The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Genes and Development

Volumn 15, Issue 15, 2001, Pages 2010-2022

  Reissmann, E ^a   Jornvall H ^a   Blokzijl, A ^a   Andersson, O ^a   Chang, C ^a   Minchiotti, G ^a   Persico, M G ^a   Ibanez C F ^a   Brivanlou, A H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

ActRIIB; Cripto; Mesendoderm; Oep; TGF ; Xnr1

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR; PROTEIN ALK 4; PROTEIN ALK 7; PROTEIN NODAL; PROTEIN SERINE THREONINE KINASE; PROTEIN XNR 1; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; ENDODERM; GASTRULA; MESODERM; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; VERTEBRATE; XENOPUS;

ABNORMALITIES; ACTIVIN RECEPTORS; ACTIVIN RECEPTORS, TYPE I; AMINO ACID SEQUENCE; ANIMALS; ECTODERM; EMBRYO, NONMAMMALIAN; EPIDERMAL GROWTH FACTOR; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; NEOPLASM PROTEINS; PHYLOGENY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GROWTH FACTOR; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; VERTEBRATES; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA; VERTEBRATA;

EID: 0035425463     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.201801     Document Type: Article

References (71)

1. Endodermal Nodal-related signals and mesoderm induction in Xenopus
2. The ALK-2 and ALK-4 Activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds
3. Mechanisms of left-right determination in vertebrates
4. Xenopus GDF6, a new antagonist of noggin and a partner of BMPs
5. A Xenopus type I receptor mediates mesodermal but not neural specification during embryogenesis
6. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
7. Direct binding of smad3 and smad4 to critical TGF-β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
8. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
9. Activin signaling has an early function in Xenopus early development
10. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling form the extraembryonic yolk syncytial layer
11. Zebrafish organizer development and germ-layer formation require nodal-related signals
12. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
13. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
14. Activin signaling and response to a morphogen gradient
15. Direct and continuous assessment by cells of their position in a morphogen gradient
16. Spemann's organizer
17. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
18. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
19. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo
20. Inhibition of activin receptor signaling promotes neuralization in Xenopus
21. Embryonic expression and functional analysis of a Xenopus Activin receptor
22. Follistatin, an antagonist of Activin, is expressed in the Spemann organizer and displays direct neuralizing activity
23. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
24. The orphan receptor serine-threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line
25. Xnr4: A Xenopus Nodal-related gene expressed in the Spemann organizer
26. Vertebrate mesendoderm induction and patterning
27. The TGFβ superfamily: New members, new receptors, and new genetic tests of function in different organisms
28. The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development
29. Rapid and efficient site-specific mutagenesis without phenotypic selection
30. A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone
31. Conserved left-right asymmetry of Nodal expression and alterations in murine situs inversus
32. A Xenopus Nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation
33. A type I serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus
34. XTrR-I is a TGFβ receptor and overexpression of a truncated form of the receptor inhibits axis formation and dorsalizing activity
35. TGF-β signal transduction
36. Cloning of a second type of Activin receptor and functional characterization in Xenopus embryos
37. Functional analysis of activins during mammalian development
38. Different phenotypes of mice deficient in either activins or activin receptor type II
39. Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
40. Upstream sequences required for tissue-specific activation of the cardiac actin gene in Xenopus laevis embryos
41. Differential effects on Xenopus development of interference with type IIA and type IIB Activin receptors
42. Multiple genes for Xenopus Activin receptor expressed during early embryogenesis
43. A carboxyl-terminal truncated version of the Activin receptor mediates Activin signals in early Xenopus embryos
44. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
45. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
46. Xenopus Nodal-related signaling is essential for mesendodermal patterning during early embryogenesis
47. Conversion of zebrafish blastomeres to an endodermal fate by TGF-β-related signaling
48. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
49. Cardiac looping and the vertebrate left-right axis: Antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway
50. Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry
51. Cyclops encodes a nodal-related factor involved in midline signaling
52. A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system
53. Functional differences among Xenopus Nodal-related genes in left-right axis determination
54. Induction of the zebrafish ventral brain and floor plate requires cyclops/Nodal signaling
55. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
56. Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: Does activin play a role in mesoderm induction?
57. The EGF-CFC gene family in vertebrate development
58. BMP signaling is required for heart formation in vertebrates
59. Expression of Xenopus homolog Brachyury T is an immediate-early resprons to mesoderm induction
60. A nodal-related gene defines a physical and functional domain within the Spemann organizer
61. The type II Activin receptors are essential for egg cylinder growth, gastrulation and rostral head development in mice
62. Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center
63. Goosecoid expression in neuroectoderm and mesoderm is disrupted in zebrafish cyclops gastrulas
64. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
65. Molecular cloning of a novel Type I receptor serine/threonine kinase of the TGFβ superfamily from rat brain
66. The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals
67. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGFβ
68. The Xenopus X1Hbox6 homeoprotein, a marker of posterior neural induction, is expressed in proliferating neurons
69. A two-step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos
70. Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation