The concentrative nucleoside transporter family, SLC28

Pflugers Archiv European Journal of Physiology

Volumn 447, Issue 5, 2004, Pages 728-734

  Gray, Jennifer H ^a   Owen, Ryan P ^a   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CNT1; CNT2; CNT3; Concentrative transporter; Nucleoside; Nucleoside analog; Sodium dependent

Indexed keywords

CAPECITABINE; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 2; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 3; CYTARABINE; DOXIFLURIDINE; GEMCITABINE; LAMIVUDINE; NUCLEOSIDE; NUCLEOSIDE ANALOG; NUCLEOSIDE TRANSPORTER; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

AMINO ACID SEQUENCE; BINDING AFFINITY; EPITHELIUM; GENETIC VARIABILITY; HUMAN; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; MULTIGENE FAMILY; NUCLEOSIDE TRANSPORT PROTEINS; NUCLEOSIDES; SODIUM;

EID: 1242340288     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1107-y     Document Type: Review

References (56)

1. Anderson CM, Xiong W, Young JD, Cass CE, Parkinson FE (1996) Demonstration of the existence of mRNAs encoding N1/ cif and N2/cit sodium/nucleoside cotransporters in rat brain. Brain Res Mol Brain Res 42:358-361
2. Belt JA, Marina NM, Phelps DA, Crawford CR (1993) Nucleoside transport in normal and neoplastic cells. Adv Enzyme Regul 33:235-252
3. +-nucleoside cotransporter. J Biol Chem 270:13596-13599
4. Craig JE, Zhang Y, Gallagher MP (1994) Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186. Mol Microbiol 11:1159-1168
5. Del Santo B, Valdes R, Mata J, Felipe A, Casado FJ, Pastor-Anglada M (1998) Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells. Hepatology 28:1504-1511
6. Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM (2000) Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes. Drug Metab Dispos 28:1135-1140
7. +-dependent nucleoside transport in liver: two different isoforms from the same gene family are expressed in liver cells. Biochem J 330:997-1001
8. Galmarini CM, Mackey JR, Dumontet C (2001) Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 15:875-890
9. Gerstin KM, Dresser MJ, Wang J, Giacomini KM (2000) Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine. Pharm Res 17:906-910
10. Gerstin KM, Dresser MJ, Giacomini KM (2002) Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. Am J Physiol 283:F344-F349
11. Gomez-Angelats M, del Santo B, Mercader J, Ferrer-Martinez A, Felipe A, Casado J, Pastor-Anglada M (1996) Hormonal regulation of concentrative nucleoside transport in liver parenchymal cells. Biochem J 313:915-920
12. Graham KA, Leithoff J, Coe IR, Mowles D, Mackey JR, Young JD, Cass CE (2000) Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides Nucleotides Nucleic Acids 19:415-434
13. +-nucleoside cotransporter rCNT1. J Biol Chem 276:27981-27988
14. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD (1994) Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J Biol Chem 269:17757-17760
15. Jackson EK, Dubey RK (2001) Role of the extracellular cAMP-adenosine pathway in renal physiology. Am J Physiol 281:F597-F612
16. Jakobs ES, Paterson AR (1986) Sodium-dependent, concentrative nucleoside transport in cultured intestinal epithelial cells. Biochem Biophys Res Commun 140:1028-1035
17. Karle JM, Anderson LW, Dietrick DD, Cysyk RL (1980) Determination of serum and plasma uridine levels in mice, rats, and humans by high-pressure liquid chromatography. Anal Biochem 109:41-46
18. Lai Y, Bakken AH, Unadkat JD (2002) Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies. J Biol Chem 277:37711-37717
19. Le Hir M, Dubach UC (1984) Sodium gradient-energized concentrative transport of adenosine in renal brush border vesicles. Pflugers Arch 401:58-63
20. Le Hir M, Dubach UC (1985) Uphill transport of pyrimidine nucleosides in renal brush border vesicles. Pflugers Arch 404:238-243
21. + nucleoside cotransporters hCNT1 and hCNT2. J Biol Chem 274:24475-24484
22. Lostao MP, Mata JF, Larrayoz IM, Inzillo SM, Casado FJ, Pastor-Anglada M (2000) Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes. FEBS Lett 481:137-140
23. Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE, Young JD (1999) Gemcitabine transport in Xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst 91:1876-1881
24. Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM (2001) Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. Am J Physiol 280:F879-F885
