Identification of putative potassium channel homologues in pathogenic protozoa

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Prole, David L ^a   Marrion, Neil V ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; ARTICLE; BABESIA BOVIS; CHANNEL GATING; CONTROLLED STUDY; CRYPTOSPORIDIUM HOMINIS; CRYPTOSPORIDIUM MURIS; CRYPTOSPORIDIUM PARVUM; ENTAMOEBA HISTOLYTICA; GENE SEQUENCE; GENETIC VARIABILITY; GENOMICS; GIARDIA LAMBLIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; MARKER GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PLASMODIUM KNOWLESI; PLASMODIUM VIVAX; POTASSIUM CHANNEL GENE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN TARGETING; PROTOZOAL GENETICS; SEQUENCE HOMOLOGY; TOXOPLASMA GONDII; TRICHOMONAS VAGINALIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LEISHMANIA; METABOLISM; MOLECULAR GENETICS; PARASITE; PROTEIN SUBUNIT; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; TRICHOMONAS;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; LEISHMANIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PARASITES; POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRICHOMONAS;

EID: 84857377666     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032264     Document Type: Article

References (149)

1. Wiser MF, (2011) Protozoa and Human disease New York Garland Science.
2. Prole DL, Taylor CW, (2011) Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites. PLoS One 6 (10): e26218.
3. Castillo E, Dea-Ayuela MA, Bolás-Fernández F, Rangel M, González-Rosende ME, (2010) The kinetoplastid chemotherapy revisited: current drugs, recent advances and future perspectives. Curr Med Chem 17: 4027-4051.
4. Monzote L, Siddiq A, (2011) Drug development to protozoan diseases. Open Med Chem J 5: 1-3.
5. Petersen I, Eastman R, Lanzer M, (2011) Drug-resistant malaria: molecular mechanisms and implications for public health. FEBS Lett 585: 1551-1562.
6. Miller C, (2000) An overview of the potassium channel family. Genome Biol 1 (4): REVIEWS0004.
7. Kuo MM, Haynes WJ, Loukin SH, Kung C, Saimi Y, (2005) Prokaryotic K+ channels: from crystal structures to diversity. FEMS Microbiol Rev 29: 961-985.
8. Ward JM, Maser P, Schroeder JI, (2009) Plant ion channels: gene families, physiology, and functional genomics analyses. Annu Rev Physiol 71: 59-82.
9. Gajdanowicz P, Michard E, Sandmann M, Rocha M, Corrêa LG, et al. (2011) Potassium (K+) gradients serve as a mobile energy source in plant vascular tissues. Proc Natl Acad Sci U S A 108: 864-869.
10. Roberts SK, (2003) TOK homologue in Neurospora crassa: first cloning and functional characterization of an ion channel in a filamentous fungus. Eukaryot Cell 2: 181-190.
11. Ahmed A, Sesti F, Ilan N, Shih TM, Sturley SL, et al. (1999) A molecular target for viral killer toxin: TOK1 potassium channels. Cell 99: 283-291.
12. Loukin SH, Kuo MM, Zhou XL, Haynes WJ, Kung C, et al. (2005) Microbial K+ channels. J Gen Physiol 125: 521-527.
13. Haynes WJ, Ling KY, Saimi Y, Kung C, (2003) PAK paradox: Paramecium appears to have more K+-channel genes than humans. Eukaryot Cell 2: 737-745.
14. Ellekvist P, Ricke CH, Litman T, Salanti A, Colding H, et al. (2004) Molecular cloning of a K+ channel from the malaria parasite Plasmodium falciparum. Biochem Biophys Res Commun 318: 477-484.
15. Waller KL, McBride SM, Kim K, McDonald TV, (2008) Characterization of two putative potassium channels in Plasmodium falciparum. Malar J 7: 19.
16. Ellekvist P, Maciel J, Mlambo G, Ricke CH, Colding H, et al. (2008) Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption. Proc Natl Acad Sci U S A 105: 6398-6402.
17. Jimenez V, Henriquez M, Galanti N, Riquelme G, (2011) Electrophysiological characterization of potassium conductive pathways in Trypanosoma cruzi. J Cell Biochem 112: 1093-1102.
