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Volumn 78, Issue 12, 2009, Pages 1428-1437

Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation

Author keywords

Adenosine; Adenosine receptor; Epilepsy; Epileptogenesis; Focal drug delivery

Indexed keywords

ABT 702; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; ADENOSINE TRIPHOSPHATE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; FELBAMATE; GABAPENTIN; LORAZEPAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PARVOVIRUS VECTOR; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TARIQUIDAR; TIAGABINE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID; VIGABATRIN;

EID: 70349984540     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.08.005     Document Type: Note
Times cited : (58)

References (75)
  • 2
    • 56349138032 scopus 로고    scopus 로고
    • Several major antiepileptic drugs are substrates for human P-glycoprotein
    • Luna-Tortos C., Fedrowitz M., and Loscher W. Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology 55 (2008) 1364-1375
    • (2008) Neuropharmacology , vol.55 , pp. 1364-1375
    • Luna-Tortos, C.1    Fedrowitz, M.2    Loscher, W.3
  • 3
    • 57349170750 scopus 로고    scopus 로고
    • One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures
    • Hughes J.R. One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures. Neurol Res 30 (2008) 920-925
    • (2008) Neurol Res , vol.30 , pp. 920-925
    • Hughes, J.R.1
  • 4
    • 57449119700 scopus 로고    scopus 로고
    • Neuronismo y reticulismo: neuronal-glial circuits unify the reticular and neuronal theories of brain organization
    • Verkhratsky A. Neuronismo y reticulismo: neuronal-glial circuits unify the reticular and neuronal theories of brain organization. Acta Physiol (Oxf) 195 (2009) 111-122
    • (2009) Acta Physiol (Oxf) , vol.195 , pp. 111-122
    • Verkhratsky, A.1
  • 5
    • 33846621575 scopus 로고    scopus 로고
    • The tripartite synapse: roles for gliotransmission in health and disease
    • Halassa M.M., Fellin T., and Haydon P.G. The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol Med 13 (2007) 54-63
    • (2007) Trends Mol Med , vol.13 , pp. 54-63
    • Halassa, M.M.1    Fellin, T.2    Haydon, P.G.3
  • 6
    • 41549146380 scopus 로고    scopus 로고
    • Loss of astrocytic domain organization in the epileptic brain
    • Oberheim N.A., Tian G.F., Han X., Peng W., Takano T., Ransom B., et al. Loss of astrocytic domain organization in the epileptic brain. J Neurosci 28 (2008) 3264-3276
    • (2008) J Neurosci , vol.28 , pp. 3264-3276
    • Oberheim, N.A.1    Tian, G.F.2    Han, X.3    Peng, W.4    Takano, T.5    Ransom, B.6
  • 7
    • 33745873475 scopus 로고    scopus 로고
    • Astrocyte control of synaptic transmission and neurovascular coupling
    • Haydon P.G., and Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86 (2006) 1009-1031
    • (2006) Physiol Rev , vol.86 , pp. 1009-1031
    • Haydon, P.G.1    Carmignoto, G.2
  • 10
    • 57349185900 scopus 로고    scopus 로고
    • Astroglial metabolic networks sustain hippocampal synaptic transmission
    • Rouach N., Koulakoff A., Abudara V., Willecke K., and Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 322 (2008) 1551-1555
    • (2008) Science , vol.322 , pp. 1551-1555
    • Rouach, N.1    Koulakoff, A.2    Abudara, V.3    Willecke, K.4    Giaume, C.5
  • 11
    • 36549071601 scopus 로고    scopus 로고
    • Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    • Ravizza T., Gagliardi B., Noe F., Boer K., Aronica E., and Vezzani A. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 29 (2008) 142-160
    • (2008) Neurobiol Dis , vol.29 , pp. 142-160
    • Ravizza, T.1    Gagliardi, B.2    Noe, F.3    Boer, K.4    Aronica, E.5    Vezzani, A.6
  • 13
    • 39149122180 scopus 로고    scopus 로고
    • The adenosine kinase hypothesis of epileptogenesis
    • Boison D. The adenosine kinase hypothesis of epileptogenesis. Prog Neurobiol 84 (2008) 249-262
    • (2008) Prog Neurobiol , vol.84 , pp. 249-262
    • Boison, D.1
  • 14
    • 33745755958 scopus 로고    scopus 로고
    • Purinergic transmission in the central nervous system
    • North R.A., and Verkhratsky A. Purinergic transmission in the central nervous system. Pflugers Arch 452 (2006) 479-485
    • (2006) Pflugers Arch , vol.452 , pp. 479-485
    • North, R.A.1    Verkhratsky, A.2
  • 15
    • 4344617761 scopus 로고    scopus 로고
