Deficiency of αb crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction

Free Radical Biology and Medicine

Volumn 53, Issue 5, 2012, Pages 1111-1122

  Dou, Guorui ^a,b   Sreekumar, Parameswaran G ^a   Spee, Christine ^a,c   He, Shikun ^a,c   Ryan, Stephen J ^a,c   Kannan, Ram ^a,c   Hinton, David R ^a,c  

^a DOHENY EYE INSTITUTE   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

B Crystallin; Apoptosis; Endoplasmic reticulum (ER) stress; Mitochondria; Retinal pigment epithelium (RPE)

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; ALPHA B CRYSTALLIN; ALPHA CRYSTALLIN; CASPASE 3; CASPASE 4; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SALUBRINAL; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; TUNICAMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; UPREGULATION;

ALPHA-CRYSTALLIN B CHAIN; ANIMALS; APOPTOSIS; CINNAMATES; ENDOPLASMIC RETICULUM; HUMANS; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATIVE STRESS; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIOUREA;

MUS;

EID: 84865473926     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.06.042     Document Type: Article

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