Identification and analysis of cation channel homologues in human pathogenic fungi

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Prole, David L ^a   Taylor, Colin W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CATION CHANNEL; CCH1 PROTEIN; FUNGAL PROTEIN; LIGAND GATED ION CHANNEL; MITOCHONDRIAL CALCIUM UNIPORTER; POTASSIUM CHANNEL; SODIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; ASPERGILLUS; ASPERGILLUS CLAVATUS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; BLASTOMYCES DERMATITIDIS; CANDIDA ALBICANS; CELL MEMBRANE; COCCIDIOIDES IMMITIS; COCCIDIOIDES POSADASII; CRYPTOCOCCUS; CRYPTOCOCCUS GATTII; CRYPTOCOCCUS NEOFORMANS; DRUG TARGETING; FUNGAL GENE; FUNGAL GENOME; FUNGUS; GENETIC CODE; HISTOPLASMA CAPSULATUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PARACOCCIDIOIDES BRASILIENSIS; PROTEIN ANALYSIS; PROTEIN SUBUNIT; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SPECIES COMPARISON; TRICHOPHYTON RUBRUM; UNINDEXED SEQUENCE;

AMINO ACID SEQUENCE; CALCIUM CHANNELS; CATIONS; FUNGI; HUMANS; ION CHANNELS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PHYLOGENY; POTASSIUM CHANNELS; SEQUENCE ALIGNMENT; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

ANIMALIA; ASPERGILLUS; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 84864433653     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042404     Document Type: Article

References (156)

1. Gullo A, ((2009)) Invasive fungal infections: the challenge continues. Drugs 69 Suppl 1: 65--73.
2. Faguy DM, ((2011)) Fungal pathogens: an overview. Radiol Technol 82:: 321--340.
3. Havlickova B, Czaika VA, Friedrich M, ((2008)) Epidemiological trends in skin mycoses worldwide. Mycoses 51 Suppl 4: 2--15.
4. Miceli MH, Diaz JA, Lee SA, ((2011)) Emerging opportunistic yeast infections. Lancet Infect Dis 11:: 142--151.
5. Hedayati MT, Pasqualotto AC, Warn PA, Bowyer P, Denning DW, ((2007)) Aspergillus flavus: human pathogen, allergen and mycotoxin producer. Microbiology 153:: 1677--1692.
6. Marr KA, Patterson T, Denning D, ((2002)) Aspergillosis. Pathogenesis, clinical manifestations, and therapy. Infect Dis Clin North Am 16:: 875--894.
7. Agarwal R, ((2009)) Allergic bronchopulmonary aspergillosis. Chest 135:: 805--826.
8. Patterson K, Strek ME, ((2010)) Allergic bronchopulmonary aspergillosis. Proc Am Thorac Soc 7:: 237--244.
9. Deus Filho A, ((2009)) Chapter 2: coccidioidomycosis. J Bras Pneumol 35:: 920--930.
10. Borchers AT, Gershwin ME, ((2010)) The immune response in Coccidioidomycosis. Autoimmun Rev 10:: 94--102.
11. Brummer E, Castaneda E, Restrepo A, ((1993)) Paracoccidioidomycosis: an update. Clin Microbiol Rev 6:: 89--117.
12. Aide MA, ((2009)) Chapter 4- histoplasmosis. J Bras Pneumol 35:: 1145--1151.
13. Nosanchuk JD, Zancope-Oliveira RM, Hamilton AJ, Guimaraes AJ, ((2012)) Antibody therapy for histoplasmosis. Front Microbiol 3:: 21.
14. Kronstad JW, Attarian R, Cadieux B, Choi J, D'Souza CA, et al. ((2011)) Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box. Nat Rev Microbiol 9:: 193--203.
15. Kozubowski L, Heitman J, ((2012)) Profiling a killer, the development of Cryptococcus neoformans. FEMS Microbiol Rev 36:: 78--94.