    • Astrocyte responses to neuronal activity
    • Schipke C.G., and Kettenmann H. Astrocyte responses to neuronal activity. Glia 47 (2004) 226-232
    • (2004) Glia , vol.47 , pp. 226-232
    • Schipke, C.G.1    Kettenmann, H.2
  • 16
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • Pocock J.M., and Kettenmann H. Neurotransmitter receptors on microglia. Trends Neurosci 30 (2007) 527-535
    • (2007) Trends Neurosci , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 17
    • 46449134214 scopus 로고    scopus 로고
    • Purinergic signalling and disorders of the central nervous system
    • Burnstock G. Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 7 (2008) 575-590
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 575-590
    • Burnstock, G.1
  • 18
    • 0026459032 scopus 로고
    • Adenosine: a potential mediator of seizure arrest and postictal refractoriness
    • During M.J., and Spencer D.D. Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol 32 (1992) 618-624
    • (1992) Ann Neurol , vol.32 , pp. 618-624
    • During, M.J.1    Spencer, D.D.2
  • 19
    • 13544274000 scopus 로고    scopus 로고
    • Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies
    • Boison D. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist 11 (2005) 25-36
    • (2005) Neuroscientist , vol.11 , pp. 25-36
    • Boison, D.1
  • 20
    • 0021900731 scopus 로고
    • Adenosine formation. Evidence for a direct biochemical link with energy metabolism
    • Newby A.C., Worku Y., and Holmquist C.A. Adenosine formation. Evidence for a direct biochemical link with energy metabolism. Adv Myocardiol 6 (1985) 273-284
    • (1985) Adv Myocardiol , vol.6 , pp. 273-284
    • Newby, A.C.1    Worku, Y.2    Holmquist, C.A.3
  • 21
    • 0018937105 scopus 로고
    • Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure
    • Schrader J., Wahl M., Kuschinsky W., and Kreutzberg G.W. Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure. Pflugers Arch 387 (1980) 245-251
    • (1980) Pflugers Arch , vol.387 , pp. 245-251
    • Schrader, J.1    Wahl, M.2    Kuschinsky, W.3    Kreutzberg, G.W.4
  • 22
    • 0021183624 scopus 로고
    • Adenosine modulation of amygdala kindling
    • Dragunow M., and Goddard G.V. Adenosine modulation of amygdala kindling. Exp Neurol 84 (1984) 654-665
    • (1984) Exp Neurol , vol.84 , pp. 654-665
    • Dragunow, M.1    Goddard, G.V.2
  • 23
    • 47349125847 scopus 로고    scopus 로고
    • A(2A) adenosine receptor and its modulators: Overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists
    • Cristalli G., Lambertucci C., Marucci G., Volpini R., and Dal Ben D. A(2A) adenosine receptor and its modulators: Overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists. Curr Pharm Des 14 (2008) 1525-1552
    • (2008) Curr Pharm Des , vol.14 , pp. 1525-1552
    • Cristalli, G.1    Lambertucci, C.2    Marucci, G.3    Volpini, R.4    Dal Ben, D.5
  • 24
    • 38149003880 scopus 로고    scopus 로고
    • Adenosine and its receptors: multiple modulatory functions and potential therapeutic targets for neurologic disease
    • Benarroch E.E. Adenosine and its receptors: multiple modulatory functions and potential therapeutic targets for neurologic disease. Neurology 70 (2008) 231-236
    • (2008) Neurology , vol.70 , pp. 231-236
    • Benarroch, E.E.1
  • 25
    • 33644770260 scopus 로고    scopus 로고
    • Adenosine receptors as therapeutic targets
    • Jacobson K.A., and Gao Z.G. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5 (2006) 247-264
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 247-264
    • Jacobson, K.A.1    Gao, Z.G.2
  • 26
    • 0033995205 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine kinase inhibitors
    • Kowaluk E.A., and Jarvis M.F. Therapeutic potential of adenosine kinase inhibitors. Expert Opin Investig Drugs 9 (2000) 551-564
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 551-564
    • Kowaluk, E.A.1    Jarvis, M.F.2
  • 27
    • 13444273445 scopus 로고    scopus 로고
    • Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors
    • McGaraughty S., Cowart M., Jarvis M.F., and Berman R.F. Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors. Curr Top Med Chem 5 (2005) 43-58
    • (2005) Curr Top Med Chem , vol.5 , pp. 43-58
    • McGaraughty, S.1    Cowart, M.2    Jarvis, M.F.3    Berman, R.F.4
  • 28
    • 58149232589 scopus 로고    scopus 로고
    • How do seizures stop?
