphin, E., Prongay, A. J., Reichert, P., Lundell, D. J., Narula, S. K., and Weber, P. C. (1999) Nat. Struct. Biol. 6, 233-242
8. Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., and Tainer, J. A. (1998) Science 279, 2121-2126
9. Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., and Snyder, S. H. (1991) Nature 351, 714-718
10. Siddhanta, U., Presta, A., Fan, B., Wolan, D., Rousseau, D. L., and Stuehr, D. J. (1998) J. Biol. Chem. 273, 18950-18958
11. Matsuda, H., and Iyanagi, T. (1999) Biochim. Biophys. Acta 1473, 345-355
12. Abu-Soud, H. M., Yoho, L. L., and Stuehr, D. J. (1994) J. Biol. Chem. 269, 32047-32050
13. Craig, D. H., Chapman, S. K., and Daff, S. (2002) J. Biol. Chem. 277, 33987-33994
14. Konas, D. W., Zhu, K., Sharma, M., Aulak, K. S., Brudvig, G. W., and Stuehr, D. J. (2004) J. Biol. Chem. 279, 35412-35425
15. Welland, A., Garnaud, P. E., Kitamura, M., Miles, C. S., and Daff, S. (2008) Biochemistry 47, 9771-9780
16. Ilagan, R. P., Tiso, M., Konas, D. W., Hemann, C., Durra, D., Hille, R., and Stuehr, D. J. (2008) J. Biol. Chem. 283, 19603-19615
17. Shimanuki, T., Sato, H., Daff, S., Sagami, I., and Shimizu, T. (1999) J. Biol. Chem. 274, 26956-26961
18. Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., and Getzoff, E. D. (1999) EMBO J. 18, 6271-6281
19. Garcin, E. D., Bruns, C. M., Lloyd, S. J., Hosfield, D. J., Tiso, M., Gachhui, R., Stuehr, D. J., Tainer, J. A., and Getzoff, E. D. (2004) J. Biol. Chem. 279, 37918-37927
20. Panda, K., Haque, M. M., Garcin-Hosfield, E. D., Durra, D., Getzoff, E. D., and Stuehr, D. J. (2006) J. Biol. Chem. 281, 36819-36827
21. Yadav, J., Fujiwara, S., Sagami, I., and Shimizu, T. (2004) Chem. Lett. 33, 752-753
22. Yumoto, T., Sagami, I., Daff, S., and Shimizu, T. (2000) J. Inorg. Biochem. 82, 163-170
23. Adak, S., Ghosh, S., Abu-Soud, H. M., and Stuehr, D. J. (1999) J. Biol. Chem. 274, 22313-22320
24. Panda, K., Adak, S., Aulak, K. S., Santolini, J., McDonald, J. F., and Stuehr, D. J. (2003) J. Biol. Chem. 278, 37122-37131
25. Stuehr, D. J., and Ikeda-Saito, M. (1992) J. Biol. Chem. 267, 20547-20550
26. Ghosh, D. K., Crane, B. R., Ghosh, S., Wolan, D., Gachhui, R., Crooks, C., Presta, A., Tainer, J. A., Getzoff, E. D., and Stuehr, D. J. (1999) EMBO J. 18, 6260-6270
27. Adak, S., Crooks, C., Wang, Q., Crane, B. R., Tainer, J. A., Getzoff, E. D., and Stuehr, D. J. (1999) J. Biol. Chem. 274, 26907-26911
28. McMillan, K., and Masters, B. S. (1993) Biochemistry 32, 9875-9880
29. Gorren, A. C., Schmidt, K., and Mayer, B. (2002) Biochemistry 41, 7819-7829
30. Adak, S., Santolini, J., Tikunova, S., Wang, Q., Johnson, J. D., and Stuehr, D. J. (2001) J. Biol. Chem. 276, 1244-1252
31. Tejero, J., Biswas, A., Wang, Z. Q., Page, R. C., Haque, M. M., Hemann, C., Zweier, J. L., Misra, S., and Stuehr, D. J. (2008) J. Biol. Chem. 283, 33498-33507
32. Xia, C., Misra, I., Iyanagi, T., and Kim, J. J. (2009) J. Biol. Chem. 284, 30708-30717
33. Schwede, T., Kopp, J., Guex, N., and Peitsch, M. C. (2003) Nucleic Acids Res. 31, 3381-3385
34. Chen, R., Li, L., and Weng, Z. (2003) Proteins 52, 80-87
