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Volumn 5, Issue 3, 2012, Pages 249-260

Molecular regulation of lymphangiogenesis in development and tumor microenvironment

Author keywords

Lymphangiogenesis; Lymphatic endothelial cell; Tumor metastasis; Tumor microenvironment

Indexed keywords

ANGIOPOIETIN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; PODOPLANIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PROX1; TRANSCRIPTION FACTOR SOX18; UNCLASSIFIED DRUG; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 3;

EID: 84864419163     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-012-0119-6     Document Type: Article
Times cited : (16)

References (164)
  • 1
    • 0037428102 scopus 로고    scopus 로고
    • Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    • Abtahian F, Guerriero A et al (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299(5604):247–251.
    • (2003) Science , vol.299 , Issue.5604 , pp. 247-251
    • Abtahian, F.1    Guerriero, A.2
  • 2
    • 0033082959 scopus 로고    scopus 로고
    • Roles of ephrinB ligands and EphB receptors in cardiovascular development: Demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
    • Adams RH, Wilkinson GA et al (1999) Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 13(3):295–306.
    • (1999) Genes Dev , vol.13 , Issue.3 , pp. 295-306
    • Adams, R.H.1    Wilkinson, G.A.2
  • 3
    • 69949160832 scopus 로고    scopus 로고
    • Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth
    • Albuquerque RJ, Hayashi T et al (2009) Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med 15(9):1023–1030.
    • (2009) Nat Med , vol.15 , Issue.9 , pp. 1023-1030
    • Albuquerque, R.J.1    Hayashi, T.2
  • 4
    • 81255188905 scopus 로고    scopus 로고
    • The lymphatic vasculature in disease
    • Alitalo K (2011) The lymphatic vasculature in disease. Nat Med 17 (11):1371–1380.
    • (2011) Nat Med , vol.17 , Issue.11 , pp. 1371-1380
    • Alitalo, K.1
  • 5
    • 32244443955 scopus 로고    scopus 로고
    • B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    • Angeli V, Ginhoux F et al (2006) B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203–215.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 203-215
    • Angeli, V.1    Ginhoux, F.2
  • 6
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin HG, Young Koh G et al (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 10(3):165–177.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.3 , pp. 165-177
    • Augustin, H.G.1    Young Koh, G.2
  • 7
    • 33846333812 scopus 로고    scopus 로고
    • Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fastinginduced adipose factor
    • Backhed F, Crawford PA et al (2007) Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fastinginduced adipose factor. Proc Natl Acad Sci USA 104(2):606–611.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.2 , pp. 606-611
    • Backhed, F.1    Crawford, P.A.2
  • 8
    • 13844273017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor D is dispensable for development of the lymphatic system
    • Baldwin ME, Halford MM et al (2005) Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol 25(6):2441–2449.
    • (2005) Mol Cell Biol , vol.25 , Issue.6 , pp. 2441-2449
    • Baldwin, M.E.1    Halford, M.M.2
  • 9
    • 20144369085 scopus 로고    scopus 로고
    • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    • Baluk P, Tammela T et al (2005) Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest 115(2):247–257.
    • (2005) J Clin Invest , vol.115 , Issue.2 , pp. 247-257
    • Baluk, P.1    Tammela, T.2
  • 10
    • 34948814992 scopus 로고    scopus 로고
    • Functionally specialized junctions between endothelial cells of lymphatic vessels
    • Baluk P, Fuxe J et al (2007) Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med 204(10):2349– 2362.
    • (2007) J Exp Med 204(10):2349– , pp. 2362
    • Baluk, P.1    Fuxe, J.2
  • 11
    • 70349658714 scopus 로고    scopus 로고
    • TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    • Baluk P, Yao LC et al (2009) TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest 119(10):2954–2964.
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 2954-2964
    • Baluk, P.1    Yao, L.C.2
  • 12
    • 68349105030 scopus 로고    scopus 로고
    • Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    • Bazigou E, Xie S et al (2009) Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell 17(2):175–186.
    • (2009) Dev Cell , vol.17 , Issue.2 , pp. 175-186
    • Bazigou, E.1    Xie, S.2
  • 13
    • 0036494541 scopus 로고    scopus 로고
    • Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer
    • Beasley NJ, Prevo R et al (2002) Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 62 (5):1315–1320.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1315-1320
    • Beasley, N.J.1    Prevo, R.2
  • 14
    • 77952885004 scopus 로고    scopus 로고
    • Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
    • Bertozzi CC, Schmaier AA et al (2010) Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 116(4):661–670.
    • (2010) Blood , vol.116 , Issue.4 , pp. 661-670
    • Bertozzi, C.C.1    Schmaier, A.A.2
  • 15
    • 80052161700 scopus 로고    scopus 로고
    • CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
    • Bos FL, Caunt M et al (2011) CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. Circ Res 109 (5):486–491.
    • (2011) Circ Res , vol.109 , Issue.5 , pp. 486-491
    • Bos, F.L.1    Caunt, M.2
  • 16
    • 0034669139 scopus 로고    scopus 로고
    • Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators
    • Bowles J, Schepers G et al (2000) Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 227(2):239–255.
    • (2000) Dev Biol , vol.227 , Issue.2 , pp. 239-255
    • Bowles, J.1    Schepers, G.2
  • 17
    • 77951296956 scopus 로고    scopus 로고
    • Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis
    • Carramolino L, Fuentes J et al (2010) Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis. Circ Res 106(7):1197–1201.
    • (2010) Circ Res , vol.106 , Issue.7 , pp. 1197-1201
    • Carramolino, L.1    Fuentes, J.2
  • 18
    • 41249088330 scopus 로고    scopus 로고
    • Blocking neuropilin-2 function inhibits tumor cell metastasis
    • Caunt M, Mak J et al (2008) Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell 13(4):331–342.
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 331-342
    • Caunt, M.1    Mak, J.2
  • 19
    • 77951833399 scopus 로고    scopus 로고
    • Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
    • Chen L, Mupo A et al (2010) Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189(3):417–424.
    • (2010) J Cell Biol , vol.189 , Issue.3 , pp. 417-424
    • Chen, L.1    Mupo, A.2
  • 20
    • 84861794046 scopus 로고    scopus 로고
    • Blood flow reprograms lymphatic vessels to blood vessels
    • Chen CY, Bertozzi C et al (2012) Blood flow reprograms lymphatic vessels to blood vessels. J Clin Invest 122(6):2006–2017.
