-
1
-
-
0031438047
-
TGF-β signalling from cell embrane to nucleus through SMAD proteins
-
Heldin CH, Miyazono K, ten Dijke P. TGF-β signalling from cell embrane to nucleus through SMAD proteins. Nmature. 1997;390:465-471.
-
(1997)
Nmature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
ten Dijke, P.3
-
2
-
-
0038682002
-
Mechanisms ot TGF-β signaling from cell membrane to the nucleus
-
Shi Y, Massague J. Mechanisms ot TGF-β signaling from cell membrane to the nucleus. Cell. 2003;113:685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
3
-
-
23044466047
-
Specificity and versatility in TGF-β signaling through Smads
-
Feng XH. Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu Rev Cell Dev Biol. 2005;21:659-693.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
4
-
-
30144440059
-
Transforming growth factor-β signal transduction in angiogenesis and vascular disorders
-
Bertolino P, Deckers M, Lebrin F, ten Dijke P Transforming growth factor-β signal transduction in angiogenesis and vascular disorders. Chest. 2005;128:585S-590S.
-
(2005)
Chest
, vol.128
-
-
Bertolino, P.1
Deckers, M.2
Lebrin, F.3
ten Dijke, P.4
-
5
-
-
0029064474
-
Specific binding of endocrine transforming growth factor-β 1 to vascular endothelium
-
Dickson K, Philip A, Warshawsky H, O'Connor McCourt M, Bergeron JJ. Specific binding of endocrine transforming growth factor-β 1 to vascular endothelium. J Clin Invest. 1995;95:2539-2554.
-
(1995)
J Clin Invest
, vol.95
, pp. 2539-2554
-
-
Dickson, K.1
Philip, A.2
Warshawsky, H.3
O'Connor McCourt, M.4
Bergeron, J.J.5
-
6
-
-
0030579203
-
TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
-
Oshima M, Oshima H, Taketo MM. TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol. 1996;179:297-302.
-
(1996)
Dev Biol
, vol.179
, pp. 297-302
-
-
Oshima, M.1
Oshima, H.2
Taketo, M.M.3
-
7
-
-
17744397294
-
Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice
-
Larsson J, Goumans MJ, Sjostrand LJ, et al. Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice. EMBO J. 2001;20:1663-1673.
-
(2001)
EMBO J
, vol.20
, pp. 1663-1673
-
-
Larsson, J.1
Goumans, M.J.2
Sjostrand, L.J.3
-
8
-
-
33847635618
-
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling
-
Kano MR. Bae Y, Iwata C. etal. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling. Proc Natl Acad Sci U S A. 2007;104:3460-3465.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3460-3465
-
-
Kano, M.R.1
Bae, Y.2
Iwata, C.3
-
9
-
-
33745515023
-
Tumour microenvironment. TGF-β: The molecular Jekyll and Hyde of cancer
-
Bierie B, Moses HL. Tumour microenvironment. TGF-β: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer. 2006:6:506-520.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
10
-
-
17744390184
-
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
-
Mandriota SJ, Jussila L Jeltsch M, et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. 2001;20:672-682.
-
(2001)
EMBO J
, vol.20
, pp. 672-682
-
-
Mandriota, S.J.1
Jussila, L.2
Jeltsch, M.3
-
11
-
-
0035126049
-
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
-
Stacker SA, Caesar C, Baldwin ME, etal. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med. 2001;7:186-191.
-
(2001)
Nat Med
, vol.7
, pp. 186-191
-
-
Stacker, S.A.1
Caesar, C.2
Baldwin, M.E.3
-
12
-
-
30544452034
-
Hepatocyte growth factor promotes lymphatic vessel formation and function
-
Kajiya K, Hirakawa S, Ma B, Drinnenberg I, Detmar M. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005;24:2885-2895.
-
(2005)
EMBO J
, vol.24
, pp. 2885-2895
-
-
Kajiya, K.1
Hirakawa, S.2
Ma, B.3
Drinnenberg, I.4
Detmar, M.5
-
13
-
-
5444266254
-
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
-
Cao R, Bjorndahl MA, Religa P, et al. PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell. 2004;6:333-345.
