-
1
-
-
33846816853
-
Edward Jenner and the history of smallpox and vaccination
-
Riedel, S. (2005) Edward Jenner and the history of smallpox and vaccination Proc. (Baylor Univ. Med. Cent.) 18, 21-25
-
(2005)
Proc. (Baylor Univ. Med. Cent.)
, vol.18
, pp. 21-25
-
-
Riedel, S.1
-
2
-
-
4444342539
-
Passive antibody therapy for infectious diseases
-
Casadevall, A., Dadachova, E., and Pirofski, L. A. (2004) Passive antibody therapy for infectious diseases Nat. Rev. Microbiol. 2, 695-703
-
(2004)
Nat. Rev. Microbiol.
, vol.2
, pp. 695-703
-
-
Casadevall, A.1
Dadachova, E.2
Pirofski, L.A.3
-
3
-
-
78149413840
-
The state of antibody therapy
-
Elbakri, A., Nelson, P. N., and Abu Odeh, R. O. (2010) The state of antibody therapy Hum. Immunol. 71, 1243-1250
-
(2010)
Hum. Immunol.
, vol.71
, pp. 1243-1250
-
-
Elbakri, A.1
Nelson, P.N.2
Abu Odeh, R.O.3
-
4
-
-
78149269335
-
'Biosimilar' drugs poised to penetrate market
-
Ledford, H. (2010) 'Biosimilar' drugs poised to penetrate market Nature 468, 18-19
-
(2010)
Nature
, vol.468
, pp. 18-19
-
-
Ledford, H.1
-
5
-
-
70449375361
-
Whatβs fueling the biotech engine-2008
-
Aggarwal, S. (2009) Whatβs fueling the biotech engine-2008 Nat. Biotechnol. 27, 987-993
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 987-993
-
-
Aggarwal, S.1
-
6
-
-
78651387929
-
Antibody-based therapeutics to watch in 2011
-
Reichert, J. M. (2011) Antibody-based therapeutics to watch in 2011 MAbs 3, 76-99
-
(2011)
MAbs
, vol.3
, pp. 76-99
-
-
Reichert, J.M.1
-
7
-
-
84875225262
-
-
FDA Approved Drug Products, U.S. Food and Drug Administration
-
(2012) FDA Approved Drug Products, In http://www.accessdata.fda.gov/ scripts/cder/drugsatfda/index.cfm, U.S. Food and Drug Administration.
-
(2012)
-
-
-
8
-
-
77951614830
-
Monoclonal antibodies: Versatile platforms for cancer immunotherapy
-
Weiner, L. M., Surana, R., and Wang, S. (2010) Monoclonal antibodies: versatile platforms for cancer immunotherapy Nat. Rev. Immunol. 10, 317-327
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 317-327
-
-
Weiner, L.M.1
Surana, R.2
Wang, S.3
-
10
-
-
43049088156
-
In vivo selection of intrabodies specifically targeting protein-protein interactions: A general platform for an "undruggable" class of disease targets
-
Visintin, M., Melchionna, T., Cannistraci, I., and Cattaneo, A. (2008) In vivo selection of intrabodies specifically targeting protein-protein interactions: A general platform for an "undruggable" class of disease targets J. Biotechnol. 135, 1-15
-
(2008)
J. Biotechnol.
, vol.135
, pp. 1-15
-
-
Visintin, M.1
Melchionna, T.2
Cannistraci, I.3
Cattaneo, A.4
-
11
-
-
0008486660
-
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation
-
Sunada, H., Magun, B. E., Mendelsohn, J., and MacLeod, C. L. (1986) Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation Proc. Natl. Acad. Sci. U.S.A. 83, 3825-3829
-
(1986)
Proc. Natl. Acad. Sci. U.S.A.
, vol.83
, pp. 3825-3829
-
-
Sunada, H.1
Magun, B.E.2
Mendelsohn, J.3
MacLeod, C.L.4
-
12
-
-
17444403242
-
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
-
Li, S., Schmitz, K. R., Jeffrey, P. D., Wiltzius, J. J. W., Kussie, P., and Ferguson, K. M. (2005) Structural basis for inhibition of the epidermal growth factor receptor by cetuximab Cancer Cell 7, 301-311
-
(2005)
Cancer Cell
, vol.7
, pp. 301-311
-
-
Li, S.1
Schmitz, K.R.2
Jeffrey, P.D.3
Wiltzius, J.J.W.4
Kussie, P.5
Ferguson, K.M.6
-
13
-
-
77958484636
-
Molecular imaging of HER2-positive breast cancer: A step toward an individualized 'image and treat' strategy
-
Capala, J. and Bouchelouche, K. (2010) Molecular imaging of HER2-positive breast cancer: a step toward an individualized 'image and treat' strategy Curr. Opin. Oncol. 22, 559-566
-
(2010)
Curr. Opin. Oncol.
, vol.22
, pp. 559-566
-
-
Capala, J.1
Bouchelouche, K.2
-
14
-
-
0042738861
-
CAC10-vcMMAE, an anti-CD30-monomethyl auristatin e conjugate with potent and selective antitumor activity
-
Francisco, J. A., Cerveny, C. G., Meyer, D. L., Mixan, B. J., Klussman, K., Chace, D. F., Rejniak, S. X., Gordon, K. A., DeBlanc, R., Toki, B. E., Law, C.-L., Doronina, S. O., Siegall, C. B., Senter, P. D., and Wahl, A. F. (2003) cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity Blood 102, 1458-1465
-
(2003)
Blood
, vol.102
, pp. 1458-1465
-
-
Francisco, J.A.1
Cerveny, C.G.2
Meyer, D.L.3
Mixan, B.J.4
Klussman, K.5
Chace, D.F.6
Rejniak, S.X.7
Gordon, K.A.8
Deblanc, R.9
Toki, B.E.10
Law, C.-L.11
Doronina, S.O.12
Siegall, C.B.13
Senter, P.D.14
Wahl, A.F.15
-
15
-
-
77955312203
-
Antibody-drug conjugates: Targeted drug delivery for cancer
-
Alley, S. C., Okeley, N. M., and Senter, P. D. (2010) Antibody-drug conjugates: Targeted drug delivery for cancer Curr. Opin. Chem. Biol. 14, 529-537
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, pp. 529-537
-
-
Alley, S.C.1
Okeley, N.M.2
Senter, P.D.3
-
16
-
-
0031905710
-
Fc receptors are required in passive and active immunity to melanoma
-
Clynes, R., Takechi, Y., Moroi, Y., Houghton, A., and Ravetch, J. V. (1998) Fc receptors are required in passive and active immunity to melanoma Proc. Natl. Acad. Sci. U.S.A. 95, 652-656
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 652-656
-
-
Clynes, R.1
Takechi, Y.2
Moroi, Y.3
Houghton, A.4
Ravetch, J.V.5
-
17
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
-
Clynes, R. A., Towers, T. L., Presta, L. G., and Ravetch, J. V. (2000) Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets Nat. Med. 6, 443-446
-
(2000)
Nat. Med.
, vol.6
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
18
-
-
12944309909
-
Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
-
Sampson, J. H., Crotty, L. E., Lee, S., Archer, G. E., Ashley, D. M., Wikstrand, C. J., Hale, L. P., Small, C., Dranoff, G., Friedman, A. H., Friedman, H. S., and Bigner, D. D. (2000) Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors Proc. Natl. Acad. Sci. U.S.A. 97, 7503-7508
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 7503-7508
-
-
Sampson, J.H.1
Crotty, L.E.2
Lee, S.3
Archer, G.E.4
Ashley, D.M.5
Wikstrand, C.J.6
Hale, L.P.7
Small, C.8
Dranoff, G.9
Friedman, A.H.10
Friedman, H.S.11
Bigner, D.D.12
-
19
-
-
84875213963
-
-
Garland Science, New York
-
Murphy, K. P., Travers, P., Walport, M., and Janeway, C. (2008) Janewayβs Immunobiology, Garland Science, New York
-
(2008)
Janewayβs Immunobiology
-
-
Murphy, K.P.1
Travers, P.2
Walport, M.3
Janeway, C.4
-
20
-
-
37549036732
-
Fcγ receptors as regulators of immune responses
-
Nimmerjahn, F. and Ravetch, J. V. (2008) Fcγ receptors as regulators of immune responses Nat Rev Immunol 8, 34-47
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 34-47
-
-
Nimmerjahn, F.1
Ravetch, J.V.2
-
21
-
-
0037033448
-
Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells
-
Dhodapkar, K. M., Krasovsky, J., Williamson, B., and Dhodapkar, M. V. (2002) Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells J. Exp. Med. 195, 125-133
-
(2002)
J. Exp. Med.
, vol.195
, pp. 125-133
-
-
Dhodapkar, K.M.1
Krasovsky, J.2
Williamson, B.3
Dhodapkar, M.V.4
-
22
-
-
0037442125
-
Targeting apoptotic tumor cells to FcγR provides efficient and versatile vaccination against tumors by dendritic cells
-
Akiyama, K., Ebihara, S., Yada, A., Matsumura, K., Aiba, S., Nukiwa, T., and Takai, T. (2003) Targeting apoptotic tumor cells to FcγR provides efficient and versatile vaccination against tumors by dendritic cells J. Immunol. 170, 1641-1648
-
(2003)
J. Immunol.
, vol.170
, pp. 1641-1648
-
-
Akiyama, K.1
Ebihara, S.2
Yada, A.3
Matsumura, K.4
Aiba, S.5
Nukiwa, T.6
Takai, T.7
-
23
-
-
33644831870
-
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells
-
Cioca, D. P., Deak, E., Cioca, F., and Paunescu, V. (2005) Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells J. Immunother. 29, 41-52
-
(2005)
J. Immunother.
, vol.29
, pp. 41-52
-
-
Cioca, D.P.1
Deak, E.2
Cioca, F.3
Paunescu, V.4
-
24
-
-
70349243743
-
In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb
-
Murillo, O., Dubrot, J., Palazon, A., Arina, A., Azpilikueta, A., Alfaro, C., Solano, S., Ochoa, M. C., Berasain, C., Gabari, I., Perez-Gracia, J. L., Berraondo, P., Hervas-Stubbs, S., and Melero, I. (2009) In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb Eur. J. Immunol. 39, 2424-2436
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 2424-2436
-
-
Murillo, O.1
Dubrot, J.2
Palazon, A.3
Arina, A.4
Azpilikueta, A.5
Alfaro, C.6
Solano, S.7
Ochoa, M.C.8
Berasain, C.9
Gabari, I.10
Perez-Gracia, J.L.11
Berraondo, P.12
Hervas-Stubbs, S.13
Melero, I.14
-
25
-
-
77950517325
-
The safety and side effects of monoclonal antibodies
-
Hansel, T. T., Kropshofer, H., Singer, T., Mitchell, J. A., and George, A. J. T. (2010) The safety and side effects of monoclonal antibodies Nat. Rev. Drug Discovery 9, 325-338
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 325-338
-
-
Hansel, T.T.1
Kropshofer, H.2
Singer, T.3
Mitchell, J.A.4
George, A.J.T.5
-
26
-
-
78649642694
-
Have we overestimated the benefit of human(ized) antibodies?
