Increased intratumoral lymphatic vessel density correlates with lymph node metastasis in early gastric carcinoma

Annals of Surgical Oncology

Volumn 17, Issue 1, 2010, Pages 73-80

  Lee, Kyoungbun ^a   Park, Do Joong ^b   Choe, Gheeyoung ^b   Kim, Hyung Ho ^b   Kim, Woo Ho ^c   Lee, Hye Seung ^b  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER INVASION; DIAGNOSTIC TEST; DIGITAL IMAGING; EARLY CANCER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPH VESSEL DENSITY; MAJOR CLINICAL STUDY; MALE; MICROVESSEL DENSITY; PREDICTOR VARIABLE; STOMACH CARCINOMA;

ADENOCARCINOMA, MUCINOUS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD31; CARCINOMA, SIGNET RING CELL; FEMALE; HUMANS; LYMPH NODES; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 74649086696     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0707-y     Document Type: Article

References (35)

1. T Yokota S Ishiyama T Saito S Teshima Y Narushima K Murata K Iwamoto, et al. 2004 Lymph node metastasis as a significant prognostic factor in gastric cancer: a multiple logistic regression analysis Scand J Gastroenterol. 39 380 384 10.1080/00365520310008629 1:STN:280:DC%2BD2c3is1Kitw%3D%3D 15125471 (Pubitemid 38526727)
2. S Folli P Morgagni F Roviello G De Manzoni D Marrelli L Saragoni A Di Leo, et al. 2001 Risk factors for lymph node metastases and their prognostic significance in early gastric cancer (EGC) for the Italian Research Group for Gastric Cancer (IRGGC) Jpn J Clin Oncol. 31 495 499 10.1093/jjco/hye107 1:STN:280:DC%2BD3MnltFKitg%3D%3D 11696619
3. T Yokota T Saito S Teshima Y Yamada K Iwamoto M Takahashi Y Kunii, et al. 2001 Probability of lymph node metastasis in small gastric cancer tumor: is it an indication for limited surgery? Int Surg. 86 206 209 1:STN:280: DC%2BD38zhsV2ksw%3D%3D 12056462
4. JY An YH Baik MG Choi JH Noh TS Sohn S Kim 2007 Predictive factors for lymph node metastasis in early gastric cancer with submucosal invasion: analysis of a single institutional experience Ann Surg 246 749 753 10.1097/SLA. 0b013e31811f3fb7 17968165 (Pubitemid 350035650)
5. Y Maehara A Kabashima T Koga E Tokunaga H Takeuchi Y Kakeji K Sugimachi 2000 Vascular invasion and potential for tumor angiogenesis and metastasis in gastric carcinoma Surgery. 128 408 416 10.1067/msy.2000.107265 1:STN:280:DC%2BD3cvmtVOgtQ%3D%3D 10965312 (Pubitemid 30690787)
6. A Sako J Kitayama M Ishikawa H Yamashita H Nagawa 2006 Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer Gastric Cancer. 9 295 302 10.1007/s10120-006-0396-1 17235632 (Pubitemid 44846553)
7. Z Gombos X Xu CS Chu PJ Zhang G Acs 2005 Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix Clin Cancer Res. 11 8364 8371 10.1158/1078-0432.CCR-05-1238 1:CAS:528:DC%2BD2MXht1KjsrnJ 16322297 (Pubitemid 41746949)
8. Y Kitadai M Kodama S Cho T Kuroda T Ochiumi S Kimura S Tanaka, et al. 2005 Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes Int J Cancer. 115 388 392 10.1002/ijc.20859 1:CAS:528:DC%2BD2MXkt1Clur8%3D 15688374 (Pubitemid 40663742)
9. HD Liu LH Zhao YF Zhang YL Li XD Li SC Yang YM Li, et al. 2005 Morphologic features of lymphatic in periphery region of gastric carcinoma and colon carcinoma Ai Zheng. 24 699 703 15946482
10. P Liang JW Hong H Ubukata HR Liu Y Watanabe M Katano G Motohashi, et al. 2006 Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma Virchows Arch. 448 570 575 10.1007/s00428-006-0166-9 16496172 (Pubitemid 44490554)
11. Y Nakamura H Yasuoka M Tsujimoto K Kurozumi M Nakahara K Nakao, et al. 2006 Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer J Clin Pathol. 59 77 82 10.1136/jcp.2005.028779 1:STN:280:DC%2BD28%2FgvVaqtA%3D%3D 16394285 (Pubitemid 43076243)
12. AA Roma C Magi-Galluzzi MA Kral TT Jin EA Klein M Zhou 2006 Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma Mod Pathol. 19 392 398 10.1038/modpathol.3800546 16400321 (Pubitemid 43276993)
13. I Kaneko S Tanaka S Oka T Kawamura T Hiyama M Ito M Yoshihara, et al. 2007 Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer Dis Colon Rectum. 50 13 21 10.1007/s10350-006-0745-5 17115337
14. A Longatto-Filho C Pinheiro SM Pereira D Etlinger MA Moreira LF Jube GS Queiroz, et al. 2007 Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix Gynecol Oncol. 107 45 51 10.1016/j.ygyno.2007.05.029 17604828 (Pubitemid 47495944)