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 2006-2017
    • Chen, C.Y.1    Bertozzi, C.2
  • 21
    • 57049158279 scopus 로고    scopus 로고
    • TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair
    • Clavin NW, Avraham T et al (2008) TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair. Am J Physiol Heart Circ Physiol 295(5):H2113–2127.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.5 , pp. H2113-H2127
    • Clavin, N.W.1    Avraham, T.2
  • 22
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124(2):263–266.
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 23
    • 78549282833 scopus 로고    scopus 로고
    • Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin
    • Cueni LN, Chen L et al (2010) Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood 116(20):4376–4384.
    • (2010) Blood , vol.116 , Issue.20 , pp. 4376-4384
    • Cueni, L.N.1    Chen, L.2
  • 24
    • 46049111407 scopus 로고    scopus 로고
    • Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    • Dellinger M, Hunter R et al (2008) Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol 319(2):309–320.
    • (2008) Dev Biol , vol.319 , Issue.2 , pp. 309-320
    • Dellinger, M.1    Hunter, R.2
  • 25
    • 34247116441 scopus 로고    scopus 로고
    • Physiological roles of PKB/Akt isoforms in development and disease
    • Dummler B, Hemmings BA (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 35(Pt 2):231–235.
    • (2007) Biochem Soc Trans , vol.35 , pp. 231-235
    • Dummler, B.1    Hemmings, B.A.2
  • 26
    • 0032582502 scopus 로고    scopus 로고
    • Cardiovascular failure in mouse embryos deficient in VEGF receptor- 3
    • Dumont DJ, Jussila L et al (1998) Cardiovascular failure in mouse embryos deficient in VEGF receptor- 3. Science 282(5390):946–949.
    • (1998) Science , vol.282 , Issue.5390 , pp. 946-949
    • Dumont, D.J.1    Jussila, L.2
  • 27
    • 80052211625 scopus 로고    scopus 로고
    • Angiopoietin-1 and −2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis
    • Fagiani E, Lorentz P et al (2011) Angiopoietin-1 and −2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis. Cancer Res 71(17):5717–5727.
    • (2011) Cancer Res , vol.71 , Issue.17 , pp. 5717-5727
    • Fagiani, E.1    Lorentz, P.2
  • 28
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF (R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer C, Jonckx B et al (2007) Anti-PlGF inhibits growth of VEGF (R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131(3):463–475.
    • (2007) Cell , vol.131 , Issue.3 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2
  • 29
    • 75649083174 scopus 로고    scopus 로고
    • Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NFkappaB and Prox 1
    • Flister MJ, Wilber A et al (2010) Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NFkappaB and Prox 1. Blood 115(2):418–429.
    • (2010) Blood , vol.115 , Issue.2 , pp. 418-429
    • Flister, M.J.1    Wilber, A.2
  • 30
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • Forster R, Schubel A et al (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99(1):23–33.
    • (1999) Cell , vol.99 , Issue.1 , pp. 23-33
    • Forster, R.1    Schubel, A.2
  • 31
    • 57349142376 scopus 로고    scopus 로고
    • Sox18 induces development of the lymphatic vasculature in mice
    • Francois M, Caprini A et al (2008) Sox18 induces development of the lymphatic vasculature in mice. Nature 456(7222):643–647.
    • (2008) Nature , vol.456 , Issue.7222 , pp. 643-647
    • Francois, M.1    Caprini, A.2
  • 32
    • 55849149808 scopus 로고    scopus 로고
    • Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    • Fu J, Gerhardt H et al (2008) Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest 118(11):3725–3737.
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3725-3737
    • Fu, J.1    Gerhardt, H.2
  • 33
    • 77950279550 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: Novel insights through intravital imaging in pre-clinical models
    • Fukumura D, Duda DG et al (2010) Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation 17(3):206–225.
    • (2010) Microcirculation , vol.17 , Issue.3 , pp. 206-225
    • Fukumura, D.1    Duda, D.G.2
  • 34
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin- 1
    • Gale N, Thurston G et al (2002) Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin- 1. Dev Cell 3(3):411.
    • (2002) Dev Cell , vol.3 , Issue.3 , pp. 411
    • Gale, N.1    Thurston, G.2
  • 35
    • 77955982948 scopus 로고    scopus 로고
    • Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    • Geudens I, Herpers R et al (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler Thromb Vasc Biol 30(9):1695–1702.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.9 , pp. 1695-1702
    • Geudens, I.1    Herpers, R.2
  • 36
    • 78650919021 scopus 로고    scopus 로고
    • Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity
    • Gjini E, Hekking LH et al (2011) Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity. Dis Model Mech 4(1):57–66.
    • (2011) Dis Model Mech , vol.4 , Issue.1 , pp. 57-66
    • Gjini, E.1    Hekking, L.H.2
  • 37
    • 0031892090 scopus 로고    scopus 로고
    • A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
    • Gunn MD, Tangemann K et al (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci USA 95(1):258–263.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.1 , pp. 258-263
    • Gunn, M.D.1    Tangemann, K.2
  • 38
    • 0034554844 scopus 로고    scopus 로고
    • VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis
    • Hamada K, Oike Y et al (2000) VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis. Blood 96(12):3793–3800.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3793-3800
    • Hamada, K.1    Oike, Y.2
  • 39
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 40
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K et al (2002) Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94 (11):819–825.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.11 , pp. 819-825
    • He, Y.1    Kozaki, K.2
  • 41
    • 1242269816 scopus 로고    scopus 로고
    • Role of lymphangiogenic factors in tumor metastasis
    • He Y, Karpanen T et al (2004a) Role of lymphangiogenic factors in tumor metastasis. Biochim Biophys Acta 1654(1):3–12.
    • (2004) Biochim Biophys Acta , vol.1654 , Issue.1 , pp. 3-12
    • He, Y.1    Karpanen, T.2
  • 42
    • 2542512275 scopus 로고    scopus 로고
    • Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
    • He Y, Rajantie I et al (2004b) Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res 64(11):3737–3740.
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3737-3740
    • He, Y.1    Rajantie, I.2
  • 43
    • 21144437844 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    • He Y, Rajantie I et al (2005) Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65(11):4739–4746.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4739-4746
    • He, Y.1    Rajantie, I.2
  • 44
    • 0031571211 scopus 로고    scopus 로고
    • Identification and characterization of a novel beta chemokine containing six conserved cysteines
    • Hedrick JA, Zlotnik A (1997) Identification and characterization of a novel beta chemokine containing six conserved cysteines. J Immunol 159(4):1589–1593.