-
Getts, D. R., Getts, M. T., McCarthy, D. P., Chastain, E. M., and Miller, S. D. (2010) Have we overestimated the benefit of human(ized) antibodies? mAbs 2, 682-694
-
(2010)
MAbs
, vol.2
, pp. 682-694
-
-
Getts, D.R.1
Getts, M.T.2
McCarthy, D.P.3
Chastain, E.M.4
Miller, S.D.5
-
27
-
-
77953658260
-
The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions
-
Harding, F. A., Stickler, M. M., Razo, J., and DuBridge, R. (2010) The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions mAbs 2, 256-265
-
(2010)
MAbs
, vol.2
, pp. 256-265
-
-
Harding, F.A.1
Stickler, M.M.2
Razo, J.3
Dubridge, R.4
-
28
-
-
33847399072
-
FcγR: The key to optimize therapeutic antibodies?
-
Siberil, S., Dutertre, C.-A., Fridman, W.-H., and Teillaud, J.-L. (2007) FcγR: The key to optimize therapeutic antibodies? Crit. Rev. Oncol. Hematol. 62, 26-33
-
(2007)
Crit. Rev. Oncol. Hematol.
, vol.62
, pp. 26-33
-
-
Siberil, S.1
Dutertre, C.-A.2
Fridman, W.-H.3
Teillaud, J.-L.4
-
29
-
-
27144550160
-
Arming antibodies: Prospects and challenges for immunoconjugates
-
Wu, A. and Senter, P. (2005) Arming antibodies: prospects and challenges for immunoconjugates Nat. Biotechnol. 23, 1137-1146
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1137-1146
-
-
Wu, A.1
Senter, P.2
-
30
-
-
0036781811
-
Ligand-targeted therapeutics in anticancer therapy
-
Allen, T. M. (2002) Ligand-targeted therapeutics in anticancer therapy Nat. Rev. Cancer 2, 750-763
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 750-763
-
-
Allen, T.M.1
-
31
-
-
33747855481
-
Comparing antibody and small-molecule therapies for cancer
-
Imai, K. and Takaoka, A. (2006) Comparing antibody and small-molecule therapies for cancer Nat. Rev. Cancer 6, 714-727
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 714-727
-
-
Imai, K.1
Takaoka, A.2
-
32
-
-
17644416719
-
Targeting the innate immune response with improved vaccine adjuvants
-
Pashine, A., Valiante, N. M., and Ulmer, J. B. (2005) Targeting the innate immune response with improved vaccine adjuvants Nat. Med. 11, S63-S68
-
(2005)
Nat. Med.
, vol.11
-
-
Pashine, A.1
Valiante, N.M.2
Ulmer, J.B.3
-
33
-
-
78649241632
-
Grand Challenge Commentary: Synthetic immunology to engineer human immunity
-
Spiegel, D. A. (2010) Grand Challenge Commentary: Synthetic immunology to engineer human immunity Nat. Chem. Biol. 6, 871-872
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 871-872
-
-
Spiegel, D.A.1
-
34
-
-
78649852204
-
Development of antibody surrogates for the treatment of cancers and autoimmune disease
-
Kodadek, T. (2010) Development of antibody surrogates for the treatment of cancers and autoimmune disease Curr. Opin. Chem. Biol. 14, 721-727
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, pp. 721-727
-
-
Kodadek, T.1
-
35
-
-
74949107560
-
Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
-
Ducry, L. and Stump, B. (2010) Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies Bioconjugate Chem. 21, 5-13
-
(2010)
Bioconjugate Chem.
, vol.21
, pp. 5-13
-
-
Ducry, L.1
Stump, B.2
-
36
-
-
77749239974
-
Bispecific antibodies for cancer immunotherapy: Current perspectives
-
Müller, D. and Kontermann, R. E. (2010) Bispecific antibodies for cancer immunotherapy: Current perspectives BioDrugs 24, 89-98
-
(2010)
BioDrugs
, vol.24
, pp. 89-98
-
-
Müller, D.1
Kontermann, R.E.2
-
37
-
-
67449156132
-
Bispecific T-cell engaging antibodies for cancer therapy
-
Baeuerle, P. A. and Reinhardt, C. (2009) Bispecific T-cell engaging antibodies for cancer therapy Cancer Res. 69, 4941-4944
-
(2009)
Cancer Res.
, vol.69
, pp. 4941-4944
-
-
Baeuerle, P.A.1
Reinhardt, C.2
-
38
-
-
70349743967
-
Targeting a homogeneously glycosylated antibody Fc to bind cancer cells using a synthetic receptor ligand
-
Xiao, J., Chen, R., Pawlicki, M. A., and Tolbert, T. J. (2009) Targeting a homogeneously glycosylated antibody Fc to bind cancer cells using a synthetic receptor ligand J. Am. Chem. Soc. 131, 13616-13618
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 13616-13618
-
-
Xiao, J.1
Chen, R.2
Pawlicki, M.A.3
Tolbert, T.J.4
-
39
-
-
80054001296
-
Carbohydrates and immunology: Synthetic oligosaccharide antigens for vaccine formulation
-
Morelli, L., Poletti, L., and Lay, L. (2011) Carbohydrates and immunology: Synthetic oligosaccharide antigens for vaccine formulation Eur. J. Org. Chem. 2011, 5723-5777
-
(2011)
Eur. J. Org. Chem.
, vol.2011
, pp. 5723-5777
-
-
Morelli, L.1
Poletti, L.2
Lay, L.3
-
40
-
-
78650091945
-
Chemically self-assembled antibody nanorings (CSANs): Design and characterization of an anti-CD3 IgM biomimetic
-
Li, Q., So, C. R., Fegan, A., Cody, V., Sarikaya, M., Vallera, D. A., and Wagner, C. R. (2010) Chemically self-assembled antibody nanorings (CSANs): Design and characterization of an anti-CD3 IgM biomimetic J. Am. Chem. Soc. 132, 17247-17257
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 17247-17257
-
-
Li, Q.1
So, C.R.2
Fegan, A.3
Cody, V.4
Sarikaya, M.5
Vallera, D.A.6
Wagner, C.R.7
-
41
-
-
57749097107
-
Self-Assembly of Antibodies by Chemical Induction
-
Li, Q., Hapka, D., Chen, H., Vallera, D. A., and Wagner, C. R. (2008) Self-Assembly of Antibodies by Chemical Induction Angew. Chem., Int. Ed. 47, 10179-10182
-
(2008)
Angew. Chem., Int. Ed.
, vol.47
, pp. 10179-10182
-
-
Li, Q.1
Hapka, D.2
Chen, H.3
Vallera, D.A.4
Wagner, C.R.5
-
42
-
-
55949097146
-
In vivo supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic against the Escherichia coli O157 AB5 toxins
-
Kitov, P. I., Mulvey, G. L., Griener, T. P., Lipinski, T., Solomon, D., Paszkiewicz, E., Jacobson, J. M., Sadowska, J. M., Suzuki, M., Yamamura, K.-I., Armstrong, G. D., and Bundle, D. R. (2008) In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins Proc. Natl. Acad. Sci. U.S.A. 105, 16837-16842
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 16837-16842
-
-
Kitov, P.I.1
Mulvey, G.L.2
Griener, T.P.3
Lipinski, T.4
Solomon, D.5
Paszkiewicz, E.6
Jacobson, J.M.7
Sadowska, J.M.8
Suzuki, M.9
Yamamura, K.-I.10
Armstrong, G.D.11
Bundle, D.R.12
-
43
-
-
38349033369
-
An entropically efficient supramolecular inhibition strategy for shiga toxins
-
Kitov, P. I., Lipinski, T., Paszkiewicz, E., Solomon, D., Sadowska, J. M., Grant, G. A., Mulvey, G. L., Kitova, E. N., Klassen, J. S., Armstrong, G. D., and Bundle, D. R. (2008) An entropically efficient supramolecular inhibition strategy for shiga toxins Angew. Chem., Int. Ed. 47, 672-676
-
(2008)
Angew. Chem., Int. Ed.
, vol.47
, pp. 672-676
-
-
Kitov, P.I.1
Lipinski, T.2
Paszkiewicz, E.3
Solomon, D.4
Sadowska, J.M.5
Grant, G.A.6
Mulvey, G.L.7
Kitova, E.N.8
Klassen, J.S.9
Armstrong, G.D.10
Bundle, D.R.11
-
44
-
-
0037433202
-
Designing protein dimerizers: The importance of ligand conformational equilibria
-
Carlson, J. C. T., Kanter, A., Thuduppathy, G. R., Cody, V., Pineda, P. E., Mcivor, R. S., and Wagner, C. R. (2003) Designing protein dimerizers: the importance of ligand conformational equilibria J. Am. Chem. Soc. 125, 1501-1507
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 1501-1507
-
-
Carlson, J.C.T.1
Kanter, A.2
Thuduppathy, G.R.3
Cody, V.4
Pineda, P.E.5
McIvor, R.S.6
Wagner, C.R.7
-
45
-
-
0016206309
-
Cell mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes
-
Shearer, G. M. (1974) Cell mediated cytotoxicity to trinitrophenyl- modified syngeneic lymphocytes Eur. J. Immunol. 4, 527-533
-
(1974)
Eur. J. Immunol.
, vol.4
, pp. 527-533
-
-
Shearer, G.M.1
-
46
-
-
0018656735
-
ADCC against human erythrocyte target cells: Role of the anti-target cell antibodies in determining lymphocyte killer activity
-
Nelson, D. L., Poplack, D. G., Holiman, B. J., and Henkart, P. A. (1979) ADCC against human erythrocyte target cells: role of the anti-target cell antibodies in determining lymphocyte killer activity Clin. Exp. Immunol. 35, 447-453
-
(1979)
Clin. Exp. Immunol.