18. Goldstein SA, Wang KW, Ilan N, Pausch MH, (1998) Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. J Mol Med (Berl) 76: 13-20.
19. Mangubat EZ, Tseng TT, Jakobsson E, (2003) Phylogenetic analyses of potassium channel auxiliary subunits. J Mol Microbiol Biotechnol 5: 216-224.
20. Pongs O, Schwarz JR, (2010) Ancillary subunits associated with voltage-dependent K+ channels. Physiol Rev 90: 755-796.
21. Campomanes CR, Carroll KI, Manganas LN, Hershberger ME, Gong B, et al. (2002) Kvβ subunit oxidoreductase activity and Kv1 potassium channel trafficking. J Biol Chem 277: 8298-8305.
22. Rodrigo GC, Standen NB, (2005) ATP-sensitive potassium channels. Curr Pharm Des 11: 1915-1940.
23. Jarmuszkiewicz W, Matkovic K, Koszela-Piotrowska I, (2010) Potassium channels in the mitochondria of unicellular eukaryotes and plants. FEBS Lett 584: 2057-2062.
24. Szewczyk A, Jarmuszkiewicz W, Kunz WS, (2009) Mitochondrial potassium channels. IUBMB Life 61: 134-143.
25. Mazzanti M, DeFelice LJ, Cohn J, Malter H, (1990) Ion channels in the nuclear envelope. Nature 343: 764-767.
26. Quesada I, Rovira JM, Martin F, Roche E, Nadal A, et al. (2002) Nuclear KATP channels trigger nuclear Ca2+ transients that modulate nuclear function. Proc Natl Acad Sci U S A 99: 9544-9549.
27. Yamashita M, Sugioka M, Ogawa Y, (2006) Voltage- and Ca2+-activated potassium channels in Ca2+ store control Ca2+ release. FEBS J 273: 3585-3597.
28. Chen Y, Sánchez A, Rubio ME, Kohl T, Pardo LA, et al. (2011) Functional Kv10.1 channels localize to the inner nuclear membrane. PLoS One 6 (5): e19257.
29. Bao L, Hadjiolova K, Coetzee WA, Rindler MJ, (2011) Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits. Am J Physiol Heart Circ Physiol 300: H262-70.
30. Ng KE, Schwarzer S, Duchen MR, Tinker A, (2010) The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1. J Membr Biol 234: 137-147.
31. Geng X, Li L, Watkins S, Robbins PD, Drain P, (2003) The insulin secretory granule is the major site of KATP channels of the endocrine pancreas. Diabetes 52: 767-776.
32. Kelly ML, Abu-Hamdah R, Jeremic A, Cho SJ, Ilie AE, et al. (2005) Patch clamped single pancreatic zymogen granules: direct measurements of ion channel activities at the granule membrane. Pancreatology 5: 443-449.
33. Ward JM, Schroeder JI, (1994) Calcium-Activated K+ Channels and Calcium-Induced Calcium Release by Slow Vacuolar Ion Channels in Guard Cell Vacuoles Implicated in the Control of Stomatal Closure. Plant Cell 6: 669-683.
34. Isayenkov S, Isner JC, Maathuis FJ, (2011) Rice two-pore K+ channels are expressed in different types of vacuoles. Plant Cell 23: 756-768.
35. Gobert A, Isayenkov S, Voelker C, Czempinski K, Maathuis FJ, (2007) The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis. Proc Natl Acad Sci U S A 104: 10726-10731.
36. Remillard CV, Yuan JX, (2004) Activation of K+ channels: an essential pathway in programmed cell death. Am J Physiol Lung Cell Mol Physiol 286: L49-67.
37. Waller KL, Kim K, McDonald TV, (2008) Plasmodium falciparum: growth response to potassium channel blocking compounds. Exp Parasitol 120: 280-285.
38. Gardner MJ, Hall N, Fung E, White O, Berriman M, et al. (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419: 498-511.
39. Gardner MJ, Shallom SJ, Carlton JM, Salzberg SL, Nene V, (2002) Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Nature 419: 531-534.
40. Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, et al. (2008) Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 455: 757-763.
41. Lorenzi H, Caler E, Galinsky K, Schobel S, Brunk BP, et al. (2008) Annotation of Toxoplasma gondii ME49. EMBL/GenBank/DDBJ databases.
