Synthesis of 4-aza analog of ramelteon: A novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[d]furo[2,3-b]pyridine derivative as melatonin receptor ligand

Tetrahedron Letters

Volumn 52, Issue 23, 2011, Pages 3009-3011

  Koike, Tatsuki ^a   Hoashi, Yasutaka ^a   Takai, Takafumi ^a   Uchikawa, Osamu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Cyclopenta d furo 2,3 b pyridine; Desilylation cyclization; Intramolecular Diels Alder reaction; Ramelteon

Indexed keywords

FLUORIDE; LIGAND; MELATONIN RECEPTOR; PYRROLO[2,3 B]PYRIDINE DERIVATIVE; RAMELTEON; TRICYCLIC 1,6,7,8 TETRAHYDRO 2H CYCLOPENTA[DEXTRO]FURO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BROMINATION; CYCLIZATION; DESILYLATION; DIELS ALDER REACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; FRIEDEL CRAFTS REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGENATION; MICROWAVE COOKING; MICROWAVE IRRADIATION;

ALNUS;

EID: 79955649962     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.03.147     Document Type: Article

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