, vol.35
, pp. 447-453
-
-
Nelson, D.L.1
Poplack, D.G.2
Holiman, B.J.3
Henkart, P.A.4
-
47
-
-
0015896846
-
Effect of immunoglobulin class and affinity on the initiation of complement-dependent damage to liposomal model membranes sensitized with dinitrophenylated phospholipids
-
Six, H. R., Uemura, K., and Kinsky, S. C. (1973) Effect of immunoglobulin class and affinity on the initiation of complement-dependent damage to liposomal model membranes sensitized with dinitrophenylated phospholipids Biochemistry 12, 4003-4011
-
(1973)
Biochemistry
, vol.12
, pp. 4003-4011
-
-
Six, H.R.1
Uemura, K.2
Kinsky, S.C.3
-
48
-
-
0024575860
-
Designing CD4 immunoadhesins for AIDS therapy
-
Capon, D. J., Chamow, S. M., Mordenti, J., Marsters, S. A., Gregory, T., Mitsuya, H., Byrn, R. A., Lucas, C., Wurm, F. M., and Groopman, J. E. 1989, Designing CD4 immunoadhesins for AIDS therapy Nature 337, 525-531
-
(1989)
Nature
, vol.337
, pp. 525-531
-
-
Capon, D.J.1
Chamow, S.M.2
Mordenti, J.3
Marsters, S.A.4
Gregory, T.5
Mitsuya, H.6
Byrn, R.A.7
Lucas, C.8
Wurm, F.M.9
Groopman, J.E.10
-
49
-
-
0024549563
-
Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules
-
Traunecker, A., Schneider, J., Kiefer, H., and Karjalainen, K. (1989) Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules Nature 339, 68-70
-
(1989)
Nature
, vol.339
, pp. 68-70
-
-
Traunecker, A.1
Schneider, J.2
Kiefer, H.3
Karjalainen, K.4
-
50
-
-
0025269979
-
Biological properties of a CD4 immunoadhesin
-
Byrn, R. A., Mordenti, J., Lucas, C., Smith, D., Marsters, S. A., Johnson, J. S., Cossum, P., Chamow, S. M., and Wurm, F. M. 1990, Biological properties of a CD4 immunoadhesin Nature 344, 667-670
-
(1990)
Nature
, vol.344
, pp. 667-670
-
-
Byrn, R.A.1
Mordenti, J.2
Lucas, C.3
Smith, D.4
Marsters, S.A.5
Johnson, J.S.6
Cossum, P.7
Chamow, S.M.8
Wurm, F.M.9
-
51
-
-
0038465268
-
Redirecting the immune response: Ligand-mediated immunogenicity
-
Shokat, K. M. and Schultz, P. G. (1991) Redirecting the immune response: ligand-mediated immunogenicity J. Am. Chem. Soc. 113, 1861-1862
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 1861-1862
-
-
Shokat, K.M.1
Schultz, P.G.2
-
52
-
-
0029787127
-
Redirecting circulating antibodies via ligand-hapten conjugates eliminates target cells in vivo
-
Lussow, A. R., Buelow, R., Fanget, L., Peretto, S., Gao, L., and Pouletty, P. (1996) Redirecting circulating antibodies via ligand-hapten conjugates eliminates target cells in vivo J. Immunother. Emphasis Tumor Immunol. 19, 257-265
-
(1996)
J. Immunother. Emphasis Tumor Immunol.
, vol.19
, pp. 257-265
-
-
Lussow, A.R.1
Buelow, R.2
Fanget, L.3
Peretto, S.4
Gao, L.5
Pouletty, P.6
-
53
-
-
0026560664
-
Antibody targeting to bacterial cells using receptor-specific ligands
-
Bertozzi, C. R. and Bednarski, M. D. (1992) Antibody targeting to bacterial cells using receptor-specific ligands J. Am. Chem. Soc. 114, 2242-2245
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 2242-2245
-
-
Bertozzi, C.R.1
Bednarski, M.D.2
-
54
-
-
0001194625
-
A receptor-mediated immune response using synthetic glycoconjugates
-
Bertozzi, C. R. and Bednarski, M. D. (1992) A receptor-mediated immune response using synthetic glycoconjugates J. Am. Chem. Soc. 114, 5543-5546
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 5543-5546
-
-
Bertozzi, C.R.1
Bednarski, M.D.2
-
55
-
-
0032811377
-
Bacteria targeted by human natural antibodies using alpha -gal conjugated receptor-specific glycopolymers
-
Li, J., Zacharek, S., Chen, X., Wang, J., Zhang, W., Janczuk, A., and Wang, P. G. (1999) Bacteria targeted by human natural antibodies using alpha -gal conjugated receptor-specific glycopolymers Bioorg. Med. Chem. 7, 1549-1558
-
(1999)
Bioorg. Med. Chem.
, vol.7
, pp. 1549-1558
-
-
Li, J.1
Zacharek, S.2
Chen, X.3
Wang, J.4
Zhang, W.5
Janczuk, A.6
Wang, P.G.7
-
56
-
-
0037448910
-
Using bifunctional polymers presenting vancomycin and fluorescein groups to direct anti-fluorescein antibodies to self-assembled monolayers presenting d -alanine- d -alanine groups
-
Metallo, S. J., Kane, R. S., Holmlin, R. E., and Whitesides, G. M. (2003) Using bifunctional polymers presenting vancomycin and fluorescein groups to direct anti-fluorescein antibodies to self-assembled monolayers presenting d -alanine- d -alanine groups J. Am. Chem. Soc. 125, 4534-4540
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 4534-4540
-
-
Metallo, S.J.1
Kane, R.S.2
Holmlin, R.E.3
Whitesides, G.M.4
-
57
-
-
33645859599
-
Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide
-
Krishnamurthy, V. M., Quinton, L. J., Estroff, L. A., Metallo, S. J., Isaacs, J. M., Mizgerd, J. P., and Whitesides, G. M. (2006) Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide Biomaterials 27, 3663-3674
-
(2006)
Biomaterials
, vol.27
, pp. 3663-3674
-
-
Krishnamurthy, V.M.1
Quinton, L.J.2
Estroff, L.A.3
Metallo, S.J.4
Isaacs, J.M.5
Mizgerd, J.P.6
Whitesides, G.M.7
-
58
-
-
1642299756
-
Design and synthesis of alpha Gal-conjugated peptide T20 as novel antiviral agent for HIV-immunotargeting
-
Naicker, K. P., Li, H., Heredia, A., Song, H., and Wang, L.-X. (2004) Design and synthesis of alpha Gal-conjugated peptide T20 as novel antiviral agent for HIV-immunotargeting Org. Biomol. Chem. 2, 660-664
-
(2004)
Org. Biomol. Chem.
, vol.2
, pp. 660-664
-
-
Naicker, K.P.1
Li, H.2
Heredia, A.3
Song, H.4
Wang, L.-X.5
-
59
-
-
50449087950
-
Neutralization of HIV-1 by redirection of natural antibodies
-
Perdomo, M. F., Levi, M., Saellberg, M., and Vahlne, A. (2008) Neutralization of HIV-1 by redirection of natural antibodies Proc. Natl. Acad. Sci. U.S.A. 105, 12515-12520
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 12515-12520
-
-
Perdomo, M.F.1
Levi, M.2
Saellberg, M.3
Vahlne, A.4
-
60
-
-
70450188855
-
An antibody-recruiting small molecule that targets HIV gp120
-
Parker, C. G., Domaoal, R. A., Anderson, K. S., and Spiegel, D. A. (2009) An antibody-recruiting small molecule that targets HIV gp120 J. Am. Chem. Soc. 131, 16392-16394
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 16392-16394
-
-
Parker, C.G.1
Domaoal, R.A.2
Anderson, K.S.3
Spiegel, D.A.4
-
61
-
-
79751517940
-
Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis
-
Gavrilyuk, J., Uehara, H., Otsubo, N., Hessell, A., Burton, D. R., and Barbas, C. F., 3rd (2010) Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis ChemBioChem 11, 2113-2118
-
(2010)
ChemBioChem
, vol.11
, pp. 2113-2118
-
-
Gavrilyuk, J.1
Uehara, H.2
Otsubo, N.3
Hessell, A.4
Burton, D.R.5
Barbas Iii, C.F.6
-
62
-
-
0036219732
-
Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors
-
Lu, Y. and Low, P. S. (2002) Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors Cancer Immunol. Immunother. 51, 153-162
-
(2002)
Cancer Immunol. Immunother.
, vol.51
, pp. 153-162
-
-
Lu, Y.1
Low, P.S.2
-
63
-
-
23244454577
-
Folate receptor-targeted immunotherapy: Induction of humoral and cellular immunity against hapten-decorated cancer cells
-
Lu, Y., Sega, E., and Low Philip, S. (2005) Folate receptor-targeted immunotherapy: induction of humoral and cellular immunity against hapten-decorated cancer cells Int. J. Cancer. 116, 710-719
-
(2005)
Int. J. Cancer.
