The marine sponge-derived polyketide endoperoxide plakortide F acid mediates its antifungal activity by interfering with calcium homeostasis

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 4, 2011, Pages 1611-1621

  Xu, Tao ^a,d   Feng, Qin ^a   Jacob, Melissa R ^a   Avula, Bharathi ^a   Mask, Melanie M ^c   Baerson, Scott R ^c   Tripathi, Siddharth K ^a   Mohammed, Rabab ^b,e   Hamann, Mark T ^a,b   Khan, Ikhlas A ^a,b   Walker, Larry A ^a,b   Clark, Alice M ^a,b   Agarwal, Ameeta K ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c NATURAL PRODUCTS UTILIZATION RESEARCH UNIT   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e Beni Suef University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; AMPHOTERICIN B; ANTIFUNGAL AGENT; BETA GALACTOSIDASE; CALCINEURIN; CALCIUM CHANNEL; CALCIUM ION; CYCLOSPORIN; ENDOPEROXIDE; PLAKORTIDE F ACID; PROTEIN CCH1; PROTEIN MID1; PROTEIN PMC1; PROTEIN PMR1; TACROLIMUS; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLUS FUMIGATUS; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CANDIDA ALBICANS; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; GENE EXPRESSION; GENE EXPRESSION PROFILING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SPONGE (PORIFERA); WILD TYPE; YEAST CELL;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CALCIUM; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; DIOXANES; HOMEOSTASIS;

EID: 79953173960     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01022-10     Document Type: Article

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