    • (1997) J Immunol , vol.159 , Issue.4 , pp. 1589-1593
    • Hedrick, J.A.1    Zlotnik, A.2
  • 45
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellstrom M, Kalen M et al (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126(14):3047–3055.
    • (1999) Development , vol.126 , Issue.14 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2
  • 46
    • 34247108244 scopus 로고    scopus 로고
    • Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL- 1, and CD 44
    • Hidalgo A, Peired AJ et al (2007) Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL- 1, and CD 44. Immunity 26(4):477–489.
    • (2007) Immunity , vol.26 , Issue.4 , pp. 477-489
    • Hidalgo, A.1    Peired, A.J.2
  • 47
    • 17144402207 scopus 로고    scopus 로고
    • VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa S, Kodama S et al (2005) VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 201(7):1089–1099.
    • (2005) J Exp Med , vol.201 , Issue.7 , pp. 1089-1099
    • Hirakawa, S.1    Kodama, S.2
  • 48
    • 63449128207 scopus 로고    scopus 로고
    • Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
    • Hogan BM, Bos FL et al (2009) Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nat Genet 41(4):396–398.
    • (2009) Nat Genet , vol.41 , Issue.4 , pp. 396-398
    • Hogan, B.M.1    Bos, F.L.2
  • 49
    • 66349133061 scopus 로고    scopus 로고
    • Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment
    • Holopainen T, Huang H et al (2009) Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 69(11):4656– 4664.
    • (2009) Cancer Res 69(11):4656– , pp. 4664
    • Holopainen, T.1    Huang, H.2
  • 50
    • 84859089030 scopus 로고    scopus 로고
    • Effects of angiopoietin-2- blocking antibody on endothelial cell-cell junctions and lung metastasis
    • Holopainen T, Saharinen P et al (2012) Effects of angiopoietin-2- blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461–475.
    • (2012) J Natl Cancer Inst , vol.104 , Issue.6 , pp. 461-475
    • Holopainen, T.1    Saharinen, P.2
  • 51
    • 0036840138 scopus 로고    scopus 로고
    • Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
    • Hong YK, Harvey N et al (2002) Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn 225 (3):351–357.
    • (2002) Dev Dyn , vol.225 , Issue.3 , pp. 351-357
    • Hong, Y.K.1    Harvey, N.2
  • 52
    • 42749085069 scopus 로고    scopus 로고
    • Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma
    • Horiguchi A, Ito K et al (2008) Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma. Urology 71(5):928–932.
    • (2008) Urology , vol.71 , Issue.5 , pp. 928-932
    • Horiguchi, A.1    Ito, K.2
  • 53
    • 0031571802 scopus 로고    scopus 로고
    • Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension
    • Hromas R, Kim CH et al (1997) Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J Immunol 159(6):2554–2558.
    • (1997) J Immunol , vol.159 , Issue.6 , pp. 2554-2558
    • Hromas, R.1    Kim, C.H.2
  • 54
    • 0041806539 scopus 로고    scopus 로고
    • Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease- 2
    • Hu B, Guo P et al (2003) Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease- 2. Proc Natl Acad Sci USA 100(15):8904–8909.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.15 , pp. 8904-8909
    • Hu, B.1    Guo, P.2
  • 55
    • 31544447172 scopus 로고    scopus 로고
    • Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway
    • Hu B, Jarzynka MJ et al (2006) Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res 66(2):775–783.
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 775-783
    • Hu, B.1    Jarzynka, M.J.2
  • 56
    • 62349108155 scopus 로고    scopus 로고
    • Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice
    • Ichise H, Ichise T et al (2009) Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice. Development 136(2):191–195.
    • (2009) Development , vol.136 , Issue.2 , pp. 191-195
    • Ichise, H.1    Ichise, T.2
  • 57
    • 34249297624 scopus 로고    scopus 로고
    • Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway
    • Imanishi Y, Hu B et al (2007) Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway. Cancer Res 67(9):4254–4263.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4254-4263
    • Imanishi, Y.1    Hu, B.2
  • 58
    • 80051693575 scopus 로고    scopus 로고
    • Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
    • Imanishi Y, Hu B et al (2011) Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. J Biol Chem 286(33):29249–29260.
    • (2011) J Biol Chem , vol.286 , Issue.33 , pp. 29249-29260
    • Imanishi, Y.1    Hu, B.2
  • 59
    • 34249650289 scopus 로고    scopus 로고
    • Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study
    • Irigoyen M, Anso E et al (2007) Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study. Biochim Biophys Acta 1773(6):880–890.
    • (2007) Biochim Biophys Acta , vol.1773 , Issue.6 , pp. 880-890
    • Irigoyen, M.1    Anso, E.2
  • 60
    • 0035886820 scopus 로고    scopus 로고
    • Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium
    • Irjala H, Johansson EL et al (2001) Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium. J Exp Med 194(8):1033–1042.
    • (2001) J Exp Med , vol.194 , Issue.8 , pp. 1033-1042
    • Irjala, H.1    Johansson, E.L.2
  • 61
    • 58249124355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C and CC chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype
    • Issa A, Le TX et al (2009) Vascular endothelial growth factor-C and CC chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype. Cancer Res 69(1):349–357.
    • (2009) Cancer Res , vol.69 , Issue.1 , pp. 349-357
    • Issa, A.1    Le, T.X.2
  • 62
    • 35948974298 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis
    • Iwata C, Kano MR et al (2007) Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis. Cancer Res 67(21):10181–10189.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10181-10189
    • Iwata, C.1    Kano, M.R.2
  • 63
    • 56849101013 scopus 로고    scopus 로고
    • Hematopoietic stem cells contribute to lymphatic endothelium
    • Jiang S, Bailey AS et al (2008) Hematopoietic stem cells contribute to lymphatic endothelium. PLoS One 3(11):e3812.
    • (2008) Plos One , vol.3 , Issue.11
    • Jiang, S.1    Bailey, A.S.2
  • 64
    • 44449119392 scopus 로고    scopus 로고
    • Cell traffic and the lymphatic endothelium
    • Johnson LA, Jackson DG (2008) Cell traffic and the lymphatic endothelium. Ann N Y Acad Sci 1131:119–133.
    • (2008) Ann N Y Acad Sci , vol.1131 , pp. 119-133
    • Johnson, L.A.1    Jackson, D.G.2
  • 65
    • 33751528001 scopus 로고    scopus 로고
    • An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
    • Johnson LA, Clasper S et al (2006) An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med 203(12):2763–2777.
