메뉴 건너뛰기




Volumn 2, Issue SPEC. ISS.3, 2010, Pages 108-118

Adenosine Kinase is a new therapeutic target to prevent ischemic neuronal death

Author keywords

Adenosine; Adenosine kinase; Gene knockout; Ischemia; Neuroprotection; Reperfusion; Stroke; Transgenic mice

Indexed keywords

4 (N PHENYLAMINO) 5 PHENYL 7 (5' DEOXY BETA DEXTRO RIBOFURASONYL)PYRROLO[2,3 D]PYRIMIDINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 4 AMINO 8 CHLORO 1 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 4 ANILINO 5 PHENYLPYRROLO[2,3 D]PYRIMIDINE 7 (5 DEOXYRIBOSIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5' DEOXYIODOTUBERCIDIN; 8 (3 CHLOROSTYRYL)CAFFEINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; CHLORO N (6) (3 IODOBENZYL)ADENOSINE 5' N METHYLURONAMIDE; UNCLASSIFIED DRUG;

EID: 84863945852     PISSN: None     EISSN: 18773818     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (17)

References (145)
  • 1
    • 0038060334 scopus 로고    scopus 로고
    • Ischemic tolerance and endogenous neuroprotection
    • Dirnagl, U.; Simon, R.P.; Hallenbeck, J.M. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci., 2003, 26(5), 248-254.
    • (2003) Trends Neurosci , vol.26 , Issue.5 , pp. 248-254
    • Dirnagl, U.1    Simon, R.P.2    Hallenbeck, J.M.3
  • 2
    • 0037307212 scopus 로고    scopus 로고
    • To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: A review on the stress-activated signaling pathways and apoptotic pathways
    • Liou, A.K.; Clark, R.S.; Henshall, D.C.; Yin, X.M.; Chen, J. To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog. Neurobiol., 2003, 69(2), 103-142.
    • (2003) Prog. Neurobiol , vol.69 , Issue.2 , pp. 103-142
    • Liou, A.K.1    Clark, R.S.2    Henshall, D.C.3    Yin, X.M.4    Chen, J.5
  • 4
    • 0033593458 scopus 로고    scopus 로고
    • Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis
    • De Keyser, J.; Schaaf, M.; Teelken, A. Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis. Neurosci. Lett., 1999, 260(1), 74-76.
    • (1999) Neurosci. Lett , vol.260 , Issue.1 , pp. 74-76
    • de Keyser, J.1    Schaaf, M.2    Teelken, A.3
  • 5
    • 1842483228 scopus 로고    scopus 로고
    • The rise and fall of NMDA antagonists for ischemic stroke
    • Hoyte, L.; Barber, P.A.; Buchan, A.M.; Hill, M.D. The rise and fall of NMDA antagonists for ischemic stroke. Curr. Mol. Med., 2004, 4(2), 131-136.
    • (2004) Curr. Mol. Med , vol.4 , Issue.2 , pp. 131-136
    • Hoyte, L.1    Barber, P.A.2    Buchan, A.M.3    Hill, M.D.4
  • 6
    • 3042706276 scopus 로고    scopus 로고
    • Lost in translation: Taking neuroprotection from animal models to clinical trials
    • Hoyte, L.; Kaur, J.; Buchan, A.M. Lost in translation: taking neuroprotection from animal models to clinical trials. Exp. Neurol., 2004, 188(2), 200-204.
    • (2004) Exp. Neurol , vol.188 , Issue.2 , pp. 200-204
    • Hoyte, L.1    Kaur, J.2    Buchan, A.M.3
  • 7
    • 0346787871 scopus 로고    scopus 로고
    • Neuroprotection in cerebral ischaemia: Facts and fancies--the need for new approaches
    • Wahlgren, N.G.; Ahmed, N. Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approaches. Cerebrovasc. Dis., 2004, 17 Suppl 1, 153-166.
    • (2004) Cerebrovasc. Dis , vol.17 , Issue.SUPPL. 1 , pp. 153-166
    • Wahlgren, N.G.1    Ahmed, N.2
  • 9
    • 13844315635 scopus 로고    scopus 로고
    • Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs
    • Fredholm, B.B.; Chen, J.F.; Masino, S.A.; Vaugeois, J.M. Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs. Annu. Rev. Pharmacol. Toxicol., 2005, 45, 385-412.
    • (2005) Annu. Rev. Pharmacol. Toxicol , vol.45 , pp. 385-412
    • Fredholm, B.B.1    Chen, J.F.2    Masino, S.A.3    Vaugeois, J.M.4
  • 10
    • 0034923094 scopus 로고    scopus 로고
    • The role and regulation of adenosine in the central nervous system
    • Dunwiddie, T.V.; Masino, S.A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci., 2001, 24, 31-55.
    • (2001) Annu. Rev. Neurosci , vol.24 , pp. 31-55
    • Dunwiddie, T.V.1    Masino, S.A.2
  • 11
    • 16344372309 scopus 로고    scopus 로고
    • Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
    • Cunha, R.A. Neuroprotection by adenosine in the brain: from A1 receptor activation to A2A receptor blockade. Purinergic Signaling, 2005, 1, 111-134.
    • (2005) Purinergic Signaling , vol.1 , pp. 111-134
    • Cunha, R.A.1
  • 12
    • 13544274000 scopus 로고    scopus 로고
    • Adenosine and epilepsy: From therapeutic rationale to new therapeutic strategies
    • Boison, D. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist, 2005, 11(1), 25-36.
    • (2005) Neuroscientist , vol.11 , Issue.1 , pp. 25-36
    • Boison, D.1
  • 13
    • 0023882404 scopus 로고
    • How does adenosine inhibit transmitter release?
    • Fredholm, B.B.; Dunwiddie, T.V. How does adenosine inhibit transmitter release? Trends Pharmacol. Sci., 1988, 9, 130-134.
    • (1988) Trends Pharmacol. Sci , vol.9 , pp. 130-134
    • Fredholm, B.B.1    Dunwiddie, T.V.2
  • 14
    • 0035255227 scopus 로고    scopus 로고
    • Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors
    • Cunha, R.A. Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem. Int., 2001, 38(2), 107-125.
    • (2001) Neurochem. Int , vol.38 , Issue.2 , pp. 107-125
    • Cunha, R.A.1
  • 15
    • 0030610310 scopus 로고    scopus 로고
    • Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum
    • Dixon, A.K.; Widdowson, L.; Richardson, P.J. Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum. J. Neurochem., 1997, 69(1), 315-321.
    • (1997) J. Neurochem , vol.69 , Issue.1 , pp. 315-321
    • Dixon, A.K.1    Widdowson, L.2    Richardson, P.J.3
  • 16
    • 0032217258 scopus 로고    scopus 로고
    • Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro
    • O'Kane, E.M.; Stone, T.W. Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro. Eur. J. Pharmacol., 1998, 362(1), 17-25.
    • (1998) Eur. J. Pharmacol , vol.362 , Issue.1 , pp. 17-25
    • O'Kane, E.M.1    Stone, T.W.2
  • 17
    • 0033390941 scopus 로고    scopus 로고
    • Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats
    • Lopes, L.V.; Cunha, R.A.; Ribeiro, J.A. Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats. J. Neurophysiol., 1999, 82(6), 3196-3203.
    • (1999) J. Neurophysiol , vol.82 , Issue.6 , pp. 3196-3203
    • Lopes, L.V.1    Cunha, R.A.2    Ribeiro, J.A.3
  • 18
    • 0036882237 scopus 로고    scopus 로고
    • Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy
    • Gorter, J.A.; van Vliet, E.A.; Lopes da Silva, F.H.; Isom, L.L.; Aronica, E. Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy. Eur. J. Neurosci., 2002, 16(2), 360-364.
    • (2002) Eur. J. Neurosci , vol.16 , Issue.2 , pp. 360-364
    • Gorter, J.A.1    van Vliet, E.A.2    da Silva, F.H.L.3    Isom, L.L.4    Aronica, E.5
  • 19
    • 0021894314 scopus 로고
    • Adenosine as a neuromodulator
    • S.H. Adenosine as a neuromodulator. Annu. Rev. Neurosci., 1985, 8, 103-124.