, vol.116
, pp. 710-719
-
-
Lu, Y.1
Sega, E.2
Low Philip, S.3
-
64
-
-
35549002578
-
Folate-targeted dinitrophenyl hapten immunotherapy: Effect of linker chemistry on antitumor activity and allergic potential
-
Lu, Y., You, F., Vlahov, I., Westrick, E., Fan, M., Low, P. S., and Leamon, C. P. (2007) Folate-targeted dinitrophenyl hapten immunotherapy: Effect of linker chemistry on antitumor activity and allergic potential Mol. Pharmaceutics 4, 695-706
-
(2007)
Mol. Pharmaceutics
, vol.4
, pp. 695-706
-
-
Lu, Y.1
You, F.2
Vlahov, I.3
Westrick, E.4
Fan, M.5
Low, P.S.6
Leamon, C.P.7
-
65
-
-
0038641840
-
Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst
-
Rader, C., Sinha, S. C., Popkov, M., Lerner, R. A., and Barbas, C. F., III (2003) Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst Proc. Natl. Acad. Sci. U.S.A. 100, 5396-5400
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 5396-5400
-
-
Rader, C.1
Sinha, S.C.2
Popkov, M.3
Lerner, R.A.4
Barbas Iii, C.F.5
-
66
-
-
7444249590
-
Chemical adaptor immunotherapy: Design, synthesis, and evaluation of novel integrin-targeting devices
-
Li. (2004) Chemical adaptor immunotherapy: Design, synthesis, and evaluation of novel integrin-targeting devices J. Med. Chem. 47, 5630-5640
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5630-5640
-
-
Li1
-
67
-
-
33746344379
-
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector
-
Popkov, M., Rader, C., Gonzalez, B., Sinha, S. C., and Barbas, C. F., III (2006) Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector Int. J. Cancer 119, 1194-1207
-
(2006)
Int. J. Cancer
, vol.119
, pp. 1194-1207
-
-
Popkov, M.1
Rader, C.2
Gonzalez, B.3
Sinha, S.C.4
Barbas Iii, C.F.5
-
68
-
-
33846061734
-
Chemically programmed antibodies: Endothelin receptor targeting CovX-Bodies
-
Doppalapudi, V., Tryder, N., Li, L., Aja, T., Griffith, D., Liao, F.-F., Roxas, G., Ramprasad, M., Bradshaw, C., and Barbas, C. (2007) Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies Bioorg. Med. Chem. Lett. 17, 501-506
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 501-506
-
-
Doppalapudi, V.1
Tryder, N.2
Li, L.3
Aja, T.4
Griffith, D.5
Liao, F.-F.6
Roxas, G.7
Ramprasad, M.8
Bradshaw, C.9
Barbas, C.10
-
69
-
-
33846295955
-
Bifunctional ligands that target cells displaying the alpha vbeta 3 integrin
-
Owen, R. M., Carlson, C. B., Xu, J., Mowery, P., Fasella, E., and Kiessling, L. L. (2007) Bifunctional ligands that target cells displaying the alpha vbeta 3 integrin ChemBioChem 8, 68-82
-
(2007)
ChemBioChem
, vol.8
, pp. 68-82
-
-
Owen, R.M.1
Carlson, C.B.2
Xu, J.3
Mowery, P.4
Fasella, E.5
Kiessling, L.L.6
-
70
-
-
33847739736
-
Selective tumor cell targeting using low-affinity, multivalent interactions
-
Carlson, C. B., Mowery, P., Owen, R. M., Dykhuizen, E. C., and Kiessling, L. L. (2007) Selective tumor cell targeting using low-affinity, multivalent interactions ACS Chem. Biol. 2, 119-127
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 119-127
-
-
Carlson, C.B.1
Mowery, P.2
Owen, R.M.3
Dykhuizen, E.C.4
Kiessling, L.L.5
-
71
-
-
45249120121
-
Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells
-
OßReilly, M. K., Collins, B. E., Han, S., Liao, L., Rillahan, C., Kitov, P. I., Bundle, D. R., and Paulson, J. C. (2008) Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells J. Am. Chem. Soc. 130, 7736-7745
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 7736-7745
-
-
Oßreilly, M.K.1
Collins, B.E.2
Han, S.3
Liao, L.4
Rillahan, C.5
Kitov, P.I.6
Bundle, D.R.7
Paulson, J.C.8
-
72
-
-
79955022805
-
Supramolecular complexing of membrane siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM
-
Cui, L., Kitov, P. I., Completo, G. C., Paulson, J. C., and Bundle, D. R. (2011) Supramolecular complexing of membrane siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM Bioconjugate Chem. 22, 546-550
-
(2011)
Bioconjugate Chem.
, vol.22
, pp. 546-550
-
-
Cui, L.1
Kitov, P.I.2
Completo, G.C.3
Paulson, J.C.4
Bundle, D.R.5
-
73
-
-
63149182641
-
Instant immunity through chemically programmable vaccination and covalent self-assembly
-
Popkov, M., Gonzalez, B., Sinha, S. V., and Barbas, C. F., III (2009) Instant immunity through chemically programmable vaccination and covalent self-assembly Proc. Natl. Acad. Sci. U.S.A. 106, 4378-4383
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 4378-4383
-
-
Popkov, M.1
Gonzalez, B.2
Sinha, S.V.3
Barbas Iii, C.F.4
-
74
-
-
67649635515
-
An efficient chemical approach to bispecific antibodies and antibodies of high valency
-
Gavrilyuk, J., Wuellner, U., Salahuddin, S., Goswami, R., Sinha, S., and Barbas, C. (2009) An efficient chemical approach to bispecific antibodies and antibodies of high valency Bioorg. Med. Chem. Lett. 19, 3716-3720
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 3716-3720
-
-
Gavrilyuk, J.1
Wuellner, U.2
Salahuddin, S.3
Goswami, R.4
Sinha, S.5
Barbas, C.6
-
75
-
-
72249105755
-
Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer
-
Murelli, R. P., Zhang, A. X., Michel, J., Jorgensen, W. L., and Spiegel, D. A. (2009) Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer J. Am. Chem. Soc. 131, 17090-17092
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 17090-17092
-
-
Murelli, R.P.1
Zhang, A.X.2
Michel, J.3
Jorgensen, W.L.4
Spiegel, D.A.5
-
76
-
-
77955575201
-
Expanding the concept of chemically programmable antibodies to RNA aptamers: Chemically programmed biotherapeutics
-
Wuellner, U., Gavrilyuk, J., and Barbas, C. (2010) Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics Angew. Chem., Int. Ed. 49, 5934-5937
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 5934-5937
-
-
Wuellner, U.1
Gavrilyuk, J.2
Barbas, C.3
-
77
-
-
78651091039
-
Chemical generation of bispecific antibodies
-
Doppalapudi, V. R., Huang, J., Liu, D., Jin, P., Liu, B., Li, L., Desharnais, J., Hagen, C., Levin, N. J., Shields, M. J., Parish, M., Murphy, R. E., Del Rosario, J., Oates, B. D., Lai, J.-Y., Matin, M. J., Ainekulu, Z., Bhat, A., Bradshaw, C. W., Woodnutt, G., Lerner, R. A., and Lappe, R. W. (2010) Chemical generation of bispecific antibodies Proc. Natl. Acad. Sci. U.S.A. 107, 22611-22616
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 22611-22616
-
-
Doppalapudi, V.R.1
Huang, J.2
Liu, D.3
Jin, P.4
Liu, B.5
Li, L.6
Desharnais, J.7
Hagen, C.8
Levin, N.J.9
Shields, M.J.10
Parish, M.11
Murphy, R.E.12
Del Rosario, J.13
Oates, B.D.14
Lai, J.-Y.15
Matin, M.J.16
Ainekulu, Z.17
Bhat, A.18
Bradshaw, C.W.19
Woodnutt, G.20
Lerner, R.A.21
Lappe, R.W.22
more..
-
78
-
-
81555214659
-
A chemically induced vaccine strategy for prostate cancer
-
Dubrovska, A., Kim, C., Elliott, J., Shen, W., Kuo, T.-H., Koo, D.-I., Li, C., Tuntland, T., Chang, J., Groessl, T., Wu, X., Gorney, V., Ramirez Montagut, T., Spiegel, D., Cho, C., and Schultz, P. (2011) A chemically induced vaccine strategy for prostate cancer ACS Chem. Biol. 6, 1223-1231
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 1223-1231
-
-
Dubrovska, A.1
Kim, C.2
Elliott, J.3
Shen, W.4
Kuo, T.-H.5
Koo, D.-I.6
Li, C.7
Tuntland, T.8
Chang, J.9
Groessl, T.10
Wu, X.11
Gorney, V.12
Ramirez Montagut, T.13
Spiegel, D.14
Cho, C.15
Schultz, P.16
-
79
-
-
84857584455
-
Reprogramming urokinase into an antibody-recruiting anticancer agent
-
Jakobsche, C. E., McEnaney, P. J., Zhang, A. X., and Spiegel, D. A. (2011) Reprogramming urokinase into an antibody-recruiting anticancer agent ACS Chem. Biol. 7, 316-321
-
(2011)
ACS Chem. Biol.
, vol.7
, pp. 316-321
-
-
Jakobsche, C.E.1
McEnaney, P.J.2
Zhang, A.X.3
Spiegel, D.A.4
-
80
-
-
0021678856
-
A unique natural human IgG antibody with anti-alpha -galactosyl specificity
-
Galili, U., Rachmilewitz, E. A., Peleg, A., and Flechner, I. (1984) A unique natural human IgG antibody with anti-alpha -galactosyl specificity J. Exp. Med. 160, 1519-1531
-
(1984)
J. Exp. Med.
, vol.160
, pp. 1519-1531
-
-
Galili, U.1
Rachmilewitz, E.A.2
Peleg, A.3
Flechner, I.4
-
81
-
-
0027944492
-
Characterization and affinity isolation of xenoreactive human natural antibodies
-
Parker, W., Bruno, D., Holzknecht, Z. E., and Platt, J. L. (1994) Characterization and affinity isolation of xenoreactive human natural antibodies J. Immunol. 153, 3791-3803
-
(1994)
J. Immunol.
, vol.153
, pp. 3791-3803
-
-
Parker, W.1
Bruno, D.2
Holzknecht, Z.E.3
Platt, J.L.4
-
82
-
-
0000665022
-
Evolutionary relationship between the natural anti-Gal antibody and the Galalpha 1 -> 3Gal epitope in primates
-
Galili, U., Clark, M. R., Shohet, S. B., Buehler, J., and Macher, B. A. (1987) Evolutionary relationship between the natural anti-Gal antibody and the Galalpha 1 -> 3Gal epitope in primates Proc. Natl. Acad. Sci. U.S.A. 84, 1369-1373
-
(1987)
Proc. Natl. Acad. Sci. U.S.A.
, vol.84
, pp. 1369-1373
-
-
Galili, U.1
Clark, M.R.2
Shohet, S.B.3
Buehler, J.4
MacHer, B.A.5
-
83
-
-
0021718202
-
Natural DNP-binding immunoglobulins and antibody multispecificity
-
Ortega, E., Kostovetzky, M., and Larralde, C. (1984) Natural DNP-binding immunoglobulins and antibody multispecificity Mol. Immunol. 21, 883-888
-
(1984)
Mol. Immunol.
, vol.21
, pp. 883-888
-
-
Ortega, E.1
Kostovetzky, M.2
Larralde, C.3
-
84
-
-
0015792347
-
Natural antibodies specific to the 2,4-dinitrophenyl group
-
Farah, F. S. (1973) Natural antibodies specific to the 2,4-dinitrophenyl group Immunology 25, 217-226
-
(1973)
Immunology
, vol.25
, pp. 217-226
-
-
Farah, F.S.1
-
85
-
-
77952926530
-
Nitroaromatic compounds, from synthesis to biodegradation
-
Ju, K.-S. and Parales, R. (2010) Nitroaromatic compounds, from synthesis to biodegradation Microbiol. Mol. Biol. Rev. 74, 250
-
(2010)
Microbiol. Mol. Biol. Rev.
, vol.74
, pp. 250
-
-
Ju, K.-S.1
Parales, R.2
-
86
-
-
84875225045
-
-
2,4-Dinitrophenol (CASRN 51-28-5), In, United States Environmental Protection Agency.
-
2,4-Dinitrophenol (CASRN 51-28-5), In http://www.epa.gov/ncea/iris/subst/ 0152.htm, United States Environmental Protection Agency.