35. Matter, H., Kumar, H. S., Fedorov, R., Frey, A., Kotsonis, P., Hartmann, E., Fröhlich, L. G., Reif, A., Pfleiderer, W., Scheurer, P., Ghosh, D. K., Schlichting, I., and Schmidt, H. H. (2005) J. Med. Chem. 48, 4783-4792
36. Tsodikov, O. V., Record, M. T., Jr., and Sergeev, Y. V. (2002) J. Comput. Chem. 23, 600-609
37. Noble, M. A., Munro, A. W., Rivers, S. L., Robledo, L., Daff, S. N., Yellowlees, L. J., Shimizu, T., Sagami, I., Guillemette, J. G., and Chapman, S. K. (1999) Biochemistry 38, 16413-16418
38. Gao, Y. T., Smith, S. M., Weinberg, J. B., Montgomery, H. J., Newman, E., Guillemette, J. G., Ghosh, D. K., Roman, L. J., Martasek, P., and Salerno, J. C. (2004) J. Biol. Chem. 279, 18759-18766
39. Presta, A., Weber-Main, A. M., Stankovich, M. T., and Stuehr, D. (1998) J. Am. Chem. Soc. 120, 9460-9465
40. Ost, T. W., and Daff, S. (2005) J. Biol. Chem. 280, 965-973
41. Adak, S., Wang, Q., and Stuehr, D. J. (2000) J. Biol. Chem. 275, 17434-17439
42. Haque, M. M., Panda, K., Tejero, J., Aulak, K. S., Fadlalla, M. A., Mustovich, A. T., and Stuehr, D. J. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 9254-9259
43. Salerno, J. C. (2008) FEBS Lett. 582, 1395-1399
44. Feng, C., Roman, L. J., Hazzard, J. T., Ghosh, D. K., Tollin, G., and Masters, B. S. (2008) FEBS Lett. 582, 2768-2772
45. Tetreault, M., Cusanovich, M., Meyer, T., Axelrod, H., and Okamura, M. Y. (2002) Biochemistry 41, 5807-5815
46. Hall, D. A., Vander Kooi, C. W., Stasik, C. N., Stevens, S. Y., Zuiderweg, E. R., and Matthews, R. G. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 9521-9526
47. Medina, M., Abagyan, R., Gomez-Moreno, C., and Fernandez-Recio, J. (2008) Proteins 72, 848-862
48. Sheinerman, F. B., Norel, R., and Honig, B. (2000) Curr. Opin. Struct. Biol. 10, 153-159
49. Wang, M., Roberts, D. L., Paschke, R., Shea, T. M., Masters, B. S., and Kim, J. J. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 8411-8416
50. Santolini, J., Adak, S., Curran, C. M., and Stuehr, D. J. (2001) J. Biol. Chem. 276, 1233-1243
51. Haque, M. M., Fadlalla, M., Wang, Z. Q., Ray, S. S., Panda, K., and Stuehr, D. J. (2009) J. Biol. Chem. 284, 19237-19247
52. Wei, C. C., Wang, Z. Q., Tejero, J., Yang, Y. P., Hemann, C., Hille, R., and Stuehr, D. J. (2008) J. Biol. Chem. 283, 11734-11742
53. Ilagan, R. P., Tejero, J., Aulak, K. S., Ray, S. S., Hemann, C., Wang, Z. Q., Gangoda, M., Zweier, J. L., and Stuehr, D. J. (2009) Biochemistry 48, 3864-3876
54. Tiso, M., Tejero, J., Panda, K., Aulak, K. S., and Stuehr, D. J. (2007) Biochemistry 46, 14418-14428
55. Roman, L. J., and Masters, B. S. (2006) J. Biol. Chem. 281, 23111-23118
56. Stuehr, D. J., Tejero, J., and Haque, M. M. (2009) FEBS J. 276, 3959-3974
57. Ghosh, D. K., and Salerno, J. C. (2003) Front Biosci. 8, d193-d209
58. Toogood, H. S., van Thiel, A., Scrutton, N. S., and Leys, D. (2005) J. Biol. Chem. 280, 30361-30366
59. Leys, D., Basran, J., Talfournier, F., Sutcliffe, M. J., and Scrutton, N. S. (2003) Nat. Struct. Biol. 10, 219-225
60. Kang, S. A., and Crane, B. R. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 15465-15470