Arming antibodies: Prospects and challenges for immunoconjugates

Nature Biotechnology

Volumn 23, Issue 9, 2005, Pages 1137-1146

  Wu, Anna M ^a   Senter, Peter D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SEATTLE GENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; IMMUNOLOGY; MEDICAL APPLICATIONS; MOLECULAR STRUCTURE; ONCOLOGY; RADIOISOTOPES; TISSUE; TOXIC MATERIALS;

CLINICAL DEVELOPMENT; PROTEIN ENGINEERING; RADIOIMMUNOCONJUGATES; TOXIC AGENTS;

MONOCLONAL ANTIBODIES;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID BIOTIN Y 90; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; AURISTATIN PE; BR96 DOXORUBICIN; CAMPTOTHECIN; CANTUZUMAB MERTANSINE; CEA CIDE Y 90; DOXORUBICIN; EPRATUZUMAB; GCR 3888; GEMTUZUMAB OZOGAMICIN; IBRITUMOMAB TIUXETAN; LABETUZUMAB; LIVER ENZYME; LYMPHOCIDE Y90; MITOMYCIN C; MLN 2704; MLN 591 RL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HUN901 DM1; PACLITAXEL; PEMTUMOMAB; PENTACEA; RADIOPHARMACEUTICAL AGENT; SGN 15; TALLYSOMYCIN; TOSITUMOMAB; TOSITUMOMAB I 131; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTIBODY SPECIFICITY; B CELL LYMPHOMA; BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CHILL; CLINICAL TRIAL; COLORECTAL CANCER; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; DRUG UPTAKE; FEVER; GASTROINTESTINAL TOXICITY; HAIRY CELL LEUKEMIA; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LYMPHOMA; MYELOID LEUKEMIA; NEUTROPENIA; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; RADIOIMMUNOTHERAPY; REVIEW; SOLID TUMOR; STOMACH CANCER; TARGET ORGAN; TOXICITY; VEIN OCCLUSION;

AMINOGLYCOSIDES; ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; BIOTINYLATION; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTHERAPY; MODELS, CHEMICAL; NEOPLASMS; PRODRUGS; PROTEIN ENGINEERING; RADIOIMMUNOTHERAPY; RADIOISOTOPES; TIME FACTORS;

EID: 27144550160     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1141     Document Type: Review

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