-
(2004)
Cancer Cell
, vol.6
, pp. 333-345
-
-
Cao, R.1
Bjorndahl, M.A.2
Religa, P.3
-
14
-
-
20444389049
-
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
-
Tammela T, Saaristo A, Lohela M, et al. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood. 2005;105:4642-4648.
-
(2005)
Blood
, vol.105
, pp. 4642-4648
-
-
Tammela, T.1
Saaristo, A.2
Lohela, M.3
-
15
-
-
0036745659
-
Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis
-
Veikkola T, Alitalo K. Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis. Dev Cell. 2002;3:302-304.
-
(2002)
Dev Cell
, vol.3
, pp. 302-304
-
-
Veikkola, T.1
Alitalo, K.2
-
16
-
-
31944443701
-
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: A role for FGF signaling in lymphangiogenesis
-
Shin JW, Min M, Larrleu-Lahargue F. et al. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006;17:576-584.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 576-584
-
-
Shin, J.W.1
Min, M.2
Larrleu-Lahargue, F.3
-
17
-
-
0141996422
-
Vascular endothelial growth factor receptor-2: Its unique signaling and specific ligand, VEGF-E
-
Shibuya M. Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. Cancer Sci. 2003;94:751-756.
-
(2003)
Cancer Sci
, vol.94
, pp. 751-756
-
-
Shibuya, M.1
-
18
-
-
11144355004
-
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
-
Cursiefen C, Chen L, Borges LP, et al. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest. 2004;113:1040-1050.
-
(2004)
J Clin Invest
, vol.113
, pp. 1040-1050
-
-
Cursiefen, C.1
Chen, L.2
Borges, L.P.3
-
19
-
-
17744396472
-
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
-
Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. 2001;20:1223-1231.
-
(2001)
EMBO J
, vol.20
, pp. 1223-1231
-
-
Veikkola, T.1
Jussila, L.2
Makinen, T.3
-
20
-
-
9144236286
-
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
-
Karkkainen MJ, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 2004;5:74-80.
-
(2004)
Nat Immunol
, vol.5
, pp. 74-80
-
-
Karkkainen, M.J.1
Haiko, P.2
Sainio, K.3
-
21
-
-
33846688115
-
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
-
Laakkonen P, Waltari M, Holopainen T, et al. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. Cancer Res. 2007;67:593-599.
-
(2007)
Cancer Res
, vol.67
, pp. 593-599
-
-
Laakkonen, P.1
Waltari, M.2
Holopainen, T.3
-
22
-
-
33846857321
-
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
-
Hirakawa S, Brown LF, Kodama S. Paavonen K, Alitalo K, Detmar M. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood. 2007;109:1010-1017.
-
(2007)
Blood
, vol.109
, pp. 1010-1017
-
-
Hirakawa, S.1
Brown, L.F.2
Kodama, S.3
Paavonen, K.4
Alitalo, K.5
Detmar, M.6
-
23
-
-
0346458751
-
Lymphatic vasculature development
-
Oliver G. Lymphatic vasculature development. Nat Rev Immunol. 2004;4:35-45.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 35-45
-
-
Oliver, G.1
-
24
-
-
0033578853
-
Proxl function is required for the development of the murine lymphatic system
-
Wigle JT, Oliver G. Proxl function is required for the development of the murine lymphatic system. Cell. 1999;98:769-778.
-
(1999)
Cell
, vol.98
, pp. 769-778
-
-
Wigle, J.T.1
Oliver, G.2
-
25
-
-
0037007216
-
An essential role for Proxl in the induction of the lymphatic endothelial cell phenotype
-
Wigle JT, Harvey N, Detmar M, etal. An essential role for Proxl in the induction of the lymphatic endothelial cell phenotype. EMBO J. 2002;21:1505-1513.