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2763-2777
    • Johnson, L.A.1    Clasper, S.2
  • 66
    • 84864874616 scopus 로고    scopus 로고
    • An Unexpected Role of Semaphorin3A/Neuropilin-1 Signaling in Lymphatic Vessel Maturation and Valve Formation
    • Jurisic G, Maby-El Hajjami H et al (2012) “An Unexpected Role of Semaphorin3A/Neuropilin-1 Signaling in Lymphatic Vessel Maturation and Valve Formation”. Circ Res 2012 Jun 20. doi:10.1161/CIRCRESAHA.112.269399.
    • (2012) Circ Res
    • Jurisic, G.1    Maby-El Hajjami, H.2
  • 67
    • 35348901875 scopus 로고    scopus 로고
    • CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    • Kabashima K, Shiraishi N et al (2007) CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol 171(4):1249–1257.
    • (2007) Am J Pathol , vol.171 , Issue.4 , pp. 1249-1257
    • Kabashima, K.1    Shiraishi, N.2
  • 68
    • 0028938746 scopus 로고
    • Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
    • Kaipainen A, Korhonen J et al (1995) Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 92(8):3566–3570.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.8 , pp. 3566-3570
    • Kaipainen, A.1    Korhonen, J.2
  • 69
    • 79955954437 scopus 로고    scopus 로고
    • Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax
    • Kanady JD, Dellinger MT et al (2011) Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev Biol 354(2):253–266.
    • (2011) Dev Biol , vol.354 , Issue.2 , pp. 253-266
    • Kanady, J.D.1    Dellinger, M.T.2
  • 70
    • 63849230366 scopus 로고    scopus 로고
    • Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages
    • Kang S, Lee SP et al (2009) Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages. Blood 113(11):2605–2613.
    • (2009) Blood , vol.113 , Issue.11 , pp. 2605-2613
    • Kang, S.1    Lee, S.P.2
  • 71
    • 0034041161 scopus 로고    scopus 로고
    • Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
    • Karkkainen MJ, Ferrell RE et al (2000) Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nat Genet 25 (2):153–159.
    • (2000) Nat Genet , vol.25 , Issue.2 , pp. 153-159
    • Karkkainen, M.J.1    Ferrell, R.E.2
  • 72
    • 0035940403 scopus 로고    scopus 로고
    • A model for gene therapy of human hereditary lymphedema
    • Karkkainen MJ, Saaristo A et al (2001) A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci USA 98 (22):12677–12682.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.22 , pp. 12677-12682
    • Karkkainen, M.J.1    Saaristo, A.2
  • 73
    • 9144236286 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    • Karkkainen MJ, Haiko P et al (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5(1):74–80.
    • (2004) Nat Immunol , vol.5 , Issue.1 , pp. 74-80
    • Karkkainen, M.J.1    Haiko, P.2
  • 74
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • Karpanen T, Egeblad M et al (2001) Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 61(5):1786–1790.
    • (2001) Cancer Res , vol.61 , Issue.5 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2
  • 75
    • 33746503288 scopus 로고    scopus 로고
    • Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
    • Karpanen T, Heckman CA et al (2006) Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J 20 (9):1462–1472.
    • (2006) FASEB J , vol.20 , Issue.9 , pp. 1462-1472
    • Karpanen, T.1    Heckman, C.A.2
  • 76
    • 67049167170 scopus 로고    scopus 로고
    • Critical role of CD11b+macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution
    • Kataru RP, Jung K et al (2009) Critical role of CD11b+macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood 113(22):5650–5659.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5650-5659
    • Kataru, R.P.1    Jung, K.2
  • 77
    • 78751688024 scopus 로고    scopus 로고
    • T lymphocytes negatively regulate lymph node lymphatic vessel formation
    • Kataru RP, Kim H et al (2011) T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity 34(1):96–107.
    • (2011) Immunity , vol.34 , Issue.1 , pp. 96-107
    • Kataru, R.P.1    Kim, H.2
  • 78
    • 84863012056 scopus 로고    scopus 로고
    • Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature
    • Kazenwadel J, Secker GA et al (2012) “Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature”. Blood 119(5):1283–1291.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1283-1291
    • Kazenwadel, J.1    Secker, G.A.2
  • 79
    • 24644501637 scopus 로고    scopus 로고
    • The crucial role of macrophages in lymphangiogenesis
    • Kerjaschki D (2005) The crucial role of macrophages in lymphangiogenesis. J Clin Invest 115(9):2316–2319.
    • (2005) J Clin Invest , vol.115 , Issue.9 , pp. 2316-2319
    • Kerjaschki, D.1
  • 80
    • 10744229023 scopus 로고    scopus 로고
    • Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates
    • Kerjaschki D, Regele HM et al (2004) Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol 15(3):603–612.
    • (2004) J am Soc Nephrol , vol.15 , Issue.3 , pp. 603-612
    • Kerjaschki, D.1    Regele, H.M.2
  • 81
    • 0006677050 scopus 로고    scopus 로고
    • Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway
    • Kim I, Kim HG et al (2000) Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway. Circ Res 86(1):24–29.
    • (2000) Circ Res , vol.86 , Issue.1 , pp. 24-29
    • Kim, I.1    Kim, H.G.2
  • 82
    • 77953926282 scopus 로고    scopus 로고
    • Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature
    • Kim H, Nguyen VP et al (2010a) Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol 10:72.
    • (2010) BMC Dev Biol , vol.10 , pp. 72
    • Kim, H.1    Nguyen, V.P.2
  • 83
    • 78650315639 scopus 로고    scopus 로고
    • CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche
    • Kim M, Koh YJ et al (2010b) CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res 70(24):10411–10421.
    • (2010) Cancer Res , vol.70 , Issue.24 , pp. 10411-10421
    • Kim, M.1    Koh, Y.J.2
  • 84
    • 84862648524 scopus 로고    scopus 로고
    • Regulation and implications of inflammatory lymphangiogenesis
    • Kim H, Kataru RP et al (2012) Regulation and implications of inflammatory lymphangiogenesis. Trends Immunol 33(7):350–356.
    • (2012) Trends Immunol , vol.33 , Issue.7 , pp. 350-356
    • Kim, H.1    Kataru, R.P.2
  • 85
    • 0034192370 scopus 로고    scopus 로고
    • Establishment and characterization of a human lung cancer cell line NCI- H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation
    • Kozaki K, Miyaishi O et al (2000) Establishment and characterization of a human lung cancer cell line NCI- H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation. Cancer Res 60(9):2535–2540.
