Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein

Biochemistry

Volumn 45, Issue 41, 2006, Pages 12596-12609

  Konas, David W ^a,b   Takaya, Naoki ^a,c   Sharma, Manisha ^a   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MONTCLAIR STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOSYNTHESIS; CATALYSIS; MUTAGENESIS; NITROGEN OXIDES; REDOX REACTIONS; THERMODYNAMICS;

ELECTRON TRANSFER; FLAVIN REDUCTION; NITRIC OXIDE SYNTHASES (NOS); REDUCTASE;

PROTEINS;

ASPARTIC ACID; CALMODULIN; CYTOCHROME B5 REDUCTASE; CYTOCHROME C OXIDASE; FLAVINE ADENINE NUCLEOTIDE; MUTANT PROTEIN; NEURONAL NITRIC OXIDE SYNTHASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGEN; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SEMIQUINONE; PRIMER DNA; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; NONHUMAN; OXIDATION; PRIORITY JOURNAL; REDUCTION; STRUCTURE ANALYSIS; THERMODYNAMICS; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; IN VITRO STUDY; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; BASE SEQUENCE; CATALYTIC DOMAIN; DNA PRIMERS; ELECTRON TRANSPORT; FLAVIN-ADENINE DINUCLEOTIDE; HYDROGEN BONDING; KINETICS; MUTAGENESIS, SITE-DIRECTED; NADP; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; RATS; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 33750061297     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061011t     Document Type: Article

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