Synthesis of a novel series of tricyclic dihydrofuran derivatives: Discovery of 8,9-dihydrofuro[3,2-c ]pyrazolo[1,5-a ]pyridines as melatonin receptor (MT1/MT2) ligands

Journal of Medicinal Chemistry

Volumn 54, Issue 12, 2011, Pages 4207-4218

  Koike, Tatsuki ^a   Takai, Takafumi ^a   Hoashi, Yasutaka ^a   Nakayama, Masaharu ^a   Kosugi, Yohei ^a   Nakashima, Masato ^a   Yoshikubo, Shin Ichi ^a   Hirai, Keisuke ^a   Uchikawa, Osamu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIHYDRO 2H INDENO [5,4 B] FURAN; 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDINE DERIVATIVE; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MOLECULAR SCAFFOLD; N [2 (2 (TRIFLUOROMETHYL) 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] ACETAMIDE; N [2 (2 CYCLOPROPYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] ACETAMIDE; N [2 (2 CYCLOPROPYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] PROPANAMIDE; N [2 (2 ETHYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] ACETAMIDE; N [2 (2 ETHYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] PROPANAMIDE; N [2 (2 METHYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] ACETAMIDE; N [2 (2 METHYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] PROPANAMIDE; N [2 (2 PHENYL 7,8 DIHYDRO 1H FURO [3,2 E] BENZIMIDAZOL 1 YL) ETHYL] ACETAMIDE; N [2 (2 PHENYL 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL) ETHYL] ACETAMIDE; N [2 (7 PHENYL 1,2 DIHYDROFURO [2,3 E] IMIDAZO [1,2 A] PYRIDIN 8 YL) ETHYL] ACETAMIDE; N[2 (2 (TRIFLUOROMETHYL) 8,9 DIHYDROFURO [3,2 C] PYRAZOLO [1,5 A] PYRIDIN 1 YL)ETHYL] PROPANAMIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL CAT; LIPOPHILICITY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; WAKEFULNESS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CATS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; FEMALE; FURANS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; LIGANDS; MALE; MICROSOMES, LIVER; PYRAZOLES; PYRIDINES; RATS; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959455122     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200385u     Document Type: Article

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