    • (2000) Cancer Res , vol.60 , Issue.9 , pp. 2535-2540
    • Kozaki, K.1    Miyaishi, O.2
  • 86
    • 0035849792 scopus 로고    scopus 로고
    • Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis
    • Kozaki K, Koshikawa K et al (2001) Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. Oncogene 20 (31):4228–4234.
    • (2001) Oncogene , vol.20 , Issue.31 , pp. 4228-4234
    • Kozaki, K.1    Koshikawa, K.2
  • 87
    • 0035860182 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietin in liver regeneration
    • Kraizer Y, Mawasi N et al (2001) Vascular endothelial growth factor and angiopoietin in liver regeneration. Biochem Biophys Res Commun 287(1):209–215.
    • (2001) Biochem Biophys Res Commun , vol.287 , Issue.1 , pp. 209-215
    • Kraizer, Y.1    Mawasi, N.2
  • 88
    • 0037310399 scopus 로고    scopus 로고
    • Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats
    • Krishnan J, Kirkin V et al (2003) Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res 63(3):713–722.
    • (2003) Cancer Res , vol.63 , Issue.3 , pp. 713-722
    • Krishnan, J.1    Kirkin, V.2
  • 89
    • 33745700696 scopus 로고    scopus 로고
    • Receptor tyrosine kinase EphB4 is a survival factor in breast cancer
    • Kumar SR, Singh J et al (2006) Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol 169(1):279–293.
    • (2006) Am J Pathol , vol.169 , Issue.1 , pp. 279-293
    • Kumar, S.R.1    Singh, J.2
  • 90
    • 84856540111 scopus 로고    scopus 로고
    • RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice
    • Lapinski PE, Kwon S et al (2012) “RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice”. J Clin Invest 122(2):733–747.
    • (2012) J Clin Invest , vol.122 , Issue.2 , pp. 733-747
    • Lapinski, P.E.1    Kwon, S.2
  • 91
    • 37349069359 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    • Ledgerwood LG, Lal G et al (2008) The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol 9(1):42–53.
    • (2008) Nat Immunol , vol.9 , Issue.1 , pp. 42-53
    • Ledgerwood, L.G.1    Lal, G.2
  • 92
    • 74649086696 scopus 로고    scopus 로고
    • Increased intratumoral lymphatic vessel density correlates with lymph node metastasis in early gastric carcinoma
    • Lee K, Park do J et al (2010) Increased intratumoral lymphatic vessel density correlates with lymph node metastasis in early gastric carcinoma. Ann Surg Oncol 17(1):73–80.
    • (2010) Ann Surg Oncol , vol.17 , Issue.1 , pp. 73-80
    • Lee, K.1    Park Do, J.2
  • 93
    • 77951847278 scopus 로고    scopus 로고
    • Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
    • Lin FJ, Chen X et al (2010) Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest 120(5):1694–1707.
    • (2010) J Clin Invest , vol.120 , Issue.5 , pp. 1694-1707
    • Lin, F.J.1    Chen, X.2
  • 94
    • 0033748035 scopus 로고    scopus 로고
    • Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse
    • Luther SA, Tang HL et al (2000) Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc Natl Acad Sci USA 97 (23):12694–12699.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.23 , pp. 12694-12699
    • Luther, S.A.1    Tang, H.L.2
  • 95
    • 0035122695 scopus 로고    scopus 로고
    • Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor- 3
    • Makinen T, Jussila L et al (2001) Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor- 3. Nat Med 7(2):199–205.
    • (2001) Nat Med , vol.7 , Issue.2 , pp. 199-205
    • Makinen, T.1    Jussila, L.2
  • 96
    • 13244292521 scopus 로고    scopus 로고
    • PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    • Makinen T, Adams RH et al (2005) PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 19(3):397–410.
    • (2005) Genes Dev , vol.19 , Issue.3 , pp. 397-410
    • Makinen, T.1    Adams, R.H.2
  • 97
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A, Allavena P et al (2008) Cancer-related inflammation. Nature 454(7203):436–444.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2
  • 98
    • 24644474779 scopus 로고    scopus 로고
    • Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
    • Maruyama K, Ii M et al (2005) Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest 115(9):2363–2372.
    • (2005) J Clin Invest , vol.115 , Issue.9 , pp. 2363-2372
    • Maruyama, K.1    Ii, M.2
  • 99
    • 77950899035 scopus 로고    scopus 로고
    • Transmural flow modulates cell and fluid transport functions of lymphatic endothelium
    • Miteva DO, Rutkowski JM et al (2010) Transmural flow modulates cell and fluid transport functions of lymphatic endothelium. Circ Res 106(5):920–931.
    • (2010) Circ Res , vol.106 , Issue.5 , pp. 920-931
    • Miteva, D.O.1    Rutkowski, J.M.2
  • 100
    • 20444414142 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes LYVE-1- positive lymphatic vessel formation
    • Morisada T, Oike, Y et al (2005) “Angiopoietin-1 promotes LYVE-1- positive lymphatic vessel formation”. Blood 105(12):4649–4656
    • (2005) Blood , vol.105 , Issue.12 , pp. 4649-4656
    • Morisada, T.1    Oike, Y.2
  • 101
    • 70349306570 scopus 로고    scopus 로고
    • Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha
    • Mouta-Bellum C, Kirov A et al (2009) Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn 238(10):2670–2679.
    • (2009) Dev Dyn , vol.238 , Issue.10 , pp. 2670-2679
    • Mouta-Bellum, C.1    Kirov, A.2
  • 102
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A, Homey B et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410(6824):50–56.
    • (2001) Nature , vol.410 , Issue.6824 , pp. 50-56
    • Muller, A.1    Homey, B.2
  • 103
    • 0030876818 scopus 로고    scopus 로고
    • Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p 13
    • Nagira M, Imai T et al (1997) Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p 13. J Biol Chem 272(31):19518–19524.
    • (1997) J Biol Chem , vol.272 , Issue.31 , pp. 19518-19524
    • Nagira, M.1    Imai, T.2
  • 104
    • 77949898210 scopus 로고    scopus 로고
    • ALK1 signaling regulates early postnatal lymphatic vessel development
    • Niessen K, Zhang G et al (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115(8):1654–1661.
    • (2010) Blood , vol.115 , Issue.8 , pp. 1654-1661
    • Niessen, K.1    Zhang, G.2
  • 105
    • 80051877458 scopus 로고    scopus 로고
    • The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development
    • Niessen K, Zhang G et al (2011) The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development. Blood 118 (7):1989–1997.
