Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation

European Journal of Biochemistry

Volumn 271, Issue 17, 2004, Pages 3547-3555

  Sahin, Bogachan ^a   Kansy, Janice W ^a   Nairn, Angus C ^b,c   Spychala, Jozef ^d   Ealick, Steven E ^e   Fienberg, Allen A ^c,f   Greene, Robert W ^a,g   Bibb, James A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f Intra Cellular Therapies Inc   (United States)

^g VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

Adenosine kinase; Adenosine regulation; CNS; Protein serine threonine kinases

Indexed keywords

ADENOSINE KINASE; BRAIN ENZYME; COMPLEMENTARY DNA; ISOENZYME;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; GENE OVEREXPRESSION; HOMEOSTASIS; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS;

ADENOSINE; ADENOSINE KINASE; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CLONING, MOLECULAR; HOMEOSTASIS; HUMANS; ISOENZYMES; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; TISSUE DISTRIBUTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 4544335760     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04291.x     Document Type: Article

References (34)

1. Fredholm, B.B. (2003) Adenosine receptors as targets for drug development. Drug News Perspect. 16, 283-289.
2. Strecker, R.E., Morairty, S., Thakkar, M.M., Porkka-Heiskanen, T., Basheer, R., Dauphin, L.J., Rainnie, D.G., Portas, C.M., Greene, R.W. & McCarley, R.W. (2000) Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav. Brain Res. 115, 183-204.
3. Ledent, C., Vaugeois, J.M., Schiffmann, S.N., Pedrazzini, T., El Yacoubi, M., Vanderhaeghen, J.J., Constentin, J., Heath, J.K., Vassart, G. & Parmentier, M. (1997) Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674-678.
4. Fredholm, B.B., Battig, K., Holmen, J., Nehlig, A. & Zvartau, E.E. (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev. 51, 83-133.
5. Cass, C.E., Young, J.D. & Baldwin, S.A. (1998) Recent advances in the molecular biology of nucleoside transporters of mammalian cells. Biochem. Cell Biol. 76, 761-770.
6. Arch., J.R. & Newsholme, E.A. (1978) Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues of vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine. Biochem. J. 174, 965-977.
7. Mathews, I.I., Erion, M.D. & Ealick, S.E. (1998) Structure of human adenosine kinase at 1.5 Å resolution. Biochemistry 37, 15607-15620.
8. Spychala, J., Datta, N.S., Takabayashi, K., Datta, M., Fox, I.H., Gribbin, T. & Mitchell, B.S. (1996) Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Proc. Natl Acad. Sci. USA 93, 1232-1237.
9. Latini, S. & Pedata, F. (2001) Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J. Neurochem. 79, 463-484.
10. Brundege, J.M. & Dunwiddie, T.V. (1996) Modulation of excitatory synaptic transmission by adenosine released from single hippocampal pyramidal neurons. J. Neurosci. 16, 5603-5612.
11. Kaczmarek, L.K., Jennings, K.R., Strumwasser, F., Nairn, A.C., Walter, U., Wilson, F.D. & Greengard, P. (1980) Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proc. Natl Acad. Sci. USA 77, 7487-7491.
12. Woodgett, J.R. & Hunter, T. (1987) Isolation and characterization of two distinct forms of protein kinase C. J. Biol. Chem. 262, 4836-4843.
13. Bibb, J.A., Nishi, A., O'Callaghan, J.P., Snyder, G.L., Horiuchi, A.M.L., Ule, J., Pelech, S.L., Meijer, L., Saito, T., Hisanaga, T., Czernik, A.J., Nairn, A.C. & Greengard, P. (2001) Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. J. Biol. Chem. 276, 14490-14497.
14. Bibb, J.A., Snyder, G.L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A.A., Tsai, L.H., Kwon, Y.T., Girault, J.A., Czernik, A.J., Huganir, R.L., Hemmings, H.C Jr, Nairn, A.C. & Greengard, P. (1999) Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 402, 669-671.
15. Spychala, J. & Mitchell, B.S. (2002) Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. J. Lab. Clin. Med. 140, 84-91.
