Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 1, 2012, Pages

  Zhao, Fang ^a,b   Huang, Fengjie ^a   Tang, Mengxiong ^a,b   Li, Xiaoming ^a,b   Zhang, Nina ^a,b   Amfilochiadis, Akis ^a   Li, Yiming ^c   Hu, Renming ^c   Jin, Tianru ^b,d   Peng, Chun ^e   Wang, Qinghua ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c FUDAN UNIVERSITY   (China)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e YORK UNIVERSITY   (Canada)

Author keywords

Activin receptor like kinase 7; Akt; Caspase 3; Insulin; X linked inhibitor of apoptosis protein

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ACTIVIN RECEPTOR LIKE KINASE 7; CASPASE 3; CYTOKINE; GLUCOSE; PALMITIC ACID; PROTEIN KINASE B; PROTEIN NODAL; SMAD2 PROTEIN; SMAD3 PROTEIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; DOWN-REGULATION; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; NODAL PROTEIN; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TISSUE CULTURE TECHNIQUES; UP-REGULATION;

EID: 84863707357     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00074.2012     Document Type: Article

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