    • (2011) Blood , vol.118 , Issue.7 , pp. 1989-1997
    • Niessen, K.1    Zhang, G.2
  • 106
    • 77951498501 scopus 로고    scopus 로고
    • VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
    • Nilsson I, Bahram F et al (2010) VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 29(8):1377–1388.
    • (2010) EMBO J , vol.29 , Issue.8 , pp. 1377-1388
    • Nilsson, I.1    Bahram, F.2
  • 107
    • 65649096621 scopus 로고    scopus 로고
    • FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc 1
    • Norrmen C, Ivanov KI et al (2009) FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc 1. J Cell Biol 185(3):439–457.
    • (2009) J Cell Biol , vol.185 , Issue.3 , pp. 439-457
    • Norrmen, C.1    Ivanov, K.I.2
  • 108
    • 79954530514 scopus 로고    scopus 로고
    • Biological basis of therapeutic lymphangiogenesis
    • Norrmen C, Tammela T et al (2011) Biological basis of therapeutic lymphangiogenesis. Circulation 123(12):1335–1351.
    • (2011) Circulation , vol.123 , Issue.12 , pp. 1335-1351
    • Norrmen, C.1    Tammela, T.2
  • 109
    • 47149083462 scopus 로고    scopus 로고
    • Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis
    • Oka M, Iwata C et al (2008) Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood 111(9):4571–4579.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4571-4579
    • Oka, M.1    Iwata, C.2
  • 110
    • 67049114117 scopus 로고    scopus 로고
    • Alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation
    • Okazaki T, Ni A et al (2009) alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation. Am J Pathol 174 (6): 2378–2387.
    • (2009) Am J Pathol , vol.174 , Issue.6 , pp. 2378-2387
    • Okazaki, T.1    Ni, A.2
  • 111
    • 0036208217 scopus 로고    scopus 로고
    • The rediscovery of the lymphatic system: Old and new insights into the development and biological function of the lymphatic vasculature
    • Oliver G, Detmar M (2002) The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev 16(7):773–783.
    • (2002) Genes Dev , vol.16 , Issue.7 , pp. 773-783
    • Oliver, G.1    Detmar, M.2
  • 112
    • 0033846016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing
    • Paavonen K, Puolakkainen P et al (2000) Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol 156(5):1499–1504.
    • (2000) Am J Pathol , vol.156 , Issue.5 , pp. 1499-1504
    • Paavonen, K.1    Puolakkainen, P.2
  • 113
    • 0037036136 scopus 로고    scopus 로고
    • Lymphatic metastasis in the absence of functional intratumor lymphatics
    • Padera TP, Kadambi A et al (2002) Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296 (5574):1883–1886.
    • (2002) Science , vol.296 , Issue.5574 , pp. 1883-1886
    • Padera, T.P.1    Kadambi, A.2
  • 114
    • 0026699255 scopus 로고
    • FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
    • [published erratum appears in Cancer Res 1993 Aug 15;53(16):3845]
    • Pajusola K, Aprelikova O et al (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines [published erratum appears in Cancer Res 1993 Aug 15;53(16):3845]. Cancer Res 52(20):5738–5743.
    • (1992) Cancer Res , vol.52 , Issue.20 , pp. 5738-5743
    • Pajusola, K.1    Aprelikova, O.2
  • 115
    • 0034737422 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
    • Papapetropoulos A, Fulton D et al (2000) Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. J Biol Chem 275(13):9102–9105
    • (2000) J Biol Chem , vol.275 , Issue.13 , pp. 9102-9105
    • Papapetropoulos, A.1    Fulton, D.2
  • 116
    • 0034069877 scopus 로고    scopus 로고
    • Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice
    • Pennisi D, Gardner J et al (2000) Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet 24(4):434–437.
    • (2000) Nat Genet , vol.24 , Issue.4 , pp. 434-437
    • Pennisi, D.1    Gardner, J.2
  • 117
    • 18544386859 scopus 로고    scopus 로고
    • Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
    • Petrova TV, Makinen T et al (2002) Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J 21(17):4593–4599.
    • (2002) EMBO J , vol.21 , Issue.17 , pp. 4593-4599
    • Petrova, T.V.1    Makinen, T.2
  • 118
    • 4644362609 scopus 로고    scopus 로고
    • Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    • Petrova TV, Karpanen T et al (2004) Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med 10(9):974–981.
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 974-981
    • Petrova, T.V.1    Karpanen, T.2
  • 119
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4(1):71–78.
    • (2004) Nat Rev Cancer , vol.4 , Issue.1 , pp. 71-78
    • Pollard, J.W.1
  • 120
    • 10644277784 scopus 로고    scopus 로고
    • Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER- 1)
    • Prevo R, Banerji S et al (2004) Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER- 1). J Biol Chem 279(50):52580–52592.
    • (2004) J Biol Chem , vol.279 , Issue.50 , pp. 52580-52592
    • Prevo, R.1    Banerji, S.2
  • 121
    • 46049109335 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis and melanoma metastasis
    • Rinderknecht M, Detmar M (2008) Tumor lymphangiogenesis and melanoma metastasis. J Cell Physiol 216(2):347–354.
    • (2008) J Cell Physiol , vol.216 , Issue.2 , pp. 347-354
    • Rinderknecht, M.1    Detmar, M.2
  • 122
    • 2642641324 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C
    • Ristimaki A, Narko K et al (1998) Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J Biol Chem 273(14):8413–8418.
    • (1998) J Biol Chem , vol.273 , Issue.14 , pp. 8413-8418
    • Ristimaki, A.1    Narko, K.2
  • 123
    • 33645046619 scopus 로고    scopus 로고
    • Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR- 2
    • Roberts N, Kloos B et al (2006) Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR- 2. Cancer Res 66(5):2650–2657.
    • (2006) Cancer Res , vol.66 , Issue.5 , pp. 2650-2657
    • Roberts, N.1    Kloos, B.2
  • 124
    • 43749106257 scopus 로고    scopus 로고
    • P19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis
    • Ruddell A, Kelly-Spratt KS et al (2008) p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis. Oncogene 27 (22): 3145–3155.
