Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7654-7661

  Attia, Mohamed I ^a   Witt Enderby, Paula A ^b   Julius, Justin ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Universigy of Pittsburgh   (United States)

Author keywords

6a,7 Dihydrodiindole; Melatoninergic ligands; Nitrogen heterocycles; Pentacyclic

Indexed keywords

2 (2 HYDROXYMETHYL 5 METHOXYINDOLIN 1 YLMETHYL) MELATONIN; 2 (2 HYDROXYMETHYLINDOLIN 1 YLMETHYL) MELATONIN; 2,3 DIHYDRODIINDOLE; 6A,7 DIHYDRODIINDOLE; LIGAND; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; INDOLES; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MELATONIN; POLYCYCLIC COMPOUNDS; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 49149116600     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.012     Document Type: Article

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