    • Lado F.A., and Moshe S.L. How do seizures stop?. Epilepsia 49 (2008) 1651-1664
    • (2008) Epilepsia , vol.49 , pp. 1651-1664
    • Lado, F.A.1    Moshe, S.L.2
  • 30
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm B.B., Ijzerman A.P., Jacobson K.A., Klotz K.N., and Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53 (2001) 527-552
    • (2001) Pharmacol Rev , vol.53 , pp. 527-552
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.N.4    Linden, J.5
  • 31
    • 46749132311 scopus 로고    scopus 로고
    • Adenosine dysfunction in astrogliosis: cause for seizure generation?
    • Li T., Lan J.Q., Fredholm B.B., Simon R.P., and Boison D. Adenosine dysfunction in astrogliosis: cause for seizure generation?. Neuron Glia Biol 3 (2007) 353-366
    • (2007) Neuron Glia Biol , vol.3 , pp. 353-366
    • Li, T.1    Lan, J.Q.2    Fredholm, B.B.3    Simon, R.P.4    Boison, D.5
  • 33
    • 36849073199 scopus 로고    scopus 로고
    • Different cellular sources and different roles of adenosine: A(1) receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A(2A) receptor-mediated facilitation of plasticity
    • Cunha R.A. Different cellular sources and different roles of adenosine: A(1) receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A(2A) receptor-mediated facilitation of plasticity. Neurochem Int 52 (2008) 65-72
    • (2008) Neurochem Int , vol.52 , pp. 65-72
    • Cunha, R.A.1
  • 34
    • 0018121433 scopus 로고
    • Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine
    • Arch J.R., and Newsholme E.A. Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine. Biochem J 174 (1978) 965-977
    • (1978) Biochem J , vol.174 , pp. 965-977
    • Arch, J.R.1    Newsholme, E.A.2
  • 35
    • 38849100495 scopus 로고    scopus 로고
    • Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
    • Li T., Ren G., Lusardi T., Wilz A., Lan J.Q., Iwasato T., et al. Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest 118 (2008) 571-582
    • (2008) J Clin Invest , vol.118 , pp. 571-582
    • Li, T.1    Ren, G.2    Lusardi, T.3    Wilz, A.4    Lan, J.Q.5    Iwasato, T.6
  • 36
    • 8644249153 scopus 로고    scopus 로고
    • Focally injected adenosine prevents seizures in the rat
    • Anschel D.J., Ortega E.L., Kraus A.C., and Fisher R.S. Focally injected adenosine prevents seizures in the rat. Exp Neurol 190 (2004) 544-547
    • (2004) Exp Neurol , vol.190 , pp. 544-547
    • Anschel, D.J.1    Ortega, E.L.2    Kraus, A.C.3    Fisher, R.S.4
  • 37
    • 0030436331 scopus 로고    scopus 로고
    • Developments in purine and pyridimidine receptor-based therapeutics
    • Spedding M., and Williams M. Developments in purine and pyridimidine receptor-based therapeutics. Drug Dev Res 39 (1996) 436-441
    • (1996) Drug Dev Res , vol.39 , pp. 436-441
    • Spedding, M.1    Williams, M.2
  • 38
    • 0032834219 scopus 로고    scopus 로고
    • Developments in P2 receptor targeted therapeutics
    • Williams M. Developments in P2 receptor targeted therapeutics. Prog Brain Res 120 (1999) 93-106
    • (1999) Prog Brain Res , vol.120 , pp. 93-106
    • Williams, M.1
  • 39
    • 0034658221 scopus 로고    scopus 로고
    • Purinergic and pyrimidinergic receptors as potential drug targets
    • Williams M., and Jarvis M.F. Purinergic and pyrimidinergic receptors as potential drug targets. Biochem Pharmacol 59 (2000) 1173-1185
    • (2000) Biochem Pharmacol , vol.59 , pp. 1173-1185
    • Williams, M.1    Jarvis, M.F.2
  • 40
    • 0037478606 scopus 로고    scopus 로고
    • 1 receptor activation in a mouse model of pharmacoresistant epilepsy
    • 1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia 44 (2003) 877-885