    • (1985) Annu. Rev. Neurosci , vol.8 , pp. 103-124
  • 20
    • 0030222504 scopus 로고    scopus 로고
    • A2 adenosine receptors: Their presence and neuromodulatory role in the central nervous system
    • Latini, S.; Pazzagli, M.; Pepeu, G.; Pedata, F. A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system. Gen. Pharmacol., 1996, 27(6), 925-933.
    • (1996) Gen. Pharmacol , vol.27 , Issue.6 , pp. 925-933
    • Latini, S.1    Pazzagli, M.2    Pepeu, G.3    Pedata, F.4
  • 21
    • 0027135594 scopus 로고
    • Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes
    • Kirkpatrick, K.A.; Richardson, P.J. Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes. Br. J. Pharmacol., 1993, 110(3), 949-954.
    • (1993) Br. J. Pharmacol , vol.110 , Issue.3 , pp. 949-954
    • Kirkpatrick, K.A.1    Richardson, P.J.2
  • 22
    • 0028983106 scopus 로고
    • Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat
    • Cunha, R.A.; Constantino, M.C.; Sebastiao, A.M.; Ribeiro, J.A. Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport, 1995, 6(11), 1583-1588.
    • (1995) Neuroreport , vol.6 , Issue.11 , pp. 1583-1588
    • Cunha, R.A.1    Constantino, M.C.2    Sebastiao, A.M.3    Ribeiro, J.A.4
  • 23
    • 0028984662 scopus 로고
    • Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci
    • Cunha, R.A.; Johansson, B.; Fredholm, B.B.; Ribeiro, J.A.; Sebastiao, A.M. Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci. Lett., 1995, 196(1-2), 41-44.
    • (1995) Lett , vol.196 , Issue.1-2 , pp. 41-44
    • Cunha, R.A.1    Johansson, B.2    Fredholm, B.B.3    Ribeiro, J.A.4    Sebastiao, A.M.5
  • 24
    • 0028181462 scopus 로고
    • Adenosine A2a receptor-mediated modulation of striatal [3H]GABA and [3H]acetylcholine release
    • Kirk, I.P.; Richardson, P.J. Adenosine A2a receptor-mediated modulation of striatal [3H]GABA and [3H]acetylcholine release. J. Neurochem., 1994, 62(3), 960-966.
    • (1994) J. Neurochem , vol.62 , Issue.3 , pp. 960-966
    • Kirk, I.P.1    Richardson, P.J.2
  • 25
    • 0029665969 scopus 로고    scopus 로고
    • Adenosine A2 receptor-mediated excitatory actions on the nervous system
    • Sebastiao, A.M.; Ribeiro, J.A. Adenosine A2 receptor-mediated excitatory actions on the nervous system. Prog. Neurobiol., 1996, 48(3), 167-189.
    • (1996) Prog. Neurobiol , vol.48 , Issue.3 , pp. 167-189
    • Sebastiao, A.M.1    Ribeiro, J.A.2
  • 26
    • 0034765853 scopus 로고    scopus 로고
    • Adenosine in the central nervous system: Release mechanisms and extracellular concentrations
    • Latini, S.; Pedata, F. Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J. Neurochem., 2001, 79(3), 463-484.
    • (2001) J. Neurochem , vol.79 , Issue.3 , pp. 463-484
    • Latini, S.1    Pedata, F.2
  • 27
    • 1242340288 scopus 로고    scopus 로고
    • The concentrative nucleoside transporter family, SLC28
    • Gray, J.H.; Owen, R.P.; Giacomini, K.M. The concentrative nucleoside transporter family, SLC28. Pflugers Arch., 2004, 447(5), 728-734.
    • (2004) Pflugers Arch , vol.447 , Issue.5 , pp. 728-734
    • Gray, J.H.1    Owen, R.P.2    Giacomini, K.M.3
  • 29
    • 0018939050 scopus 로고
    • Regional and subcellular distribution of S-adenosylhomocysteine hydrolase in the adult rat brain
    • Broch, O.J.; Ueland, P.M. Regional and subcellular distribution of S-adenosylhomocysteine hydrolase in the adult rat brain. J. Neurochem., 1980, 35(2), 484-488.
    • (1980) J. Neurochem , vol.35 , Issue.2 , pp. 484-488
    • Broch, O.J.1    Ueland, P.M.2
  • 31
    • 0018362953 scopus 로고
    • Correlation of 5'- nucleotidase activity and selective transneuronal transfer of adenosine in the hippocampus
    • Schubert, P.; Komp, W.; Kreutzberg, G.W. Correlation of 5'- nucleotidase activity and selective transneuronal transfer of adenosine in the hippocampus. Brain Res., 1979, 168(2), 419-424.
    • (1979) Brain Res , vol.168 , Issue.2 , pp. 419-424
    • Schubert, P.1    Komp, W.2    Kreutzberg, G.W.3
  • 32
    • 39149122180 scopus 로고    scopus 로고
    • The adenosine kinase hypothesis of epileptogenesis
    • D. The adenosine kinase hypothesis of epileptogenesis. Prog. Neurobiol., 2008, 84(3), 249-262.
    • (2008) Prog. Neurobiol , vol.84 , Issue.3 , pp. 249-262
  • 33
    • 70349984540 scopus 로고    scopus 로고
    • Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation
    • Boison, D.; Stewart, K.-A. Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation. Biochem. Pharmacol., 2009, 78(12), 1428-1437.
    • (2009) Biochem. Pharmacol , vol.78 , Issue.12 , pp. 1428-1437
    • Boison, D.1    Stewart, K.-A.2
  • 34
    • 77953613420 scopus 로고    scopus 로고
    • Adenosine signalling and function in glial cells
    • Boison, D.; Chen, J.F.; Fredholm, B.B. Adenosine signalling and function in glial cells. Cell Death Differ., 2010, 17(7), 1071-1082.
    • (2010) Cell Death Differ , vol.17 , Issue.7 , pp. 1071-1082
    • Boison, D.1    Chen, J.F.2    Fredholm, B.B.3
  • 35
    • 33750943168 scopus 로고    scopus 로고
    • Adenosine kinase, epilepsy and stroke: Mechanisms and therapies. Trends Pharmacol
    • Boison, D. Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol. Sci., 2006, 27(12), 652-658.
    • (2006) Sci , vol.27 , Issue.12 , pp. 652-658
    • Boison, D.1
  • 36
    • 0027935403 scopus 로고
    • Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices
    • Pak, M.A.; Haas, H.L.; Decking, U.K.M.; Schrader, J. Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices. Neuropharmacol., 1994, 33, 1049-1053.
    • (1994) Neuropharmacol , vol.33 , pp. 1049-1053
    • Pak, M.A.1    Haas, H.L.2    Decking, U.K.M.3    Schrader, J.4
  • 38
    • 0026344738 scopus 로고
    • Adenosine: Origin and clinical roles
    • Newby, A.C. Adenosine: origin and clinical roles. Adv. Exp. Med. Biol., 1991, 309A, 265-270.
    • (1991) Adv. Exp. Med. Biol , vol.309 A , pp. 265-270
    • Newby, A.C.1
  • 39
    • 0035019784 scopus 로고    scopus 로고
    • Changes in hippocampal adenosine efflux, ATP levels, and synaptic transmission induced by increased temperature
    • Masino, S.A.; Latini, S.; Bordoni, F.; Pedata, F.; Dunwiddie, T.V. Changes in hippocampal adenosine efflux, ATP levels, and synaptic transmission induced by increased temperature. Synapse, 2001, 41(1), 58-64.