16. Chaturvedi V, Chaturvedi S, ((2011)) Cryptococcus gattii: a resurgent fungal pathogen. Trends Microbiol 19:: 564--571.
17. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, et al. ((2009)) Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23:: 525--530.
18. Didier ES, Weiss LM, ((2011)) Microsporidiosis: not just in AIDS patients. Curr Opin Infect Dis 24:: 490--495.
19. Anane S, Attouchi H, ((2010)) Microsporidiosis: epidemiology, clinical data and therapy. Gastroenterol Clin Biol 34:: 450--464.
20. Pfaller MA, ((2012)) Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment. Am J Med 125:: S3--13.
21. Hille B (2001) Ionic Channels of Excitable Membranes. Third Edition. Sunderland, Massachusetts: Sinauer Associates Inc. 814 p.
22. Yu FH, Catterall WA, ((2004)) The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis. Sci STKE 2004:: re15.
23. Dong XP, Wang X, Xu H, ((2010)) TRP channels of intracellular membranes. J Neurochem 113:: 313--328.
24. Kaczorowski GJ, McManus OB, Priest BT, Garcia ML, ((2008)) Ion channels as drug targets: the next GPCRs. J Gen Physiol 131:: 399--405.
25. Wulff H, Castle NA, Pardo LA, ((2009)) Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov 8:: 982--1001.
26. Alexander SP, Mathie A, Peters JA, ((2011)) Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164 Suppl 1: S1--324.
27. Moran MM, McAlexander MA, Biro T, Szallasi A, ((2011)) Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 10:: 601--620.
28. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, et al. ((2011)) Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476:: 341--345.
29. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R, ((2011)) A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476:: 336--340.
30. Thompson AJ, Lummis SC, ((2007)) The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets 11:: 527--540.
31. Jarvis MF, Khakh BS, ((2009)) ATP-gated P2X cation-channels. Neuropharmacology 56:: 208--215.
32. Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, et al. ((2010)) Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 62:: 405--496.
33. Albuquerque EX, Pereira EF, Alkondon M, Rogers SW, ((2009)) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89:: 73--120.
34. Ketchum KA, Joiner WJ, Sellers AJ, Kaczmarek LK, Goldstein SA, ((1995)) A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376:: 690--695.
35. Zhou XL, Vaillant B, Loukin SH, Kung C, Saimi Y, ((1995)) YKC1 encodes the depolarization-activated K+ channel in the plasma membrane of yeast. FEBS Lett 373:: 170--176.
36. Paidhungat M, Garrett S, ((1997)) A homolog of mammalian, voltage-gated calcium channels mediates yeast pheromone-stimulated Ca2+ uptake and exacerbates the cdc1(Ts) growth defect. Mol Cell Biol 17:: 6339--6347.
37. Fischer M, Schnell N, Chattaway J, Davies P, Dixon G, et al. ((1997)) The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating. FEBS Lett 419:: 259--262.
38. Palmer CP, Zhou XL, Lin J, Loukin SH, Kung C, et al. ((2001)) A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca2+-permeable channel in the yeast vacuolar membrane. Proc Natl Acad Sci U S A 98:: 7801--7805.
39. Denis V, Cyert MS, ((2002)) Internal Ca2+ release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue. J Cell Biol 156:: 29--34.
40. Baev D, Rivetta A, Li XS, Vylkova S, Bashi E, et al. ((2003)) Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1. Infect Immun 71:: 3251--3260.
41. Roberts SK, ((2003)) TOK homologue in Neurospora crassa: first cloning and functional characterization of an ion channel in a filamentous fungus. Eukaryot Cell 2:: 181--190.
42. Lew RR, Nasserifar S, ((2009)) Transient responses during hyperosmotic shock in the filamentous fungus Neurospora crassa. Microbiol. 155:: 903--11.
43. Cai X, Clapham DE, ((2012)) Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol 29:: 91--100.
44. Bencina M, Bagar T, Lah L, Krasevec N, ((2009)) A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species. Fungal Genet Biol 46 Suppl 1: S93--S104.