    • (2003) Epilepsia , vol.44 , pp. 877-885
    • Gouder, N.1    Fritschy, J.M.2    Boison, D.3
  • 41
    • 0028675228 scopus 로고
    • Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine
    • Monopoli A., Conti A., Dionisotti S., Casati C., Camaioni E., Cristalli G., et al. Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 44 (1994) 1305-1312
    • (1994) Arzneimittelforschung , vol.44 , pp. 1305-1312
    • Monopoli, A.1    Conti, A.2    Dionisotti, S.3    Casati, C.4    Camaioni, E.5    Cristalli, G.6
  • 42
    • 0033697042 scopus 로고    scopus 로고
    • ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat
    • Kowaluk E.A., Mikusa J., Wismer C.T., Zhu C.Z., Schweitzer E., Lynch J.J., et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat. J Pharmacol Exp Ther 295 (2000) 1165-1174
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1165-1174
    • Kowaluk, E.A.1    Mikusa, J.2    Wismer, C.T.3    Zhu, C.Z.4    Schweitzer, E.5    Lynch, J.J.6
  • 43
    • 0033680092 scopus 로고    scopus 로고
    • ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. I. In vitro characterization and acute antinociceptive effects in the mouse
    • Jarvis M.F., Yu H., Kohlhaas K., Alexander K., Lee C.H., Jiang M., et al. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. I. In vitro characterization and acute antinociceptive effects in the mouse. J Pharmacol Exp Ther 295 (2000) 1156-1164
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1156-1164
    • Jarvis, M.F.1    Yu, H.2    Kohlhaas, K.3    Alexander, K.4    Lee, C.H.5    Jiang, M.6
  • 44
    • 0035066663 scopus 로고    scopus 로고
    • The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury
    • Suzuki R., Stanfa L.C., Kowaluk E.A., Williams M., Jarvis M.F., and Dickenson A.H. The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury. Br J Pharmacol 132 (2001) 1615-1623
    • (2001) Br J Pharmacol , vol.132 , pp. 1615-1623
    • Suzuki, R.1    Stanfa, L.C.2    Kowaluk, E.A.3    Williams, M.4    Jarvis, M.F.5    Dickenson, A.H.6
  • 45
    • 0842284006 scopus 로고    scopus 로고
    • Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis
    • Gouder N., Scheurer L., Fritschy J.-M., and Boison D. Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J Neurosci 24 (2004) 692-701
    • (2004) J Neurosci , vol.24 , pp. 692-701
    • Gouder, N.1    Scheurer, L.2    Fritschy, J.-M.3    Boison, D.4
  • 46
    • 33747780797 scopus 로고    scopus 로고
    • Purinergic control of neuropathic pain
    • McGaraughty S., and Jarvis M.F. Purinergic control of neuropathic pain. Drug Dev Res 67 (2006) 376-388
    • (2006) Drug Dev Res , vol.67 , pp. 376-388
    • McGaraughty, S.1    Jarvis, M.F.2
  • 47
    • 0036345575 scopus 로고    scopus 로고
    • Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats
    • Jarvis M.F., Mikusa J., Chu K.L., Wismer C.T., Honore P., Kowaluk E.A., et al. Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats. Pharmacol Biochem Behav 73 (2002) 573-581
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 573-581
    • Jarvis, M.F.1    Mikusa, J.2    Chu, K.L.3    Wismer, C.T.4    Honore, P.5    Kowaluk, E.A.6
  • 53
    • 46149117721 scopus 로고    scopus 로고
    • Silk polymer-based adenosine release: therapeutic potential for epilepsy
    • Wilz A., Pritchard E.M., Li T., Lan J.Q., Kaplan D.L., and Boison D. Silk polymer-based adenosine release: therapeutic potential for epilepsy. Biomaterials 29 (2008) 3609-3616
    • (2008) Biomaterials , vol.29 , pp. 3609-3616
    • Wilz, A.1    Pritchard, E.M.2    Li, T.3    Lan, J.Q.4    Kaplan, D.L.5    Boison, D.6
  • 54
    • 0026073291 scopus 로고
    • Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line