    • (2001) Synapse , vol.41 , Issue.1 , pp. 58-64
    • Masino, S.A.1    Latini, S.2    Bordoni, F.3    Pedata, F.4    Dunwiddie, T.V.5
  • 40
    • 33646537781 scopus 로고    scopus 로고
    • Sustained elevation of extracellular adenosine and activation of A (1) receptors underlie the post-ischaemic inhibition of neuronal function in rat hippocampus in vitro
    • Pearson, T.; Damian, K.; Lynas, R.E.; Frenguelli, B.G. Sustained elevation of extracellular adenosine and activation of A (1) receptors underlie the post-ischaemic inhibition of neuronal function in rat hippocampus in vitro. J. Neurochem., 2006, 97(5), 1357-1368.
    • (2006) J. Neurochem , vol.97 , Issue.5 , pp. 1357-1368
    • Pearson, T.1    Damian, K.2    Lynas, R.E.3    Frenguelli, B.G.4
  • 41
    • 58849135694 scopus 로고    scopus 로고
    • Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus
    • Etherington, L.A.; Patterson, G.E.; Meechan, L.; Boison, D.; Irving, A.J.; Dale, N.; Frenguelli, B. Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. Neuropharmacology, 2009, 56(2), 429-437.
    • (2009) Neuropharmacology , vol.56 , Issue.2 , pp. 429-437
    • Etherington, L.A.1    Patterson, G.E.2    Meechan, L.3    Boison, D.4    Irving, A.J.5    Dale, N.6    Frenguelli, B.7
  • 42
    • 0032559866 scopus 로고    scopus 로고
    • The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia-in vivo study
    • Kobayashi, T.; Yamada, T.; Okada, Y. The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia-in vivo study. Brain Res., 1998, 787(2), 211-219.
    • (1998) Brain Res , vol.787 , Issue.2 , pp. 211-219
    • Kobayashi, T.1    Yamada, T.2    Okada, Y.3
  • 44
    • 37549033536 scopus 로고    scopus 로고
    • Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism
    • Pignataro, G.; Maysami, S.; Studer, F.E.; Wilz, A.; Simon, R. P.; Boison, D. Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. J. Cereb. Blood Flow Metab., 2008, 28, 17-23.
    • (2008) J. Cereb. Blood Flow Metab , vol.28 , pp. 17-23
    • Pignataro, G.1    Maysami, S.2    Studer, F.E.3    Wilz, A.4    Simon, R.P.5    Boison, D.6
  • 45
    • 34250770500 scopus 로고    scopus 로고
    • Adenosine, an endogenous distress signal, modulates tissue damage and repair
    • Fredholm, B.B. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ 2007, 14(7), 1315-1323.
    • (2007) Cell Death Differ , vol.14 , Issue.7 , pp. 1315-1323
    • Fredholm, B.B.1
  • 46
    • 34250703015 scopus 로고    scopus 로고
    • Aspects of the general biology of adenosine A2A signaling
    • Fredholm, B.B.; Chern, Y.; Franco, R.; Sitkovsky, M. Aspects of the general biology of adenosine A2A signaling. Prog. Neurobiol., 2007, 83(5), 263-276.
    • (2007) Prog. Neurobiol , vol.83 , Issue.5 , pp. 263-276
    • Fredholm, B.B.1    Chern, Y.2    Franco, R.3    Sitkovsky, M.4
  • 47
    • 70349658689 scopus 로고    scopus 로고
    • Adenosine-based modulation of brain activity
    • D. Adenosine-based modulation of brain activity. Curr. Neuropharmacol., 2009, 7(3), 158-159.
    • (2009) Curr. Neuropharmacol , vol.7 , Issue.3 , pp. 158-159
  • 48
    • 33749370520 scopus 로고    scopus 로고
    • Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes
    • Morrison, R.R.; Teng, B.; Oldenburg, P.J.; Katwa, L.C.; Schnermann, J.B.; Mustafa, S.J. Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes. Am. J. Physiol. Heart Circ. Physiol., 2006, 291(4), H1875-1882.
    • (2006) Am. J. Physiol. Heart Circ. Physiol , vol.291 , Issue.4
    • Morrison, R.R.1    Teng, B.2    Oldenburg, P.J.3    Katwa, L.C.4    Schnermann, J.B.5    Mustafa, S.J.6
  • 50
    • 4344610549 scopus 로고    scopus 로고
    • Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro
    • Olsson, T.; Cronberg, T.; Rytter, A.; Asztely, F.; Fredholm, B.B.; Smith, M.L.; Wieloch, T. Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro. Eur. J. Neurosci., 2004, 20(5), 1197-1204.
    • (2004) Eur. J. Neurosci , vol.20 , Issue.5 , pp. 1197-1204
    • Olsson, T.1    Cronberg, T.2    Rytter, A.3    Asztely, F.4    Fredholm, B.B.5    Smith, M.L.6    Wieloch, T.7
  • 51
    • 47349101224 scopus 로고    scopus 로고
    • Modulation of ischemic brain injury and neuroinflammation by adenosine A(2A) receptors
    • Chen, J.F.; Pedata, F. Modulation of ischemic brain injury and neuroinflammation by adenosine A(2A) receptors. Curr. Pharm. Des., 2008, 14(15), 1490-1499.
    • (2008) Curr. Pharm. Des , vol.14 , Issue.15 , pp. 1490-1499
    • Chen, J.F.1    Pedata, F.2
  • 52
  • 54
    • 0024397625 scopus 로고
    • Deoxycoformycin antagonizes ischemia-induced neuronal degeneration
    • Phillis, J.W.; O'Regan, M.H. Deoxycoformycin antagonizes ischemia-induced neuronal degeneration. Brain Res. Bull., 1989, 22(3), 537-540.
    • (1989) Brain Res. Bull , vol.22 , Issue.3 , pp. 537-540
    • Phillis, J.W.1    O'Regan, M.H.2
  • 55
    • 20344374724 scopus 로고    scopus 로고
    • Adenosine and adenine nucleotides as regulators of cerebral blood flow: Roles of acidosis, cell swelling, and KATP channels
    • Phillis, J.W. Adenosine and adenine nucleotides as regulators of cerebral blood flow: roles of acidosis, cell swelling, and KATP channels. Crit. Rev. Neurobiol., 2004, 16(4), 237-270.
    • (2004) Crit. Rev. Neurobiol , vol.16 , Issue.4 , pp. 237-270
    • Phillis, J.W.1
  • 56
    • 47349125085 scopus 로고    scopus 로고
    • Potential therapeutic interest of adenosine A(2A) receptors in psychiatric disorders
    • Cunha, R.A.; Ferre, S.; Vaugeois, J.M.; Chen, J.F. Potential therapeutic interest of adenosine A(2A) receptors in psychiatric disorders. Curr. Pharm. Des., 2008, 14(15), 1512-1524.
    • (2008) Curr. Pharm. Des , vol.14 , Issue.15 , pp. 1512-1524
    • Cunha, R.A.1    Ferre, S.2    Vaugeois, J.M.3    Chen, J.F.4
  • 57
    • 15244351970 scopus 로고    scopus 로고
    • The protective effect of adenosine A2A receptor antagonism in cerebral ischemia
    • Pedata, F.; Gianfriddo, M.; Turchi, D.; Melani, A. The protective effect of adenosine A2A receptor antagonism in cerebral ischemia. Neurol. Res., 2005, 27(2), 169-174.
    • (2005) Neurol. Res , vol.27 , Issue.2 , pp. 169-174
    • Pedata, F.1    Gianfriddo, M.2    Turchi, D.3    Melani, A.4
  • 58
    • 0034943057 scopus 로고    scopus 로고
    • Adenosine extracellular brain concentrations and role of A2A receptors in ischemia
    • Pedata, F.; Corsi, C.; Melani, A.; Bordoni, F.; Latini, S. Adenosine extracellular brain concentrations and role of A2A receptors in ischemia. Ann. N.Y. Acad. Sci., 2001, 939, 74-84.
