Reassessing the melatonin pharmacophore-Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3383-3391

  Rivara, Silvia ^a   Diamantini, Giuseppe ^b   Di Giacomo, Barbara ^b   Lamba, Doriano ^c   Gatti, Giuseppe ^b   Lucini, Valeria ^d   Pannacci, Marilou ^d   Mor, Marco ^a   Spadoni, Gilberto ^b   Tarzia, Giorgio ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

Conformational analysis; Enantiomeric resolution; Melatonin; Molecular modeling; Pharmacophore model; X ray crystal structure

Indexed keywords

3 (ACETYLAMINOMETHYL) 2 (ETHOXYCARBONYL) 6 METHOXY 1,3,4,5 TETRAHYDROBENZ[CD]INDOLE; LIGAND; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN DERIVATIVE; MELATONIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIRALITY; CONFORMATION; CRYSTALLOGRAPHY; ENANTIOMER; LIQUID CHROMATOGRAPHY; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; RACEMIC MIXTURE; RAT; STRUCTURE ANALYSIS; X RAY;

3T3 CELLS; ANIMALS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; MELATONIN; MICE; MODELS, MOLECULAR; RECEPTORS, MELATONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33645919613     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.053     Document Type: Article

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