-
(2002)
EMBO J
, vol.21
, pp. 1505-1513
-
-
Wigle, J.T.1
Harvey, N.2
Detmar, M.3
-
26
-
-
18544386859
-
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
-
Petrova TV, Makinen T Makela TP, et al. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 2002;21:4593-4599.
-
(2002)
EMBO J
, vol.21
, pp. 4593-4599
-
-
Petrova, T.V.1
Makinen, T.2
Makela, T.P.3
-
27
-
-
0036840138
-
Proxl is a master control gene in the program specifying lymphatic endothelial cell fate
-
Hong YK, Harvey N, Noh YH, et al. Proxl is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn. 2002; 225:351-357.
-
(2002)
Dev Dyn
, vol.225
, pp. 351-357
-
-
Hong, Y.K.1
Harvey, N.2
Noh, Y.H.3
-
28
-
-
34247198981
-
Prox1 Induces lymphatic endothelial differentiation via integrin α9 and other signaling cascades
-
Mishima K, Watabe T, Saito A, et al. Prox1 Induces lymphatic endothelial differentiation via integrin α9 and other signaling cascades. Mol Biol Cell. 2007;18:1421-1429.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1421-1429
-
-
Mishima, K.1
Watabe, T.2
Saito, A.3
-
29
-
-
0027321548
-
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
-
Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A. 1993;90:8424-8428.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 8424-8428
-
-
Nagy, A.1
Rossant, J.2
Nagy, R.3
Abramow-Newerly, W.4
Roder, J.C.5
-
30
-
-
15244341029
-
Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells
-
Suzuki H, Watabe T, Kato M, Miyazawa K, Miyazono K. Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Blood. 2005;105:2372-2379.
-
(2005)
Blood
, vol.105
, pp. 2372-2379
-
-
Suzuki, H.1
Watabe, T.2
Kato, M.3
Miyazawa, K.4
Miyazono, K.5
-
31
-
-
0024312217
-
Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β1 precursor
-
Brunner AM, Marquardt H, Malacko AR. Lioubin MN, Purchio AF. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β1 precursor. J Biol Chem. 1989;264:13660-13664.
-
(1989)
J Biol Chem
, vol.264
, pp. 13660-13664
-
-
Brunner, A.M.1
Marquardt, H.2
Malacko, A.R.3
Lioubin, M.N.4
Purchio, A.F.5
-
32
-
-
33646461868
-
Early lymph vessel development from embryonic stem cells
-
Kreuger J, Nilsson I, Kerjaschki D, Petrova T, Alitalo K, Claesson-Welsh L. Early lymph vessel development from embryonic stem cells. Arterioscler Thromb Vasc Biol. 2006;26:1073-1078.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1073-1078
-
-
Kreuger, J.1
Nilsson, I.2
Kerjaschki, D.3
Petrova, T.4
Alitalo, K.5
Claesson-Welsh, L.6
-
33
-
-
31544461226
-
Induction of lymphatic endothelial cell differentiation in embryoid bodies
-
Liersch R, Nay F, Lu L, Detmar M. Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood. 2006:107:1214-1216.
-
(2006)
Blood
, vol.107
, pp. 1214-1216
-
-
Liersch, R.1
Nay, F.2
Lu, L.3
Detmar, M.4
-
34
-
-
14244269759
-
The lymphangiogenic vascular endothelial growth factors VEGF-C and-D are ligands for the integrin α9β1
-
Vlahakis NE, Young BA, Atakilit A, Sheppard D. The lymphangiogenic vascular endothelial growth factors VEGF-C and-D are ligands for the integrin α9β1. J Biol Chem. 2005:280:4544-4552.
-
(2005)
J Biol Chem
, vol.280
, pp. 4544-4552
-
-
Vlahakis, N.E.1
Young, B.A.2
Atakilit, A.3
Sheppard, D.4
-
35
-
-
0037620888
-
Synthesis and activity of new aryland heteroarylsubstituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
-
Sawyer JS, Anderson BD, Beight DW, et al. Synthesis and activity of new aryland heteroarylsubstituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain. J Med Chem. 2003;46:3953-3956.