    • Aebischer P., Tresco P.A., Winn S.R., Greene L.A., and Jaeger C.B. Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line. Exp Neurol 111 (1991) 269-275
    • (1991) Exp Neurol , vol.111 , pp. 269-275
    • Aebischer, P.1    Tresco, P.A.2    Winn, S.R.3    Greene, L.A.4    Jaeger, C.B.5
  • 55
    • 0038703753 scopus 로고    scopus 로고
    • Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery
    • Schneider B.L., Schwenter F., Pralong W.F., and Aebischer P. Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery. Mol Ther 7 (2003) 506-514
    • (2003) Mol Ther , vol.7 , pp. 506-514
    • Schneider, B.L.1    Schwenter, F.2    Pralong, W.F.3    Aebischer, P.4
  • 56
    • 16244364339 scopus 로고    scopus 로고
    • 1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts
    • 1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Exp Neurol 193 (2005) 53-64
    • (2005) Exp Neurol , vol.193 , pp. 53-64
    • Güttinger, M.1    Padrun, V.2    Pralong, W.3    Boison, D.4
  • 57
    • 34347389850 scopus 로고    scopus 로고
    • Cell and gene therapies for refractory epilepsy
    • Boison D. Cell and gene therapies for refractory epilepsy. Curr Neuropharmacol 5 (2007) 115-125
    • (2007) Curr Neuropharmacol , vol.5 , pp. 115-125
    • Boison, D.1
  • 58
    • 39149095942 scopus 로고    scopus 로고
    • Cell and gene therapies in epilepsy - promising avenues or blind alleys?
    • Loscher W., Gernert M., and Heinemann U. Cell and gene therapies in epilepsy - promising avenues or blind alleys?. Trends Neurosci 31 (2008) 62-73
    • (2008) Trends Neurosci , vol.31 , pp. 62-73
    • Loscher, W.1    Gernert, M.2    Heinemann, U.3
  • 59
    • 35348903757 scopus 로고    scopus 로고
    • Concise review: prospects of stem cell therapy for temporal lobe epilepsy
    • Shetty A.K., and Hattiangady B. Concise review: prospects of stem cell therapy for temporal lobe epilepsy. Stem Cells 25 (2007) 2396-2407
    • (2007) Stem Cells , vol.25 , pp. 2396-2407
    • Shetty, A.K.1    Hattiangady, B.2
  • 61
    • 34249694599 scopus 로고    scopus 로고
    • Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants
    • Li T., Steinbeck J.A., Lusardi T., Koch P., Lan J.Q., Wilz A., et al. Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain 130 (2007) 1276-1288
    • (2007) Brain , vol.130 , pp. 1276-1288
    • Li, T.1    Steinbeck, J.A.2    Lusardi, T.3    Koch, P.4    Lan, J.Q.5    Wilz, A.6
  • 62
    • 39949083205 scopus 로고    scopus 로고
    • Critical issues of clinical human embryonic stem cell therapy for brain repair
    • Li J.Y., Christophersen N.S., Hall V., Soulet D., and Brundin P. Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci 31 (2008) 146-153
    • (2008) Trends Neurosci , vol.31 , pp. 146-153
    • Li, J.Y.1    Christophersen, N.S.2    Hall, V.3    Soulet, D.4    Brundin, P.5
  • 63
    • 35349013559 scopus 로고    scopus 로고
    • Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control
    • Ren G., Li T., Lan J.Q., Wilz A., Simon R.P., and Boison D. Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp Neurol 208 (2007) 26-37
    • (2007) Exp Neurol , vol.208 , pp. 26-37
    • Ren, G.1    Li, T.2    Lan, J.Q.3    Wilz, A.4    Simon, R.P.5    Boison, D.6
  • 64
    • 64549142358 scopus 로고    scopus 로고
    • Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis
    • Li T., Ren G., Kaplan D.L., and Boison D. Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis. Epilepsy Res 84 (2009) 238-241
    • (2009) Epilepsy Res , vol.84 , pp. 238-241
    • Li, T.1    Ren, G.2    Kaplan, D.L.3    Boison D4
  • 65
    • 0024362609 scopus 로고
    • Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector
