Desensitisation of the adenosine A1 receptor by the A(2A) receptor in the rat striatum

Journal of Neurochemistry

Volumn 69, Issue 1, 1997, Pages 315-321

  Dixon, Alistair K ^a,b   Widdowson, Leon ^a   Richardson, Peter J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Acetylcholine; Adenosine receptor; Desensitisation; Protein kinase C; Striatum

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; PROTEIN KINASE C; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 2 CHLORO N(6)CYCLOPENTYLADENOSINE; 2-CHLORO-N(6)CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE RECEPTOR; ANTIHYPERTENSIVE AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE; N (2 GUANIDINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N-(2-GUANIDINOETHYL)-5-ISOQUINOLINESULFONAMIDE; PHENETHYLAMINE DERIVATIVE; SULFONAMIDE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; TRITIUM; XANTHINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CORPUS STRIATUM; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; SENSITIVITY AND SPECIFICITY; SYNAPTOSOME; WISTAR RAT;

ANIMALIA;

ADENOSINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; CORPUS STRIATUM; ENZYME INHIBITORS; ISOQUINOLINES; PHENETHYLAMINES; PRESYNAPTIC TERMINALS; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; SENSITIVITY AND SPECIFICITY; SULFONAMIDES; SYNAPTOSOMES; TRIAZINES; TRIAZOLES; TRITIUM; XANTHINES;

EID: 0030610310     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69010315.x     Document Type: Article

References (40)

1. 2A purine receptors regulate striatal acetylcholine release. J. Neurochem. 55, 31-38.
2. 1 selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn Schmiedebergs Arch. Pharmacol. 335, 59-63.
3. Budd D. C. and Nicholls D. G. (1995) Protein kinase C-mediated suppression of the presynaptic adenosine A1 receptor by a facilitatory metabotropic glutamate receptor. J. Neurochem. 65, 615-621.
4. 2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction. Eur. J. Pharmacol. 271, 349-355.
5. Correia de Sá P., Sebastião A. M., and Ribeiro J. A. (1991) Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat. Br. J. Pharmacol. 103, 1614-1620.
6. - generation respectively. J. Clin. Invest. 85, 1150-1157.
7. 3H]-acetylcholine release from different areas of the rat hippocampus. J. Neurochem. 63, 207-214.
8. 2A receptors in the rat hippocampus. Brain Res. 649, 208-216.
9. Dixon A. K., Gubitz A. K., Sirinathsinghji D. J. S., Richardson P. J., and Freeman T. C. (1996) Tissue distribution of adenosine receptor messenger-RNAs in the rat. Br. J. Pharmacol. 118, 1461-1468.
10. Dolphin A. C. and Prestwich S. A. (1985) Pertussis toxin reverses adenosine inhibition on neuronal glutamate release. Nature 316, 148-150.
11. 2 receptors in rat striatal membranes. Proc. Natl. Acad. Sci. USA 88, 7238-7241.
12. 2 receptors in rat neostriatal membranes. Eur. J. Pharmacol. 244, 311-315.
13. 2 dopamine receptors in rat striatum. Mol. Brain Res. 14, 186-195.
14. Fredholm B. B., Abbracchio M. P., Burnstock G., Daly J. W., Harden T. K., Jacobson K. A., Leff P., and Williams M. (1994) Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46, 143-156.
15. 2a receptor involves activation of both N-and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals. J. Neurochem. 67, 374-381.
16. Herbert J. M., Augerau J. M., Gleye J., and Maffrand J. P. (1990) Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 172, 993-999.
17. Hidaka H. and Kobayashi R. (1992) Pharmacology of protein kinase inhibitors. Annu. Rev. Pharmacol. Toxicol. 32, 377-397.
18. James S., Xuereb J., Askalan R., and Richardson P. J. (1992) Adenosine receptors in post mortem human brain. Br. J. Pharmacol. 105, 238-244.
19. 2A receptors in rat brain tissue. J. Pharmacol. Exp. Ther. 251, 888-893.
20. Keiding R., Horder M., Gerhardt W., Pitkanen E., Tenhunnen R., Stromme J. H., Theorsden L., Waldenstrom J., Tryding N., and Westlund L. (1974) Recommended methods for the determination of four enzymes in blood. Scand. J. Clin. Lab. Invest. 33, 291-306.
21. 3H]acetylcholine release. J. Neurochem. 62, 960-966.
22. Kirkpatrick K. A. and Richardson P. J. (1993) Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes. Br. J. Pharmacol. 110, 949-954.
23. 2 dopamine receptor gene expression by cholinergic neurons in the rat striatum. Neurosci. Lett. 117, 248-252.
24. Lohse M. J., Lenschow V., and Schwabe U. (1984) Two affinity states of RI adenosine receptors in brain membranes-analysis of guanine-nucleotide and temperature effects on radioligand binding. Mol. Pharmacol. 26, 1-9.
25. 1 adenosine receptors. Naunyn Schmeidebergs Arch. Pharmacol. 337, 687-689.
26. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurements with Folin phenol reagent. J. Biol. Chem. 193, 265-275.
27. 2A receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. J. Pharmacol. Exp. Ther. 252, 1134-1141.
28. 1 adenosine receptor from rat brain. Mol. Pharmacol. 40, 1-7.
29. 2a receptor mediated modulation of electrically evoked endogenous GABA release from slices of rat globus pallidus. J. Neurochem. 60, 2334-2337.
30. 2 receptors in unilaterally 6-hydroxydopamine-lesioned rats. Eur. J. Pharmacol. 251, 21-25.
31. Poucher S. M., Keddie J. R., Singh P., Caulkett P. W. R., Jones G., and Collis M. G. (1995) The in vitro pharmacology of ZM 241385, a potent, non-xanthine, A(2a) selective adenosine receptor antagonist. Br. J. Pharmacol. 115, 1096-1102.
32. Premont J., Perez M., Blanc G., Tassin J.-P., Thierry H.-M., Herve D., and Bockaert J. (1979) Adenosine-sensitive adenylate cyclase in rat brain homogenates: kinetic characteristics, specificity, topographical, subcellular and cellular distribution. Mol. Pharmacol. 16, 790-804.
33. 2A adenosine receptors in DDT1 MF-2 smooth-muscle cells. Mol. Pharmacol. 37, 149-156.
34. Richardson P. J., Brown S. J., Bailyes E. M., and Luzio J. P. (1987) Ectoenzymes control adenosine modulation of immnunoisolated cholinergic synapses. Nature 327, 232-234.
35. 1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum and basal ganglia. Brain Res. 677, 193-203.
36. 2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J. Neurochem. 57, 1062-1067.
37. Spielman W. S., Arend L. J., and Forrest J. N. (1987) The renal and epithelial actions of adenosine, in Topics and Perspectives in Adenosine Research (Gerlach E. and Becker B. F., eds), pp. 249-260. Springer-Verlag, Berlin.
38. 2+ channels by protein kinase C in rat central and peripheral neurons: disruption of G-protein mediated inhibition. Neuron 11, 305-320.
39. 2A receptor regulation of apomorphine induced turning in rats with unilateral striatal dopamine denervation. Psychopharmacology 111, 383-388.
40. 2+-dependent regulation of presynaptic stimulus-secretion coupling. J. Neurochem. 53, 1188-1194.