-
(2003)
J Med Chem
, vol.46
, pp. 3953-3956
-
-
Sawyer, J.S.1
Anderson, B.D.2
Beight, D.W.3
-
36
-
-
0036082554
-
Inhibition of transforming growth factor (TGF)-β 1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542
-
Laping NJ, Grygielko E, Mathur A, et al. Inhibition of transforming growth factor (TGF)-β 1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol Pharmacol. 2002;62:58-64.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 58-64
-
-
Laping, N.J.1
Grygielko, E.2
Mathur, A.3
-
37
-
-
20144369085
-
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
-
Baluk P, Tammela T, Ator E, et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 2005; 115:247-257.
-
(2005)
J Clin Invest
, vol.115
, pp. 247-257
-
-
Baluk, P.1
Tammela, T.2
Ator, E.3
-
38
-
-
0242330126
-
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGF-β/ALK5 signaling
-
Goumans MJ. Valdimarsdottir G, Itoh S, etal. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGF-β/ALK5 signaling. Mol Cell. 2003;12:817-828.
-
(2003)
Mol Cell
, vol.12
, pp. 817-828
-
-
Goumans, M.J.1
Valdimarsdottir, G.2
Itoh, S.3
-
39
-
-
0347363474
-
TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells
-
Watabe T, Nishihara A, Mishima K. et al. TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol. 2003;163:1303-1311.
-
(2003)
J Cell Biol
, vol.163
, pp. 1303-1311
-
-
Watabe, T.1
Nishihara, A.2
Mishima, K.3
-
40
-
-
33846140150
-
Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1
-
Gale NW, Prevo R, Espinosa J, et al. Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1 Mol Cell Biol. 2007;27:595-604.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 595-604
-
-
Gale, N.W.1
Prevo, R.2
Espinosa, J.3
-
41
-
-
10344227188
-
IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells
-
Groger M, Loewe R, Holnthoner W, et al. IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. J Immunol. 2004;173:7161-7169.
-
(2004)
J Immunol
, vol.173
, pp. 7161-7169
-
-
Groger, M.1
Loewe, R.2
Holnthoner, W.3
-
42
-
-
4544388334
-
Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation
-
Carroll PA, Brazeau E, Lagunoff M. Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation. Virology. 2004;328:7-18.
-
(2004)
Virology
, vol.328
, pp. 7-18
-
-
Carroll, P.A.1
Brazeau, E.2
Lagunoff, M.3
-
43
-
-
35948974298
-
Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis
-
Iwata C, Kano MR, Komuro A, et al. Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis. Cancer Res. 2007;67:10181-10189.
-
(2007)
Cancer Res
, vol.67
, pp. 10181-10189
-
-
Iwata, C.1
Kano, M.R.2
Komuro, A.3
-
44
-
-
33751320565
-
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo
-
Ge R, Rajeev V, Ray P, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo. Clin Cancer Res. 2006;12:4315-4330.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4315-4330
-
-
Ge, R.1
Rajeev, V.2
Ray, P.3
-
45
-
-
34848857434
-
Transforming growth factor-β and the immune response: Implications for anticancer therapy
-
Wrzensinski SH, Wan YY, Ravel I RA. Transforming growth factor-β and the immune response: implications for anticancer therapy. Clin Cancer Res. 2007;13:5262-5270.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5262-5270
-
-
Wrzensinski, S.H.1
Wan, Y.Y.2
Ravel, I.R.3
-
46
-
-
36148936760
-
VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes
-
Halin C, Tobler NE, Vigl B, Brown LF, Detmar M. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood. 2007;110:3158-3167.
-
(2007)
Blood
, vol.110
, pp. 3158-3167
-
-
Halin, C.1
Tobler, N.E.2
Vigl, B.3
Brown, L.F.4
Detmar, M.5
-
47
-
-
32244443955
-
B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
-
Angeli V, Ginhoux F, Llodra J, et al. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity. 2006;24:203-215.
-
(2006)
Immunity
, vol.24
, pp. 203-215
-
-
Angeli, V.1
Ginhoux, F.2
Llodra, J.3
|