Product and contaminant measurement in bioprocess development by SELDI-MS

Biotechnology Progress

Volumn 26, Issue 3, 2010, Pages 881-887

  Berrill, Alex ^a,b   Ho, Sa V ^b   Bracewell, Daniel G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

ApoA IM; Bioprocess development; E. coli; Process analytical technology; SELDI MS

Indexed keywords

ANALYTICAL APPROACH; ANALYTICAL METHOD; ANALYTICAL PROCESS; APOLIPOPROTEINS; BIOLOGICAL MOLECULE; BIOPROCESS DEVELOPMENT; BIOPROCESSES; CARDIO-VASCULAR DISEASE; COMPLEX MIXTURE; E. COLI; IN-PROCESS; LASER DESORPTION IONIZATION; MASS SPECTROSCOPY; MINIMAL SAMPLE VOLUME; MUTATED GENES; NATURALLY OCCURRING; PHASE DEVELOPMENT; PROCESS ANALYTICAL TECHNOLOGY; PROCESS STEPS; RAPID ANALYSIS; SAMPLE PRETREATMENT; SELDI-MS; SMALL SAMPLES; THERAPEUTIC PROTEIN;

DESORPTION; ESCHERICHIA COLI; MASS SPECTROMETRY;

IMPURITIES;

APOLIPOPROTEIN A1; ESCHERICHIA COLI PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; CHEMISTRY; COMPARATIVE STUDY; ESCHERICHIA COLI; FLOCCULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METHODOLOGY; OXIDATION REDUCTION REACTION; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROCEDURES;

APOLIPOPROTEIN A-I; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLOCCULATION; HUMANS; OXIDATION-REDUCTION; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77954692685     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.376     Document Type: Article

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