25. Mangravite LM, Xiao G, Giacomini KM (2003) Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am J Physiol 284:F902-F910.
26. Mata JF, Garcia-Manteiga JM, Lostao MP, Fernandez-Veledo S, Guillen-Gomez E, Larrayoz IM, Lloberas J, Casado FJ, Pastor-Anglada M (2001) Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5′-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Mol Pharmacol 59:1542-1548
27. +-nucleoside transporters in the human intestine. Am J Physiol 280:G475-G481
28. Norholm MH, Dandanell G (2001) Specificity and topology of the Escherichia coli xanthosine permease, a representative of the NHS subfamily of the major facilitator superfamily. J Bacteriol 183:4900-4904
29. Pastor-Anglada M, Felipe A, Casado FJ, del Santo B, Mata JF, Valdes R (1998) Nucleoside transporters and liver cell growth. Biochem Cell Biol 76:771-777
30. Pastor-Anglada M, Casado FJ, Valdes R, Mata J, Garcia-Manteiga J, Molina M (2001) Complex regulation of nucleoside transporter expression in epithelial and immune system cells. Mol Membr Biol 18:81-85
31. Patel DH, Crawford CR, Naeve CW, Belt JA (2000) Cloning, genomic organization and chromosomal localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2). Gene 242:51-58
32. +-nucleoside purine (N1) transporter. Pharm Res 15:950-952
33. Pennycooke M, Chaudary N, Shuralyova I, Zhang Y, Coe IR (2001) Differential expression of human nucleoside transporters in normal and tumor tissue. Biochem Biophys Res Commun 280:951-995
34. +- dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells. Biochim Biophys Acta 1028:289-298
35. +-nucleoside cotransporter (hCNT1). Am J Physiol 272:C707-C714
36. +/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol 15:203-211
37. +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem 276:2914-2927
38. +-dependent uridine uptake in the regenerating rat liver. FEBS Lett 316:85-88
39. +- dependent nucleoside transporter (hSPNT1) in a mammalian expression system. J Pharmacol Exp Ther 289:1487-1491
40. Schwenk M, Hegazy E, Lopez del Pino V (1984) Uridine uptake by isolated intestinal epithelial cells of guinea pig. Biochim Biophys Acta 805:370-374
41. Soler AP, Gilliard G, Xiong Y, Knudsen KA, Martin JL, De Suarez CB, Mota Gamboa JD, Mosca W, Zoppi LB (2001) Overexpression of neural cell adhesion molecule in Chagas' myocarditis. Hum Pathol 32:149-155
42. Soler C, Felipe A, Mata JF, Casado FJ, Celada A, Pastor-Anglada M (1998) Regulation of nucleoside transport by lipopolysaccharide, phorbol esters, and tumor necrosis factor-alpha in human B-lymphocytes. J Biol Chem 273:26939-26945
43. Spector R (1980) Thymidine accumulation by choroid plexus in vitro. Arch Biochem Biophys 205:85-93
44. Spector R (1982) Nucleoside transport in choroid plexus: mechanism and specificity. Arch Biochem Biophys 216:693-703
45. Spector R, Huntoon S (1984) Specificity and sodium dependence of the active nucleoside transport system in choroid plexus. J Neurochem 42:1048-1052
46. Strauss PR, Sheehan JM, Kashket ER (1976) Membrane transport by murine lymphocytes. I. A rapid sampling technique as applied to the adenosine and thymidine systems. J Exp Med 144:1009-1021
47. Ungemach FR, Hegner D (1978) Uptake of thymidine into isolated rat hepatocytes. Evidence for two transport systems. Hoppe Seylers Z Physiol Chem 359:845-856
48. Valdes R, Casado FJ, Pastor-Anglada M (2002) Cell-cycle-dependent regulation of CNT1, a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs. Biochem Biophys Res Commun 296:575-579
49. Vijayalakshmi D, Belt JA (1988) Sodium-dependent nucleoside transport in mouse intestinal epithelial cells. Two transport systems with differing substrate specificities. J Biol Chem 263:19419-19423
50. +-dependent nucleoside transporters. J Biol Chem 272:28845-28848
51. Wang J, Giacomini KM (1999) Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter. J Biol Chem 274:2298-2302
52. +-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Am J Physiol 273:F1058-F1065
53. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM (1992) Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. J Biol Chem 267:8813-8818
54. Xiao G, Wang J, Tangen T, Giacomini KM (2001) A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans. Mol Pharmacol 59:339-348
55. Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD (2001) Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol 18:161-167
56. +-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti). Am J Physiol 283:C155-C168