45. Liu M, Du P, Heinrich G, Cox GM, Gelli A, ((2006)) Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. Eukaryot Cell 5:: 1788--1796.
46. Cai X, ((2012)) P2X receptor homologs in basal fungi. Purinergic Signal 8:: 11--13.
47. Kozubowski L, Lee SC, Heitman J, ((2009)) Signalling pathways in the pathogenesis of Cryptococcus. Cell Microbiol 11:: 370--380.
48. Cunningham KW, ((2011)) Acidic calcium stores of Saccharomyces cerevisiae. Cell Calcium 50:: 129--138.
49. Silverman-Gavrila LB, Lew RR, ((2002)) An IP3-activated Ca2+ channel regulates fungal tip growth. J. Cell Sci. 115:: 5013--5025.
50. Belde PJ, Vossen JH, Borst-Pauwels GW, Theuvenet AP, ((1993)) Inositol 1,4,5-trisphosphate releases Ca2+ from vacuolar membrane vesicles of Saccharomyces cerevisiae. FEBS Lett 323:: 113--118.
51. Cornelius G, Gebauer G, Techel D, ((1989)) Inositol trisphosphate induces calcium release from Neurospora crassa vacuoles. Biochem Biophys Res Commun 162:: 852--856.
52. Calvert CM, Sanders D, ((1995)) Inositol trisphosphate-dependent and-independent Ca2+ mobilization pathways at the vacuolar membrane of Candida albicans. J Biol Chem 270:: 7272--7280.
53. Peyretaillade E, El Alaoui H, Diogon M, Polonais V, Parisot N, et al. ((2011)) Extreme reduction and compaction of microsporidian genomes. Res Microbiol 162:: 598--606.
54. Salkoff L, Jegla T, ((1995)) Surfing the DNA databases for K+ channels nets yet more diversity.Neuron. 15:: 489--492.
55. Goldstein SA, Wang KW, Ilan N, Pausch MH, ((1998)) Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. J Mol Med (Berl) 76:: 13--20.
56. Miller C, ((2000)) An overview of the potassium channel family. Genome Biol 1:: REVIEWS0004.
57. Enyedi P, Czirjak G, ((2010)) Molecular background of leak K+ currents: two-pore domain potassium channels. Physiol Rev 90:: 559--605.
58. Prole DL, Marrion NV, ((2012)) Identification of putative potassium channel homologues in pathogenic protozoa. PLoS One 7:: e32264.
59. Miller AN, Long SB, ((2012)) Crystal structure of the human two-pore domain potassium channel K2P1. Science 335:: 432--436.
60. Brohawn SG, del Marmol J, MacKinnon R, ((2012)) Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science 335:: 436--441.
61. Roller A, Natura G, Bihler H, Slayman CL, Eing C, et al. ((2005)) In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance. Pflugers Arch 451:: 362--370.
62. Bertl A, Ramos J, Ludwig J, Lichtenberg-Frate H, Reid J, et al. ((2003)) Characterization of potassium transport in wild-type and isogenic yeast strains carrying all combinations of trk1, trk2 and tok1 null mutations. Mol Microbiol 47:: 767--780.
63. Maresova L, Urbankova E, Gaskova D, Sychrova H, ((2006)) Measurements of plasma membrane potential changes in Saccharomyces cerevisiae cells reveal the importance of the Tok1 channel in membrane potential maintenance. FEMS Yeast Res 6:: 1039--1046.
64. Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, et al. ((1996)) A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties. J Biol Chem 271:: 4183--4187.
65. Bertl A, Bihler H, Reid JD, Kettner C, Slayman CL, ((1998)) Physiological characterization of the yeast plasma membrane outward rectifying K+ channel, DUK1 (TOK1), in situ. J Membr Biol 162:: 67--80.
