Intratumoral Lymphatics and Lymphatic Invasion Are Associated with Tumor Aggressiveness and Poor Prognosis in Renal Cell Carcinoma

Urology

Volumn 71, Issue 5, 2008, Pages 928-932

  Horiguchi, Akio ^a   Ito, Keiichi ^a   Sumitomo, Makoto ^a   Kimura, Fumihiro ^a   Asano, Tomohiko ^a   Hayakawa, Masamichi ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; MONOCLONAL ANTIBODY D2-40; PODOPLANIN; TUMOR MARKER;

ADULT; AGED; ANTIGEN RECOGNITION; ARTICLE; CANCER INVASION; CANCER SURVIVAL; CLEAR CELL CARCINOMA; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; UNIVARIATE ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; FEMALE; HUMANS; KIDNEY NEOPLASMS; LYMPHATIC METASTASIS; LYMPHOID TISSUE; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS;

EID: 42749085069     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2007.11.076     Document Type: Article

References (19)

1. Nathanson S.D. Insights into the mechanisms of lymph node metastasis. Cancer 98 (2003) 413-423
2. Stacker S.A., Achen M.G., Jussila L., et al. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2 (2002) 573-583
3. Gombos Z., Xu X., Chu C.S., et al. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 11 (2005) 8364-8371
4. Schoppmann S.F., Bayer G., Aumayr K., et al. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann Surg 240 (2004) 306-312
5. Hall F.T., Freeman J.L., Asa S.L., et al. Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 129 (2003) 716-719
6. Saad R.S., Kordunsky L., Liu Y.L., et al. Lymphatic microvessel density as prognostic marker in colorectal cancer. Mod Pathol 19 (2006) 1317-1323
7. Zeng Y., Opeskin K., Horvath L.G., et al. Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate 65 (2005) 222-230
8. Miyata Y., Kanda S., Ohba K., et al. Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis. J Urol 176 (2006) 348-353
9. Pantuck A.J., Zisman A., Dorey F., et al. Renal cell carcinoma with retroperitoneal lymph nodes: impact on survival and benefits of immunotherapy. Cancer 97 (2003) 2995-3002
10. Blute M.L., Leibovich B.C., Cheville J.C., et al. A protocol for performing extended lymph node dissection using primary tumor pathological features for patients treated with radical nephrectomy for clear cell renal cell carcinoma. J Urol 172 (2004) 465-469
11. Canfield S.E., Kamat A.M., Sanchez-Ortiz R.F., et al. Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease (clinical stage TxN1-2M0): the impact of aggressive surgical resection on patient outcome. J Urol 175 (2006) 864-869
12. Sabo E., Boltenko A., Sova Y., et al. Microscopic analysis and significance of vascular architectural complexity in renal cell carcinoma. Clin Cancer Res 7 (2001) 533-537
13. Goncalves P.D., Srougi M., Dall'lio M.F., et al. Low clinical stage renal cell carcinoma: relevance of microvascular tumor invasion as a prognostic parameter. J Urol 172 (2004) 470-474
14. Ishikawa Y., Akasaka Y., Kiguchi H., et al. The human renal lymphatics under normal and pathological conditions. Histopathology 49 (2006) 265-273
15. Schacht V., Dadras S.S., Johnson L.A., et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 166 (2005) 913-921
16. Horiguchi A., Sumitomo M., Asakuma J., et al. Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma. J Urol 176 (2006) 1631-1635
17. Vermeulen P.B., Gasparini G., Fox S.B., et al. Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer 38 (2002) 1564-1579
18. Fiedler U., Christian S., Koidl S., et al. The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors. Am J Pathol 168 (2006) 1045-1053
19. Arigami T., Natsugoe S., Uenosono Y., et al. Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer. Br J Cancer 93 (2005) 688-693