-
-
-
-
88
-
-
0025029650
-
Environmental nitrophenols and autoimmunity
-
Lauer, K. (1990) Environmental nitrophenols and autoimmunity Mol. Immunol. 27, 697-698
-
(1990)
Mol. Immunol.
, vol.27
, pp. 697-698
-
-
Lauer, K.1
-
89
-
-
79961234884
-
Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids
-
Gauba, V., Grünewald, J., Gorney, V., Deaton, L. M., Kang, M., Bursulaya, B., Ou, W., Lerner, R. A., Schmedt, C., Geierstanger, B. H., Schultz, P. G., and Ramirez-Montagut, T. (2011) Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids Proc. Natl. Acad. Sci. U.S.A. 108, 12821-12826
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 12821-12826
-
-
Gauba, V.1
Grünewald, J.2
Gorney, V.3
Deaton, L.M.4
Kang, M.5
Bursulaya, B.6
Ou, W.7
Lerner, R.A.8
Schmedt, C.9
Geierstanger, B.H.10
Schultz, P.G.11
Ramirez-Montagut, T.12
-
90
-
-
63149104746
-
Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids
-
Grünewald, J., Hunt, G. S., Dong, L., Niessen, F., Wen, B. G., Tsao, M.-L., Perera, R., Kang, M., Laffitte, B. A., Azarian, S., Ruf, W., Nasoff, M., Lerner, R. A., Schultz, P. G., and Smider, V. V. (2009) Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids Proc. Natl. Acad. Sci. U.S.A. 106, 4337-4342
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 4337-4342
-
-
Grünewald, J.1
Hunt, G.S.2
Dong, L.3
Niessen, F.4
Wen, B.G.5
Tsao, M.-L.6
Perera, R.7
Kang, M.8
Laffitte, B.A.9
Azarian, S.10
Ruf, W.11
Nasoff, M.12
Lerner, R.A.13
Schultz, P.G.14
Smider, V.V.15
-
91
-
-
49649110168
-
Immunochemical termination of self-tolerance
-
Grünewald, J., Tsao, M.-L., Perera, R., Dong, L., Niessen, F., Wen, B. G., Kubitz, D. M., Smider, V. V., Ruf, W., Nasoff, M., Lerner, R. A., and Schultz, P. G. (2008) Immunochemical termination of self-tolerance Proc. Natl. Acad. Sci. U.S.A. 105, 11276-11280
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 11276-11280
-
-
Grünewald, J.1
Tsao, M.-L.2
Perera, R.3
Dong, L.4
Niessen, F.5
Wen, B.G.6
Kubitz, D.M.7
Smider, V.V.8
Ruf, W.9
Nasoff, M.10
Lerner, R.A.11
Schultz, P.G.12
-
92
-
-
63849233160
-
Immunostimulatory activity of haptenated proteins
-
Palm, N. W. and Medzhitov, R. (2009) Immunostimulatory activity of haptenated proteins Proc. Natl. Acad. Sci. U.S.A. 106, 4782-4787
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 4782-4787
-
-
Palm, N.W.1
Medzhitov, R.2
-
93
-
-
0030923295
-
Evidence for hapten recognition in receptor-mediated intracellular uptake of a hapten-protein conjugate by murine macrophage
-
Cherukuri, A., Durack, G., and Voss, E. W., Jr. (1997) Evidence for hapten recognition in receptor-mediated intracellular uptake of a hapten-protein conjugate by murine macrophage Mol. Immunol. 34, 21-32
-
(1997)
Mol. Immunol.
, vol.34
, pp. 21-32
-
-
Cherukuri, A.1
Durack, G.2
Voss Jr., E.W.3
-
94
-
-
0029590066
-
Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes
-
Wagner, J., Lerner, R. A., and Barbas, C. F., III (1995) Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes Science 270, 1797-1800
-
(1995)
Science
, vol.270
, pp. 1797-1800
-
-
Wagner, J.1
Lerner, R.A.2
Barbas Iii, C.F.3
-
95
-
-
0031457319
-
Immune versus natural selection: Antibody aldolases with enzymic rates but broader scope
-
Barbas, C. F., Heine, A., Zhong, G., Hoffmann, T., Gramatikova, S., Bjrnestedt, R., List, B., Anderson, J., Stura, E. A., Wilson, I. A., and Lerner, R. A. (1997) Immune versus natural selection: antibody aldolases with enzymic rates but broader scope Science 278, 2085-2092
-
(1997)
Science
, vol.278
, pp. 2085-2092
-
-
Barbas, C.F.1
Heine, A.2
Zhong, G.3
Hoffmann, T.4
Gramatikova, S.5
Bjrnestedt, R.6
List, B.7
Anderson, J.8
Stura, E.A.9
Wilson, I.A.10
Lerner, R.A.11
-
96
-
-
33746642087
-
Breaking the one antibody-one target axiom
-
Guo, F., Das, S., Mueller, B., Barbas, C., Lerner, R., and Sinha, S. (2006) Breaking the one antibody-one target axiom Proc. Natl. Acad. Sci. U.S.A. 103, 11009-11014
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 11009-11014
-
-
Guo, F.1
Das, S.2
Mueller, B.3
Barbas, C.4
Lerner, R.5
Sinha, S.6
-
97
-
-
60449100413
-
Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2
-
Gavrilyuk, J., Wuellner, U., and Barbas, C. (2009) Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2 Bioorg. Med. Chem. Lett. 19, 1421-1424
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 1421-1424
-
-
Gavrilyuk, J.1
Wuellner, U.2
Barbas, C.3
-
98
-
-
0036837384
-
Reactive immunization: A unique approach to catalytic antibodies
-
Tanaka, F. and Barbas, C. F. (2002) Reactive immunization: a unique approach to catalytic antibodies J. Immunol. Methods 269, 67-79
-
(2002)
J. Immunol. Methods
, vol.269
, pp. 67-79
-
-
Tanaka, F.1
Barbas, C.F.2
-
99
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal, A., Siegel, R., Xu, J., and Ward, E. (2010) Cancer statistics, 2010 CA Cancer J. Clin. 60, 277-300
-
(2010)
CA Cancer J. Clin.
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
100
-
-
11144242211
-
Chemotherapy and the war on cancer
-
Chabner, B. A. and Roberts, T. G. (2005) Chemotherapy and the war on cancer Nat. Rev. Cancer 5, 65-72
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 65-72
-
-
Chabner, B.A.1
Roberts, T.G.2
-
101
-
-
39749166975
-
DNA repair pathways as targets for cancer therapy
-
Helleday, T., Petermann, E., Lundin, C., Hodgson, B., and Sharma, R. (2008) DNA repair pathways as targets for cancer therapy Nat. Rev. Cancer. 8, 193-204
-
(2008)
Nat. Rev. Cancer.
, vol.8
, pp. 193-204
-
-
Helleday, T.1
Petermann, E.2
Lundin, C.3
Hodgson, B.4
Sharma, R.5
-
102
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant, D., Duran, R., and Gottlieb, E. (2010) Targeting metabolic transformation for cancer therapy Nat. Rev. Cancer. 10, 267-277
-
(2010)
Nat. Rev. Cancer.
, vol.10
, pp. 267-277
-
-
Tennant, D.1
Duran, R.2
Gottlieb, E.3
-
103
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang, J., Yang, P., and Gray, N. (2009) Targeting cancer with small molecule kinase inhibitors Nat. Rev. Cancer. 9, 28-39
-
(2009)
Nat. Rev. Cancer.
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.2
Gray, N.3
-
104
-
-
77954939175
-
Prostate cancer as a model for tumour immunotherapy
-
Drake, C. G. (2010) Prostate cancer as a model for tumour immunotherapy Nat. Rev. Immunol. 10, 580-593
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 580-593
-
-
Drake, C.G.1
-
105
-
-
77953143235
-
Targeted cancer therapies
-
Aggarwal, S. (2010) Targeted cancer therapies Nat. Rev. Drug Discovery 9, 427-428
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 427-428
-
-
Aggarwal, S.1
-
106
-
-
36248976197
-
Alpha-v integrins as therapeutic targets in oncology
-
Nemeth, J. A., Nakada, M. T., Trikha, M., Lang, Z., Gordon, M. S., Jayson, G. C., Corringham, R., Prabhakar, U., Davis, H. M., and Beckman, R. A. (2007) Alpha-v integrins as therapeutic targets in oncology Cancer Invest. 25, 632-646
-
(2007)
Cancer Invest.
, vol.25
, pp. 632-646
-
-
Nemeth, J.A.1
Nakada, M.T.2
Trikha, M.3
Lang, Z.4
Gordon, M.S.5
Jayson, G.C.6
Corringham, R.7
Prabhakar, U.8
Davis, H.M.9
Beckman, R.A.10
-
107
-
-
0037278885
-
Integrin adhesion receptors in tumor metastasis
-
Felding-Habermann, B. (2003) Integrin adhesion receptors in tumor metastasis Clin. Exp. Metastasis 20, 203-213
-
(2003)
Clin. Exp. Metastasis
, vol.20
, pp. 203-213
-
-
Felding-Habermann, B.1
-
108
-
-
0034934528
-
Studies on the expression of alpha(v)beta3 integrin receptors in non-malignant and malignant human cervical tumor tissues
-
Chattopadhyay, N. and Chatterjee, A. (2001) Studies on the expression of alpha(v)beta3 integrin receptors in non-malignant and malignant human cervical tumor tissues J. Exp. Clin. Cancer Res. 20, 269-275
-
(2001)
J. Exp. Clin. Cancer Res.
, vol.20
, pp. 269-275
-
-
Chattopadhyay, N.1
Chatterjee, A.2
-
109
-
-
0031594601
-
Alphav integrins mediate adhesion and migration of breast carcinoma cell lines
-
Wong, N. C., Mueller, B. M., Barbas, C. F., Ruminski, P., Quaranta, V., Lin, E. C., and Smith, J. W. (1998) Alphav integrins mediate adhesion and migration of breast carcinoma cell lines Clin. Exp. Metastasis 16, 50-61
-
(1998)
Clin. Exp. Metastasis
, vol.16
, pp. 50-61
-
-
Wong, N.C.1
Mueller, B.M.2
Barbas, C.F.3
Ruminski, P.4
Quaranta, V.5
Lin, E.C.6
Smith, J.W.7
-
110
-
-
0037317520
-
The endothelin axis: Emerging role in cancer
-
Nelson, J., Bagnato, A., Battistini, B., and Nisen, P. (2003) The endothelin axis: emerging role in cancer Nat. Rev. Cancer 3, 110-116
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 110-116
-
-
Nelson, J.1
Bagnato, A.2
Battistini, B.3
Nisen, P.4
-
111
-
-
0036884694
-
New therapeutics that antagonize endothelin: Promises and frustrations
-
Remuzzi, G., Perico, N., and Benigni, A. (2002) New therapeutics that antagonize endothelin: promises and frustrations Nat. Rev. Drug Discovery 1, 986-1001
-
(2002)
Nat. Rev. Drug Discovery
, vol.1
, pp. 986-1001
-
-
Remuzzi, G.1
Perico, N.2
Benigni, A.3
-
112
-
-
20044366257
-
Endothelin antagonism in pulmonary hypertension, heart failure, and beyond
-
Attin, T., Camidge, R., Newby, D. E., and Webb, D. J. (2005) Endothelin antagonism in pulmonary hypertension, heart failure, and beyond Heart 91, 825-831
-
(2005)
Heart
, vol.91
, pp. 825-831
-
-
Attin, T.1
Camidge, R.2
Newby, D.E.3
Webb, D.J.4
-
113
-
-
79960320269
-
Antitumor efficacy of a thrombospondin 1 mimetic CovX-Body
-
Li, L. N., Leedom, T. A., Do, J., Huang, H. H., Lai, J. Y., Johnson, K., Osothprarop, T. F., Rizzo, J. D., Doppalapudi, V. R., Bradshaw, C. W., Lappe, R. W., Woodnutt, G., Levin, N. J., and Pirie-Shepherd, S. R. (2011) Antitumor efficacy of a thrombospondin 1 mimetic CovX-Body Transl. Oncol. 4, 239-247
-
(2011)
Transl. Oncol.
