The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain

Journal of Biological Chemistry

Volumn 279, Issue 34, 2004, Pages 35412-35425

  Konas, David W ^a   Zhu, Keng ^b   Sharma, Manisha ^a   Aulak, Kulwant S ^a   Brudvig, Gary W ^b   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; RATE CONSTANTS; REACTION KINETICS; REDUCTION;

FLAVOPROTEINS; NEURONAL NITRIC-OXIDE SYNTHASE (NNOS);

PROTEINS;

AROMATIC AMINO ACID; CALMODULIN; CYTOCHROME C; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; FLAVOPROTEIN; MUTANT PROTEIN; NEURONAL NITRIC OXIDE SYNTHASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMOREACTIVITY; CONFORMATIONAL EQUILIBRIUM; DISSOCIATION; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME REGULATION; ENZYME REPRESSION; PRE STEADY STATE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; REDUCTION KINETICS; STEADY STATE; WILD TYPE;

ANIMALS; CATALYSIS; ELECTRON TRANSPORT; FLAVIN MONONUCLEOTIDE; FLAVIN-ADENINE DINUCLEOTIDE; FLAVOPROTEINS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; NADP; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; RATS;

EID: 4143083758     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400872200     Document Type: Article

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