    • (2008) Oncogene , vol.27 , Issue.22 , pp. 3145-3155
    • Ruddell, A.1    Kelly-Spratt, K.S.2
  • 125
    • 8644291673 scopus 로고    scopus 로고
    • Visualization of lymphatic vessels through NF-kappaB activity
    • Saban MR, Memet S et al (2004) Visualization of lymphatic vessels through NF-kappaB activity. Blood 104(10):3228–3230.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3228-3230
    • Saban, M.R.1    Memet, S.2
  • 126
    • 84857026228 scopus 로고    scopus 로고
    • Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    • Sabine A, Agalarov Y et al (2012) “Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation”. Dev Cell 22(2):430–444.
    • (2012) Dev Cell , vol.22 , Issue.2 , pp. 430-444
    • Sabine, A.1    Agalarov, Y.2
  • 127
    • 77951821586 scopus 로고    scopus 로고
    • Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
    • Saharinen P, Helotera H et al (2010) Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev 24(9):875–880.
    • (2010) Genes Dev , vol.24 , Issue.9 , pp. 875-880
    • Saharinen, P.1    Helotera, H.2
  • 128
    • 10244253876 scopus 로고    scopus 로고
    • CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium
    • Salmi M, Koskinen K et al (2004) CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Blood 104(13):3849–3857.
    • (2004) Blood , vol.104 , Issue.13 , pp. 3849-3857
    • Salmi, M.1    Koskinen, K.2
  • 129
    • 0036696817 scopus 로고    scopus 로고
    • Twenty pairs of sox: Extent, homology, and nomenclature of the mouse and human sox transcription factor gene families
    • Schepers GE, Teasdale RD et al (2002) Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 3(2):167–170
    • (2002) Dev Cell , vol.3 , Issue.2 , pp. 167-170
    • Schepers, G.E.1    Teasdale, R.D.2
  • 130
    • 0025076869 scopus 로고
    • Microlymphatics and lymph flow
    • Schmid-Schonbein GW (1990) Microlymphatics and lymph flow. Physiol Rev 70(4):987–1028.
    • (1990) Physiol Rev , vol.70 , Issue.4 , pp. 987-1028
    • Schmid-Schonbein, G.W.1
  • 131
    • 0035149320 scopus 로고    scopus 로고
    • Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer.
    • Schoppmann SF, Birner P et al (2001) “Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer.”. Anticancer Res 21(4A):2351–2355.
    • (2001) Anticancer Res , vol.21 , Issue.4A , pp. 2351-2355
    • Schoppmann, S.F.1    Birner, P.2
  • 132
    • 80053925054 scopus 로고    scopus 로고
    • Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer
    • Schulz P, Fischer C et al (2011) Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer. FASEB J 25(10):3325–3335.
    • (2011) FASEB J , vol.25 , Issue.10 , pp. 3325-3335
    • Schulz, P.1    Fischer, C.2
  • 133
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: Lymphocyte egress from lymphoid organs
    • Schwab SR, Cyster JG (2007) Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 8(12):1295–1301.
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 134
    • 77952231121 scopus 로고    scopus 로고
    • Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL 21
    • Shields JD, Kourtis IC et al (2010) Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL 21. Science 328(5979):749–752.
    • (2010) Science , vol.328 , Issue.5979 , pp. 749-752
    • Shields, J.D.1    Kourtis, I.C.2
  • 135
    • 33947393171 scopus 로고    scopus 로고
    • Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice
    • Shimoda H, Bernas MJ et al (2007) Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice. Cell Tissue Res 328(2):329–337.
    • (2007) Cell Tissue Res , vol.328 , Issue.2 , pp. 329-337
    • Shimoda, H.1    Bernas, M.J.2
  • 136
    • 33845711358 scopus 로고    scopus 로고
    • Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
    • Shiojima I, Walsh K (2006) Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev 20 (24):3347–3365.
    • (2006) Genes Dev , vol.20 , Issue.24 , pp. 3347-3365
    • Shiojima, I.1    Walsh, K.2
  • 137
    • 77954491955 scopus 로고    scopus 로고
    • B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes
    • Shrestha B, Hashiguchi T et al (2010) B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes. J Immunol 184 (9):4819–4826.
    • (2010) J Immunol , vol.184 , Issue.9 , pp. 4819-4826
    • Shrestha, B.1    Hashiguchi, T.2
  • 138
    • 77950469880 scopus 로고    scopus 로고
    • The nuclear hormone receptor Coup- TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells
    • Srinivasan RS, Geng X et al (2010) The nuclear hormone receptor Coup- TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev 24(7):696–707.
    • (2010) Genes Dev , vol.24 , Issue.7 , pp. 696-707
    • Srinivasan, R.S.1    Geng, X.2
  • 139
    • 0036310316 scopus 로고    scopus 로고
    • The role of tumor lymphangiogenesis in metastatic spread
    • Stacker SA, Baldwin ME et al (2002) The role of tumor lymphangiogenesis in metastatic spread. FASEB J 16(9):922–934.
    • (2002) FASEB J , vol.16 , Issue.9 , pp. 922-934
    • Stacker, S.A.1    Baldwin, M.E.2
  • 140
    • 12244287614 scopus 로고    scopus 로고
    • Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma
    • Straume O, Jackson DG et al (2003) Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res 9(1):250–256.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 250-256
    • Straume, O.1    Jackson, D.G.2
  • 141
    • 0030480322 scopus 로고    scopus 로고
    • Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    • Suri C, Jones PF et al (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87 (7):1171–1180
    • (1996) Cell , vol.87 , Issue.7 , pp. 1171-1180
    • Suri, C.1    Jones, P.F.2
  • 142
    • 77955301210 scopus 로고    scopus 로고
    • Essential in vivo roles of the Ctype lectin receptor CLEC-2: Embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets
    • Suzuki-Inoue K, Inoue O et al (2010) “Essential in vivo roles of the Ctype lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets”. J Biol Chem 285(32):24494–24507.
    • (2010) J Biol Chem , vol.285 , Issue.32 , pp. 24494-24507
    • Suzuki-Inoue, K.1    Inoue, O.2
  • 143
    • 0032836105 scopus 로고    scopus 로고
    • Mechanics of interstitiallymphatic fluid transport: Theoretical foundation and experimental validation
    • Swartz MA, Kaipainen A et al (1999) Mechanics of interstitiallymphatic fluid transport: theoretical foundation and experimental validation. J Biomech 32(12):1297–1307.
    • (1999) J Biomech , vol.32 , Issue.12 , pp. 1297-1307
    • Swartz, M.A.1    Kaipainen, A.2
  • 144
    • 20444389049 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
    • Tammela T, Saaristo A et al (2005) Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood 105(12):4642–4648.
