메뉴 건너뛰기




Volumn 7, Issue 4, 2001, Pages 415-432

Recent developments in the discovery of novel adenosine kinase inhibitors: Mechanism of action and therapeutic potential

Author keywords

A 134974; ABT 702; Adenosine; Adenosine kinase; Analgesia; Epilepsy; Inflammation; P3269; P683

Indexed keywords

4 ANILINO 5 PHENYLPYRROLO[2,3 D]PYRIMIDINE 7 (5 DEOXYRIBOSIDE); A 134974; ABT 702; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR STIMULATING AGENT; ARISTEROMYCIN; DEOXYADENOSINE; GP 3269; GP 515; GP 947; P 3269; PUROMYCIN; THEOPHYLLINE; TUBERCIDIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0035727596     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.2001.tb00208.x     Document Type: Review
Times cited : (34)

References (82)
  • 2
    • 0016707514 scopus 로고
    • Structural requirements for activity of nucleosides as substrates for adenosine kinase: Orientation of substituents on the pentafuranosyl ring
    • (1975) Mol Pharmacol , vol.11 , pp. 803-808
    • Bennett, L.L.1    Hill, D.L.2
  • 15
    • 0008682339 scopus 로고    scopus 로고
    • Heterocyclic substituted cyclopentane compounds. 1997 U.S. Patents No. 5,665,721 and No. 2000 6,143,749
    • Cowart, M.1    Bhagwat, S.S.2
  • 23
    • 0023187620 scopus 로고
    • Consequences of activation and adenosine mediated inhibition of granulocytes during myocardial ischemia
    • (1987) Fed Proc , vol.46 , pp. 2407-2412
    • Engler, R.L.1
  • 29
    • 0030441284 scopus 로고    scopus 로고
    • Anti-inflammatory effects of adenosine kinase inhibitors in acute and chronic inflammation
    • (1996) Drug Dev Res , vol.39 , pp. 371-376
    • Firestein, G.S.1
  • 38
    • 0033680092 scopus 로고    scopus 로고
    • ABT-702, a novel orally effective adenosine kinase (AK) inhibitor analgesic with anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in mice
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1156-1164
    • Jarvis, M.F.1    Yu, H.2    Wismer, C.3
  • 40
    • 0026739165 scopus 로고
    • Spinally mediated antinociception is induced in mice by an adenosine kinase, but not an adenosine deaminase inhibitor
    • (1992) Life Sci , vol.51 , pp. 171-176
    • Keil, G.J.1    Delander, G.E.2
  • 46
    • 0033697042 scopus 로고    scopus 로고
    • ABT-702, a novel orally effective adenosine kinase (AK) inhibitor analgesic with anti-inflammatory properties. II. Antinociceptive and anti-inflammatory effects in rat models of persistent, inflammatory, and neuropathic pain
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1165-1174
    • Kowaluk, E.A.1    Wismer, C.2    Mikusa, J.3
  • 47
    • 0035927430 scopus 로고    scopus 로고
    • Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d] pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor
    • (2001) J Med Chem , vol.44 , pp. 2133-2138
    • Lee, C.-H.1    Jiang, M.2    Cowart, M.3
  • 58
    • 0027418487 scopus 로고
    • Acadesine: Prototype adenosine regulating agent for treating myocardial ischemia-reperfusion injury
    • (1993) Drug Dev Res , vol.23 , pp. 336-343
    • Mullane, K.1    Young, M.2
  • 64
    • 0027231268 scopus 로고
    • The adenosine kinase inhibitor, 5-iodotubercidin, is not protective against cerebral ischemic injury in the gerbil
    • (1993) Life Sci , vol.53 , pp. 497-502
    • Phillis, J.W.1    Smith-Barbour, M.2
  • 65
    • 0028891913 scopus 로고
    • Antinociception by adenosine analogs and an adenosine kinase inhibitor: Dependence on formalin concentration
    • (1995) Eur J Pharmacol , vol.286 , pp. 177-184
    • Poon, A.1    Sawynok, J.2
  • 66
    • 0031914926 scopus 로고    scopus 로고
    • Antinociception by adenosine analogs and inhibition of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat
    • (1998) Pain , vol.74 , pp. 235-245
    • Poon, A.1    Sawynok, J.2
  • 68
    • 0031884745 scopus 로고    scopus 로고
    • Peripheral antinociceptive effect of an adenosine kinase inhibitor with augmentation by an adenosine deaminase inhibitor, in the rat formalin test
    • (1998) Pain , vol.74 , pp. 75-81
    • Sawynok, J.1    Reid, A.2    Poon, A.3
  • 82
    • 0035968056 scopus 로고    scopus 로고
    • A-134974, a novel adenosine kinase inhibitor, releives tactile allodynia via spinal sites of action in peripheral nerve injured rats
    • (2001) Brain Res , vol.905 , pp. 104-110
    • Zhu, C.Z.1    Mikusa, J.2    Chu, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.