Overexpression of Adenosine Kinase in Epileptic Hippocampus Contributes to Epileptogenesis

Journal of Neuroscience

Volumn 24, Issue 3, 2004, Pages 692-701

  Gouder, Nicolette ^a   Scheurer, Louis ^a   Fritschy, Jean Marc ^a   Boison, Detlev ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

Adenosine; Adenosine kinase; Epilepsy; Iodotubercidin; Kainic acid; Seizure susceptibility

Indexed keywords

5 IODOTUBERCIDIN; ADENOSINE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; KAINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN REGION; BRAIN STEM; BRAIN TISSUE; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; EPILEPSY; EPILEPTOGENESIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOUSE; NERVE CELL; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEIZURE; TEMPORAL LOBE EPILEPSY;

ACTION POTENTIALS; ADENOSINE KINASE; ANIMALS; ANTICONVULSANTS; ASTROCYTES; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITORS; EPILEPSY, TEMPORAL LOBE; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MICE; NEURONS; RECEPTOR, ADENOSINE A1; TUBERCIDIN; XANTHINES;

EID: 0842284006     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4781-03.2004     Document Type: Article

References (36)

1. Boison D, Scheurer L, Tseng JL, Aebischer P, Mohler H (1999) Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer. Exp Neurol 160:164-174.
2. Boison D, Huber A, Padrun V, Déglon N, Aebischer P, Möhler H (2002a) Seizure suppression by adenosine releasing cells is independent of seizure frequency. Epilepsia 43:788-796.
3. Boison D, Scheurer L, Zumsteg V, Rülicke T, Litynski P, Fowler B, Brandner S, Mohler H (2002b) Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci USA 99:6985-6990.
4. Bontemps F, Van den Berghe G, Hers HG (1983) Evidence for a substrate cycle between AMP and adenosine in isolated hepatocytes. Proc Natl Acad Sci USA 80:2829-2833.
5. Bouilleret V, Ridoux V, Depaulis A, Marescaux C, Nehlig A, Le Gal La Salle G (1999) Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 89:717-729.
6. Bouilleret V, Loup F, Kiener T, Marescaux C, Fritschy JM (2000) Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus 10:305-324.
7. Braas KM, Newby AC, Wilson VS, Snyder SH (1986) Adenosine-containing neurons in the brain localized by immunocytochemistry. J Neurosci 6:1952-1961.
8. Chakraborty A, Das I, Datta R, Sen B, Bhattacharyya D, Mandal C, Datta AK (2002) A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function. J Biol Chem 277:47451-47460.
9. Delaney SM, Geiger JD (1996) Brain regional levels of adenosine and adenosine nucleotides in rats killed by high-energy focused microwave irradiation. J Neurosci Methods 64:151-156.
10. Dunwiddie TV, Diao L (1994) Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses. J Pharmacol Exp Ther 268:537-545.
11. Dunwiddie TV, Masino SA (2001) The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24:31-55.
12. During MJ, Spencer DD (1992) Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol 32:618-624.
13. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51:83-133.
14. Fredholm BB, AP IJ, Jacobson KA, Klotz KN, Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
15. Geiger JD, Nagy JI (1986) Distribution of adenosine deaminase activity in rat brain and spinal cord. J Neurosci 6:2707-2714.
16. 1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia 44:877-885.
17. Huber A, Padrun V, Déglon N, Aebischer P, Möhler H, Boison D (2001) Grafts of adenosine releasing cells suppress seizures in kindling epilepsy. Proc Natl Acad Sci USA 98:7611-7616.
18. Huber A, Güttinger M, Möhler H, Boison D (2002) Seizure suppression by adenosine A2A receptor activation in a rat model of audiogenic brainstem epilepsy. Neurosci Lett 329:289-292.
19. Khurgel M, Ivy GO (1996) Astrocytes in kindling: relevance to epileptogenesis. Epilepsy Res 26:163-175.
20. Knuesel I, Zuellig RA, Schaub MC, Fritschy JM (2001) Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy. Eur J Neurosci 13:1113-1124.
21. Kowaluk EA, Jarvis MF (2000) Therapeutic potential of adenosine kinase inhibitors. Expert Opin Investig Drugs 9:551-564.
22. Kowaluk EA, Bhagwat SS, Jarvis MF (1998) Adenosine kinase inhibitors. Curr Pharm Des 4:403-416.
23. Lynch III JJ, Alexander KM, Jarvis MF, Kowaluk EA (1998) Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures. Neurosci Lett 252:207-210.
24. McNally T, Helfrich RJ, Cowart M, Dorwin SA, Meuth JL, Idler KB, Klute KA, Simmer RL, Kowaluk EA, Halbert DN (1997) Cloning and expression of the adenosine kinase gene from rat and human tissues. Biochem Biophys Res Commun 231:645-650.
25. Nagy JI, Yamamoto T, Uemura H, Schrader WP (1996) Adenosine deaminase in rodent median eminence: detection by antibody to the mouse enzyme and co-localization with adenosine deaminase-complexing protein (CD26). Neuroscience 73:459-471.
26. Pak MA, Haas HL, Decking UKM, Schrader J (1994) Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices. Neuropharmacology 33:1049-1053.
27. Patel BT, Tudball N (1986) Localization of S-adenosylhomocysteine hydrolase and adenosine deaminase immunoreactivities in rat brain. Brain Res 370:250-264.
28. Pazzagli M, Corsi C, Fratti S, Pedata F, Pepeu G (1995) Regulation of extracellular adenosine levels in the striatum of aging rats. Brain Res 684:103-106.
29. Reddington M,Pusch R (1983) Adenosine metabolism in a rat hippocampal slice preparation: incorporation into S-adenosylhomocysteine. J Neurochem 40:285-290.
30. Riban V, Bouilleret V, Pham-Le BT, Fritschy JM, Marescaux C, Depaulis A (2002) Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy. Neuroscience 112:101-111.
31. Suzuki F, Junier MP, Guilhem D, Sorensen JC, Onteniente B (1995) Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor. Neuroscience 64:665-674.
32. Ugarkar BG, Castellino AJ, DaRe JM, Kopcho JJ, Wiesner JB, Schanzer JM, Erion MD (2000a) Adenosine kinase inhibitors. 2. Synthesis, enzyme inhibition, and antiseizure activity of diaryltubercidin analogues. J Med Chem 43:2894-2905.
33. Ugarkar BG, DaRe JM, Kopcho JJ, Browne CE, 3rd, Schanzer JM, Wiesner JB, Erion MD (2000b) Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem 43:2883-2893.
34. Wiesner JB, Ugarkar BG, Castellino AJ, Barankiewicz J, Dumas DP, Gruber HE, Foster AC, Erion MD (1999) Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy. J Pharmacol Exp Ther 289:1669-1677.
35. Zhu PJ, Krnjevic K (1994) Endogenous adenosine deaminase does not modulate synaptic transmission in rat hippocampal slices under normoxic or hypoxic conditions. Neuroscience 63:489-497.
36. Zumsteg V, Boison D (2002) The use of real-time PCR with fluorogenic probes for the rapid selection of mutant neuroectodermal grafts. J Neurosci Methods 120:85-94.