A2 adenosine receptors: Their presence and neuromodulatory role in the central nervous system

General Pharmacology

Volumn 27, Issue 6, 1996, Pages 925-933

  Latini, Serena ^a   Pazzagli, Marta ^a   Pepeu, Giancarlo ^a   Pedata, Felicita ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

A(2a) receptors; adenosine; central nervous system

Indexed keywords

2 CHLOROADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINO 8 CHLORO 1 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 4 AMINOBUTYRIC ACID; 6 N CYCLOPENTYLADENOSINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 [4 (2 AMINOETHYLCARBAMOYL)METHOXYPHENYL] 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ACETYLCHOLINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE RECEPTOR AFFECTING AGENT; CYCLOHEXYLADENOSINE; DOPAMINE; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; MESSENGER RNA; NEUROTRANSMITTER; PHENYLISOPROPYLADENOSINE; RADIOLIGAND; RECEPTOR SUBTYPE; UNINDEXED DRUG; ADENOSINE RECEPTOR; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

BRAIN CORTEX; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CORPUS STRIATUM; EXCITATION; HIPPOCAMPUS; HISTOCHEMISTRY; HUMAN; IN SITU HYBRIDIZATION; MOTOR ACTIVITY; NERVE CELL INHIBITION; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; TISSUE DISTRIBUTION; ANIMAL; BRAIN; BRAIN LEVEL; PHYSIOLOGY; SECRETION; SYNAPSE;

ANIMALS; BRAIN; BRAIN CHEMISTRY; HUMANS; MOTOR ACTIVITY; NEUROTRANSMITTER AGENTS; RECEPTORS, DOPAMINE D2; RECEPTORS, PURINERGIC P1; SYNAPSES;

EID: 0030222504     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(96)00044-4     Document Type: Review

References (110)

