메뉴 건너뛰기




Volumn 20, Issue 12, 2010, Pages 1319-1331

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis

Author keywords

angiogenesis; ligand binding domain; lymphangiogenesis; tyrosine kinase; VEGFR 3

Indexed keywords

LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 78649899926     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.116     Document Type: Article
Times cited : (116)

References (43)
  • 1
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-478.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 2
    • 30744432619 scopus 로고    scopus 로고
    • Endothelial cells and VEGF in vascular development
    • Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature 2005; 438:937-945.
    • (2005) Nature , vol.438 , pp. 937-945
    • Coultas, L.1    Chawengsaksophak, K.2    Rossant, J.3
  • 3
    • 59649110012 scopus 로고    scopus 로고
    • Transcriptional control of endothelial cell development
    • De Val S, Black BL. Transcriptional control of endothelial cell development. Dev Cell 2009; 16:180-195.
    • (2009) Dev Cell , vol.16 , pp. 180-195
    • De Val, S.1    Black, B.L.2
  • 4
    • 0033578853 scopus 로고    scopus 로고
    • Prox1 function is required for the development of the murine lymphatic system
    • Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell 1999; 98:769-778.
    • (1999) Cell , vol.98 , pp. 769-778
    • Wigle, J.T.1    Oliver, G.2
  • 5
    • 0036208217 scopus 로고    scopus 로고
    • The rediscovery of the lymphatic system: Old and new insights into the development and biological function of the lymphatic vasculature
    • Oliver G, Detmar M. The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev 2002; 16:773-783.
    • (2002) Genes Dev , vol.16 , pp. 773-783
    • Oliver, G.1    Detmar, M.2
  • 6
    • 57349142376 scopus 로고    scopus 로고
    • Sox18 induces development of the lymphatic vasculature in mice
    • Francois M, Caprini A, Hosking B, et al. Sox18 induces development of the lymphatic vasculature in mice. Nature 2008; 456:643-647.
    • (2008) Nature , vol.456 , pp. 643-647
    • Francois, M.1    Caprini, A.2    Hosking, B.3
  • 8
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 9
    • 0031011529 scopus 로고    scopus 로고
    • Proteolytic processing regulates receptor specifcity and activity of VEGF-C
    • Joukov V, Sorsa T, Kumar V, et al. Proteolytic processing regulates receptor specifcity and activity of VEGF-C. EMBO J 1997; 16:3898-3911.
    • (1997) EMBO J , vol.16 , pp. 3898-3911
    • Joukov, V.1    Sorsa, T.2    Kumar, V.3
  • 10
    • 0033527634 scopus 로고    scopus 로고
    • Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers
    • Stacker SA, Stenvers K, Caesar C, et al. Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. J Biol Chem 1999; 274:32127-32136.
    • (1999) J Biol Chem , vol.274 , pp. 32127-32136
    • Stacker, S.A.1    Stenvers, K.2    Caesar, C.3
  • 11
    • 33750712397 scopus 로고    scopus 로고
    • MAPping out arteries and veins
    • Lamont RE, Childs S. MAPping out arteries and veins. Sci STKE 2006; 2006:pe39.
    • (2006) Sci STKE
    • Lamont, R.E.1    Childs, S.2
  • 12
    • 0035122695 scopus 로고    scopus 로고
    • Inhibition of lymp-hangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
    • Makinen T, Jussila L, Veikkola T, et al. Inhibition of lymp-hangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med 2001; 7:199-205.
    • (2001) Nat Med , vol.7 , pp. 199-205
    • Makinen, T.1    Jussila, L.2    Veikkola, T.3
  • 13
    • 0034041161 scopus 로고    scopus 로고
    • Missense mutations interfere with VEGFR-3 signalling in primary lym-phoedema
    • Karkkainen MJ, Ferrell RE, Lawrence EC, et al. Missense mutations interfere with VEGFR-3 signalling in primary lym-phoedema. Nat Genet 2000; 25:153-159.
    • (2000) Nat Genet , vol.25 , pp. 153-159
    • Karkkainen, M.J.1    Ferrell, R.E.2    Lawrence, E.C.3
  • 14
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 2002; 94:819-825.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3
  • 15
    • 0028938746 scopus 로고
    • Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
    • Kaipainen A, Korhonen J, Mustonen T, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 1995; 92:3566-3570.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3566-3570
    • Kaipainen, A.1    Korhonen, J.2    Mustonen, T.3
  • 16
    • 0032933883 scopus 로고    scopus 로고
    • VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
    • Valtola R, Salven P, Heikkila P, et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am J Pathol 1999; 154:1381-1390.
    • (1999) Am J Pathol , vol.154 , pp. 1381-1390
    • Valtola, R.1    Salven, P.2    Heikkila, P.3
  • 17
    • 0036897107 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor receptor-3 expression on tumor microvasculature as a new progression marker in human cutaneous melanoma
