Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress

Mitochondrion

Volumn 11, Issue 2, 2011, Pages 279-286

  Ouyang, Yi Bing ^a   Xu, Li Jun ^a   Emery, John F ^a   Lee, Amy S ^b   Giffard, Rona G ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

78kDa glucose regulated protein (GRP78 HSPA5 BiP); Astrocytes; Endoplasmic reticulum; Ischemia; Mitochondria

Indexed keywords

CALCIUM ION; FREE RADICAL; GLUCOSE REGULATED PROTEIN 78;

ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM TRANSPORT; CELL FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ASTROCYTES; CALCIUM; CELLS, CULTURED; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 79251600505     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2010.10.007     Document Type: Article

References (29)

1. Deniaud A., Sharaf El Dein O., Maillier E., Poncet D., Kroemer G., Lemaire C., Brenner C. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 2008, 27(3):285-299.
2. Dong S., Teng Z., Lu F.H., Zhao Y.J., Li H., Ren H., Chen H., Pan Z.W., Lv Y.J., Yang B.F., Tian Y., Xu C.Q., Zhang W.H. Post-conditioning protects cardiomyocytes from apoptosis via PKC(epsilon)-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. Mol. Cell. Biochem. 2010, 341:195-206.
3. Giorgi C., De Stefani D., Bononi A., Rizzuto R., Pinton P. Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int. J. Biochem. Cell Biol. 2009, 41:1817-1827.
4. Hayashi T., Rizzuto R., Hajnoczky G., Su T.P. MAM: more than just a housekeeper. Trends Cell Biol. 2009, 19:81-88.
5. Hetz C.A. ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid. Redox Signal. 2007, 9(12):1345-2355.
6. Hom J.R., Gewandter J.S., Michael L., Sheu S.S., Yoon Y. Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J. Cell. Physiol. 2007, 212:498-508.
7. Kudo T., Kanemoto S., Hara H., Morimoto N., Morihara T., Kimura R., Tabira T., Imaizumi K., Takeda M. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008, 15:364-375.
8. Li J., Ni M., Lee B., Barron E., Hinton D.R., Lee A.S. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ. 2008, 15:1460-1471.
9. Misra U.K., Sharma T., Pizzo S.V. Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. J. Immunol. 2005, 175:2525-2533.
10. Morimoto N., Oida Y., Shimazawa M., Miura M., Kudo T., Imaizumi K., Hara H. Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice. Neuroscience 2007, 147:957-967.
11. Murphy A.N., Bredesen D.E., Cortopassi G., Wang E., Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc. Natl. Acad. Sci. USA 1996, 93:9893-9898.
12. Oida Y., Izuta H., Oyagi A., Shimazawa M., Kudo T., Imaizumi K., Hara H. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 2008, 1208:217-224.
13. Oida Y., Shimazawa M., Imaizumi K., Hara H. Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil. Neuroscience 2008, 151:111-119.
14. Ouyang Y., Kuroda S., Kristian T., Siesjo B.K. Release of mitochondrial aspartate aminotransferase (mAST) following transient focal cerebral ischemia suggests the opening of a mitochondrial permeability transition pore. Neurosci. Res. Commun. 1997, 20:167-173.
15. Ouyang Y.B., Xu L.J., Sun Y.J., Giffard R.G. Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress. Cell Stress Chaperones 2006, 11:180-186.
16. Ouyang Y.B., Voloboueva L.A., Xu L.J., Giffard R.G. Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia. J. Neurosci. 2007, 27:4253-4260.
17. Pandey M., Varghese M., Sindhu K.M., Sreetama S., Navneet A.K., Mohanakumar K.P., Usha R. Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease. J. Neurochem. 2008, 104:420-434.
18. Scorrano L., Oakes S.A., Opferman J.T., Cheng E.H., Sorcinelli M.D., Pozzan T., Korsmeyer S.J. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 2003, 300:135-139.
19. Shu C.W., Sun F.C., Cho J.H., Lin C.C., Liu P.F., Chen P.Y., Chang M.D., Fu H.W., Lai Y.K. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. J. Cell. Physiol. 2008, 215:627-635.
20. Sun F.C., Wei S., Li C.W., Chang Y.S., Chao C.C., Lai Y.K. Localization of GRP78 to mitochondria under the unfolded protein response. Biochem. J. 2006, 396:31-39.
21. Tu H., Nelson O., Bezprozvanny A., Wang Z., Lee S.F., Hao Y.H., Serneels L., De Strooper B., Yu G., Bezprozvanny I. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 2006, 126:981-993.
22. Wang S., Longo F.M., Chen J., Butman M., Graham S.H., Haglid K.G., Sharp F.R. Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia. Neurochem. Int. 1993, 23:575-582.
23. Wang M., Ye R., Barron E., Baumeister P., Mao C., Luo S., Fu Y., Luo B., Dubeau L., Hinton D.R., Lee A.S. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010, 17:488-498.
24. Xu L., Voloboueva L.A., Ouyang Y., Emery J.F., Giffard R.G. Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia. J. Cereb. Blood Flow Metab. 2009, 29:365-374.
25. Xu L., Emery J.F., Ouyang Y.B., Voloboueva L.A., Giffard R.G. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia 2010, 58:1042-1049.
26. Ye, R., Jung, D.Y., Jun, J.Y., Li, J., Luo, S., Ko, H.J., Kim, J.K., Lee, A.S., 2010. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 59, 6-16.
27. Yu Z., Luo H., Fu W., Mattson M.P. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp. Neurol. 1999, 155:302-314.
28. Zeng L., Lu M., Mori K., Luo S., Lee A.S., Zhu Y., Shyy J.Y. ATF6 modulates SREBP2-mediated lipogenesis. EMBO J. 2004, 23:950-958.
29. Zhang, Y., Liu, R., Ni, M., Gill, P., Lee, A. S., 2010. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. J. Biol. Chem. 285, 15065-15075.