Mechanism of RPE cell death in α-crystallin deficient mice: A novel and critical role for MRP1-mediated gsh efflux

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Sreekumar, Parameswaran G ^a   Spee, Christine ^a   Ryan, Stephen J ^a,b   Cole, Susan P C ^c   Kannan, Ram ^a,b   Hinton, David R ^a,b  

^a DOHENY EYE INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA B CRYSTALLIN; ALPHA CRYSTALLIN; GLUTAREDOXIN; GLUTAREDOXIN 1; GLUTAREDOXIN 2; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; MULTIDRUG RESISTANCE PROTEIN 1; THIOREDOXIN 1; THIOREDOXIN 2; UNCLASSIFIED DRUG; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CELL MEMBRANE; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PEPTIDE SYNTHESIS; PIGMENT EPITHELIUM; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RETINA; ACTIVE TRANSPORT; ANIMAL; CELL LINE; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY;

MURINAE; MUS;

ALPHA-CRYSTALLINS; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CELL MEMBRANE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; RETINAL PIGMENT EPITHELIUM;

EID: 84858611567     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033420     Document Type: Article

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