Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT2 melatonin receptor selective ligands

Journal of Medicinal Chemistry

Volumn 45, Issue 13, 2002, Pages 2788-2800

  Wallez, Valérie ^a   Durieux Poissonnier, Sophie ^a   Chavatte, Philippe ^a   Boutin, Jean A ^b   Audinot, Valérie ^b   Nicolas, Jean Paul ^b   Bennejean, Caroline ^c   Delagrange, Philippe ^c   Renard, Pierre ^c   Lesieur, Daniel ^a  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE; LIGAND; MELATONIN; MELATONIN RECEPTOR; N (2 BENZOFURAN 3 YL)ETHYLAMIDE; N (2 PHENYLBENZOFURAN 3 YL)ETHYLAMIDE; N ACETYL 2 (5 METHOXY 2 PHENYLBENZO[B]FURAN 3 YL)ETHYLAMINE; N ACETYL 2 [5 METHOXY 2 (2 METHOXYBENZYL)BENZO[B]FURAN 3 YL]ETHYLAMINE; N BUT 1 EN 3 OYL 2 [5 METHOXY 2 (3 METHOXYBENZYL)BENZO[B]FURAN 3 YL]ETHYLAMINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; CELL LINE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOFURANS; CELL LINE; CRICETINAE; HUMANS; LIGANDS; MELATONIN; RADIOLIGAND ASSAY; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, MELATONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037142332     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0005252     Document Type: Article

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