1. Alexander G. E. and Crutcher M. D. (1990) Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends in Neurosciences 13, 266-271.
2. 2a purine receptors regulate striatal acetycholine release. J. Neurochem. 55, 31-38.
3. 3H]phenylxanthine. Proc. Natl. Acad. Sci. USA 77, 5547-5551.
4. 3H]NECA in rat striatal membranes. Molec. Pharmacol. 29, 331-346.
5. 2 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 64-69.
6. 1-selective adenosine antagonist 8-cyclopentyl-1, 3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59-63.
7. 1H] CV 1808) labels a novel adenosine receptor in rat brain. J. Pharmacol. Exp. Ther. 363, 552-561.
8. Corradetti R., Lo Conte G., Moroni F., Passani M. B. and Pepeu G. (1984) Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur. J. Pharmacol. 104, 19-26.
9. Correira-de-Sa P., Sebastiao A. M. and Ribeiro J. A. (1991) Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat. Br. J. Pharmacol. 103, 1614-1620.
10. 2 adenosine receptors. J. Med. Chem. 35, 2363-2368.
11. 3H]CGS 21680 are different in the hippocampus and cerebral cortex and in the striatum of the rat. Drug Develop. Res. 31, 260.
12. 2a receptors in the rat hippocampus. Brain Res. 649, 208-216.
13. 3H]acetylcholine release from different areas of the rat hippocampus. J. Neurochem. 63, 207-214.
14. 2a receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci. Lett. 196, 41-44.
15. Daly J. W. (1982) Adenosine receptors: target for future drugs. J. Med. Chem. 25, 197-207.
16. DeBoer P. and Westerink B. H. C. (1994) GABAergic modulation of striatal cholinergic interneurons: an in vivo microdialysis study. J. Neurochem. 62, 70-75.
17. de Mendonça A. and Riheiro J. A. (1994) Endogenous adenosine modulates long-term potentiarion in the hippocampus. Neurosci. 62, 385-390.
18. Dolphin A. C. and Archer E. R. (1983) An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyms. Neurosci. Lett. 43, 49-54.
19. Dunwiddie T. V. (1985) The physiological roles of adenosine in the central nervous system. In International Revieu of Neurobiology (Smythies J. R. and Bradley R. J., eds), pp. 63-139. Academic Press, London
20. 2 receptor involvement in the hypomobility effects of adenosine analogues in mice. Eur. J. Pharmacol. 168, 285-288.
21. Fasthom J., Pazos A. and Palacios J. M. (1987) The distribution of adenosine A. receptors and 5′-nucleotidase in the brain of some commonly used experimental animals. Neurosci. 22, 813-826.
22. 2 mediated behaviour in short-term reserpinized mice. Eur. J. Pharmacol. 192, 30-35.
23. Ferré S., Flerrera-Marschitz M., Grabowska-Anden M., Unberstedt U., Casas M. and Andén N.-E. (1991b) Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice. Eur. J. Pharmacol. 192, 36-42.
24. 2 receptors induces catalepsy. Neurosci. Lett. 130, 162-164.
25. 2 receptors in rat striatal membranes. Proc. Nat. Acad. Sci. USA. 88, 7238-7241.
26. Ferré S., Fuxe K., von Euler G., Johansson B. and Fredholm B. B. (1992) Adenosine-dopamine interactions in the brain. Neurosci. 51, 501-512.
27. Ferré S., O'Connor W. T., Fuxe K. and Ungerstedt U. (1993a) The striatopallidal neuron: a main locus tor adenosine-dopamine interactions in the brain. J. Neurosci. 13, 5402-5406.
28. 2 receptors in rat neostriatal membranes. Eur. J. Pharmacol. 244, 311-315.
29. Feuerstein T. J., Herttig G. and Jackisch R. (1985) Modulation of hippocampal serotonin (5-HT) release by endogenous adenosine. Eur. J. Pharmacol. 107, 233-242.
30. Fredholm B. B. and Dunwiddie T. V. (1988) How does adenosine inhibit transmitter release? TiPS 9, 130-134.
31. 2 receptor interaction in the striatum as a basis for adenosine/dopamine interactions in the central nervous system. Drug Develop. Res. 28, 374-380.
32. 2 dopamine receptor-regulated gene expression of strionigral and striopallidal neurons. Science 250, 1429-1432.
33. Giovannini M. G., Casamenti F., Nistri A., Paoli F. and Pepeu G. (1991) Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis. Br. J. Pharmacol. 102, 363-568.
34. 3H]cyclohexyladenosine. J. Neurosci. 2, 1230-1241.
35. Graybiel A. M. (1990) Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci. 13, 244-254.
36. 1-selective antagonist, DPCPX. Psychopharmacology 103, 541-544.
37. Gustafsson L. E., Wiklund C. U., Wiklund N. P. and Stelius L. (1990) Subclassification of neuronal adenosine receptors. In Purines in cellular signalling: target for new drugs (Jacobson K. A., Daly J. W. and Manganiello V., eds), pp. 200-205. Springer-Verlag, New York.
38. Harms H. H., Wardeh G. and Mulder H. (1979) Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum. Neuropharmacology 18, 577-580.
39. Hirai H. and Okada Y. (1994) Adenosine facilitates glutamate release in a protein kinase-dependent manner in superior colliculus slices. Eur. J. Pharmacol. 256, 65-71.