15. L Yuanming G Feng T Lei W Ying 2007 Quantitative analysis of lymphangiogenic markers in human gastroenteric tumor Arch Med Res. 38 106 112 10.1016/j.arcmed.2006.08.009 17174733 (Pubitemid 44894621)
16. YM El-Gohary G Metwally RS Saad MJ Robinson T Mesko RJ Poppiti 2008 Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas Am J Clin Pathol. 129 578 586 10.1309/2HGNJ1GU57JMBJAQ 18343785 (Pubitemid 352029277)
17. P Gao GY Zhou QH Zhang L Xiang SL Zhang C Li YL Sun 2008 Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma Cancer Lett. 263 223 230 10.1016/j.canlet.2008.01.017 1:CAS:528:DC%2BD1cXks12ns7c%3D 18289774
18. I Van der Auwera GG Van den Eynden CG Colpaert SJ Van Laere P van Dam EA Van Marck LY Dirix, et al. 2005 Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study Clin Cancer Res. 11 7637 7642 10.1158/1078-0432.CCR-05-1142 16278382 (Pubitemid 41611604)
19. E Evangelou PA Kyzas TA Trikalinos 2005 Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach Mod Pathol. 18 1490 1497 10.1038/modpathol.3800457 1:CAS:528:DC%2BD2MXhtFahur%2FO 15990898 (Pubitemid 41509404)
20. M Miettinen AE Lindenmayer A Chaubal 1994 Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens-evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor Mod Pathol. 7 82 90 1:STN:280:DyaK2c3htFOnug%3D%3D 7512718
21. N Weidner JP Semple WR Welch J Folkman 1991 Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma N Engl J Med. 324 1 8 1:STN:280:DyaK3M%2FnsVWquw%3D%3D 1701519
22. M Mazumdar A Smith J Bacik 2003 Methods for categorizing a prognostic variable in a multivariable setting Stat Med. 22 559 571 10.1002/sim.1333 12590414 (Pubitemid 36204178)
23. Japanese Gastric Cancer Association. Treatment guidelines for gastric carcinoma in Japan. 2nd ed. Tokyo: Kanehara; 2004.
24. S Ishikawa A Togashi M Inoue S Honda F Nozawa E Toyama N Miyanari, et al. 2007 Indications for EMR/ESD in cases of early gastric cancer: relationship between histological type, depth of wall invasion, and lymph node metastasis Gastric Cancer. 10 35 38 10.1007/s10120-006-0407-2 17334716 (Pubitemid 46356260)
25. FT Hall JL Freeman SL Asa DG Jackson NJ Beasley 2003 Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma Arch Otolaryngol Head Neck Surg. 129 716 719 10.1001/archotol.129.7.716 12874070 (Pubitemid 36858956)
26. SM Maula M Luukkaa R Grenman D Jackson S Jalkanen R Ristamaki 2003 Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region Cancer Res. 63 1920 1926 1:CAS:528:DC%2BD3sXivFynsb4%3D 12702584
27. A Inoue H Moriya N Katada S Tanabe N Kobayashi M Watanabe I Okayasu, et al. 2008 Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis Pathol Int. 58 611 619 10.1111/j.1440-1827.2008.02279.x 1:CAS:528:DC%2BD1cXhtlaksrzN 18801080
28. D Zhao J Pan XQ Li XY Wang C Tang M Xuan 2008 Intratumoral lymphangiogenesis in oral squamous cell carcinoma and its clinicopathological significance J Oral Pathol Med. 37 616 625 1:STN:280:DC%2BD1cjksVGktg%3D%3D 19012622
29. MB Listrom CM Fenoglio-Preiser 1987 Lymphatic distribution of the stomach in normal, inflammatory, hyperplastic, and neoplastic tissue Gastroenterology. 93 506 514 1:STN:280:DyaL2s3nslagtg%3D%3D 3301516
30. CS Williams RD Leek AM Robson S Banerji R Prevo AL Harris DG Jackson 2003 Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer J Pathol. 200 195 206 10.1002/path.1343 1:CAS:528:DC%2BD3sXlsFeisrs%3D 12754740 (Pubitemid 36748028)
31. O Straume DG Jackson LA Akslen 2003 Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma Clin Cancer Res. 9 250 256 1:CAS:528:DC%2BD3sXnt1OktQ%3D%3D 12538477
32. S Ding C Li S Lin Y Yang D Liu Y Han Y Zhang, et al. 2006 Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions Hum Pathol. 37 861 866 10.1016/j.humpath.2006.02.006 1:CAS:528:DC%2BD28XlvFGmsLo%3D 16784986 (Pubitemid 43902946)
33. X Che S Hokita S Natsugoe G Tanabe M Baba S Takao T Aikou 1998 Tumor angiogenesis related to growth pattern and lymph node metastasis in early gastric cancer Chin Med J (Engl) 111 1090 1093 1:STN:280:DC%2BD3M7mt12ntg%3D%3D
34. Y Cao 2005 Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis Nat Rev Cancer. 5 735 743 10.1038/nrc1693 1:CAS:528:DC%2BD2MXpsleksL8%3D 16079909 (Pubitemid 41486366)
35. DG Altman B Lausen W Sauerbrei M Schumacher 1994 Dangers of using "optimal" cutpoints in the evaluation of prognostic factors J Natl Cancer Inst. 86 829 835 10.1093/jnci/86.11.829 1:STN:280:DyaK2c3jvVOjtQ%3D%3D 8182763