Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19237-19247

  Haque, Mohammad Mahfuzul ^a   Fadlalla, Mohammed ^a   Wang, Zhi Qiang ^a,b   Ray, Sougata Sinha ^a   Panda, Koustubh ^c   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b KENT STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALCUTTA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC BEHAVIOR; CITRULLINE; CONSERVED RESIDUES; ELECTRON FLUX; MUTATIONAL EFFECTS; N-O COMPLEXES; NADPH OXIDATION; NITRIC OXIDE SYNTHASES; NITRIC-OXIDE SYNTHASE; NO DISSOCIATION; NO OXIDATION; OXIDE COMPLEXES; OXYGEN REACTIVITY; POINT MUTATIONS; PROTEIN-PROTEIN INTERACTIONS; SUBDOMAIN; WILD TYPES;

ENZYMES; HEMOGLOBIN; NITRIC OXIDE; OXIDATION; OXYGEN; PORPHYRINS;

COMPLEXATION;

ARGININE; ASPARAGINE; CALMODULIN; FLAVINE MONONUCLEOTIDE; GLUTAMIC ACID; HEME; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; MUTANT; NONHUMAN; OXIDATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STEADY STATE; SURFACE CHARGE; WILD TYPE;

BINDING SITES; CALMODULIN; CATALYSIS; FERROUS COMPOUNDS; FLAVIN MONONUCLEOTIDE; FLAVIN-ADENINE DINUCLEOTIDE; HEME; KINETICS; MUTANT PROTEINS; NADP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; OXYGEN; POINT MUTATION; TEMPERATURE; TIME FACTORS;

EID: 67749124524     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.013144     Document Type: Article

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