ALK7 is a novel marker for adipocyte differentiation

Journal of Medical Investigation

Volumn 53, Issue 3-4, 2006, Pages 238-245

  Kogame, Masahiro ^a   Matsuo, Shinji ^a   Nakatani, Masashi ^a   Kurisaki, Akira ^a   Nishitani, Hiromu ^a   Tsuchida, Kunihiro ^a   Sugino, Hiromu ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Activin; Adipocyte differentiation; Adipogenesis; ALK7; TGF beta

Indexed keywords

ACTIVIN; ACTIVIN AB; ACTIVIN RECEPTOR LIKE KINASE 7; MYELOPID; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACTIVIN RECEPTORS, TYPE I; ACTIVINS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION REGULATION; GENETIC MARKERS; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33750378873     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.53.238     Document Type: Article

References (27)

1. Chang H, Brown CW, Matzuk MM: Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23:787-823, 2002
2. Tsuchida K: Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Curr Drug Targets Immune Endocr Metabol Disord 4:157-166, 2004
3. Zimmerman CM, Padgett RW: Transforming growth factor beta signaling mediators and modulators. Gene 249:17-30, 2000
4. Sugino H, Tsuchida K: Activin and follistatin. In: Canalis E ed. Skeletal Growth Factors. Lippincott Williams & Wilkins, Philadelphia, 2000, pp. 251-263
5. Blobe GC, Schiemann WP, Lodish HF: Role of transforming growth factor beta in human disease. N Engl J Med 342:1350-1358, 2000
6. Gaddy-Kurten D, Tsuchida K, Vale W: Activins and the receptor serine kinase superfamily. Recent Prog Horm Res 50:109-129, 1995
7. Mathews LS, Vale WW: Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65:973-982, 1991
8. Massague J, Seoane J, Wotton D: Smad transcription factors. Genes Dev 19:2783-2810, 2005
9. Lorentzon M, Hoffer B, Ebendal T, Olson L, Tomac A: Habrec 1, a novel serine/threonine kinase TGF-beta type I-like receptor, has a specific cellular expression suggesting function in the developing organism and adult brain. Exp Neurol 142:351-360, 1996
10. Ryden M, Imamura T, Jornvall H, Belluardo N, Neveu I, Trupp M, Okadome T, ten Dijke P, Ibanez CF: A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. J Biol Chem 271:30603-30609, 1996
11. Tsuchida K, Sawchenko PE, Nishikawa S, Vale WW: Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain. Mol Cell Neurosci 7:467-478, 1996
12. Reissmann E, Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH: The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev 15:2010-2022, 2001
13. Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H: Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol Cell Endocrinol 220:59-65, 2004
14. Kang Y, Reddi AH: Identification and cloning of a novel type I serine/threonine kinase receptor of the TGF-beta/BMP superfamily in rat prostate. Biochem Mol Biol Int 40:993-1001, 1996
15. Hirai S, Yamanaka M, Kawachi H, Matsui T, Yano H: Activin A inhibits differentiation of 3T3-L1 preadipocyte. Mol Cell Endocrinol 232: 21-26, 2005
16. Cole KA, Harmon AW, Harp JB, Patel YM: Rb regulates C/EBPbeta-DNA-binding activity during 3T3-L1 adipogenesis. Am J Physiol Cell Physiol 286:C349-354, 2004
17. Hwang CS, Loftus TM, Mandrup S, Lane MD: Adipocyte differentiation and leptin expression. Annu Rev Cell Dev Biol 13:231-259, 1997
18. Yagi K, Kondo D, Okazaki Y, Kano K: A novel preadipocyte cell line established from mouse adult mature adipocytes. Biochem Biophys Res Commun 321:967-974, 2004
19. MacDougald OA, Lane MD: Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 64: 345-373, 1995
20. Shi Y, Burn P: Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. Nat Rev Drug Discov 3:695-710, 2004
21. Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM: Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem 276:34167-34174, 2001
22. Roelen BA, Dijke P: Controlling mesenchymal stem cell differentiation by TGFBeta family members. J Orthop Sci 8:740-748, 2003
23. Yamaguchi A: Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-beta superfamily. Semin Cell Biol 6:165-173, 1995
24. Choy L, Skillington J, Derynck R: Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 149:667-682, 2000
25. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L: Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol 23:7230-7242, 2003
26. Kim HS, Liang L, Dean RG, Hausman DB, Hartzell DL, Baile CA: Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. Biochem Biophys Res Commun 281:902-906, 2001
27. Watanabe R, Yamada Y, Ihara Y, Someya Y, Kubota A, Kagimoto S, Kuroe A, Iwakura T, Shen ZP, Inada A, Adachi T, Ban N, Miyawaki K, Sunaga Y, Tsuda K, Seino Y: The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals. Biochem Biophys Res Commun 254:707-712, 1999