Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 11, 2009, Pages 4337-4342

  Grünewald, Jan ^a,b   Hunt, Grady S ^a   Dong, Liqun ^b   Niessen, Frank ^a   Wen, Ben G ^b   Tsao, Meng Lin ^a,c   Perera, Roshan ^a,d   Kang, Mingchao ^a   Laffitte, Bryan A ^b   Azarian, Sassan ^b   Ruf, Wolfram ^a   Nasoff, Marc ^b   Lerner, Richard A ^a   Schultz, Peter G ^a,b   Smider, Vaughn V ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

Genetic code; Retinol binding protein; Tumor necrosis factor; Vaccination p nitrophenylalanine

Indexed keywords

4 NITROPHENYLALANINE; AUTOANTIBODY; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; LIPOPOLYSACCHARIDE; PHENYLALANINE DERIVATIVE; POLYCLONAL ANTIBODY; RETINOL BINDING PROTEIN 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDOTOXEMIA; IMMUNOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; SURFACE PROPERTY; T LYMPHOCYTE; WILD TYPE;

AMINO ACIDS; ANIMALS; ANTIBODY FORMATION; AUTOANTIBODIES; AUTOANTIGENS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; MICE; PHENYLALANINE; PROTEIN ENGINEERING; SELF TOLERANCE; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; MUS;

EID: 63149104746     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900507106     Document Type: Article

References (27)

1. Goodnow CC (2007) Multistep pathogenesis of autoimmune disease. Cell 130:25-35.
2. Dalum I, et al. (1999) Therapeutic antibodies elicited by immunization against TNF-alpha. Nat Biotechnol 17:666-669.
3. Zuany-Amorim C, et al. (2004) Induction of TNF-alpha autoantibody production by AutoVac TNF106: A novel therapeutic approach for the treatment of allergic diseases. Int Arch Allergy Immunol 133:154-163.
4. Weigle WO (1965) The induction of autoimmunity in rabbits following injection of heterologous or altered homologous thyroglobulin. J Exp Med 121:289-308.
5. Leitner WW, et al. (2003) Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat Med 9:33-39.
6. Hill NJ, King C, Flodstrom-Tullberg M (2008) Recent acquisitions on the genetic basis of autoimmune disease. Front Biosci 13:4838-4851.
7. Small EJ, et al. (2006) Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 24:3089-3094.
8. Schlom J, Gulley JL, Arlen PM (2007) Role of vaccine therapy in cancer: Biology and practice. Curr Oncol 14:238-245.
9. Berd D (2004) M-Vax: An autologous, hapten-modified vaccine for human cancer. Expert Rev Vaccines 3:521-527.
10. Aulak KS, et al. (2001) Proteomic method identifies proteins nitrated in vivo during inflammatory challenge. Proc Natl Acad Sci USA 98:12056-12061.
11. Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87:315-424.
12. Hardy LL, Wick DA, Webb JR (2008) Conversion of tyrosine to the inflammation-associated analog 3'-nitrotyrosine at either TCR-or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic cho-riomeningitis virus glycoprotein 33 by CD8 T cells. J Immunol 180:5956-5962.
13. Grünewald J et al. (2008) Immunochemical termination of self-tolerance. Proc Natl Acad Sci USA 105:11276-11280.
14. Kilpatrick KE, et al. (1997) Rapid development of affinity matured monoclonal antibodies using RIMMS. Hybridoma 16:381-389.
15. Niessen F, et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452:654-658.
16. Zanotti G, Berni R (2004) Plasma retinol-binding protein: Structure and interactions with retinol, retinoids, and transthyretin. Vitam Horm 69:271-295.
17. Raghu P, Sivakumar B (2004) Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: Implications in vitamin A homeostasis and transthyretin amyloidosis. Biochim Biophys Acta 1703:1-9.
18. Vogel S, et al. (2002) Retinol-binding protein-deficient mice: Biochemical basis for impaired vision. Biochemistry 41:15360-15368.
19. Cowan SW, Newcomer ME, Jones TA (1990) Crystallographic refinement of human serum retinol binding protein at 2A resolution. Proteins 8:44-61.
20. Greene LH, et al. (2001) Role of conserved residues in structure and stability: Trypto-phansofhuman serum retinol-binding protein, a model for the lipocalin superfamily. Protein Sci 10:2301-2316.
21. Cantaert T, et al. (2006) Citrullinated proteins in rheumatoid arthritis: Crucial but not sufficient! Arthritis Rheum 54:3381-3389.
22. Backlund J, et al. (2002) Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis. Proc Natl Acad Sci USA 99:9960-9965.
23. Dzhambazov B, et al. (2005) The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans Eur J Immunol 35:357-366.
24. Klareskog L, Ronnelid J, Lundberg K, Padyukov L, Alfredsson L (2008) Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 26:651-675.
25. Sollid LM (2000) Molecular basis of celiac disease. Annu Rev Immunol 18:53-81.
26. Toews GB, Bergstresser PR, Streilein JW (1980) Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124:445-453.
27. Klock HE, Koesema EJ, Knuth MW, Lesley SA (2008) Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts. Proteins 71:982-994.