    • (2001) Ann. N.Y. Acad. Sci , vol.939 , pp. 74-84
    • Pedata, F.1    Corsi, C.2    Melani, A.3    Bordoni, F.4    Latini, S.5
  • 59
    • 0038507314 scopus 로고    scopus 로고
    • Sensitivity to selective adenosine A1 and A2A receptor antagonists of the release of glutamate induced by ischemia in rat cerebrocortical slices
    • Marcoli, M.; Raiteri, L.; Bonfanti, A.; Monopoli, A.; Ongini, E.; Raiteri, M.; Maura, G. Sensitivity to selective adenosine A1 and A2A receptor antagonists of the release of glutamate induced by ischemia in rat cerebrocortical slices. Neuropharmacology, 2003, 45(2), 201-210.
    • (2003) Neuropharmacology , vol.45 , Issue.2 , pp. 201-210
    • Marcoli, M.1    Raiteri, L.2    Bonfanti, A.3    Monopoli, A.4    Ongini, E.5    Raiteri, M.6    Maura, G.7
  • 60
    • 33644956171 scopus 로고    scopus 로고
    • The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia
    • Melani, A.; Gianfriddo, M.; Vannucchi, M.G.; Cipriani, S.; Baraldi, P.G.; Giovannini, M.G.; Pedata, F. The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia. Brain Res., 2006, 1073-1074, 470-480.
    • (2006) Brain Res , vol.1073-1074 , pp. 470-480
    • Melani, A.1    Gianfriddo, M.2    Vannucchi, M.G.3    Cipriani, S.4    Baraldi, P.G.5    Giovannini, M.G.6    Pedata, F.7
  • 61
    • 7044247188 scopus 로고    scopus 로고
    • Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
    • Yu, L.; Huang, Z.; Mariani, J.; Wang, Y.; Moskowitz, M.; Chen, J.F. Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury. Nat. Med., 2004, 10(10), 1081-1087.
    • (2004) Nat. Med , vol.10 , Issue.10 , pp. 1081-1087
    • Yu, L.1    Huang, Z.2    Mariani, J.3    Wang, Y.4    Moskowitz, M.5    Chen, J.F.6
  • 63
    • 70349331090 scopus 로고    scopus 로고
    • Adenosine receptors and neurological disease: Neuroprotection and neurodegeneration
    • Stone, T.W.; Ceruti, S.; Abbracchio, M.P. Adenosine receptors and neurological disease: neuroprotection and neurodegeneration. Handb. Exp. Pharmacol., 2009, 193, 535-587.
    • (2009) Handb. Exp. Pharmacol , vol.193 , pp. 535-587
    • Stone, T.W.1    Ceruti, S.2    Abbracchio, M.P.3
  • 64
    • 0034720179 scopus 로고    scopus 로고
    • Adenosine receptor up-regulation: Initiated upon preconditioning but not upheld
    • von Arnim, C.A.; Timmler, M.; Ludolph, A.C.; Riepe, M.W. Adenosine receptor up-regulation: initiated upon preconditioning but not upheld. Neuroreport, 2000, 11(6), 1223-1226.
    • (2000) Neuroreport , vol.11 , Issue.6 , pp. 1223-1226
    • von Arnim, C.A.1    Timmler, M.2    Ludolph, A.C.3    Riepe, M.W.4
  • 66
    • 62549102923 scopus 로고    scopus 로고
    • Preconditioning and tolerance against cerebral ischaemia: From experimental strategies to clinical use
    • Dirnagl, U.; Becker, K.; Meisel, A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol., 2009, 8(4), 398-412.
    • (2009) Lancet Neurol , vol.8 , Issue.4 , pp. 398-412
    • Dirnagl, U.1    Becker, K.2    Meisel, A.3
  • 67
    • 0037162691 scopus 로고    scopus 로고
    • Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    • Nakatomi, H.; Kuriu, T.; Okabe, S.; Yamamoto, S.; Hatano, O.; Kawahara, N.; Tamura, A.; Kirino, T.; Nakafuku, M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell, 2002, 110(4), 429-441.
    • (2002) Cell , vol.110 , Issue.4 , pp. 429-441
    • Nakatomi, H.1    Kuriu, T.2    Okabe, S.3    Yamamoto, S.4    Hatano, O.5    Kawahara, N.6    Tamura, A.7    Kirino, T.8    Nakafuku, M.9
  • 68
    • 33745763116 scopus 로고    scopus 로고
    • Cerebral preconditioning and ischaemic tolerance
    • J.M. Cerebral preconditioning and ischaemic tolerance. Nat. Rev. Neurosci., 2006, 7(6), 437-448.
    • (2006) Nat. Rev. Neurosci , vol.7 , Issue.6 , pp. 437-448
  • 69
    • 33744992256 scopus 로고    scopus 로고
    • Prevention of inflammation is a mechanism of preconditioning-induced neuroprotection against focal cerebral ischemia
    • Bowen, K.K.; Naylor, M.; Vemuganti, R. Prevention of inflammation is a mechanism of preconditioning-induced neuroprotection against focal cerebral ischemia. Neurochem. Int., 2006, 49(2), 127-135.
    • (2006) Neurochem. Int , vol.49 , Issue.2 , pp. 127-135
    • Bowen, K.K.1    Naylor, M.2    Vemuganti, R.3
  • 70
    • 1842614423 scopus 로고    scopus 로고
    • Putative endogenous mediators of preconditioning-induced ischemic tolerance in rat brain identified by genomic and proteomic analysis
    • Dhodda, V.K.; Sailor, K.A.; Bowen, K.K.; Vemuganti, R. Putative endogenous mediators of preconditioning-induced ischemic tolerance in rat brain identified by genomic and proteomic analysis. J. Neurochem., 2004, 89(1), 73-89.
    • (2004) J. Neurochem , vol.89 , Issue.1 , pp. 73-89
    • Dhodda, V.K.1    Sailor, K.A.2    Bowen, K.K.3    Vemuganti, R.4
  • 71
    • 0033397736 scopus 로고    scopus 로고
    • Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: Involvement of adenosine A1 receptors and K(ATP) channels
    • Plamondon, H.; Blondeau, N.; Heurteaux, C.; Lazdunski, M. Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. J. Cereb. Blood Flow Metab., 1999, 19(12), 1296-1308.
    • (1999) J. Cereb. Blood Flow Metab , vol.19 , Issue.12 , pp. 1296-1308
    • Plamondon, H.1    Blondeau, N.2    Heurteaux, C.3    Lazdunski, M.4
  • 72
    • 33846635975 scopus 로고    scopus 로고
    • Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: A speculative synthesis
    • Stenzel-Poore, M.P.; Stevens, S.L.; King, J.S.; Simon, R.P. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke, 2007, 38(2 Suppl), 680-685.
    • (2007) Stroke , vol.38 , Issue.2 SUPPL. , pp. 680-685
    • Stenzel-Poore, M.P.1    Stevens, S.L.2    King, J.S.3    Simon, R.P.4
  • 73
    • 0031657749 scopus 로고    scopus 로고
    • Ischemic preconditioning and brain tolerance: Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression
    • discussion 1950-1
    • Barone, F.C.; White, R.F.; Spera, P.A.; Ellison, J.; Currie, R. W.; Wang, X.; Feuerstein, G.Z. Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression. Stroke, 1998, 29(9), 1937-1950;discussion 1950-1.
    • (1998) Stroke , vol.29 , Issue.9 , pp. 1937-1950
    • Barone, F.C.1    White, R.F.2    Spera, P.A.3    Ellison, J.4    Currie, R.W.5    Wang, X.6    Feuerstein, G.Z.7
  • 74
    • 45549098351 scopus 로고    scopus 로고
    • Molecular mechanism of preconditioning
    • Das, M.; Das, D.K. Molecular mechanism of preconditioning. IUBMB Life, 2008, 60(4), 199-203.
    • (2008) IUBMB Life , vol.60 , Issue.4 , pp. 199-203
    • Das, M.1    Das, D.K.2
  • 76
    • 0034846624 scopus 로고    scopus 로고
    • Adenosine, adenosine receptors and myocardial protection: An updated overview
    • Mubagwa, K.; Flameng, W. Adenosine, adenosine receptors and myocardial protection: an updated overview. Cardiovasc. Res., 2001, 52(1), 25-39.