    • Clarijs R, Schalkwijk L, Hofmann UB, Ruiter DJ, de Waal RM. Induction of vascular endothelial growth factor receptor-3 expression on tumor microvasculature as a new progression marker in human cutaneous melanoma. Cancer Res 2002; 62:7059-7065.
    • (2002) Cancer Res , vol.62 , pp. 7059-7065
    • Clarijs, R.1    Schalkwijk, L.2    Hofmann, U.B.3    Ruiter, D.J.4    De Waal, R.M.5
  • 18
    • 18544393909 scopus 로고    scopus 로고
    • Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis
    • Kubo H, Fujiwara T, Jussila L, et al. Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. Blood 2000; 96:546-553.
    • (2000) Blood , vol.96 , pp. 546-553
    • Kubo, H.1    Fujiwara, T.2    Jussila, L.3
  • 19
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela T, Zarkada G, Wallgard E, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008; 454:656-660.
    • (2008) Nature , vol.454 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2    Wallgard, E.3
  • 20
    • 0032582502 scopus 로고    scopus 로고
    • Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
    • Dumont DJ, Jussila L, Taipale J, et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998; 282:946-949.
    • (1998) Science , vol.282 , pp. 946-949
    • Dumont, D.J.1    Jussila, L.2    Taipale, J.3
  • 21
    • 0034554844 scopus 로고    scopus 로고
    • VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangio-genesis and hematopoiesis
    • Hamada K, Oike Y, Takakura N, et al. VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangio-genesis and hematopoiesis. Blood 2000; 96:3793-3800.
    • (2000) Blood , vol.96 , pp. 3793-3800
    • Hamada, K.1    Oike, Y.2    Takakura, N.3
  • 22
    • 47949083776 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor (VEGF-C) and VEGF-D is not equivalent to VEGFR-3-null in mouse embryos
    • Haiko P, Makinen T, Keskitalo S, et al. Deletion of vascular endothelial growth factor (VEGF-C) and VEGF-D is not equivalent to VEGFR-3-null in mouse embryos. Mol Cell Biol 2008; 28:4843-4850.
    • (2008) Mol Cell Biol , vol.28 , pp. 4843-4850
    • Haiko, P.1    Makinen, T.2    Keskitalo, S.3
  • 23
    • 0030008349 scopus 로고    scopus 로고
    • Effcient in vivo manipulation of mouse genomic sequences at the zygote stage
    • Lakso M, Pichel JG, Gorman JR, et al. Effcient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci USA 1996; 93:5860-5865.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5860-5865
    • Lakso, M.1    Pichel, J.G.2    Gorman, J.R.3
  • 24
    • 0033593793 scopus 로고    scopus 로고
    • LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specifc receptor for hy-aluronan
    • Banerji S, Ni J, Wang SX, et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specifc receptor for hy-aluronan. J Cell Biol 1999; 144:789-801.
    • (1999) J Cell Biol , vol.144 , pp. 789-801
    • Banerji, S.1    Ni, J.2    Wang, S.X.3
  • 25
    • 46949088172 scopus 로고    scopus 로고
    • Expression of the hyaluro-nan receptor LYVE-1 is not restricted to the lymphatic vascu-lature;LYVE-1 is also expressed on embryonic blood vessels
    • Gordon EJ, Gale NW, Harvey NL. Expression of the hyaluro-nan receptor LYVE-1 is not restricted to the lymphatic vascu-lature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn 2008; 237:1901-1909.
    • (2008) Dev Dyn , vol.237 , pp. 1901-1909
    • Gordon, E.J.1    Gale, N.W.2    Harvey, N.L.3
  • 26
    • 0035940403 scopus 로고    scopus 로고
    • A model for gene therapy of human hereditary lymphedema
    • Karkkainen MJ, Saaristo A, Jussila L, et al. A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci USA 2001; 98:12677-12682.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12677-12682
    • Karkkainen, M.J.1    Saaristo, A.2    Jussila, L.3
  • 27
    • 10044287078 scopus 로고    scopus 로고
    • Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1
    • Zhang X, Groopman JE, Wang JF. Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1. J Cell Physiol 2005; 202:205-214.
    • (2005) J Cell Physiol , vol.202 , pp. 205-214
    • Zhang, X.1    Groopman, J.E.2    Wang, J.F.3
  • 28
    • 33746503288 scopus 로고    scopus 로고
    • Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
    • Karpanen T, Heckman CA, Keskitalo S, et al. Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J 2006; 20:1462-1472.
    • (2006) FASEB J , vol.20 , pp. 1462-1472
    • Karpanen, T.1    Heckman, C.A.2    Keskitalo, S.3
  • 29
    • 77951498501 scopus 로고    scopus 로고
    • VEGF receptor 2/-3 het-erodimers detected in situ by proximity ligation on angiogenic sprouts
    • Nilsson I, Bahram F, Li X, et al. VEGF receptor 2/-3 het-erodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 2010; 29:1377-1388.
    • (2010) EMBO J , vol.29 , pp. 1377-1388
    • Nilsson, I.1    Bahram, F.2    Li, X.3
  • 30
    • 9144236286 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C is required for sprouting of the frst lymphatic vessels from embryonic veins