, vol.4
, pp. 239-247
-
-
Li, L.N.1
Leedom, T.A.2
Do, J.3
Huang, H.H.4
Lai, J.Y.5
Johnson, K.6
Osothprarop, T.F.7
Rizzo, J.D.8
Doppalapudi, V.R.9
Bradshaw, C.W.10
Lappe, R.W.11
Woodnutt, G.12
Levin, N.J.13
Pirie-Shepherd, S.R.14
-
114
-
-
79952271693
-
Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth
-
Huang, H., Lai, J.-Y., Do, J., Liu, D., Li, L., Del Rosario, J., Doppalapudi, V. R., Pirie-Shepherd, S., Levin, N., Bradshaw, C., Woodnutt, G., Lappe, R., and Bhat, A. (2011) Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth Clin. Cancer Res. 17, 1001-1011
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1001-1011
-
-
Huang, H.1
Lai, J.-Y.2
Do, J.3
Liu, D.4
Li, L.5
Del Rosario, J.6
Doppalapudi, V.R.7
Pirie-Shepherd, S.8
Levin, N.9
Bradshaw, C.10
Woodnutt, G.11
Lappe, R.12
Bhat, A.13
-
115
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington, A. D. and Szostak, J. W. (1990) In vitro selection of RNA molecules that bind specific ligands Nature 346, 818-822
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
116
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
Tuerk, C. and Gold, L. (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase Science 249, 505-510
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
117
-
-
33947602811
-
Siglecs and their roles in the immune system
-
Crocker, P. R., Paulson, J. C., and Varki, A. (2007) Siglecs and their roles in the immune system Nat. Rev. Immunol. 7, 255-266
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 255-266
-
-
Crocker, P.R.1
Paulson, J.C.2
Varki, A.3
-
118
-
-
1942503277
-
Folate receptor-targeted immunotherapy of cancer: Mechanism and therapeutic potential
-
Lu, Y., Sega, E., Leamon, C., and Low, P. (2004) Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential Adv. Drug Delivery Rev. 56, 1161-1176
-
(2004)
Adv. Drug Delivery Rev.
, vol.56
, pp. 1161-1176
-
-
Lu, Y.1
Sega, E.2
Leamon, C.3
Low, P.4
-
119
-
-
62149129236
-
Therapeutic antibodies: Successes, limitations and hopes for the future
-
Chames, P., Van Regenmortel, M., Weiss, E., and Baty, D. (2009) Therapeutic antibodies: successes, limitations and hopes for the future Br. J. Pharmacol. 157, 220-233
-
(2009)
Br. J. Pharmacol.
, vol.157
, pp. 220-233
-
-
Chames, P.1
Van Regenmortel, M.2
Weiss, E.3
Baty, D.4
-
120
-
-
0025250015
-
Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice
-
Ellenhorn, J. D., Schreiber, H., and Bluestone, J. A. (1990) Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice J. Immunol. 144, 2840-2846
-
(1990)
J. Immunol.
, vol.144
, pp. 2840-2846
-
-
Ellenhorn, J.D.1
Schreiber, H.2
Bluestone, J.A.3
-
121
-
-
0035871863
-
The combination of chemotherapy and systemic immunotherapy with soluble B7-immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses
-
Runyon, K., Lee, K., Zuberek, K., Collins, M., Leonard, J. P., and Dunussi Joannopoulos, K. (2001) The combination of chemotherapy and systemic immunotherapy with soluble B7-immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses Blood 97, 2420-2426
-
(2001)
Blood
, vol.97
, pp. 2420-2426
-
-
Runyon, K.1
Lee, K.2
Zuberek, K.3
Collins, M.4
Leonard, J.P.5
Dunussi Joannopoulos, K.6
-
122
-
-
0035889129
-
Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody
-
Ruf, P. and Lindhofer, H. (2001) Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody Blood 98, 2526-2534
-
(2001)
Blood
, vol.98
, pp. 2526-2534
-
-
Ruf, P.1
Lindhofer, H.2
-
123
-
-
47149094444
-
Induction of long-lasting antitumor immunity by concomitant cell therapy with allogeneic lymphocytes and trifunctional bispecific antibody
-
Morecki, S., Lindhofer, H., Yacovlev, E., Gelfand, Y., Ruf, P., and Slavin, S. (2008) Induction of long-lasting antitumor immunity by concomitant cell therapy with allogeneic lymphocytes and trifunctional bispecific antibody Exp. Hematol. 36, 997-1003
-
(2008)
Exp. Hematol.
, vol.36
, pp. 997-1003
-
-
Morecki, S.1
Lindhofer, H.2
Yacovlev, E.3
Gelfand, Y.4
Ruf, P.5
Slavin, S.6
-
124
-
-
77956444662
-
A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules
-
Zhang, A., Murelli, R., Barinka, C., Michel, J., Cocleaza, A., Jorgensen, W., Lubkowski, J., and Spiegel, D. (2010) A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules J. Am. Chem. Soc. 132, 12711-12716
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 12711-12716
-
-
Zhang, A.1
Murelli, R.2
Barinka, C.3
Michel, J.4
Cocleaza, A.5
Jorgensen, W.6
Lubkowski, J.7
Spiegel, D.8
-
125
-
-
0030341967
-
Analysis of glycosylation of prostate-specific membrane antigen derived from LNCaP cells, prostatic carcinoma tumors, and serum from prostate cancer patients
-
Holmes, E. H., Greene, T. G., Tino, W. T., Boynton, A. L., Aldape, H. C., Misrock, S. L., and Murphy, G. P. (1996) Analysis of glycosylation of prostate-specific membrane antigen derived from LNCaP cells, prostatic carcinoma tumors, and serum from prostate cancer patients Prostate Suppl. 7, 25-29
-
(1996)
Prostate Suppl.
, vol.7
, pp. 25-29
-
-
Holmes, E.H.1
Greene, T.G.2
Tino, W.T.3
Boynton, A.L.4
Aldape, H.C.5
Misrock, S.L.6
Murphy, G.P.7
-
126
-
-
82555173080
-
Prostate-specific membrane antigen as a potential novel vascular target for treatment of glioblastoma multiforme
-
Wernicke, A. G., Edgar, M., Lavi, E., Liu, H., Salerno, P., Bander, N., and Gutin, P. (2011) Prostate-specific membrane antigen as a potential novel vascular target for treatment of glioblastoma multiforme Archi. Pathol. Lab. Med. 135, 1486-1489
-
(2011)
Archi. Pathol. Lab. Med.
, vol.135
, pp. 1486-1489
-
-
Wernicke, A.G.1
Edgar, M.2
Lavi, E.3
Liu, H.4
Salerno, P.5
Bander, N.6
Gutin, P.7
-
127
-
-
80455174758
-
Folate hydrolase (prostate-specific antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature
-
Samplaski, M., Heston, W., Elson, P., Magi Galluzzi, C., and Hansel, D. (2011) Folate hydrolase (prostate-specific antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature Mod. Pathol. 24, 1521-1529
-
(2011)
Mod. Pathol.
, vol.24
, pp. 1521-1529
-
-
Samplaski, M.1
Heston, W.2
Elson, P.3
Magi Galluzzi, C.4
Hansel, D.5
-
128
-
-
70449532104
-
Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers
-
Haffner, M., Kronberger, I., Ross, J., Sheehan, C., Zitt, M., Mhlmann, G., Ofner, D., Zelger, B., Ensinger, C., Yang, X., Geley, S., Margreiter, R., and Bander, N. (2009) Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers Hum. Pathol. 40, 1754-1761
-
(2009)
Hum. Pathol.
, vol.40
, pp. 1754-1761
-
-
Haffner, M.1
Kronberger, I.2
Ross, J.3
Sheehan, C.4
Zitt, M.5
Mhlmann, G.6
Ofner, D.7
Zelger, B.8
Ensinger, C.9
Yang, X.10
Geley, S.11
Margreiter, R.12
Bander, N.13
-
129
-
-
0036906177
-
UPAR: A versatile signalling orchestrator
-
Blasi, F. and Carmeliet, P. (2002) uPAR: a versatile signalling orchestrator Nat. Rev. Mol. Cell Biol. 3, 932-943
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 932-943
-
-
Blasi, F.1
Carmeliet, P.2
-
130
-
-
3042743709
-
The urokinase receptor as a potential target in cancer therapy
-
Romer, J., Nielsen, B., and Ploug, M. (2004) The urokinase receptor as a potential target in cancer therapy Curr. Pharm. Des. 10, 2359-2376
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 2359-2376
-
-
Romer, J.1
Nielsen, B.2
Ploug, M.3
-
131
-
-
0030788411
-
The urokinase-type plasminogen activator system in cancer metastasis: A review
-
Andreasen, P. A., Kjller, L., Christensen, L., and Duffy, M. J. (1997) The urokinase-type plasminogen activator system in cancer metastasis: a review Int. J. Cancer 72, 1-22
-
(1997)
Int. J. Cancer
, vol.72
, pp. 1-22
-
-
Andreasen, P.A.1
Kjller, L.2
Christensen, L.3
Duffy, M.J.4
-
132
-
-
0023735157
-
Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report
-
Duffy, M. J., Ogrady, P., Devaney, D., OßSiorain, L., Fennelly, J. J., and Lijnen, H. J. (1988) Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report Cancer 62, 531-533
-
(1988)
Cancer
, vol.62
, pp. 531-533
-
-
Duffy, M.J.1
Ogrady, P.2
Devaney, D.3
Oßsiorain, L.4
Fennelly, J.J.5
Lijnen, H.J.6
-
133
-
-
0032080905
-
The level of urokinase-type plasminogen activator receptor is increased in serum of ovarian cancer patients
-
Sier, C. F., Stephens, R., Bizik, J., Mariani, A., Bassan, M., Pedersen, N., Frigerio, L., Ferrari, A., Dan, K., Brnner, N., and Blasi, F. (1998) The level of urokinase-type plasminogen activator receptor is increased in serum of ovarian cancer patients Cancer Res. 58, 1843-1849
-
(1998)
Cancer Res.
