Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

Genes and Development

Volumn 24, Issue 9, 2010, Pages 875-880

  Saharinen, Pipsa ^a,b   Helotera, Hanna ^a,b,c   Miettinen, Juho ^a,b,c   Norrmen, Camilla ^a,b,c   D'Amico, Gabriela ^a,b,c   Jeltsch, Michael ^d,e   Langenberg, Tobias ^d,e   Vandevelde, Wouter ^d,e   Ny, Annelii ^d,e   Dewerchin, Mieke ^d,e   Carmeliet, Peter ^d,e   Alitalo, Kari ^a,b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

CLP24; Lymphangiogenesis; VEGFR 2; VEGFR 3

Indexed keywords

CLAUDIN; CLAUDIN LIKE PROTEIN 24; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LYMPH VESSEL; LYMPHANGIOGENESIS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; XENOPUS LAEVIS; ZEBRA FISH;

ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; LYMPHATIC VESSELS; MEMBRANE PROTEINS; MICE; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3; XENOPUS PROTEINS; ZEBRAFISH PROTEINS;

DANIO RERIO; MUS; XENOPUS LAEVIS;

EID: 77951821586     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.565010     Document Type: Article

References (25)

1. Adams RH, Alitalo K. 2007. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 8: 464-478.
2. Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, et al. 2006. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell 10: 783-795. (Pubitemid 43796150)
3. Christoforou N, Miller RA, Hill CM, Jie CC, McCallion AS, Gearhart JD. 2008. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest 118: 894-903. (Pubitemid 351364597)
4. Crawford Y, Ferrara N. 2009. VEGF inhibition: Insights from preclinical and clinical studies. Cell Tissue Res 335: 261-269.
5. Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, Witte M. 2008. Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol 319: 309-320.
6. Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K. 1998. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282: 946-949. (Pubitemid 28507528)
7. Gustafsson E, Brakebusch C, Hietanen K, Fassler R. 2001. Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice. J Cell Sci 114: 671-676. (Pubitemid 32237139)
8. Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K. 2008. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res 68: 4754-4762.
9. Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown LF, Detmar M. 2005. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 201: 1089-1099. (Pubitemid 40524677)
10. Hogan BM, Bos FL, Bussmann J, Witte M, Chi NC, Duckers HJ, Schulte-Merker S. 2009. Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nat Genet 41: 396-398.
11. Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, Jeltsch M, Jackson DG, Talikka M, Rauvala H, et al. 2004. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5: 74-80. (Pubitemid 38081471)
12. Kearsey J, Petit S, De Oliveira C, Schweighoffer F. 2004. A novel four transmembrane spanning protein, CLP24. A hypoxically regulated cell junction protein. Eur J Biochem 271: 2584-2592. (Pubitemid 38869960)
13. Lallemand Y, Luria V, Haffner-Krausz R, Lonai P. 1998. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Res 7: 105-112. (Pubitemid 28190228)
14. Lee HT, Chang YC, Tu YF, Huang CC. 2009. VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells. J Neurosci 29: 4356-4368.
15. Makinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA. 2005. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes & Dev 19: 397-410. (Pubitemid 40189302)
16. Nagy JA, Vasile E, Feng D, Sundberg C, Brown LF, Detmar MJ, Lawitts JA, Benjamin L, Tan X, Manseau EJ, et al. 2002. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med 196: 1497-1506. (Pubitemid 35424943)
17. Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Heligon C, et al. 2005. A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med 11: 998-1004. (Pubitemid 41294447)
18. Petrova TV, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Yla-Herttuala S, et al. 2004. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med 10: 974-981. (Pubitemid 39273739)
19. Reynolds LE, Hodivala-Dilke KM. 2006. Primary mouse endothelial cell culture for assays of angiogenesis. Methods Mol Med 120: 503-509.
20. Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A, Vestweber D, Deutsch U, Koh GY, et al. 2008. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol 10: 527-537. (Pubitemid 351627372)
21. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC. 1995. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66.
22. Tammela T, Alitalo K. 2010. Lymphangiogenesis: Molecular mechanisms and future promise. Cell 140: 460-476.
23. Tammela T, Zarkada G,Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, et al. 2008. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454: 656-660.
24. Wick N, Saharinen P, Saharinen J, Gurnhofer E, Steiner CW, Raab I, Stokic D, Giovanoli P, Buchsbaum S, Burchard A, et al. 2007. Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro. Physiol Genomics 28: 179-192. (Pubitemid 46702006)
25. Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Yla-Herttuala S, Shibuya M, et al. 2007. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med 204: 1431-1440. (Pubitemid 46919880)