Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl- cyclopropane carboxamide derivatives as novel melatonin receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1236-1242

  Li, Guiying ^a   Zhou, Hao ^a   Jiang, Yu ^a   Keim, Holger ^a   Topiol, Sidney W ^a   Poda, Suresh B ^a   Ren, Yong ^a   Chandrasena, Gamini ^a   Doller, Darío ^a  

^a LUNDBECK RESEARCH USA   (United States)

Author keywords

Melatonergic ligands; Melatonin

Indexed keywords

AGOMELATINE; HORMONE RECEPTOR STIMULATING AGENT; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; PIPERDIN 3 YL CYCLOPROPANE CARBOXAMIDE DERIVATIVE; PIPERIDINYLAMIDE DERIVATIVE; RAMELTEON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MICROSOME; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CYCLOPROPANES; DRUG DESIGN; HUMANS; LIGANDS; MICROSOMES; PIPERIDINES; RATS; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 79851511779     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.068     Document Type: Article

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