42. Xu P, Widmer G, Wang Y, Ozaki LS, Alves JM, et al. (2004) The genome of Cryptosporidium hominis. Nature 431: 1107-1112.
43. Bankier AT, Spriggs HF, Fartmann B, Konfortov BA, Madera M, et al. (2003) Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum. Genome Res 13: 1787-1799.
44. Abrahamsen MS, Templeton TJ, Enomoto S, Abrahante JE, Zhu G, et al. (2004) Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science 304: 441-445.
45. Brayton KA, Lau AO, Herndon DR, Hannick L, Kappmeyer LS, et al. (2007) Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa. PLoS Pathog 3 (10): 1401-1413.
46. Laurentino EC, Ruiz JC, Fazelinia G, Myler PJ, Degrave W, et al. (2004) A survey of Leishmania braziliensis genome by shotgun sequencing. Mol Biochem Parasitol 137: 81-86.
47. Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, et al. (2005) The genome of the kinetoplastid parasite, Leishmania major. Science 309: 436-442.
48. Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, et al. (2007) Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet 39: 839-847.
49. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, et al. (2005) The genome of the African trypanosome Trypanosoma brucei. Science 309: 416-422.
50. El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, et al. (2005) Comparative genomics of trypanosomatid parasitic protozoa. Science 309: 404-409.
51. Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, et al. (2005) The genome of the protist parasite Entamoeba histolytica. Nature 433: 865-868.
52. Franzén O, Jerlström-Hultqvist J, Castro E, Sherwood E, Ankarklev J, et al. (2009) Draft genome sequencing of Giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species? PLoS Pathog 5 (8): e1000560.
53. Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, et al. (2007) Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science 317: 1921-1926.
54. McArthur AG, Morrison HG, Nixon JE, Passamaneck NQ, Kim U, et al. (2000) The Giardia genome project database. FEMS Microbiol Lett 189: 271-273.
55. Jerlström-Hultqvist J, Franzén O, Ankarklev J, Xu F, Nohýnková E, et al. (2010) Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate. BMC Genomics 11: 543.
56. Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, et al. (2007) Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science 315: 207-212.
57. Heginbotham L, Lu Z, Abramson T, MacKinnon R, (1994) Mutations in the K+ channel signature sequence. Biophys J 66: 1061-1067.
58. Shealy RT, Murphy AD, Ramarathnam R, Jakobsson E, Subramaniam S, (2003) Sequence-function analysis of the K+-selective family of ion channels using a comprehensive alignment and the KcsA channel structure. Biophys J 84: 2929-2942.
59. So I, Ashmole I, Davies NW, Sutcliffe MJ, Stanfield PR, (2001) The K+ channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity. J Physiol 531: 37-50.
60. Yellen G, (2002) The voltage-gated potassium channels and their relatives. Nature 419: 35-42.
61. Salkoff L, Butler A, Ferreira G, Santi C, Wei A, (2006) High-conductance potassium channels of the SLO family. Nat Rev Neurosci 7: 921-931.
62. Wu Y, Yang Y, Ye S, Jiang Y, (2010) Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel. Nature 466: 393-397.
63. Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R, (2010) Structure of the human BK channel Ca2+-activation apparatus at 3.0 Å resolution. Science 329: 182-186.
64. Schumacher MA, Crum M, Miller MC, (2004) Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Structure 12: 849-860.
65. Zagotta WN, Olivier NB, Black KD, Young EC, Olson R, et al. (2003) Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425: 200-205.
66. Kirsch GE, Pascual JM, Shieh CC, (1995) Functional role of a conserved aspartate in the external mouth of voltage-gated potassium channels. Biophys J 68: 1804-1813.
67. Haug T, Olcese R, Toro L, Stefani E, (2004) Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect. J Gen Physiol 124: 173-184.
68. Chapman ML, Blanke ML, Krovetz HS, VanDongen AM, (2006) Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel. Pflugers Arch 451: 776-792.
69. Cordero-Morales JF, Cuello LG, Perozo E, (2006) Voltage-dependent gating at the KcsA selectivity filter. Nat Struct Mol Biol 13: 319-322.
70. Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, et al. (2006) Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol 13: 311-318.
71. Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, et al. (2010) Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev 90: 291-366.