    • (2005) Blood , vol.105 , Issue.12 , pp. 4642-4648
    • Tammela, T.1    Saaristo, A.2
  • 145
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela T, Zarkada G et al (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454 (7204):656–660.
    • (2008) Nature , vol.454 , Issue.7204 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2
  • 146
    • 34250165403 scopus 로고    scopus 로고
    • Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling
    • Taniguchi K, Kohno R et al (2007) Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol 27 (12):4541–4550.
    • (2007) Mol Cell Biol , vol.27 , Issue.12 , pp. 4541-4550
    • Taniguchi, K.1    Kohno, R.2
  • 147
    • 76749148097 scopus 로고    scopus 로고
    • Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    • Uhrin P, Zaujec J et al (2010) “Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation”. Blood 115(19):3997–4005
    • (2010) Blood , vol.115 , Issue.19 , pp. 3997-4005
    • Uhrin, P.1    Zaujec, J.2
  • 148
    • 34848868549 scopus 로고    scopus 로고
    • Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node
    • Van den Eynden GG, Vandenberghe MK et al (2007) Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node. Clin Cancer Res 13(18 Pt 1): 5391–5397.
    • (2007) Clin Cancer Res , vol.13 , Issue.18 , pp. 5391-5397
    • Van Den Eynden, G.G.1    Vandenberghe, M.K.2
  • 149
    • 77957682470 scopus 로고    scopus 로고
    • Current views on the function of the lymphatic vasculature in health and disease
    • Wang Y, Oliver G (2010) Current views on the function of the lymphatic vasculature in health and disease. Genes Dev 24(19):2115–2126.
    • (2010) Genes Dev , vol.24 , Issue.19 , pp. 2115-2126
    • Wang, Y.1    Oliver, G.2
  • 150
    • 0032577446 scopus 로고    scopus 로고
    • Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B 4
    • Wang HU, Chen ZF et al (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B 4. Cell 93(5):741–753.
    • (1998) Cell , vol.93 , Issue.5 , pp. 741-753
    • Wang, H.U.1    Chen, Z.F.2
  • 151
    • 77953029002 scopus 로고    scopus 로고
    • Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    • Wang Y, Nakayama M et al (2010) Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465(7297):483–486.
    • (2010) Nature , vol.465 , Issue.7297 , pp. 483-486
    • Wang, Y.1    Nakayama, M.2
  • 152
    • 0033559518 scopus 로고    scopus 로고
    • From head to toes: The multiple facets of Sox proteins
    • Wegner M (1999) From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res 27(6):1409–1420.
    • (1999) Nucleic Acids Res , vol.27 , Issue.6 , pp. 1409-1420
    • Wegner, M.1
  • 153
    • 0033578853 scopus 로고    scopus 로고
    • Prox1 function is required for the development of the murine lymphatic system
    • Wigle JT, Oliver G (1999) Prox1 function is required for the development of the murine lymphatic system. Cell 98(6):769–778.
    • (1999) Cell , vol.98 , Issue.6 , pp. 769-778
    • Wigle, J.T.1    Oliver, G.2
  • 154
    • 0033018615 scopus 로고    scopus 로고
    • Prox1 function is crucial for mouse lens-fibre elongation
    • Wigle JT, Chowdhury K et al (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21(3):318–322.
    • (1999) Nat Genet , vol.21 , Issue.3 , pp. 318-322
    • Wigle, J.T.1    Chowdhury, K.2
  • 155
    • 0037007216 scopus 로고    scopus 로고
    • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    • Wigle JT, Harvey N et al (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 21 (7):1505–1513.
    • (2002) EMBO J , vol.21 , Issue.7 , pp. 1505-1513
    • Wigle, J.T.1    Harvey, N.2
  • 156
    • 0035824083 scopus 로고    scopus 로고
    • Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma
    • Wiley HE, Gonzalez EB et al (2001) Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Natl Cancer Inst 93(21):1638–1643.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.21 , pp. 1638-1643
    • Wiley, H.E.1    Gonzalez, E.B.2
  • 158
    • 0031431276 scopus 로고    scopus 로고
    • TNF-alpha and IL-1 upregulate membrane-bound and soluble E-selectin through a common pathway
    • Wyble CW, Hynes KL et al (1997) TNF-alpha and IL-1 upregulate membrane-bound and soluble E-selectin through a common pathway. J Surg Res 73(2):107–112.
    • (1997) J Surg Res , vol.73 , Issue.2 , pp. 107-112
    • Wyble, C.W.1    Hynes, K.L.2
  • 159
    • 75749124699 scopus 로고    scopus 로고
    • Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR 3
    • Xu Y, Yuan L et al (2010) Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR 3. J Cell Biol 188 (1):115–130.
    • (2010) J Cell Biol , vol.188 , Issue.1 , pp. 115-130
    • Xu, Y.1    Yuan, L.2
  • 160
    • 0036803751 scopus 로고    scopus 로고
    • Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    • Yuan L, Moyon D et al (2002) Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 129(20):4797–4806.
    • (2002) Development , vol.129 , Issue.20 , pp. 4797-4806
    • Yuan, L.1    Moyon, D.2
  • 161
    • 10044287078 scopus 로고    scopus 로고
    • Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta 1
    • Zhang X, Groopman JE et al (2005) Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta 1. J Cell Physiol 202(1):205–214.
    • (2005) J Cell Physiol , vol.202 , Issue.1 , pp. 205-214
    • Zhang, X.1    Groopman, J.E.2
  • 162
    • 78649899926 scopus 로고    scopus 로고
    • VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis
    • Zhang L, Zhou F et al (2010) VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res 20(12):1319–1331.
    • (2010) Cell Res , vol.20 , Issue.12 , pp. 1319-1331
    • Zhang, L.1    Zhou, F.2
  • 163
    • 77957365795 scopus 로고    scopus 로고
    • Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development
    • Zhou F, Chang Z et al (2010) Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol 177(4):2124–2133.
    • (2010) Am J Pathol , vol.177 , Issue.4 , pp. 2124-2133
    • Zhou, F.1    Chang, Z.2
  • 164
    • 70349378298 scopus 로고    scopus 로고
    • Myeloid cells contribute to tumor lymphangiogenesis
    • Zumsteg A, Baeriswyl V et al (2009) Myeloid cells contribute to tumor lymphangiogenesis. PLoS One 4(9):e7067
    • (2009) Plos One , vol.4 , Issue.9
    • Zumsteg, A.1    Baeriswyl, V.2


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