66. Loukin SH, Saimi Y, ((1999)) K+-dependent composite gating of the yeast K+ channel, Tok1. Biophys J 77:: 3060--3070.
67. Papazian DM, Timpe LC, Jan YN, Jan LY, ((1991)) Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature 349:: 305--310.
68. Liman ER, Hess P, Weaver F, Koren G, ((1991)) Voltage-sensing residues in the S4 region of a mammalian K+ channel. Nature 353:: 752--756.
69. del Camino D, Holmgren M, Liu Y, Yellen G, ((2000)) Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature 403:: 321--325.
70. Webster SM, Del Camino D, Dekker JP, Yellen G, ((2004)) Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges. Nature 428:: 864--868.
71. Long SB, Campbell EB, Mackinnon R, ((2005)) Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309:: 903--908.
72. Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, et al. ((1998)) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:: 69--77.
73. Yellen G, ((2002)) The voltage-gated potassium channels and their relatives. 419:: 35--42.
74. Schachtman DP, Schroeder JI, Lucas WJ, Anderson JA, Gaber RF, ((1992)) Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA. 258:: 1654--8.
75. Sesti F, Rajan S, Gonzalez-Colaso R, Nikolaeva N, Goldstein SA, ((2003)) Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel. Nat Neurosci 6:: 353--61.
76. Mannikko R, Elinder F, Larsson HP, ((2002)) Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages. Nature 419:: 837--41.
77. VanderHeyden N, McLaughlin GL, Docampo R, ((2000)) Regulation of the plasma membrane potential in Pneumocystis carinii. FEMS Microbiol Lett 183:: 327--330.
78. Slayman CL, ((1965)) Electrical properties of Neurospora crassa. Effects of external cations on the intracellular potential. J Gen Physiol 49:: 69--92.
79. Ermolayeva E, Sanders D, ((1995)) Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol 61:: 3385--3390.
80. Vacata V, Kotyk A, Sigler K, ((1981)) Membrane potentials in yeast cells measured by direct and indirect methods. Biochim Biophys Acta 643:: 265--268.
81. Slayman CL, Slayman CW, ((1962)) Measurement of membrane potentials in Neurospora. Science 136:: 876--877.
82. Slayman CL, Long WS, Gradmann D, ((1976)) "Action potentials" in Neurospora crassa, a mycelial fungus. Biochim Biophys Acta 426:: 732--744.
83. Szewczyk A, Jarmuszkiewicz W, Kunz WS, ((2009)) Mitochondrial potassium channels. IUBMB Life 61:: 134--143.
84. Ng KE, Schwarzer S, Duchen MR, Tinker A, ((2010)) The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1. J Membr Biol 234:: 137--147.
85. Geng X, Li L, Watkins S, Robbins PD, Drain P, ((2003)) The insulin secretory granule is the major site of KATP channels of the endocrine pancreas. Diabetes 52:: 767--776.
86. Mazzanti M, DeFelice LJ, Cohn J, Malter H, ((1990)) Ion channels in the nuclear envelope. Nature 343:: 764--767.
87. Quesada I, Rovira JM, Martin F, Roche E, Nadal A, et al. ((2002)) Nuclear KATP channels trigger nuclear Ca2+ transients that modulate nuclear function. Proc Natl Acad Sci U S A 99:: 9544--9549.
88. Yamashita M, Sugioka M, Ogawa Y, ((2006)) Voltage- and Ca2+-activated potassium channels in Ca2+ store control Ca2+ release. FEBS J 273:: 3585--3597.
89. Chen Y, Sanchez A, Rubio ME, Kohl T, Pardo LA, et al. ((2011)) Functional Kv10.1 channels localize to the inner nuclear membrane. PLoS One 6:: e19257.
90. Bao L, Hadjiolova K, Coetzee WA, Rindler MJ, ((2011)) Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits. Am J Physiol Heart Circ Physiol 300:: H262--270.