    • Karkkainen MJ, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the frst lymphatic vessels from embryonic veins. Nat Immunol 2004; 5:74-80.
    • (2004) Nat Immunol , vol.5 , pp. 74-80
    • Karkkainen, M.J.1    Haiko, P.2    Sainio, K.3
  • 31
    • 21144437844 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    • He Y, Rajantie I, Pajusola K, et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005; 65:4739-4746.
    • (2005) Cancer Res , vol.65 , pp. 4739-4746
    • He, Y.1    Rajantie, I.2    Pajusola, K.3
  • 32
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is suffcient for normal development and angiogenesis in mice
    • Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lacking the tyrosine kinase domain is suffcient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA 1998; 95:9349-9354.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 33
    • 17044458971 scopus 로고    scopus 로고
    • Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic en-dothelial cells regulates tyrosine phosphorylation sites
    • Dixelius J, Makinen T, Wirzenius M, et al. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic en-dothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 2003; 278:40973-40979.
    • (2003) J Biol Chem , vol.278 , pp. 40973-40979
    • Dixelius, J.1    Makinen, T.2    Wirzenius, M.3
  • 34
    • 0035834793 scopus 로고    scopus 로고
    • Stimulation of beta 1 inte-grin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration
    • Wang JF, Zhang XF, Groopman JE. Stimulation of beta 1 inte-grin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration. J Biol Chem 2001; 276:41950-41957.
    • (2001) J Biol Chem , vol.276 , pp. 41950-41957
    • Wang, J.F.1    Zhang, X.F.2    Groopman, J.E.3
  • 35
    • 77954214925 scopus 로고    scopus 로고
    • Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity
    • Galvagni F, Pennacchini S, Salameh A, et al. Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity. Circ Res 2010; 106:1839-1848.
    • (2010) Circ Res , vol.106 , pp. 1839-1848
    • Galvagni, F.1    Pennacchini, S.2    Salameh, A.3
  • 36
    • 75749124699 scopus 로고    scopus 로고
    • Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3
    • Xu Y, Yuan L, Mak J, et al. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol 2010; 188:115-130.
    • (2010) J Cell Biol , vol.188 , pp. 115-130
    • Xu, Y.1    Yuan, L.2    Mak, J.3
  • 37
    • 0037352031 scopus 로고    scopus 로고
    • A highly effcient recom-bineering-based method for generating conditional knockout mutations
    • Liu P, Jenkins NA, Copeland NG. A highly effcient recom-bineering-based method for generating conditional knockout mutations. Genome Res 2003; 13:476-484.
    • (2003) Genome Res , vol.13 , pp. 476-484
    • Liu, P.1    Jenkins, N.A.2    Copeland, N.G.3
  • 38
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
    • Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 1993; 90:8424-8428.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 39
    • 0034487368 scopus 로고    scopus 로고
    • Widespread recombinase expression using FLPeR (fipper) mice
    • Farley FW, Soriano P, Steffen LS, Dymecki SM. Widespread recombinase expression using FLPeR (fipper) mice. Genesis 2000; 28:106-110.
    • (2000) Genesis , vol.28 , pp. 106-110
    • Farley, F.W.1    Soriano, P.2    Steffen, L.S.3    Dymecki, S.M.4
  • 40
    • 0035266283 scopus 로고    scopus 로고
    • Vascular en-dothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • Karpanen T, Egeblad M, Karkkainen MJ, et al. Vascular en-dothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 2001; 61:1786-1790.
    • (2001) Cancer Res , vol.61 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2    Karkkainen, M.J.3
  • 41
    • 34347217526 scopus 로고    scopus 로고
    • A protocol for isolation and culture of human umbilical vein endothe-lial cells
    • Baudin B, Bruneel A, Bosselut N, Vaubourdolle M. A protocol for isolation and culture of human umbilical vein endothe-lial cells. Nat Protocol 2007; 2:481-485.
    • (2007) Nat Protocol , vol.2 , pp. 481-485
    • Baudin, B.1    Bruneel, A.2    Bosselut, N.3    Vaubourdolle, M.4
  • 42
    • 0035355472 scopus 로고    scopus 로고
    • A single au-tophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
    • Takahashi T, Yamaguchi S, Chida K, Shibuya M. A single au-tophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J 2001; 20:2768-2778.
    • (2001) EMBO J , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 43
    • 34249666193 scopus 로고    scopus 로고
    • Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins
    • Tammela T, He Y, Lyytikka J, et al. Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins. Circ Res 2007; 100:1468-1475.
    • (2007) Circ Res , vol.100 , pp. 1468-1475
    • Tammela, T.1    He, Y.2    Lyytikka, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.