, vol.58
, pp. 1843-1849
-
-
Sier, C.F.1
Stephens, R.2
Bizik, J.3
Mariani, A.4
Bassan, M.5
Pedersen, N.6
Frigerio, L.7
Ferrari, A.8
Dan, K.9
Brnner, N.10
Blasi, F.11
-
134
-
-
1642375334
-
Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: Novel tumor-derived factors with a high prognostic and predictive impact in breast cancer
-
Harbeck, N., Kates, R., Gauger, K., Willems, A., Kiechle, M., Magdolen, V., and Schmitt, M. (2004) Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer Thrombosis Haemostasis 91, 450-456
-
(2004)
Thrombosis Haemostasis
, vol.91
, pp. 450-456
-
-
Harbeck, N.1
Kates, R.2
Gauger, K.3
Willems, A.4
Kiechle, M.5
Magdolen, V.6
Schmitt, M.7
-
135
-
-
0034901514
-
Association of urokinase-type plasminogen activator and its inhibitor with disease progression and prognosis in ovarian cancer
-
Konecny, G., Untch, M., Pihan, A., Kimmig, R., Gropp, M., Stieber, P., Hepp, H., Slamon, D., and Pegram, M. (2001) Association of urokinase-type plasminogen activator and its inhibitor with disease progression and prognosis in ovarian cancer Clin. Cancer Res. 7, 1743-1749
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1743-1749
-
-
Konecny, G.1
Untch, M.2
Pihan, A.3
Kimmig, R.4
Gropp, M.5
Stieber, P.6
Hepp, H.7
Slamon, D.8
Pegram, M.9
-
136
-
-
54149090275
-
-
2004 update, ed. p, World Health Organization, Geneva, Switzerland.
-
Mathers, C., Boerma, T., and Ma Fat, D. (2008) The Global Burden of Disease, 2004 update, ed., p 146, World Health Organization, Geneva, Switzerland.
-
(2008)
The Global Burden of Disease
, pp. 146
-
-
Mathers, C.1
Boerma, T.2
Ma Fat, D.3
-
137
-
-
82255175484
-
Vaccines for the twenty-first century society
-
Rappuoli, R., Mandl, C. W., Black, S., and De Gregorio, E. (2011) Vaccines for the twenty-first century society Nat. Rev. Immunol. 11, 865-872
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 865-872
-
-
Rappuoli, R.1
Mandl, C.W.2
Black, S.3
De Gregorio, E.4
-
138
-
-
0033979937
-
Vaccines in historic evolution and perspective: A narrative of vaccine discoveries
-
Hilleman, M. R. (2000) Vaccines in historic evolution and perspective: a narrative of vaccine discoveries Vaccine 18, 1436-1447
-
(2000)
Vaccine
, vol.18
, pp. 1436-1447
-
-
Hilleman, M.R.1
-
139
-
-
33750862932
-
Vaccine manufacturing: Challenges and solutions
-
Ulmer, J. B., Valley, U., and Rappuoli, R. (2006) Vaccine manufacturing: challenges and solutions Nat. Biotechnol. 24, 1377-1383
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1377-1383
-
-
Ulmer, J.B.1
Valley, U.2
Rappuoli, R.3
-
140
-
-
73449088379
-
Vaccines: The fourth century
-
Plotkin, S. A. (2009) Vaccines: the fourth century Clin. Vaccine Immunol. 16, 1709-1719
-
(2009)
Clin. Vaccine Immunol.
, vol.16
, pp. 1709-1719
-
-
Plotkin, S.A.1
-
141
-
-
34250331531
-
The perfect mix: Recent progress in adjuvant research
-
Guy, B. (2007) The perfect mix: recent progress in adjuvant research Nat. Rev. Microbiol. 5, 505-517
-
(2007)
Nat. Rev. Microbiol.
, vol.5
, pp. 505-517
-
-
Guy, B.1
-
142
-
-
27944454849
-
The business of making vaccines
-
Sheridan, C. (2005) The business of making vaccines Nat. Biotechnol. 23, 1359-1366
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1359-1366
-
-
Sheridan, C.1
-
143
-
-
0035823272
-
Humans as the worldβs greatest evolutionary force
-
Palumbi, S. R. (2001) Humans as the worldβs greatest evolutionary force Science 293, 1786-1790
-
(2001)
Science
, vol.293
, pp. 1786-1790
-
-
Palumbi, S.R.1
-
144
-
-
80053490673
-
Antiviral drugs for viruses other than human immunodeficiency virus
-
Razonable, R. R. (2011) Antiviral drugs for viruses other than human immunodeficiency virus Mayo Clin. Proc. 86, 1009-1026
-
(2011)
Mayo Clin. Proc.
, vol.86
, pp. 1009-1026
-
-
Razonable, R.R.1
-
145
-
-
72049112028
-
Monoclonal antibody-based therapies for microbial diseases
-
Saylor, C., Dadachova, E., and Casadevall, A. (2009) Monoclonal antibody-based therapies for microbial diseases Vaccine 27 (Suppl 6) G38-46
-
(2009)
Vaccine
, vol.27
, Issue.SUPPL. 6
, pp. 38-46
-
-
Saylor, C.1
Dadachova, E.2
Casadevall, A.3
-
146
-
-
40649127250
-
Anti-infective antibodies: A novel tool to prevent and treat nosocomial diseases
-
Nagy, E., Giefing, C., and von Gabain, A. (2008) Anti-infective antibodies: a novel tool to prevent and treat nosocomial diseases Expert Rev. Anti-Infect. Ther.. 6, 21-30
-
(2008)
Expert Rev. Anti-Infect. Ther.
, vol.6
, pp. 21-30
-
-
Nagy, E.1
Giefing, C.2
Von Gabain, A.3
-
147
-
-
57049154860
-
Antibodies for the treatment of bacterial infections: Current experience and future prospects
-
Bebbington, C. and Yarranton, G. (2008) Antibodies for the treatment of bacterial infections: current experience and future prospects Curr. Opin. Biotechnol. 19, 613-619
-
(2008)
Curr. Opin. Biotechnol.
, vol.19
, pp. 613-619
-
-
Bebbington, C.1
Yarranton, G.2
-
148
-
-
36549038193
-
Monoclonal antibodies for prophylaxis and therapy of infectious diseases
-
ter Meulen, J. (2007) Monoclonal antibodies for prophylaxis and therapy of infectious diseases Expert Opin. Emerging Drugs 12, 525-540
-
(2007)
Expert Opin. Emerging Drugs
, vol.12
, pp. 525-540
-
-
Ter Meulen, J.1
-
149
-
-
36749025848
-
Monoclonal antibodies against viruses and bacteria: A survey of patents
-
Xiao, X. and Dimitrov, D. S. (2007) Monoclonal antibodies against viruses and bacteria: a survey of patents Recent Pat. Antiinfect. Drug Discovery 2, 171-177
-
(2007)
Recent Pat. Antiinfect. Drug Discovery
, vol.2
, pp. 171-177
-
-
Xiao, X.1
Dimitrov, D.S.2
-
150
-
-
80455176681
-
Monoclonal antibodies in infectious diseases: Clinical pipeline in 2011
-
Jan, t. M. (2011) Monoclonal antibodies in infectious diseases: Clinical pipeline in 2011 Infect. Dis. Clin. North Am. 25, 789-802
-
(2011)
Infect. Dis. Clin. North Am.
, vol.25
, pp. 789-802
-
-
Jan, T.M.1
-
151
-
-
53649106826
-
Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection
-
Sekirov, I., Tam, N. M., Jogova, M., Robertson, M. L., Li, Y., Lupp, C., and Finlay, B. B. (2008) Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection Infect. Immun. 76, 4726-4736
-
(2008)
Infect. Immun.
, vol.76
, pp. 4726-4736
-
-
Sekirov, I.1
Tam, N.M.2
Jogova, M.3
Robertson, M.L.4
Li, Y.5
Lupp, C.6
Finlay, B.B.7
-
152
-
-
79952768866
-
Shifting the balance: Antibiotic effects on host-microbiota mutualism
-
Willing, B. P., Russell, S. L., and Finlay, B. B. (2011) Shifting the balance: antibiotic effects on host-microbiota mutualism Nat. Rev. Microbiol. 9, 233-243
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 233-243
-
-
Willing, B.P.1
Russell, S.L.2
Finlay, B.B.3
-
153
-
-
0034680167
-
Molecular mechanisms that confer antibacterial drug resistance
-
Walsh, C. (2000) Molecular mechanisms that confer antibacterial drug resistance Nature 406, 775-781
-
(2000)
Nature
, vol.406
, pp. 775-781
-
-
Walsh, C.1
-
154
-
-
65249146929
-
Multidrug resistance in bacteria
-
Nikaido, H. (2009) Multidrug resistance in bacteria Annu. Rev. Biochem. 78, 119-146
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 119-146
-
-
Nikaido, H.1
-
155
-
-
79953740494
-
Fix the antibiotics pipeline
-
Cooper, M. A. and Shlaes, D. (2011) Fix the antibiotics pipeline Nature 472, 32
-
(2011)
Nature
, vol.472
, pp. 32
-
-
Cooper, M.A.1
Shlaes, D.2
-
156
-
-
4444221766
-
A review of licensed viral vaccines, some of their safety concerns, and the advances in the development of investigational viral vaccines
-
Huang, D. B., Wu, J. J., and Tyring, S. K. (2004) A review of licensed viral vaccines, some of their safety concerns, and the advances in the development of investigational viral vaccines J. Infect. 49, 179-209
-
(2004)
J. Infect.
, vol.49
, pp. 179-209
-
-
Huang, D.B.1
Wu, J.J.2
Tyring, S.K.3
-
157
-
-
4344686181
-
Progress on new vaccine strategies against chronic viral infections
-
Berzofsky, J. A., Ahlers, J. D., Janik, J., Morris, J., Oh, S., Terabe, M., and Belyakov, I. M. (2004) Progress on new vaccine strategies against chronic viral infections J. Clin. Invest. 114, 450-462
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 450-462
-
-
Berzofsky, J.A.1
Ahlers, J.D.2
Janik, J.3
Morris, J.4
Oh, S.5
Terabe, M.6
Belyakov, I.M.7
-
158
-
-
0030221156
-
Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma
-
Carreiras, F., Denoux, Y., Staedel, C., Lehmann, M., Sichel, F., and Gauduchon, P. (1996) Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma Gynecol. Oncol. 62, 260-267
-
(1996)
Gynecol. Oncol.