91. Gobert A, Isayenkov S, Voelker C, Czempinski K, Maathuis FJ, ((2007)) The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis. Proc Natl Acad Sci U S A 104:: 10726--10731.
92. Kuo MM, Haynes WJ, Loukin SH, Kung C, Saimi Y, ((2005)) Prokaryotic K+ channels: from crystal structures to diversity. FEMS Microbiol Rev 29:: 961--85.
93. Loukin SH, Kuo MM, Zhou XL, Haynes WJ, Kung C, et al. ((2005)) Microbial K+ channels. J Gen Physiol 125:: 521--7.
94. Ward JM, Maser P, Schroeder JI, ((2009)) Plant ion channels: gene families, physiology, and functional genomics analyses. Annu Rev Physiol 71:: 59--82.
95. Gajdanowicz P, Michard E, Sandmann M, Rocha M, Correa LG, et al. ((2011)) Potassium K+ gradients serve as a mobile energy source in plant vascular tissues. Proc Natl Acad Sci U S A 108:: 864--9.
96. Remillard CV, Yuan JX, ((2004)) Activation of K+ channels: an essential pathway in programmed cell death. Am J Physiol Lung Cell Mol Physiol 286:: L49--67.
97. Martin DC, Kim H, Mackin NA, Maldonado-Baez L, Evangelista CC Jr, et al. ((2011)) New regulators of a high affinity Ca2+ influx system revealed through a genome-wide screen in yeast. J Biol Chem 286:: 10744--10754.
98. Cibulsky SM, Sather WA, ((2000)) The EEEE locus is the sole high-affinity Ca2+ binding structure in the pore of a voltage-gated Ca2+ channel: block by Ca2+ entering from the intracellular pore entrance. J Gen Physiol 116:: 349--362.
99. Catterall WA, ((2000)) Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 16:: 521--555.
100. Verret F, Wheeler G, Taylor AR, Farnham G, Brownlee C, ((2010)) Calcium channels in photosynthetic eukaryotes: implications for evolution of calcium-based signalling. New Phytol 187:: 23--43.
101. Wheeler GL, Brownlee C, ((2008)) Ca2+ signalling in plants and green algae- changing channels. Trends Plant Sci 13:: 506--14.
102. Parekh AB, Putney JW Jr, ((2005)) Store-operated calcium channels. Physiol Rev 85:: 757--810.
103. Iida H, Nakamura H, Ono T, Okumura MS, Anraku Y, ((1994)) MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating. Mol Cell Biol 14:: 8259--8271.
104. Locke EG, Bonilla M, Liang L, Takita Y, Cunningham KW, ((2000)) A homolog of voltage-gated Ca2+ channels stimulated by depletion of secretory Ca2+ in yeast. Mol Cell Biol 20:: 6686--6694.
105. Hong MP, Vu K, Bautos J, Gelli A, ((2010)) Cch1 restores intracellular Ca2+ in fungal cells during endoplasmic reticulum stress. J Biol Chem 285:: 10951--10958.
106. Bormann J, Tudzynski P, ((2009)) Deletion of Mid1, a putative stretch-activated calcium channel in Claviceps purpurea, affects vegetative growth, cell wall synthesis and virulence. Microbiology 155:: 3922--3933.
107. Cavinder B, Hamam A, Lew RR, Trail F, ((2011)) Mid1, a mechanosensitive calcium ion channel, affects growth, development, and ascopore discharge in the filamentous fungus Gibberella zeae. Eukaryot. Cell 10:: 832--41.
108. Peiter E, Fischer M, Sidaway K, Roberts SK, Sanders D, ((2005)) The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity. FEBS Lett 579:: 5697--5703.
109. Brand A, Lee K, Veses V, Gow NA, ((2009)) Calcium homeostasis is required for contact-dependent helical and sinusoidal tip growth in Candida albicans hyphae. Mol Microbiol 71:: 1155--1164.
