Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1622-1629

  Leclerc, Véronique ^a   Ettaoussi, Mohamed ^a   Rami, Marouan ^a   Farce, Amaury ^a   Boutin, Jean Albert ^c   Delagrange, Philippe ^b   Caignard, Daniel Henri ^b   Renard, Pierre ^b   Berthelot, Pascal ^a   Yous, Saïd ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Binding; MCA NAT; Melatonin; MT3 binding site; Naphthalenic ligands; Quinone reductase 2

Indexed keywords

(7 METHYLSULFANYL 3,4 DIHYDRO 2H NAPHTH 1 YLIDENE)ACETONITRILE; (7 METHYLSULFANYL NAPHTH 1 YL)ACETONITRILE; 2 (7 METHYLSULFAMOYL NAPHTH 1 YL)ETHYLAMINE; 2 (7 METHYLSULFANYL NAPHTH 1 YL)ETHYLAMINE; 4 (4 METHYLSULFANYL PHENYL)BUTYRIC ACID; 4 (METHYLSULFANYL PHENYL) 4 OXO BUTYRIC ACID; 5 METHOXYCARBONYLAMINO N ACETYLTRYPTAMINE; 7 METHYLSULFANYL 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; [8 (2 ACETYLAMINO ETHYL)NAPHTH 2 YL]SULFONYL CHLORIDE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN 3 RECEPTOR; MELATONIN RECEPTOR; N [2 (7 AMINO NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 BENZYLSULFANYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHOXYCARBONYLAMINO NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHYLSULFAMOYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHYLSULFAMOYL NAPHTH 1 YL)ETHYL]FURAN 2 YLCARBOXAMIDE; N [2 (7 METHYLSULFANYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHYLSULFINYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHYLSULFONYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 SULFAMOYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 (7 TRIFLUOROMETHANSULFONYL NAPHTH 1 YL)ETHYL]ACETAMIDE; N [2 [7 [(4 METHOXYBENZYL)AMINO]NAPHTH 1 YL]ETHYL]ACETAMIDE; N ACETYLTRYPTAMINE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG SYNTHESIS;

BINDING SITES; DRUG DESIGN; LIGANDS; MELATONIN; MOLECULAR STRUCTURE; NAPHTHALENES; RECEPTORS, MELATONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953188673     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.010     Document Type: Article

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