72. Kuo MM, Saimi Y, Kung C, (2003) Gain-of-function mutations indicate that Escherichia coli Kch forms a functional K+ conduit in vivo. EMBO J 22: 4049-4058.
73. MacKinnon R, Yellen G, (1990) Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science 250: 276-279.
74. MacKinnon R, Heginbotham L, Abramson T, (1990) Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron 5: 767-771.
75. Heginbotham L, MacKinnon R, (1992) The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron 8: 483-491.
76. Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, et al. (2009) Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. PLoS One 4 (10): e7496.
77. Wulff H, Castle NA, Pardo LA, (2009) Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov 8: 982-1001.
78. Weatherall KL, Goodchild SJ, Jane DE, Marrion NV, (2010) Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol 91: 242-55.
79. Yellen G, Jurman ME, Abramson T, MacKinnon R, (1991) Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science 251: 939-42.
80. Kirsch GE, Shieh CC, Drewe JA, Vener DF, Brown AM, (1993) Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores. Neuron 11: 503-512.
81. Sanguinetti MC, Chen J, Fernandez D, Kamiya K, Mitcheson J, et al. (2005) Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs. Novartis Found Symp 266: 159-166.
82. Mitcheson J, Perry M, Stansfeld P, Sanguinetti MC, Witchel H, et al. (2005) Structural determinants for high-affinity block of hERG potassium channels. Novartis Found Symp 266: 136-150.
83. Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, et al. (2010) RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J 29: 2101-2113.
84. Madeja M, Steffen W, Mesic I, Garic B, Zhorov BS, (2010) Overlapping binding sites of structurally different antiarrhythmics flecainide and propafenone in the subunit interface of potassium channel Kv2.1. J Biol Chem 285: 33898-33905.
85. Zhou Y, Tang QY, Xia XM, Lingle CJ, (2010) Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J Gen Physiol 135: 481-494.
86. Lee US, Cui J, (2010) BK channel activation: structural and functional insights. Trends Neurosci 33: 415-423.
87. Nagamune K, Moreno SN, Chini EN, Sibley LD, (2008) Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem 47: 70-81.
88. Billker O, Lourido S, Sibley LD, (2009) Calcium-dependent signaling and kinases in apicomplexan parasites. Cell Host Microbe 5: 612-22.
89. Weatherall KL, Seutin V, Liégeois JF, Marrion NV, (2011) Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels. Proc Natl Acad Sci U S A 108: 18494-18499.
90. Zhou L, Siegelbaum SA, (2007) Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy. Structure 15: 655-70.
91. Ketchum KA, Joiner WJ, Sellers AJ, Kaczmarek LK, Goldstein SA, (1995) A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376: 690-5.
92. Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, et al. (2009) SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator. Philos Trans R Soc Lond B Biol Sci 364: 257-67.
93. Akrouh A, Halcomb SE, Nichols CG, Sala-Rabanal M, (2009) Molecular biology of KATP channels and implications for health and disease. IUBMB Life 61: 971-8.
94. Aurrecoechea C, Heiges M, Wang H, Wang Z, Fischer S, et al. (2007) ApiDB: integrated resources for the apicomplexan bioinformatics resource center. Nucleic Acids Res 35: D427-30.
95. Hirsch RE, Lewis BD, Spalding EP, Sussman MR, (1998) A role for the AKT1 potassium channel in plant nutrition. Science 280: 918-21.
96. Fairman C, Zhou X, Kung C, (1999) Potassium uptake through the TOK1 K+ channel in the budding yeast. J Membr Biol 168: 149-57.
97. Latorre R, Olcese R, Basso C, Gonzalez C, Munoz F, et al. (2003) Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1. J Gen Physiol 122: 459-69.
98. Schachtman DP, Schroeder JI, Lucas WJ, Anderson JA, Gaber RF, (1992) Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA. Science 258: 1654-8.
99. Sesti F, Rajan S, Gonzalez-Colaso R, Nikolaeva N, Goldstein SA, (2003) Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel. Nat Neurosci 6: 353-61.
100. Hille B, (1992) Ionic Channels of Excitable Membranes. Second Edition Sunderland, Massachusetts Sinauer Associates Inc.