110. Uribe S, Rangel P, Pardo JP, ((1992)) Interactions of calcium with yeast mitochondria. Cell Calcium 13:: 211--217.
111. Claros MG, Vincens P, ((1996)) Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur J Biochem 241:: 779--786.
112. Wang H, Xu Z, Gao L, Hao B, ((2009)) A fungal phylogeny based on 82 complete genomes using the composition vector method. BMC Evol Biol 9:: 195.
113. Fungal Genome Initiative (2012) Broad Institute of Harvard and MIT (2012) http://www.broadinstitute.org/scientific-community/science/projects/fungal-genome-initiative/fungal-genome-initiative.
114. Docampo R, Lukes J, ((2012)) Trypanosomes and the solution to a 50-year mitochondrial calcium mystery. Trends Parasitol 28:: 31--37.
115. Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, et al. ((2010)) MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake. Nature 467:: 291--296.
116. Montell C, ((2005)) The TRP superfamily of cation channels. Sci STKE 2005:: re3.
117. Su Z, Zhou X, Loukin SH, Saimi Y, Kung C, ((2009)) Mechanical force and cytoplasmic Ca2+ activate yeast TRPY1 in parallel. J Membr Biol 227:: 141--150.
118. Dong XP, Shen D, Wang X, Dawson T, Li X, et al. ((2010)) PI(3,5)P2 Controls Membrane Traffic by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome. Nat Commun 1:: 38.
119. Su Z, Anishkin A, Kung C, Saimi Y, ((2011)) The core domain as the force sensor of the yeast mechanosensitive TRP channel. J Gen Physiol 138:: 627--640.
120. LaPlante JM, Falardeau J, Sun M, Kanazirska M, Brown EM, et al. ((2002)) Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Lett 532:: 183--187.
121. Dong XP, Cheng X, Mills E, Delling M, Wang F, et al. ((2008)) The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature 455:: 992--996.
122. Kiselyov K, Colletti GA, Terwilliger A, Ketchum K, Lyons CW, et al. ((2011)) TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium 50:: 288--294.
123. Taylor CW, Prole DL, Rahman T, ((2009)) Ca2+ channels on the move. Biochemistry 48:: 12062--12080.
124. Gees M, Colsoul B, Nilius B, ((2010)) The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol 2:: a003962.
125. Zhang YQ, Rao R, ((2010)) Beyond ergosterol: linking pH to antifungal mechanisms. Virulence 1:: 551--554.
126. Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, et al. ((2012)) Amphotericin primarily kills yeast by simply binding ergosterol. Proc Natl Acad Sci U S A 109:: 2234--2239.
127. Hill K, McNulty S, Randall AD, ((2004)) Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol 370:: 227--237.
128. Meseguer V, Karashima Y, Talavera K, D'Hoedt D, Donovan-Rodriguez T, et al. ((2008)) Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J Neurosci 28:: 576--586.
129. Alvarez J, Montero M, Garcia-Sancho J, ((1992)) High affinity inhibition of Ca2+-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem 267:: 11789--11793.
130. Tian M, Dong MQ, Chiu SW, Lau CP, Li GR, ((2006)) Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents. Br J Pharmacol 147:: 289--297.
131. Thomas GP, Karmazyn M, Zygmunt AC, Antzelevitch C, Narayanan N, ((1999)) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br J Pharmacol 126:: 1531--1533.
132. Loukin SH, Lin J, Athar U, Palmer C, Saimi Y, ((2002)) The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel. Proc Natl Acad Sci U S A 99:: 1926--1930.
133. Ahmed A, Sesti F, Ilan N, Shih TM, Sturley SL, et al. ((1999)) A molecular target for viral killer toxin: TOK1 potassium channels. Cell 99:: 283--291.
134. Xu T, Feng Q, Jacob MR, Avula B, Mask MM, et al. ((2011)) The marine sponge-derived polyketide endoperoxide plakortide F acid mediates its antifungal activity by interfering with calcium homeostasis. Antimicrob Agents Chemother 55:: 1611--1621.