    • (2001) Cardiovasc. Res , vol.52 , Issue.1 , pp. 25-39
    • Mubagwa, K.1    Flameng, W.2
  • 77
    • 0033807967 scopus 로고    scopus 로고
    • Adenosine and cardioprotection during ischaemia and reperfusion--an overview
    • Sommerschild, H.T.; Kirkeboen, K.A. Adenosine and cardioprotection during ischaemia and reperfusion--an overview. Acta Anaesthesiol. Scand., 2000, 44(9), 1038-55.
    • (2000) Acta Anaesthesiol. Scand , vol.44 , Issue.9 , pp. 1038-1055
    • Sommerschild, H.T.1    Kirkeboen, K.A.2
  • 78
    • 25144490744 scopus 로고    scopus 로고
    • Adenosine receptor signaling in the brain immune system
    • Hasko, G.; Pacher, P.; Vizi, E.S.; Illes, P. Adenosine receptor signaling in the brain immune system. Trends Pharmacol. Sci., 2005, 26(10), 511-516.
    • (2005) Trends Pharmacol. Sci , vol.26 , Issue.10 , pp. 511-516
    • Hasko, G.1    Pacher, P.2    Vizi, E.S.3    Illes, P.4
  • 79
    • 0028894724 scopus 로고
    • Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine
    • Fischer, S.; Sharma, H.S.; Karliczek, G.F.; Schaper, W. Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine. Brain Res. Mol. Brain Res., 1995, 28(1), 141-148.
    • (1995) Brain Res. Mol. Brain Res , vol.28 , Issue.1 , pp. 141-148
    • Fischer, S.1    Sharma, H.S.2    Karliczek, G.F.3    Schaper, W.4
  • 80
    • 33845216127 scopus 로고    scopus 로고
    • Adenosine and neuroprotection
    • B.B. Adenosine and neuroprotection. Int. Rev. Neurobiol., 1997, 40, 259-280.
    • (1997) Int. Rev. Neurobiol , vol.40 , pp. 259-280
  • 81
    • 33750727320 scopus 로고    scopus 로고
    • Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation
    • Akaiwa, K.; Akashi, H.; Harada, H.; Sakashita, H.; Hiromatsu, S.; Kano, T.; Aoyagi, S. Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. Brain Res., 2006, 1122(1), 47-55.
    • (2006) Brain Res , vol.1122 , Issue.1 , pp. 47-55
    • Akaiwa, K.1    Akashi, H.2    Harada, H.3    Sakashita, H.4    Hiromatsu, S.5    Kano, T.6    Aoyagi, S.7
  • 82
    • 38849100495 scopus 로고    scopus 로고
    • Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
    • Li, T.; Ren, G.; Lusardi, T.; Wilz, A.; Lan, J.Q.; Iwasato, T.; Itohara, S.; Simon, R.P.; Boison, D. Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J. Clin. Inv., 2008, 118(2), 571-582.
    • (2008) J. Clin. Inv , vol.118 , Issue.2 , pp. 571-582
    • Li, T.1    Ren, G.2    Lusardi, T.3    Wilz, A.4    Lan, J.Q.5    Iwasato, T.6    Itohara, S.7    Simon, R.P.8    Boison, D.9
  • 83
    • 0033995205 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine kinase inhibitors
    • Kowaluk, E.A.; Jarvis, M.F. Therapeutic potential of adenosine kinase inhibitors. Exp. Opin. Investig. Drugs, 2000, 9(3), 551-564.
    • (2000) Exp. Opin. Investig. Drugs , vol.9 , Issue.3 , pp. 551-564
    • Kowaluk, E.A.1    Jarvis, M.F.2
  • 84
    • 0031565281 scopus 로고    scopus 로고
    • Adenosine kinase inhibition protects brain against transient focal ischemia in rats
    • Jiang, N.; Kowaluk, E.A.; Lee, C.H.; Mazdiyasni, H.; Chopp, M. Adenosine kinase inhibition protects brain against transient focal ischemia in rats. Eur. J. Pharmacol., 1997, 320(2-3), 131-137.
    • (1997) Eur. J. Pharmacol , vol.320 , Issue.2-3 , pp. 131-137
    • Jiang, N.1    Kowaluk, E.A.2    Lee, C.H.3    Mazdiyasni, H.4    Chopp, M.5
  • 85
    • 0842284006 scopus 로고    scopus 로고
    • Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis
    • Gouder, N.; Scheurer, L.; Fritschy, J.-M.; Boison, D. Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J. Neurosci., 2004, 24(3), 692-701.
    • (2004) J. Neurosci , vol.24 , Issue.3 , pp. 692-701
    • Gouder, N.1    Scheurer, L.2    Fritschy, J.-M.3    Boison, D.4
  • 86
    • 26044440838 scopus 로고    scopus 로고
    • Astrogliosis in epilepsy leads to overexpression of adenosine kinase resulting in seizure aggravation
    • Fedele, D.E.; Gouder, N.; Güttinger, M.; Gabernet, L.; Scheurer, L.; Rulicke, T.; Crestani, F.; Boison, D. Astrogliosis in epilepsy leads to overexpression of adenosine kinase resulting in seizure aggravation. Brain, 2005, 128, 2383-2395.
    • (2005) Brain , vol.128 , pp. 2383-2395
    • Fedele, D.E.1    Gouder, N.2    Güttinger, M.3    Gabernet, L.4    Scheurer, L.5    Rulicke, T.6    Crestani, F.7    Boison, D.8
  • 88
    • 16244364339 scopus 로고    scopus 로고
    • Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts
    • Güttinger, M.; Padrun, V.; Pralong, W.; Boison, D. Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Exp. Neurol., 2005, 193, 53-64.
    • (2005) Exp. Neurol , vol.193 , pp. 53-64
    • Güttinger, M.1    Padrun, V.2    Pralong, W.3    Boison, D.4
  • 90
    • 35349013559 scopus 로고    scopus 로고
    • Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control
    • Ren, G.; Li, T.; Lan, J.Q.; Wilz, A.; Simon, R.P.; Boison, D. Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp. Neurol., 2007, 208, 26-37.
    • (2007) Exp. Neurol , vol.208 , pp. 26-37
    • Ren, G.1    Li, T.2    Lan, J.Q.3    Wilz, A.4    Simon, R.P.5    Boison, D.6
  • 91
    • 33845786142 scopus 로고    scopus 로고
    • Transgenic overexpression of adenosine kinase aggravates cell death in ischemia
    • Pignataro, G.; Simon, R.P.; Boison, D. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J. Cereb. Blood Flow Metab., 2007, 27(1), 1-5.
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , Issue.1 , pp. 1-5
    • Pignataro, G.1    Simon, R.P.2    Boison, D.3
  • 92
    • 0030696354 scopus 로고    scopus 로고
    • Adenosinergic system as an endogenous anticonvulsant mechanism
    • Gupta, Y.K.; Malhotra, J. Adenosinergic system as an endogenous anticonvulsant mechanism. Indian J. Physiol. Pharmacol., 1997, 41(4), 329-343.
    • (1997) Indian. J. Physiol. Pharmacol , vol.41 , Issue.4 , pp. 329-343
    • Gupta, Y.K.1    Malhotra, J.2
  • 93
    • 0018639982 scopus 로고
    • Purification and properties of human placental adenosine kinase
    • Andres, C.M.; Fox, I.H. Purification and properties of human placental adenosine kinase. J. Biol. Chem., 1979, 254(22), 11388-11393.
    • (1979) J. Biol. Chem , vol.254 , Issue.22 , pp. 11388-11393
    • Andres, C.M.1    Fox, I.H.2
  • 94
    • 33748450680 scopus 로고    scopus 로고
    • Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme
    • Studer, F.E.; Fedele, D.E.; Marowsky, A.; Schwerdel, C.; Wernli, K.; Vogt, K.; Fritschy, J.-M.; Boison, D. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience, 2006, 142, 125-137.