, vol.62
, pp. 260-267
-
-
Carreiras, F.1
Denoux, Y.2
Staedel, C.3
Lehmann, M.4
Sichel, F.5
Gauduchon, P.6
-
159
-
-
79952151929
-
Comparison of the mechanisms of drug resistance among HIV, Hepatitis B, and Hepatitis C
-
Margeridon-Thermet, S. and Shafer, R. W. (2010) Comparison of the mechanisms of drug resistance among HIV, Hepatitis B, and Hepatitis C Viruses 2, 2696-2739
-
(2010)
Viruses
, vol.2
, pp. 2696-2739
-
-
Margeridon-Thermet, S.1
Shafer, R.W.2
-
160
-
-
67949118684
-
A perspective on antiviral resistance
-
Griffiths, P. D. (2009) A perspective on antiviral resistance J. Clin. Virol. 46, 3-8
-
(2009)
J. Clin. Virol.
, vol.46
, pp. 3-8
-
-
Griffiths, P.D.1
-
161
-
-
0036050539
-
Strategies in the design of antiviral drugs
-
De Clercq, E. (2002) Strategies in the design of antiviral drugs Nat. Rev. Drug Discovery 1, 13-25
-
(2002)
Nat. Rev. Drug Discovery
, vol.1
, pp. 13-25
-
-
De Clercq, E.1
-
162
-
-
38449118706
-
Exploring the native human antibody repertoire to create antiviral therapeutics
-
Dessain, S. K., Adekar, S. P., and Berry, J. D. (2008) Exploring the native human antibody repertoire to create antiviral therapeutics Curr. Top. Microbiol. Immunol. 317, 155-183
-
(2008)
Curr. Top. Microbiol. Immunol.
, vol.317
, pp. 155-183
-
-
Dessain, S.K.1
Adekar, S.P.2
Berry, J.D.3
-
163
-
-
0141680855
-
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl) oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): A novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions
-
Wang, T., Zhang, Z., Wallace, O. B., Deshpande, M., Fang, H., Yang, Z., Zadjura, L. M., Tweedie, D. L., Huang, S., Zhao, F., Ranadive, S., Robinson, B. S., Gong, Y. F., Ricarrdi, K., Spicer, T. P., Deminie, C., Rose, R., Wang, H. G., Blair, W. S., Shi, P. Y., Lin, P. F., Colonno, R. J., and Meanwell, N. A. (2003) Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl) oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions J. Med. Chem. 46, 4236-4239
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4236-4239
-
-
Wang, T.1
Zhang, Z.2
Wallace, O.B.3
Deshpande, M.4
Fang, H.5
Yang, Z.6
Zadjura, L.M.7
Tweedie, D.L.8
Huang, S.9
Zhao, F.10
Ranadive, S.11
Robinson, B.S.12
Gong, Y.F.13
Ricarrdi, K.14
Spicer, T.P.15
Deminie, C.16
Rose, R.17
Wang, H.G.18
Blair, W.S.19
Shi, P.Y.20
Lin, P.F.21
Colonno, R.J.22
Meanwell, N.A.23
more..
-
164
-
-
34548288600
-
Virtual screening in drug discovery - A computational perspective
-
Reddy, A. S., Pati, S. P., Kumar, P. P., Pradeep, H. N., and Sastry, G. N. (2007) Virtual screening in drug discovery-A computational perspective Curr. Protein Pept. Sci. 8, 329-351
-
(2007)
Curr. Protein Pept. Sci.
, vol.8
, pp. 329-351
-
-
Reddy, A.S.1
Pati, S.P.2
Kumar, P.P.3
Pradeep, H.N.4
Sastry, G.N.5
-
165
-
-
27144527555
-
Recent advances in microwave-assisted combinatorial synthesis and library generation
-
Lange, T. and Lindell, S. (2005) Recent advances in microwave-assisted combinatorial synthesis and library generation Comb. Chem. High Throughput Screening 8, 595-606
-
(2005)
Comb. Chem. High Throughput Screening
, vol.8
, pp. 595-606
-
-
Lange, T.1
Lindell, S.2
-
166
-
-
77953356208
-
Development of cell-based assays for cytokine receptor signaling, using an AlphaScreen SureFire assay format
-
Osmond, R. I. W., Das, S., and Crouch, M. F. (2010) Development of cell-based assays for cytokine receptor signaling, using an AlphaScreen SureFire assay format Anal. Biochem. 403, 94-101
-
(2010)
Anal. Biochem.
, vol.403
, pp. 94-101
-
-
Osmond, R.I.W.1
Das, S.2
Crouch, M.F.3
-
167
-
-
70349286700
-
Profiling human serum antibodies with a carbohydrate antigen microarray
-
Oyelaran, O., McShane, L. M., Dodd, L., and Gildersleeve, J. C. (2009) Profiling human serum antibodies with a carbohydrate antigen microarray J. Proteome Res. 8, 4301-4310
-
(2009)
J. Proteome Res.
, vol.8
, pp. 4301-4310
-
-
Oyelaran, O.1
McShane, L.M.2
Dodd, L.3
Gildersleeve, J.C.4
-
168
-
-
68749104303
-
Anti-carbohydrate antibodies of normal sera: Findings, surprises and challenges
-
Huflejt, M. E., Vuskovic, M., Vasiliu, D., Xu, H., Obukhova, P., Shilova, N., Tuzikov, A., Galanina, O., Arun, B., Lu, K., and Bovin, N. (2009) Anti-carbohydrate antibodies of normal sera: Findings, surprises and challenges Mol. Immunol. 46, 3037-3049
-
(2009)
Mol. Immunol.
, vol.46
, pp. 3037-3049
-
-
Huflejt, M.E.1
Vuskovic, M.2
Vasiliu, D.3
Xu, H.4
Obukhova, P.5
Shilova, N.6
Tuzikov, A.7
Galanina, O.8
Arun, B.9
Lu, K.10
Bovin, N.11
-
169
-
-
79951889944
-
L-Rhamnose antigen: A promising alternative to alpha -Gal for cancer immunotherapies
-
Chen, W., Gu, L., Zhang, W., Motari, E., Cai, L., Styslinger, T. J., and Wang, P. G. (2011) L-Rhamnose antigen: a promising alternative to alpha -Gal for cancer immunotherapies ACS Chem. Biol. 6, 185-191
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 185-191
-
-
Chen, W.1
Gu, L.2
Zhang, W.3
Motari, E.4
Cai, L.5
Styslinger, T.J.6
Wang, P.G.7
-
170
-
-
78650938957
-
Identification of candidate IgG biomarkers for AlzheimerβS Disease via combinatorial library screening
-
Reddy, M. M., Wilson, R., Wilson, J., Connell, S., Gocke, A., Hynan, L., German, D., and Kodadek, T. (2011) Identification of candidate IgG biomarkers for AlzheimerβS Disease via combinatorial library screening Cell 144, 132-142
-
(2011)
Cell
, vol.144
, pp. 132-142
-
-
Reddy, M.M.1
Wilson, R.2
Wilson, J.3
Connell, S.4
Gocke, A.5
Hynan, L.6
German, D.7
Kodadek, T.8
-
171
-
-
33751540859
-
Display technologies: Application for the discovery of drug and gene delivery agents
-
Sergeeva, A., Kolonin, M. G., Molldrem, J. J., Pasqualini, R., and Arap, W. (2006) Display technologies: Application for the discovery of drug and gene delivery agents Adv. Drug Delivery Rev. 58, 1622-1654
-
(2006)
Adv. Drug Delivery Rev.
, vol.58
, pp. 1622-1654
-
-
Sergeeva, A.1
Kolonin, M.G.2
Molldrem, J.J.3
Pasqualini, R.4
Arap, W.5
-
172
-
-
42649106504
-
A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity
-
Udugamasooriya, D. G., Dineen, S. P., Brekken, R. A., and Kodadek, T. (2008) A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity J. Am. Chem. Soc. 130, 5744-5752
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 5744-5752
-
-
Udugamasooriya, D.G.1
Dineen, S.P.2
Brekken, R.A.3
Kodadek, T.4
-
173
-
-
79954602278
-
Selection of carbonic anhydrase IX inhibitors from one million DNA-Encoded compounds
-
Buller, F., Steiner, M., Frey, K., Mircsof, D., Scheuermann, J., Kalisch, M., Buhlmann, P., Supuran, C. T., and Neri, D. (2011) Selection of carbonic anhydrase IX inhibitors from one million DNA-Encoded compounds ACS Chem. Biol. 6, 336-344
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 336-344
-
-
Buller, F.1
Steiner, M.2
Frey, K.3
Mircsof, D.4
Scheuermann, J.5
Kalisch, M.6
Buhlmann, P.7
Supuran, C.T.8
Neri, D.9
-
174
-
-
78650947751
-
Discovery of modulators of protein-protein interactions: Current approaches and limitations
-
Meireles, L. M. C. and Mustata, G. (2011) Discovery of modulators of protein-protein interactions: current approaches and limitations Curr. Top. Med. Chem. 11, 248-257
-
(2011)
Curr. Top. Med. Chem.
, vol.11
, pp. 248-257
-
-
Meireles, L.M.C.1
Mustata, G.2
-
175
-
-
0032476812
-
Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
-
Mammen, M., Choi, S. K., and Whitesides, G. M. (1998) Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors Angew. Chem., Int. Ed. 37, 2755-2794
-
(1998)
Angew. Chem., Int. Ed.
, vol.37
, pp. 2755-2794
-
-
Mammen, M.1
Choi, S.K.2
Whitesides, G.M.3
-
176
-
-
77249089970
-
Bioorthogonal chemistry: Recent progress and future directions
-
Lim, R. K. V. and Lin, Q. (2010) Bioorthogonal chemistry: recent progress and future directions Chem. Commun. 46, 1589-1600
-
(2010)
Chem. Commun.
, vol.46
, pp. 1589-1600
-
-
Lim, R.K.V.1
Lin, Q.2
|