40. 2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther. 251, 47-55.
41. Jackisch R., Strittmatter H., Kasakov L. and Hertting G. (1984) Endogenous adenosine as a modulator of hippocampal acetylcholine release. Naunyn-Schmiedeberg's Arch. Pharmacol. 327, 319-325.
42. 2-adenosine antagonist in vitro and in vivo. Febs. Lett. 323, 141-144.
43. 3H]-CGS 21680 hinding sites in the rat striatum: copurification with cholinergic nerve terminals. Neurochem. Int. 23, 115-123.
44. James S., Xuereb J. H., Askalan R. and Richardson P. J. (1992) Adenosine receptors in post-mortem human brain. Br. J. Pharmacol. 105, 238-244.
45. Jarvis M. F. (1988) Autoradiographic localization and characterization of brain adenosine receptor subtypes. In Receptor localization: ligand autoradiography (Leslie F. and Altar C. A., eds), pp. 95-113. Alan R. Liss, New York.
46. 3H]CGS 21680. Eur. J. Pharmacol. 168, 243-246.
47. 2 receptors in the rat brain. Brain Res. 484, 111-118.
48. 2 receptors in rat brain. J. Pharmacol. Exp. Ther. 251, 888-893.
49. 1 receptor in the rat cortex. Mol. Pharmacol. 39, 49-54.
50. 2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices. J. Pharmacol. Exp. Trier. 267, 801-808.
51. 2 receptors in rat striatum. Biochem. Pharmacol. 444, 2365-2370.
52. 3H]CGS 21680 to rat cortex differs from its binding to rat striatum. Eur. J. Pharmacol. 247, 103-110.
53. Jonzon B. and Fredholm B. B. (1984) Adenosine-receptor mediated inhibition of noradrenaline release from slices of the rat hippocampus. Life Sci. 35, 1971-1979.
54. 3H]acetylcholine release. J. Neurochem. 62, 960-966.
55. Kirkpatrick K. A. and Richardson P. J. (1993) Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes. Br. J. Pharmacol. 110, 949-954.
56. 2a receptor-mediated modulation of striatal GABA and ACh release. Br. J. Pharmacol. 113, 43-48.
57. Le Moine C., Normand E., Guitteny A. F., Fouque B., Teoule R. and Bloch B. (1990) Dopamine receptor gene expression by enkephalin neurons in rat forebrain. Proc. Nad. Acad. Sci. USA. 87, 230-234.
58. 1 dopamine receptor gene. Proc. Natl. Acad. Sci. USA. 88, 4205-4209.
59. Linden J., Jacobson M. A., Hutchins C. and Williams M. (1994) Adenosine receptors. In Handbook of receptors and channels Vol. 1. G-protein-coupled receptors (Peroutka S. J., ed), pp. 29-44. CRC press.
60. 1 adenosine receptors. Naunyn-Schmiedebergs Arch. Pharmacol. 336, 204-210.
61. 3H]NECA binding sites by gel filtration. Naunyn-Schmiedeberg's Arch. Pharmacol. 337, 64-68.
62. 1 adenosine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 337, 687-689.
63. Londos C., Cooper D. M. F. and Wolff J. (1980) Subclasses of external adenosine receptors. Proc. Natl. Acad. Sci. USA 77, 2551-2554.
64. 2 receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. J. Pharmacol. Exp. Ther. 252, 1134-1141.
65. 2 receptor with physiological constitutive activity. Biuchem. Biophys. Res. Commun. 173, 1169-1178.
66. 2 receptors: selective localization in the human basal ganglia and alterations with disease. Neurosci. 42, 697-706.
67. 2a receptor modulation of electrically evoked endogenous GABA release from slices of rat globus pallidus. J. Neurochem. 60, 2334-2337.
68. Morgan P. F. (1991) Post receptor mechanisms. In Adenosine in the Nervous System (Stone T. W., ed), pp. 119-136. Academic Press, London.
69. Moser A., Liebetrau A. and Cramer H. (1991) Adenosine receptor-coupled adenylate cyclase in the caudate nucleus of the rat brain. Neuropharmacology 1, 769-773.
70. Myers S. and Pugsley T. A. (1986) Decrease in rat striatal dopamine synthesis and metabolism in vivo by metabolically stable adenosine receptor agonists. Brain Res. 375, 193-197.
71. 2 receptor antagonist. Eur. J. Pharmacol. 267, 335-341.
72. Okada Y. and Ozawa S. (1980) Inhibitor action of adenosine on synaptic transmission in the hippocampus of the guinea pig in vitro. Eur. J. Pharmacol. 68, 483-492.
73. Okada Y., Sakurai T. and Mori M. (1992) Excitatory effect of adenosine on neurotransmission is due to increase of transmitter release in the hippocampal slices. Neurosci. Lett. 142, 233-236.
74. 2 adenosine receptor agonist CGS 21680 enhances excitatory transmitter amino acid release from the ischemic rat cerebral cortex. Neurosci. Lett. 138, 169-172.
75. O'Regan M. H., Simpson R. E., Perkins L. M. and Phillis J. W. (1992b) Adenosine receptor agonists inhibit the release of gamma-aminobutyric acid (GABA) from the ischemic rat cerebral cortex. Brain Res. 582, 22-26.
76. 3H]-CGS 21680 as a ligand. Naunyn-Schmiedeberg's Arch. Pharmacol. 342, 85-89.
77. Pedata F., Antonelli T., Lambertini L., Beani L. and Pepeu G. (1983) Effect of adenosine, adenosine triphosphate, adenosine deaminase, dipyridamole and aminophylline on acetylcholine release from electrically-stimulated brain slices. Neuropharmacology 22, 609-614.