16. Huang, F.L. & Glinsmann, W.H. (1976) Separation and characterization of two phosphorylase phosphatase inhibitors from rabbit skeletal muscle. Eur. J. Biochem. 70, 419-426.
17. Schatzman, R.C., Raynor, R.L., Fritz, R.B. & Kuo, J.F. (1983) Purification to homogeneity, characterization and monoclonal antibodies of phospholipid-sensitive Ca2+-dependent protein kinase from spleen. Biochem. J. 209, 435-443.
18. de Jonge, H.R. & Rosen, O.M. (1977) Self-phosphorylation of cyclic guanosine 3′:5′-monophosphate-dependent protein kinase from bovine lung: effect of cyclic adenosine 3′:5′-monophosphate, cyclic guanosine 3′:5′-monophosphate and histone. J. Biol. Chem. 252, 2780-2783.
19. Campbell, D.G., Hardie, D.G. & Vulliet, P.R. (1986) Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. J. Biol. Chem. 261, 10489-10492.
20. Desdouits, F., Siciliano, J.C., Greengard, P. & Girault, J.A. (1995) Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. Proc. Natl Acad. Sci. USA 92, 2682-2685.
21. Girault, J.A., Hemmings, H.C. Jr, Williams, K.R., Nairn, A.C. & Greengard, P. (1989) Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. J. Biol. Chem. 264, 21748-21759.
22. Singh, B., Hao, W., Wu, Z., Eigl, B. & Gupta, R.S. (1996) Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species: high frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene. Eur. J. Biochem. 241, 564-571.
23. Kishimoto, A., Nishiyama, K., Nakanishi, H., Uratsuji, Y., Nomura, H., Takeyama, Y. & Nishizuka, Y. (1985) Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3′:5′- monophosphate-dependent protein kinase. J. Biol. Chem. 260, 12492-12499.
24. Gouder, N., Scheurer, L., Fritschy, J.M. & Boison, D. (2004) Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J. Neurosci. 24, 692-701.
25. Boison, D., Scheurer, L., Zumsteg, V., Rulicke, T., Litynski, P., Fowler, B., Brandner, S. & Mohler, H. (2002) Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc. Natl Acad. Sci. USA 99, 6985-6990.
26. Sakowicz, M., Grden, M. & Pawelczyk, T. (2001) Expression level of adenosine kinase in rat tissues. Lack of phosphate effect on the enzyme activity. Acta Biochim. Pol. 48, 745-754.
27. McNally, T., Helfrich, R.J., Cowart, M., Dorwin, S.A., Meuth, J.L., Idler, K.B., Klute, K.A., Simmer, R.L., Kowaluk, E.A. & Halbert, D.N. (1997) Cloning and expression of the adenosine kinase gene from rat and human tissues. Biochem. Biophys. Res. Commun. 231, 645-650.
28. Pak, A.A., Haas, H.L., Decking, U.K. & Schrader, J. (1994) Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices. Neuropharmacology 33, 1049-1053.
29. Miller, L.P., Jelovich, L.A., Yao, L., DaRe, J., Ugarkar, B. & Foster, A.C. (1996) Pre- and peristroke treatment with the adenosine kinase inhibitor, 5′-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats. Neurosci. Lett. 220, 73-76.
30. Wiesner, J.B., Ugarkar, B.G., Castellino, A.J., Barankiewicz, J., Dumas, D.P., Gruber, H.E., Foster, A.C. & Erion, M.D. (1999) Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy. J. Pharmacol. Exp. Ther. 289, 1669-1677.
31. Poon, A. & Sawynok, J. (1999) Antinociceptive and antiinflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. Eur. J. Pharmacol. 384, 123-138.
32. Pawelczyk, T., Sakowicz, M., Podgorska, M. & Szczepanska-Konkel, M. (2003) Insulin induces expression of adenosine kinase gene in rat lymphocytes by signaling through the mitogen-activated protein kinase pathway. Exp. Cell Res. 286, 152-163.
33. Mackiewicz, M., Nikonova, E.V., Zimmerman, J.E., Galante, R.J., Zhang, L., Cater, J.R., Geiger, J.D. & Pack, A.I. (2003) Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. J. Neurochem. 85, 348-357.
34. Alanko, L., Heiskanen, S., Stenberg, D. & Porkka-Heiskanen, T. (2003) Adenosine kinase and 5′-nucleotidase activity after prolonged wakefulness in the cortex and the basal forebrain of rat. Neurochem. Int. 42, 449-454.