Temperature effects on product-quality-related enzymes in batch CHO cell cultures producing recombinant tPA

Biotechnology Progress

Volumn 20, Issue 6, 2004, Pages 1888-1892

  Clark, Kevin J R ^a,b   Chaplin, Frank W R ^c   Harcum, Sarah W ^a  

^a AMRL   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c Oregon State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL GROWTH; CULTURE TEMPERATURE; FIRST-ORDER DECAY; TEMPERATURE PROFILES;

BIOREACTORS; CELL CULTURE; LOW TEMPERATURE EFFECTS; OPTIMIZATION;

ENZYMES;

PEPTIDE HYDROLASE; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CHO CELL; CRICETULUS; CULTURE TECHNIQUE; ENZYME ACTIVATION; ENZYME STABILITY; EVALUATION; HAMSTER; METHODOLOGY; PHYSIOLOGY; TEMPERATURE;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME ACTIVATION; ENZYME STABILITY; PEPTIDE HYDROLASES; RECOMBINANT PROTEINS; TEMPERATURE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 10044236577     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp049951x     Document Type: Article

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