    • (2006) Neuroscience , vol.142 , pp. 125-137
    • Studer, F.E.1    Fedele, D.E.2    Marowsky, A.3    Schwerdel, C.4    Wernli, K.5    Vogt, K.6    Fritschy, J.-M.7    Boison, D.8
  • 95
    • 0032555429 scopus 로고    scopus 로고
    • Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures
    • Lynch, J.J. 3rd; Alexander, K.M.; Jarvis, M.F.; Kowaluk, E.A. Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures. Neurosci. Lett., 1998, 252(3), 207-210.
    • (1998) Neurosci. Lett , vol.252 , Issue.3 , pp. 207-210
    • Lynch 3rd, J.J.1    Alexander, K.M.2    Jarvis, M.F.3    Kowaluk, E.A.4
  • 96
    • 34248202688 scopus 로고    scopus 로고
    • Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus
    • Frenguelli, B.G.; Wigmore, G.; Llaudet, E.; Dale, N. Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus. J. Neurochem., 2007, 101(5), 1400-1413.
    • (2007) J. Neurochem , vol.101 , Issue.5 , pp. 1400-1413
    • Frenguelli, B.G.1    Wigmore, G.2    Llaudet, E.3    Dale, N.4
  • 97
    • 0018121433 scopus 로고
    • Activities and some properties of 5'- nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine
    • Arch, J.R.; Newsholme, E.A. Activities and some properties of 5'- nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine. Biochem. J., 1978, 174(3), 965-977.
    • (1978) Biochem. J , vol.174 , Issue.3 , pp. 965-977
    • Arch, J.R.1    Newsholme, E.A.2
  • 98
    • 0027412657 scopus 로고
    • Mechanisms of elevation of adenosine levels in anoxic hepatocytes
    • Bontemps, F.; Vincent, M.F.; Van den Berge, G. Mechanisms of elevation of adenosine levels in anoxic hepatocytes. Biochem. J., 1993, 290, 671-677.
    • (1993) Biochem. J , vol.290 , pp. 671-677
    • Bontemps, F.1    Vincent, M.F.2    van den Berge, G.3
  • 99
    • 4544335760 scopus 로고    scopus 로고
    • Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation
    • Sahin, B.; Kansy, J.W.; Nairn, A.C.; Spychala, J.; Ealick, S.E.; Fienberg, A.A.; Greene, R.W.; Bibb, J.A. Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation. Eur. J. Biochem., 2004, 271(17), 3547-3555.
    • (2004) Eur. J. Biochem , vol.271 , Issue.17 , pp. 3547-3555
    • Sahin, B.1    Kansy, J.W.2    Nairn, A.C.3    Spychala, J.4    Ealick, S.E.5    Fienberg, A.A.6    Greene, R.W.7    Bibb, J.A.8
  • 100
    • 0023664279 scopus 로고
    • Isolation and characterization of adenosine kinase from Leishmania donovani
    • Datta, A.K.; Bhaumik, D.; Chatterjee, R. Isolation and characterization of adenosine kinase from Leishmania donovani. J. Biol. Chem., 1987, 262(12), 5515-5521.
    • (1987) J. Biol. Chem , vol.262 , Issue.12 , pp. 5515-5521
    • Datta, A.K.1    Bhaumik, D.2    Chatterjee, R.3
  • 102
    • 0028557874 scopus 로고
    • Adenylosuccinate synthetase - a dominant amplifiable genetic marker in mammalian cells
    • Datta, S.K.; Guicherit, O.M.; Kellems, R.E. Adenylosuccinate synthetase - a dominant amplifiable genetic marker in mammalian cells. Somat. Cell Mol. Genet., 1994, 20(5), 381-389.
    • (1994) Somat. Cell Mol. Genet , vol.20 , Issue.5 , pp. 381-389
    • Datta, S.K.1    Guicherit, O.M.2    Kellems, R.E.3
  • 103
    • 0023240964 scopus 로고
    • Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia
    • Hagberg, H.; Andersson, P.; Lacarewicz, J.; Jacobson, I.; Butcher, S.; Sandberg, M. Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J. Neurochem., 1987, 49, 227-231.
    • (1987) J. Neurochem , vol.49 , pp. 227-231
    • Hagberg, H.1    Andersson, P.2    Lacarewicz, J.3    Jacobson, I.4    Butcher, S.5    Sandberg, M.6
  • 104
    • 0032826019 scopus 로고    scopus 로고
    • Adenosine and memory storage: Effect of A(1) and A(2) receptor antagonists
    • Kopf, S.R.; Melani, A.; Pedata, F.; Pepeu, G. Adenosine and memory storage: effect of A(1) and A(2) receptor antagonists. Psychopharmacology (Berl), 1999, 146(2), 214-219.
    • (1999) Psychopharmacology (Berl) , vol.146 , Issue.2 , pp. 214-219
    • Kopf, S.R.1    Melani, A.2    Pedata, F.3    Pepeu, G.4
  • 105
    • 0142058767 scopus 로고    scopus 로고
    • Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation
    • Phillis, J.W.; O'Regan, M.H. Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation. Eur. J. Pharmacol., 2003, 476(3), 211-219.
    • (2003) Eur. J. Pharmacol , vol.476 , Issue.3 , pp. 211-219
    • Phillis, J.W.1    O'Regan, M.H.2
  • 106
    • 34247526358 scopus 로고    scopus 로고
    • Neuroprotection in ischemic mouse brain induced by stem cellderived brain implants
    • Pignataro, G.; Studer, F.E.; Wilz, A.; Simon, R.P.; Boison, D. Neuroprotection in ischemic mouse brain induced by stem cellderived brain implants. J. Cereb. Blood Flow Metab., 2007, 27(5), 919-927.
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , Issue.5 , pp. 919-927
    • Pignataro, G.1    Studer, F.E.2    Wilz, A.3    Simon, R.P.4    Boison, D.5
  • 107
    • 0025305871 scopus 로고
    • Adenosine agonists can both inhibit and enhance in vivo striatal dopamine release
    • Zetterstrom, T.; Fillenz, M. Adenosine agonists can both inhibit and enhance in vivo striatal dopamine release. Eur. J. Pharmacol., 1990, 180(1), 137-143.
    • (1990) Eur. J. Pharmacol , vol.180 , Issue.1 , pp. 137-143
    • Zetterstrom, T.1    Fillenz, M.2
  • 108
    • 0021179327 scopus 로고
    • Adenosine decreases aspartate and glutamate release from rat hippocampal slices
    • Corradetti, R.; Lo Conte, G.; Moroni, F.; Passani, M.B.; Pepeu, G. Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur. J. Pharmacol., 1984, 104, 19-26.
    • (1984) Eur. J. Pharmacol , vol.104 , pp. 19-26
    • Corradetti, R.1    Lo Conte, G.2    Moroni, F.3    Passani, M.B.4    Pepeu, G.5
  • 109
    • 0028172835 scopus 로고
    • Modulation of nerve and glial function by adenosine--role in the development of ischemic damage
    • Schubert, P.; Rudolphi, K.A.; Fredholm, B.B.; Nakamura, Y. Modulation of nerve and glial function by adenosine--role in the development of ischemic damage. Int. J. Biochem., 1994, 26(10-11), 1227-1236.
    • (1994) Int. J. Biochem , vol.26 , Issue.10-11 , pp. 1227-1236
    • Schubert, P.1    Rudolphi, K.A.2    Fredholm, B.B.3    Nakamura, Y.4
  • 110
    • 0025903392 scopus 로고
    • The electrophysiology of adenosine in the mammalian central nervous system
    • Greene, R.W.; Haas, H.L. The electrophysiology of adenosine in the mammalian central nervous system. Progr. Neurobiol., 1991, 36, 329-341.
    • (1991) Progr. Neurobiol , vol.36 , pp. 329-341
    • Greene, R.W.1    Haas, H.L.2
  • 111
    • 0023709085 scopus 로고
    • Glucose deprivation depolarizes plasma membrane of cultured astrocytes and collapses transmembrane potassium and glutamate gradients
    • Kauppinen, R.A.; Enkvist, K.; Holopainen, I.; Akerman, K.E. Glucose deprivation depolarizes plasma membrane of cultured astrocytes and collapses transmembrane potassium and glutamate gradients. Neuroscience, 1988, 26(1), 283-289.