    • Palella T.D., Hidaka Y., Silverman L.J., Levine M., Glorioso J., and Kelley W.N. Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector. Gene 80 (1989) 137-144
    • (1989) Gene , vol.80 , pp. 137-144
    • Palella, T.D.1    Hidaka, Y.2    Silverman, L.J.3    Levine, M.4    Glorioso, J.5    Kelley, W.N.6
  • 66
    • 0030872521 scopus 로고    scopus 로고
    • Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector - implications for a gene therapy approach to epilepsy
    • Freese A., Kaplitt M.G., Oconnor W.M., Abbey M., Langer D., Leone P., et al. Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector - implications for a gene therapy approach to epilepsy. Epilepsia 38 (1997) 759-766
    • (1997) Epilepsia , vol.38 , pp. 759-766
    • Freese, A.1    Kaplitt, M.G.2    Oconnor, W.M.3    Abbey, M.4    Langer, D.5    Leone, P.6
  • 67
    • 62949159436 scopus 로고    scopus 로고
    • Neuropeptide Y overexpression using recombinant adeno-associated viral vectors
    • Noe F., Frasca A., Balducci C., Carli M., Sperk G., Ferraguti F., et al. Neuropeptide Y overexpression using recombinant adeno-associated viral vectors. Neurotherapeutics 6 (2009) 300-306
    • (2009) Neurotherapeutics , vol.6 , pp. 300-306
    • Noe, F.1    Frasca, A.2    Balducci, C.3    Carli, M.4    Sperk, G.5    Ferraguti, F.6
  • 68
    • 34250683023 scopus 로고    scopus 로고
    • Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
    • Kaplitt M.G., Feigin A., Tang C., Fitzsimons H.L., Mattis P., Lawlor P.A., et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet 369 (2007) 2097-2105
    • (2007) Lancet , vol.369 , pp. 2097-2105
    • Kaplitt, M.G.1    Feigin, A.2    Tang, C.3    Fitzsimons, H.L.4    Mattis, P.5    Lawlor, P.A.6
  • 69
    • 41949110690 scopus 로고    scopus 로고
    • Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
    • Marks Jr. W.J., Ostrem J.L., Verhagen L., Starr P.A., Larson P.S., Bakay R.A., et al. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial. Lancet Neurol 7 (2008) 400-408
    • (2008) Lancet Neurol , vol.7 , pp. 400-408
    • Marks Jr., W.J.1    Ostrem, J.L.2    Verhagen, L.3    Starr, P.A.4    Larson, P.S.5    Bakay, R.A.6
  • 70
    • 68549118745 scopus 로고    scopus 로고
    • Antiepileptic effects of silk-polymer based adenosine release in kindled rats
    • Szybala C., Pritchard E.M., Wilz A., Kaplan D.L., and Boison D. Antiepileptic effects of silk-polymer based adenosine release in kindled rats. Exp Neurol 219 (2009) 126-135
    • (2009) Exp Neurol , vol.219 , pp. 126-135
    • Szybala, C.1    Pritchard, E.M.2    Wilz, A.3    Kaplan, D.L.4    Boison, D.5
  • 71
    • 0025757288 scopus 로고
    • Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy
    • Silver J.M., Shin C., and McNamara J.O. Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy. Ann Neurol 29 (1991) 356-363
    • (1991) Ann Neurol , vol.29 , pp. 356-363
    • Silver, J.M.1    Shin, C.2    McNamara, J.O.3
  • 74
    • 44549083390 scopus 로고    scopus 로고
    • Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets?
    • Masino S.A., and Geiger J.D. Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets?. Trends Neurosci 31 (2008) 273-278
    • (2008) Trends Neurosci , vol.31 , pp. 273-278
    • Masino, S.A.1    Geiger, J.D.2
  • 75
    • 0036140376 scopus 로고    scopus 로고
    • Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans
    • Eisenach J.C., Hood D.D., and Curry R. Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans. Anesthesiology 96 (2002) 24-28
    • (2002) Anesthesiology , vol.96 , pp. 24-28
    • Eisenach, J.C.1    Hood, D.D.2    Curry, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.