Designing protein dimerizers: The importance of ligand conformational equilibria

Journal of the American Chemical Society

Volumn 125, Issue 6, 2003, Pages 1501-1507

  Carlson, Jonathan C T ^a   Kanter, Aaron ^a   Thuduppathy, Guruvasuthevan R ^a   Cody, Vivian ^c   Pineda, Pamela E ^a   McIvor, R Scott ^b   Wagner, Carston R ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c H W Medical Research Inst Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; DIMERIZATION; DIMERS; ENTROPY; ESCHERICHIA COLI; INTERFACES (MATERIALS); SYNTHESIS (CHEMICAL);

CONFORMATIONAL STABILITY;

PROTEINS;

DIHYDROFOLATE REDUCTASE; LIGAND; METHOTREXATE;

AQUEOUS SOLUTION; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIMERIZATION; ENTROPY; EQUILIBRIUM CONSTANT; MOUSE; NONHUMAN; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS;

ANIMALS; DIMERIZATION; ESCHERICHIA COLI; KINETICS; LIGANDS; METHOTREXATE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SOLUTIONS; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 0037433202     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja026264y     Document Type: Article

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