    • (1988) Neuroscience , vol.26 , Issue.1 , pp. 283-289
    • Kauppinen, R.A.1    Enkvist, K.2    Holopainen, I.3    Akerman, K.E.4
  • 112
    • 0028981904 scopus 로고
    • Adenosine modulates N-methyl-D-aspartatestimulated hippocampal nitric oxide production in vivo
    • Bhardwaj, A.; Northington, F.J.; Koehler, R.C.; Stiefel, T.; Hanley, D.F.; Traystman, R.J. Adenosine modulates N-methyl-D-aspartatestimulated hippocampal nitric oxide production in vivo. Stroke, 1995, 26(9), 1627-1633.
    • (1995) Stroke , vol.26 , Issue.9 , pp. 1627-1633
    • Bhardwaj, A.1    Northington, F.J.2    Koehler, R.C.3    Stiefel, T.4    Hanley, D.F.5    Traystman, R.J.6
  • 113
    • 23144462768 scopus 로고    scopus 로고
    • What can adenosine neuromodulation do for neuroprotection
    • Ribeiro, J.A. What can adenosine neuromodulation do for neuroprotection? Curr. Drug Targets CNS Neurol. Disord., 2005, 4(4), 325-329.
    • (2005) Curr. Drug Targets CNS Neurol. Disord , vol.4 , Issue.4 , pp. 325-329
    • Ribeiro, J.A.1
  • 115
    • 0023692737 scopus 로고
    • Cyclohexyl adenosine protects against neuronal death following ischemia in the CA1 region of gerbil hippocampus
    • von Lubitz, D.K.; Dambrosia, J.M.; Kempski, O.; Redmond, D.J. Cyclohexyl adenosine protects against neuronal death following ischemia in the CA1 region of gerbil hippocampus. Stroke, 1988, 19(9), 1133-1139.
    • (1988) Stroke , vol.19 , Issue.9 , pp. 1133-1139
    • von Lubitz, D.K.1    Dambrosia, J.M.2    Kempski, O.3    Redmond, D.J.4
  • 116
    • 0025579957 scopus 로고
    • Cerebral ischemia in gerbils: Postischemic administration of cyclohexyl adenosine and 8- sulfophenyl-theophylline
    • von Lubitz, D.K.; Marangos, P.J. Cerebral ischemia in gerbils: postischemic administration of cyclohexyl adenosine and 8- sulfophenyl-theophylline. J. Mol. Neurosci., 1990, 2(1), 53-59.
    • (1990) J. Mol. Neurosci , vol.2 , Issue.1 , pp. 53-59
    • von Lubitz, D.K.1    Marangos, P.J.2
  • 117
    • 0028047656 scopus 로고
    • Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: A histopathologic study in the rat
    • Zhou, J.G.; Meno, J.R.; Hsu, S.S.; Winn, H.R. Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: a histopathologic study in the rat. J. Cereb. Blood Flow Metab., 1994, 14(1), 166-173.
    • (1994) J. Cereb. Blood Flow Metab , vol.14 , Issue.1 , pp. 166-173
    • Zhou, J.G.1    Meno, J.R.2    Hsu, S.S.3    Winn, H.R.4
  • 118
    • 0023502217 scopus 로고
    • An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus
    • Evans, M.C.; Swan, J.H.; Meldrum, B.S. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus. Neurosci. Lett., 1987, 83(3), 287-292.
    • (1987) Neurosci. Lett , vol.83 , Issue.3 , pp. 287-292
    • Evans, M.C.1    Swan, J.H.2    Meldrum, B.S.3
  • 119
    • 0031081290 scopus 로고    scopus 로고
    • Modulation of neuronal and glial cell function by adenosine and neuroprotection in vascular dementia
    • Rudolphi, K.A.; Schubert, P. Modulation of neuronal and glial cell function by adenosine and neuroprotection in vascular dementia. Behav. Brain Res., 1997, 83(1-2), 123-128.
    • (1997) Behav. Brain Res , vol.83 , Issue.1-2 , pp. 123-128
    • Rudolphi, K.A.1    Schubert, P.2
  • 120
    • 0028181236 scopus 로고
    • Chronic adenosine A1 receptor agonist and antagonist: Effect on receptor density and N-methyl-D-aspartate induced seizures in mice
    • von Lubitz, D.K.J.E.; Paul, I.A.; Ji, X.-d.; Carter, M.; Jacobson, K.A. Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice. Eur. J. Pharmacol., 1994, 253, 95-99.
    • (1994) Eur. J. Pharmacol , vol.253 , pp. 95-99
    • von Lubitz, D.K.J.E.1    Paul, I.A.2    Ji, X.-D.3    Carter, M.4    Jacobson, K.A.5
  • 121
    • 0030014586 scopus 로고    scopus 로고
    • Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist
    • Von Lubitz, D.K.; Beenhakker, M.; Lin, R.C.; Carter, M.F.; Paul, I.A.; Bischofberger, N.; Jacobson, K.A. Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. Eur. J. Pharmacol., 1996, 302(1-3), 43-48.
    • (1996) Eur. J. Pharmacol , vol.302 , Issue.1-3 , pp. 43-48
    • von Lubitz, D.K.1    Beenhakker, M.2    Lin, R.C.3    Carter, M.F.4    Paul, I.A.5    Bischofberger, N.6    Jacobson, K.A.7
  • 122
    • 0029888491 scopus 로고    scopus 로고
    • Noctural dosing of a novel delivery system of verapamil for systemic hypertension
    • W.B. Noctural dosing of a novel delivery system of verapamil for systemic hypertension. Am. J. Cardiol., 1996, 77(11), 1030.
    • (1996) Am. J. Cardiol , vol.77 , Issue.11 , pp. 1030
  • 123
    • 0025822057 scopus 로고
    • The effects of caffeine on ischemic neuronal injury as determined by magnetic resonance imaging and histopathology
    • Sutherland, G.R.; Peeling, J.; Lesiuk, H.J.; Brownstone, R. M.; Rydzy, M.; Saunders, J.K.; Geiger, J.D. The effects of caffeine on ischemic neuronal injury as determined by magnetic resonance imaging and histopathology. Neuroscience, 1991, 42(1), 171-182.
    • (1991) Neuroscience , vol.42 , Issue.1 , pp. 171-182
    • Sutherland, G.R.1    Peeling, J.2    Lesiuk, H.J.3    Brownstone, R.M.4    Rydzy, M.5    Saunders, J.K.6    Geiger, J.D.7
  • 124
    • 0024365888 scopus 로고
    • Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment
    • Rudolphi, K.A.; Keil, M.; Fastbom, J.; Fredholm, B.B. Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment. Neurosci. Lett., 1989, 103(3), 275-280.
    • (1989) Neurosci. Lett , vol.103 , Issue.3 , pp. 275-280
    • Rudolphi, K.A.1    Keil, M.2    Fastbom, J.3    Fredholm, B.B.4
  • 125
    • 0028321498 scopus 로고
    • CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil
    • Gao, Y.; Phillis, J.W. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci., 1994, 55(3), PL61-5.
    • (1994) Life Sci , vol.55 , Issue.3
    • Gao, Y.1    Phillis, J.W.2
  • 126
    • 0037427516 scopus 로고    scopus 로고
    • The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat
    • Melani, A.; Pantoni, L.; Bordoni, F.; Gianfriddo, M.; Bianchi, L.; Vannucchi, M.G.; Bertorelli, R.; Monopoli, A.; Pedata, F. The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat. Brain Res., 2003, 959(2), 243-250.
    • (2003) Brain Res , vol.959 , Issue.2 , pp. 243-250
    • Melani, A.1    Pantoni, L.2    Bordoni, F.3    Gianfriddo, M.4    Bianchi, L.5    Vannucchi, M.G.6    Bertorelli, R.7    Monopoli, A.8    Pedata, F.9
  • 127
    • 0032217044 scopus 로고    scopus 로고
    • Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats
    • Monopoli, A.; Lozza, G.; Forlani, A.; Mattavelli, A.; Ongini, E. Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. Neuroreport, 1998, 9(17), 3955-3959.