101. Dunn MJ, (1969) Alterations of red blood cell sodium transport during malarial infection. J Clin Invest 48: 674-84.
102. Ginsburg H, Handeli S, Friedman S, Gorodetsky R, Krugliak M, (1986) Effects of red blood cell potassium and hypertonicity on the growth of Plasmodium falciparum in culture. Z Parasitenkd 72: 185-99.
103. Lee P, Ye Z, Van Dyke K, Kirk RG, (1988) X-ray microanalysis of Plasmodium falciparum and infected red blood cells: effects of qinghaosu and chloroquine on potassium, sodium, and phosphorus composition. Am J Trop Med Hyg 39: 157-65.
104. Overman RR, (1948) Reversible cellular permeability alterations in disease. In vivo studies on sodium, potassium and chloride concentrations in erythrocytes of the malarious monkey. Am J Physiol 152: 113-21.
105. Mannikko R, Elinder F, Larsson HP, (2002) Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages. Nature 419: 837-41.
106. Allen RJ, Kirk K, (2004) The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum. J Biol Chem 279: 11264-72.
107. Nolan DP, Voorheis HP, (2000) Factors that determine the plasma-membrane potential in bloodstream forms of Trypanosoma brucei. Eur J Biochem 267: 4615-23.
108. Glaser TA, Utz GL, Mukkada AJ, (1992) The plasma membrane electrical gradient (membrane potential) in Leishmania donovani promastigotes and amastigotes. Mol Biochem Parasitol 51: 9-15.
109. Nagamune K, Sibley LD, (2006) Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa. Mol Biol Evol 23: 1613-27.
110. Matsumoto Y, Perry G, Scheibel LW, Aikawa M, (1987) Role of calmodulin in Plasmodium falciparum: implications for erythrocyte invasion by the merozoite. Eur J Cell Biol 45: 36-43.
111. Mazumder S, Mukherjee T, Ghosh J, Ray M, Bhaduri A, (1992) Allosteric modulation of Leishmania donovani plasma membrane Ca2+-ATPase by endogenous calmodulin. J Biol Chem 267: 18440-6.
112. Orfa Rojas M, Wasserman M, (1995) Stage-specific expression of the calmodulin gene in Plasmodium falciparum. J Biochem 118: 1118-23.
113. Bernal RM, Tovar R, Santos JI, Muñoz ML, (1998) Possible role of calmodulin in excystation of Giardia lamblia. Parasitol Res 84: 687-93.
114. Yakubu MA, Majumder S, Kierszenbaum F, (1994) Changes in Trypanosoma cruzi infectivity by treatments that affect calcium ion levels. Mol Biochem Parasitol 66: 119-25.
115. Makioka A, Kumagai M, Kobayashi S, Takeuchi T, (2002) Possible role of calcium ions, calcium channels and calmodulin in excystation and metacystic development of Entamoeba invadens. Parasitol Res 88: 837-43.
116. Song HO, Ahn MH, Ryu JS, Min DY, Joo KH, et al. (2004) Influence of calcium ion on host cell invasion and intracellular replication by Toxoplasma gondii. Korean J Parasitol 42: 185-93.
117. Pezzella N, Bouchot A, Bonhomme A, Pingret L, Klein C, et al. (1997) Involvement of calcium and calmodulin in Toxoplasma gondii tachyzoite invasion. Eur J Cell Biol 74: 92-101.
118. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R, (2008) The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A 105: 376-81.
119. Pau VP, Smith FJ, Taylor AB, Parfenova LV, Samakai E, et al. (2011) Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain. Proc Natl Acad Sci U S A 108: 17684-9.
120. Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, et al. (2007) Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A 104: 18270-5.
121. Cui J, Das S, Smith TF, Samuelson J, (2010) Trichomonas transmembrane cyclases result from massive gene duplication and concomitant development of pseudogenes. PLoS Negl Trop Dis 4: e782.
122. Schultz JE, Klumpp S, Benz R, Schürhoff-Goeters WJ, Schmid A, (1992) Regulation of adenylyl cyclase from Paramecium by an intrinsic potassium conductance. Science 255: 600-3.
123. Muhia DK, Swales CA, Eckstein-Ludwig U, Saran S, Polley SD, et al. (2003) Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J Biol Chem 278: 22014-22.
124. Weber JH, Vishnyakov A, Hambach K, Schultz A, Schultz JE, et al. (2004) Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins. Cell Signal 16: 115-25.
