Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding

Journal of Biological Chemistry

Volumn 286, Issue 18, 2011, Pages 16246-16260

  Xia, Chuanwu ^a   Hamdane, Djemel ^b   Shen, Anna L ^c   Choi, Vivian ^c   Kasper, Charles B ^c   Pearl, Naw May ^b   Zhang, Haoming ^b   Im, Sang Choul ^b   Waskell, Lucy ^b   Kim, Jung Ja P ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFACTOR BINDING; CONFORMATIONAL CHANGE; CYTOCHROME C; CYTOCHROME P450; DISULFIDE BONDS; DISULFIDE LINKAGES; DOMAIN MOVEMENT; ELECTRON TRANSFER; FREE STRUCTURES; LARGE DOMAIN; LOOP MOVEMENT; MUTANT PROTEINS; NADPH-CYTOCHROME P450 REDUCTASE; OXIDOREDUCTASES; REDOX PARTNERS; RELATIVE ORIENTATION; SURFACE CONTACT; WILD TYPES;

COVALENT BONDS; ELECTRON TRANSITIONS;

CRYSTAL STRUCTURE;

ARGININE; ASPARAGINE; ASPARTIC ACID; GLYCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME ANALYSIS; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; RAT; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CRYSTALLOGRAPHY, X-RAY; ELECTRON TRANSPORT; FLAVIN MONONUCLEOTIDE; MUTATION, MISSENSE; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS;

EID: 79955543878     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.230532     Document Type: Article

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