Release of calcium from intracellular stores and subsequent uptake by mitochondria are essential for the candidacidal activity of an N-terminal peptide of human lactoferrin

Journal of Antimicrobial Chemotherapy

Volumn 54, Issue 3, 2004, Pages 603-608

  Lupetti, Antonella ^a,b   Brouwer, Carlo P J M ^c   Dogterom Ballering, Heleen E C ^a   Senesi, Sonia ^b   Campa, Mario ^b   van Dissel, Jaap T ^a   Nibbering, Peter H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF PISA   (Italy)

^c AM Pharma   (Netherlands)

Author keywords

Lactoferrin peptide; Mitochondrial Ca2+ uptake; Mitochondrial membrane potential; Reactive oxygen species production

Indexed keywords

CALCIUM 45; CALCIUM CHELATING AGENT; CALCIUM CHLORIDE; CALCIUM ION; DICHLOROFLUORESCEIN; EGTAZIC ACID; FLUCONAZOLE; IONOMYCIN; IONOPHORE; LACTOFERRIN; OXALIC ACID; REACTIVE OXYGEN METABOLITE; RHODAMINE 123; RUTHENIUM RED;

AMINO TERMINAL SEQUENCE; ANTIFUNGAL ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANDIDA ALBICANS; CULTURE MEDIUM; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRECIPITATION; STAINING; STATISTICAL ANALYSIS;

ANTIFUNGAL AGENTS; CALCIUM; CALCIUM CHLORIDE; CALCIUM RADIOISOTOPES; CANDIDA ALBICANS; CHELATING AGENTS; DRUG RESISTANCE, FUNGAL; EGTAZIC ACID; IONOMYCIN; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; MITOCHONDRIA; OXALATES; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES; RUTHENIUM RED;

EID: 4644292546     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh385     Document Type: Article

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