125. Ono T, Cabrita-Santos L, Leitao R, Bettiol E, Purcell LA, et al. (2008) Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. PLoS Pathog 4: e1000008.
126. Burg ED, Remillard CV, Yuan JX, (2006) K+ channels in apoptosis. J Membr Biol 209: 3-20.
127. Leung YM, (2010) Voltage-gated K+ channel modulators as neuroprotective agents. Life Sci 86: 775-80.
128. Rodriguez-Menchaca AA, Navarro-Polanco RA, Ferrer-Villada T, Rupp J, Sachse FB, et al. (2008) The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A 105: 1364-8.
129. Foley M, Tilley L, (1998) Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents. Pharmacol Ther 79: 55-87.
130. de Boer TP, Nalos L, Stary A, Kok B, Houtman MJ, et al. (2010) The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel. Br J Pharmacol 159: 1532-41.
131. Serrano-Martin X, Payares G, Mendoza-Leon A, (2006) Glibenclamide, a blocker of K+ATP channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis. Antimicrob Agents Chemother 50: 4214-6.
132. Serrano-Martin X, García-Marchan Y, Fernandez A, Rodriguez N, Rojas H, et al. (2009) Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana. Antimicrob Agents Chemother 53: 1403-10.
133. Evans SG, Havlik I, (1993) Plasmodium falciparum: effects of amantadine, an antiviral, on chloroquine-resistant and-sensitive parasites in vitro and its influence on chloroquine activity. Biochem Pharmacol 45: 1168-70.
134. Khawaled R, Bruening-Wright A, Adelman JP, Maylie J, (1999) Bicuculline block of small-conductance calcium-activated potassium channels. Pflugers Arch 438: 314-21.
135. Rossokhin A, Teodorescu G, Grissmer S, Zhorov BS, (2006) Interaction of d-tubocurarine with potassium channels: molecular modeling and ligand binding. Mol Pharmacol 69: 1356-65.
136. Martin RJ, Buxton SK, Neveu C, Charvet CL, Robertson AP, (2011) Emodepside and SL0-1 potassium channels: A review: Exp Parasitol. In press.
137. Devulder J, (2010) Flupirtine in pain management: pharmacological properties and clinical use. CNS Drugs 24: 867-81.
138. Czuczwar P, Wojtak A, Cioczek-Czuczwar A, Parada-Turska J, Maciejewski R, et al. (2010) Retigabine: the newer potential antiepileptic drug. Pharmacol Rep 62: 211-9.
139. Ishii TM, Maylie J, Adelman JP, (1997) Determinants of apamin and d-tubocurarine block in SK potassium channels. J Biol Chem 272: 23195-200.
140. Lamy C, Goodchild SJ, Weatherall KL, Jane DE, Liégeois JF, et al. (2010) Allosteric block of KCa2 channels by apamin. J Biol Chem 285: 27067-77.
141. Bernsel A, Viklund H, Hennerdal A, Elofsson A, (2009) TOPCONS: consensus prediction of membrane protein topology. Nucleic Acids Res 37: W465-8.
142. Dereeper A, Guignon V, Blanc G, Audic S, Buffet S, et al. (2008) Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res 36: W465-9.
143. Yap KL, Kim J, Truong K, Sherman M, Yuan T, et al. (2000) Calmodulin target database. J Struct Funct Genomics 1: 8-14.
144. Adamczak R, Porollo A, Meller J, (2005) Combining prediction of secondary structure and solvent accessibility in proteins. Proteins 59: 467-75.
145. Wallner M, Meera P, Toro L, (1996) Determinant for β-subunit regulation in high-conductance voltage-activated and Ca2+-sensitive K+ channels: an additional transmembrane region at the N terminus. Proc Natl Acad Sci U S A 93: 14922-7.
146. Meera P, Wallner M, Song M, Toro L, (1997) Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc Natl Acad Sci U S A 94: 14066-71.
147. Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R, (2001) Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution. Nature 414: 43-8.
148. Flynn GE, Black KD, Islas LD, Sankaran B, Zagotta WN, (2007) Structure and rearrangements in the carboxy-terminal region of SpIH channels. Structure 15: 671-82.
149. Wallace AC, Laskowski RA, Thornton JM, (1995) LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng 8: 127-34.