Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis

Circulation Research

Volumn 106, Issue 7, 2010, Pages 1197-1201

  Carramolino, Laura ^a   Fuentes, Joana ^a   García Andrés, Clara ^a   Azcoitia, Valeria ^a   Riethmacher, Dieter ^b   Torres, Miguel ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Angiogenesis; Lymphangiogenesis; Lymphatics; Megakaryocytes; Meis1; Platelets

Indexed keywords

THROMBOCYTE ANTIBODY; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MEIS1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; FEMALE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; LYMPHANGIOGENESIS; MEGAKARYOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THROMBOCYTE; TISSUE DIFFERENTIATION; TISSUE STRUCTURE; WILD TYPE;

ANIMALS; ANTIBODIES; BLOOD PLATELETS; BLOOD VESSELS; CELL LINEAGE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; GESTATIONAL AGE; HOMEODOMAIN PROTEINS; INJECTIONS, INTRAPERITONEAL; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; PREGNANCY;

EID: 77951296956     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.218073     Document Type: Article

References (14)

1. Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev. 2007;21: 2422-2432. (Pubitemid 47529372)
2. Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell. 1999;98:769-778. (Pubitemid 29446894)
3. Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, Jeltsch M, Jackson DG, Talikka M, Rauvala H, Betsholtz C, Alitalo K. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 2004;5: 74-80. (Pubitemid 38081471)
4. Wigle JT, Harvey N, Detmar M, Lagutina I, Grosveld G, Gunn MD, Jackson DG, Oliver G. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 2002;21: 1505-1513. (Pubitemid 34614607)
5. Oliver G. Lymphatic vasculature development. Nat Rev. 2004;4:35-45. (Pubitemid 38084130)
6. Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science. 2003; 299:247-251. (Pubitemid 36125210)
7. Sebzda E, Hibbard C, Sweeney S, Abtahian F, Bezman N, Clemens G, Maltzman JS, Cheng L, Liu F, Turner M, Tybulewicz V, Koretzky GA, Kahn ML. Syk and Slp-76 mutant mice reveal a cell-autonomous hema-topoietic cell contribution to vascular development. Dev Cell. 2006;11: 349-361. (Pubitemid 44283944)
8. Azcoitia V, Aracil M, Martinez AC, Torres M. The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol. 2005;280:307-320. (Pubitemid 40692134)
9. Tiedt R, Schomber T, Hao-Shen H, Skoda RC. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007;109: 1503-1506. (Pubitemid 46239582)
10. Brockschnieder D, Pechmann Y, Sonnenberg-Riethmacher E, Rieth-macher D. An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis. 2006;44: 322-327. (Pubitemid 44182448)
11. Tober J, Koniski A, McGrath KE, Vemishetti R, Emerson R, de Mesy-Bentley KK, Waugh R, Palis J. The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood. 2007;109:1433-1441. (Pubitemid 46239574)
12. Uhrin P, Zaujec J, Breuss JM, Olcaydu D, Chrenek P, Stockinger H, Fuertbauer E, Moser M, Haiko P, Fassler R, Alitalo K, Binder BR, Kerjaschki D. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. January 2010; doi: 10.1182/blood-2009- 04-216069
13. Samaha FF, Kahn ML. Novel platelet and vascular roles for immu-noreceptor signaling. Arterioscler Thromb Vasc Biol. 2006;26: 2588-2593.
14. Ichikawa M, Asai T, Saito T, Seo S, Yamazaki I, Yamagata T, Mitani K, Chiba S, Ogawa S, Kurokawa M, Hirai H. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hemato-poietic stem cells in adult hematopoiesis. Nat Med. 2004;10:299-304. (Pubitemid 38667622)