78. Pedata F., Pepeu G. and Spignoli G. (1984) Biphasic effect of methylxanthines on acetylcholine release from electrically stimulated brain slices. Br. J. Pharmacol. 83, 69-73.
79. Pedata F., Giovannelli L., De Sarno P. and Pepeu G. (1986) Effect of adenosine, adenosine derivatives, and caffeine on acetylcholine release from brain synaptosomes: interaction with muscarinic autoregulatory mechanisms. J. Neurochem. 46, 1593-1598.
80. Pedata F., Pazzagli M., Tilli S. and Pepeu G. (1990) Regional differences in the electrically stimulated release of endogenous and radioactive adenosine and purine derivatives from rat brain slices. Naunyn-Schmiedeberg's Arch. Pharmacol. 342, 447-453.
81. Phillis J. W., Edstrom J. P., Kostpoulos G. K. and Kirkpatrick J. R. (1979) Effect of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex. Can. J. Physiol. Pharmacol. 57, 1289-1312.
82. +-evoked acetylcholine release from the in vivo rat cerebral cortex. Brain Res. 605, 293-297.
83. Phillis J. W., Perkins L. M. and O'Regan M. H. (1993b) Potassium-evoked efflux of transmitter amino acids and purines from rat cerebtal cortex. Brain Res. Bull. 31, 547-552.
84. Phillis J. W., Smith-Barbour M., Perkins L. M. and O'Regan M. H. (1993c) Acetylcholine output from the ischemic rat cerebral cortex: effects of adenosine agonists. Brain Res. 613, 337-340.
85. 2 dopamine-dependent activation of Fos in the striatopallidal pathway. Neurosci. 68, 721-728.
86. Pull I. and McIlwain H. (1972) Adenine derivatives as neurohumoral agents. The quantities liberated on excitation of superfused cerebral tissues. Biochem. J. 130, 975-981.
87. 3) adenosinc receptor. Progr. Neurobiol. 26, 179-209.
88. Sarges R., Howard H. R., Browne R. G., Lebel L. A., Seymour P. A. and Koe B. K. (1990) 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressant. J. Med. Chem. 33, 2240-2254.
89. 1 dopamine receptor. Brain Res. 519, 333-537.
90. 2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J. Neurochem. 57, 1062-1067.
91. 2 receptor mRNA in the human brain. Neurosci. Lett. 130, 177-181.
92. 6-phenylisopropyladenosine. Naunyn-Schmiedeberg's Arch. Pharmacol. 313, 179-187.
93. 2 adenosine receptors in the rat hippocampus. Neurosci. Lett. 138, 41-44.
94. 2a receptors in the hippocampus and motor nerve endings. In Adenosine and adenine nucleotides: from molecular biology to integrative physiology (Belardinelli L. and Pelleg A., eds), pp. 251-261. Kluwer Academic Publisher, Boston.
95. 2) antagonist inhibits induction of long-term potentiation of evoked synaptic potentials but not of the population spike in hippocampal CA1 neurones. Biochem. Biophys. Res. Commun. 181, 1010-1014.
96. Simpson R. E., O'Regan M. H., Perkins L. M. and Phillis J. W. (1992) Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists. J. Neurochem. 58, 1683-1690.
97. Snyder S. H., Katims J. J., Annau Z., Bruns R. F. and Daly J. W. (1981) Adenosine receptors and behavioural actions of methylxanthines. Proc. Natl. Acad. Sci. USA. 78, 3260-3264.
98. 2 adenosine receptors modulate acetylcholine release from brain slices. Eur. J. Pharmacol. 97, 341-342.
99. Stone T. W. and Bartrup J. T. (1991) Electropharmacology of adenosine. In Adenosine in the Nervous System (Stone T., ed), pp. 197-216. Academic Press, London.
100. Trussel L. O. and Jackson M. B. (1985) Adenosine-activated potassium conductance in cultured striatal neurons. Proc. Natl. Acad. Sci. USA. 82, 4857-4861.
101. Van Calker D., Müller M. and Hamprecht B. (1979) Adenosine regulates via two different types of receptors the accumulation of cyclic AMP in cultured brain cells. J. Neurochem. 33, 999-1005.
102. Vannucchi M. G., Casamenti F. and Pepeu G. (1990) Decrease of acetylcholine release from cortical slices in aged rats: investigations into its reversal by phosphatidylserine. J. Neurochem. 55, 819-825.
103. Vizi E. S. and Knoll J. (1976) The inhibitory effect of aclenosine and related nucleotides on the release of acetylcholine. Neurosci. 1, 391-398.
104. 3H]CGS 21680 to human and rat brain: evidence for multiple affinity sites. J. Neurochem. 55, 1765-1771.
105. White T. D. and Hoehn K. (1991) Release of adenosine and ATP from nervous tissue. In Adenosine in the nervous system (Stone T., ed), pp. 173-196. Academic Press, London.
106. Williams M. (1989) Adenosine: the prototypic neuromodulator. Neurochem. Int. 14, 249-264.
107. Williams M. (1990) Adenosine receptots: an historical perspective. In Adenosine and adenosine receptors, pp. 1-5. The Human Press, New Jersey.
108. 2 receptors in striatum. Neurosci. Lett. 41, 55-60.
109. Yamamoto C., Sawada S. and Ohno-Shosaku T. (1993) Quantal analysis of modulating action of adenosine on the mossy fiber synapse in hippocampal slices. Hippocampus 3, 87-92.
110. 3 adenosine receptor. Proc. Natl. Acad. Sci. USA 89, 7432-7436.