135. Binder U, Chu M, Read ND, Marx F, ((2010)) The antifungal activity of the Penicillium chrysogenum protein PAF disrupts calcium homeostasis in Neurospora crassa. Eukaryot Cell 9:: 1374--1382.
136. Rodrigues AA, Pina-Vaz C, Mardh PA, Martinez-de-Oliveira J, Freitas-da-Fonseca A, ((2000)) Inhibition of germ tube formation by Candida albicans by local anesthetics: an effect related to ionic channel blockade. Curr Microbiol 40:: 145--148.
137. Inoue I, Seishima M, Osada K, Kitajima Y, ((1996)) Different effects of azole-antifungal agents on the regulation of intracellular calcium concentration of Trichophyton rubrum. J Dermatol Sci 12:: 156--162.
138. Kaur R, Castano I, Cormack BP, ((2004)) Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: roles of calcium signaling and mitochondria. Antimicrob Agents Chemother 48:: 1600--1613.
139. Peterson BZ, Tanada TN, Catterall WA, ((1996)) Molecular determinants of high affinity dihydropyridine binding in L-type calcium channels. J Biol Chem 271:: 5293--5296.
140. Kraus R, Reichl B, Kimball SD, Grabner M, Murphy BJ, et al. ((1996)) Identification of benz(othi)azepine-binding regions within L-type calcium channel α1 subunits. J Biol Chem 271:: 20113--20118.
141. Striessnig J, Glossmann H, Catterall WA, ((1990)) Identification of a phenylalkylamine binding region within the α1 subunit of skeletal muscle Ca2+ channels. Proc Natl Acad Sci U S A 87:: 9108--9112.
142. McDonough SI, Boland LM, Mintz IM, Bean BP, ((2002)) Interactions among toxins that inhibit N-type and P-type calcium channels. J Gen Physiol 119:: 313--328.
143. Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J, ((2005)) International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 57:: 411--425.
144. Lupetti A, Brouwer CP, Dogterom-Ballering HE, Senesi S, Campa M, et al. ((2004)) Release of calcium from intracellular stores and subsequent uptake by mitochondria are essential for the candidacidal activity of an N-terminal peptide of human lactoferrin. J Antimicrob Chemother 54:: 603--608.
145. Sanglard D, Ischer F, Bille J, ((2001)) Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata. Antimicrob Agents Chemother 45:: 1174--1183.
146. Shingu-Vazquez M, Traven A, ((2011)) Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy. Eukaryot Cell 10:: 1376--1383.
147. Hallstrom TC, Moye-Rowley WS, ((2000)) Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J Biol Chem 275:: 37347--37356.
148. Matlib MA, Zhou Z, Knight S, Ahmed S, Choi KM, et al. ((1998)) Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem 273:: 10223--10231.
149. John Haynes W, Zhou XL, Su ZW, Loukin SH, Saimi Y, et al. ((2008)) Indole and other aromatic compounds activate the yeast TRPY1 channel. FEBS Lett 582:: 1514--1518.
150. Origins of Multicellularity Sequencing Project and Fungal Genome Initiative, Broad Institute of Harvard and MIT (2012) http://www.broadinstitute.org.
151. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, et al. ((2005)) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438:: 1151--1156.
152. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, et al. ((2004)) The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A 101:: 7329--7334.
153. Akiyoshi DE, Morrison HG, Lei S, Feng X, Zhang Q, et al. ((2009)) Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi. PLoS Pathog 5:: e1000261.
154. Prole DL, Taylor CW, ((2011)) Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites. PLoS One 6:: e26218.
155. Bernsel A, Viklund H, Hennerdal A, Elofsson A, ((2009)) TOPCONS: consensus prediction of membrane protein topology. Nucleic Acids Res 37:: W465--468.
156. Dereeper A, Guignon V, Blanc G, Audic S, Buffet S, et al. ((2008)) Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res 36:: W465--469.