    • (1998) Neuroreport , vol.9 , Issue.17 , pp. 3955-3959
    • Monopoli, A.1    Lozza, G.2    Forlani, A.3    Mattavelli, A.4    Ongini, E.5
  • 128
    • 0029417320 scopus 로고
    • The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil
    • Phillis, J.W. The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil. Brain Res., 1995, 705(1-2), 79-84.
    • (1995) Brain Res , vol.705 , Issue.1-2 , pp. 79-84
    • Phillis, J.W.1
  • 129
    • 0036124663 scopus 로고    scopus 로고
    • Hippocampal injury and neurobehavioral deficits following hyperglycemic cerebral ischemia: Effect of theophylline and ZM 241385
    • Higashi, H.; Meno, J.R.; Marwaha, A.S.; Winn, H.R. Hippocampal injury and neurobehavioral deficits following hyperglycemic cerebral ischemia: effect of theophylline and ZM 241385. J. Neurosurg., 2002, 96(1), 117-126.
    • (2002) J. Neurosurg , vol.96 , Issue.1 , pp. 117-126
    • Higashi, H.1    Meno, J.R.2    Marwaha, A.S.3    Winn, H.R.4
  • 130
    • 0343852967 scopus 로고    scopus 로고
    • Neonatal cerebral hypoxia-ischemia: The effect of adenosine receptor antagonists
    • Bona, E.; Aden, U.; Gilland, E.; Fredholm, B.B.; Hagberg, H. Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists. Neuropharmacology, 1997, 36(9), 1327-1338.
    • (1997) Neuropharmacology , vol.36 , Issue.9 , pp. 1327-1338
    • Bona, E.1    Aden, U.2    Gilland, E.3    Fredholm, B.B.4    Hagberg, H.5
  • 131
    • 0033823084 scopus 로고    scopus 로고
    • Adenosine: Does it have a neuroprotective role after all?
    • de Mendonca, A.; Sebastiao, A.M.; Ribeiro, J.A. Adenosine: does it have a neuroprotective role after all? Brain Res. Rev., 2000, 33(2-3), 258-274.
    • (2000) Brain Res. Rev , vol.33 , Issue.2-3 , pp. 258-274
    • de Mendonca, A.1    Sebastiao, A.M.2    Ribeiro, J.A.3
  • 133
    • 33750314483 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent
    • Chen, Y.; Fenoglio, K.A.; Dube, C.M.; Grigoriadis, D.E.; Baram, T.Z. Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Mol. Psychiatry, 2006, 11(11), 992-1002.
    • (2006) Mol. Psychiatry , vol.11 , Issue.11 , pp. 992-1002
    • Chen, Y.1    Fenoglio, K.A.2    Dube, C.M.3    Grigoriadis, D.E.4    Baram, T.Z.5
  • 134
    • 0031593681 scopus 로고    scopus 로고
    • Adenosine A3 receptors: Novel ligands and paradoxical effects
    • Jacobson, K.A. Adenosine A3 receptors: novel ligands and paradoxical effects. Trends Pharmacol. Sci., 1998, 19(5), 184-91.
    • (1998) Trends Pharmacol. Sci , vol.19 , Issue.5 , pp. 184-191
    • Jacobson, K.A.1
  • 135
    • 0026060970 scopus 로고
    • Brain adenosine and transmitter amino acid release from the ischemic rat cerebral cortex: Effects of the adenosine deaminase inhibitor deoxycoformycin
    • Phillis, J.W.; Walter, G.A.; Simpson, R.E. Brain adenosine and transmitter amino acid release from the ischemic rat cerebral cortex: effects of the adenosine deaminase inhibitor deoxycoformycin. J. Neurochem., 1991, 56, 644-650.
    • (1991) J. Neurochem , vol.56 , pp. 644-650
    • Phillis, J.W.1    Walter, G.A.2    Simpson, R.E.3
  • 136
    • 0030582669 scopus 로고    scopus 로고
    • Pre-and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats
    • Miller, L.P.; Jelovich, L.A.; Yao, L.P.; Dare, J.; Ugarkar, B.; Foster, A.C. Pre-and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats. Neurosci. Lett., 1996, 220(2), 73-76.
    • (1996) Neurosci. Lett , vol.220 , Issue.2 , pp. 73-76
    • Miller, L.P.1    Jelovich, L.A.2    Yao, L.P.3    Dare, J.4    Ugarkar, B.5    Foster, A.C.6
  • 137
    • 0031692409 scopus 로고    scopus 로고
    • Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion
    • Tatlisumak, T.; Takano, K.; Carano, R.A.; Miller, L.P.; Foster, A.C.; Fisher, M. Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion. Stroke, 1998, 29(9), 1952-8.
    • (1998) Stroke , vol.29 , Issue.9 , pp. 1952-1958
    • Tatlisumak, T.1    Takano, K.2    Carano, R.A.3    Miller, L.P.4    Foster, A.C.5    Fisher, M.6
  • 139
    • 0035727596 scopus 로고    scopus 로고
    • Recent developments in the discovery of novel adenosine kinase inhibitors: Mechanism of action and therapeutic potential
    • McGaraughty, S.; Cowart, M.; Jarvis, M.F. Recent developments in the discovery of novel adenosine kinase inhibitors: mechanism of action and therapeutic potential. CNS Drug Rev., 2001, 7(4), 415-432.
    • (2001) CNS Drug Rev , vol.7 , Issue.4 , pp. 415-432
    • McGaraughty, S.1    Cowart, M.2    Jarvis, M.F.3
  • 141
    • 0036345575 scopus 로고    scopus 로고
    • Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats
    • Jarvis, M.F.; Mikusa, J.; Chu, K.L.; Wismer, C.T.; Honore, P.; Kowaluk, E.A.; McGaraughty, S. Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats. Pharmacol. Biochem. Behav., 2002, 73(3), 573-581.
    • (2002) Pharmacol. Biochem. Behav , vol.73 , Issue.3 , pp. 573-581
    • Jarvis, M.F.1    Mikusa, J.2    Chu, K.L.3    Wismer, C.T.4    Honore, P.5    Kowaluk, E.A.6    McGaraughty, S.7
  • 143
    • 0036218120 scopus 로고    scopus 로고
    • Intracerebral adenosine infusion improves neurological outcome after transient focal ischemia in rats
    • Kitagawa, H.; Mori, A.; Shimada, J.; Mitsumoto, Y.; Kikuchi, T. Intracerebral adenosine infusion improves neurological outcome after transient focal ischemia in rats. Neurol. Res., 2002, 24(3), 317-323.
    • (2002) Neurol. Res , vol.24 , Issue.3 , pp. 317-323
    • Kitagawa, H.1    Mori, A.2    Shimada, J.3    Mitsumoto, Y.4    Kikuchi, T.5
  • 144
    • 0034658221 scopus 로고    scopus 로고
    • Purinergic and pyrimidinergic receptors as potential drug targets
    • Williams, M.; Jarvis, M. F. Purinergic and pyrimidinergic receptors as potential drug targets. Biochem. Pharmacol., 2000, 59(10), 1173-1185.
    • (2000) Biochem. Pharmacol , vol.59 , Issue.10 , pp. 1173-1185
    • Williams, M.1    Jarvis, M.F.2
  • 145
    • 0033532235 scopus 로고    scopus 로고
    • Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats
    • Britton, D.R.; Mikusa, J.; Lee, C.H.; Jarvis, M.F.; Williams, M.; Kowaluk, E.A. Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats. Neurosci. Lett., 1999, 266(2), 93-96.
    • (1999) Neurosci. Lett , vol.266 , Issue.2 , pp. 93-96
    • Britton, D.R.1    Mikusa, J.2    Lee, C.H.3    Jarvis, M.F.4    Williams, M.5    Kowaluk, E.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.