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Volumn 4, Issue 4, 2006, Pages 235-246

Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 7; ADENOVIRUS VECTOR; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; GROWTH FACTOR RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

EID: 33646128737     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-05-0174     Document Type: Article
Times cited : (47)

References (48)
  • 2
    • 0036024584 scopus 로고    scopus 로고
    • Ovarian cancer: Progress and continuing controversies in management
    • Moss C, Kaye SB. Ovarian cancer: progress and continuing controversies in management. Eur J Cancer 2002;38:1701-7.
    • (2002) Eur J Cancer , vol.38 , pp. 1701-1707
    • Moss, C.1    Kaye, S.B.2
  • 5
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-β signaling
    • Massagué J, Chen Y-G. Controlling TGF-β signaling. Genes Dev 2000; 6:627-44.
    • (2000) Genes Dev , vol.6 , pp. 627-644
    • Massagué, J.1    Chen, Y.-G.2
  • 6
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-β superfamily
    • Chang H, Brown CW, Matzuk MM. Genetic analysis of the mammalian transforming growth factor-β superfamily. Endocr Rev 2002;23:787-823.
    • (2002) Endocr Rev , vol.23 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 7
    • 1542673128 scopus 로고    scopus 로고
    • The TGF-β superfamily and its roles in the human ovary and placenta
    • Peng C. The TGF-β superfamily and its roles in the human ovary and placenta. J Obstet Gynaecol Can 2003;25:834-44.
    • (2003) J Obstet Gynaecol Can , vol.25 , pp. 834-844
    • Peng, C.1
  • 8
    • 33044503641 scopus 로고    scopus 로고
    • Transforming growth factor-β receptor signaling in cancer
    • Narayan S, Thangasamy T, Balusu R. Transforming growth factor-β receptor signaling in cancer. Front Biosci 2005;10:1135-45.
    • (2005) Front Biosci , vol.10 , pp. 1135-1145
    • Narayan, S.1    Thangasamy, T.2    Balusu, R.3
  • 9
    • 0035000225 scopus 로고    scopus 로고
    • The regulation of apoptosis by activin and transforming growth factor-β in early neoplastic and tumorigenic ovarian surface epithelium
    • Choi KC, Kang SK, Tai CJ, Auersperg N, Leung PC. The regulation of apoptosis by activin and transforming growth factor-β in early neoplastic and tumorigenic ovarian surface epithelium. J Clin Endocrinol Metab 2001; 86:2125-35.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2125-2135
    • Choi, K.C.1    Kang, S.K.2    Tai, C.J.3    Auersperg, N.4    Leung, P.C.5
  • 10
    • 0036205842 scopus 로고    scopus 로고
    • TGF β-induced Smad signaling remains intact in primary human ovarian cancer cells
    • Dunfield LD, Dwyer EJ, Nachtigal MW. TGF β-induced Smad signaling remains intact in primary human ovarian cancer cells. Endocrinology 2002; 143:1174-81.
    • (2002) Endocrinology , vol.143 , pp. 1174-1181
    • Dunfield, L.D.1    Dwyer, E.J.2    Nachtigal, M.W.3
  • 11
    • 0028304722 scopus 로고
    • Transforming growth factor-β inhibits proliferation of human ovarian cancer cells obtained from ascites
    • Hurteau J, Rodriguez GC, Whitaker RS, et al. Transforming growth factor-β inhibits proliferation of human ovarian cancer cells obtained from ascites. Cancer 1994;74:93-9.
    • (1994) Cancer , vol.74 , pp. 93-99
    • Hurteau, J.1    Rodriguez, G.C.2    Whitaker, R.S.3
  • 12
    • 0041314104 scopus 로고    scopus 로고
    • Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells
    • Shepherd TG, Nachtigal MW. Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells. Endocrinology 2003;144:3306-14.
    • (2003) Endocrinology , vol.144 , pp. 3306-3314
    • Shepherd, T.G.1    Nachtigal, M.W.2
  • 13
    • 0037106188 scopus 로고    scopus 로고
    • Nodal activity in the node governs left-right asymmetry
    • Brennan J, Norris DP, Robertson EJ. Nodal activity in the node governs left-right asymmetry. Genes Dev 2002;16:2339-44.
    • (2002) Genes Dev , vol.16 , pp. 2339-2344
    • Brennan, J.1    Norris, D.P.2    Robertson, E.J.3
  • 14
    • 0037019287 scopus 로고    scopus 로고
    • Determination of left-right patterning of the mouse embryo by artificial nodal flow
    • Nonaka S, Shiratori H, Saijoh Y, Hamada H. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 2002;418:96-9.
    • (2002) Nature , vol.418 , pp. 96-99
    • Nonaka, S.1    Shiratori, H.2    Saijoh, Y.3    Hamada, H.4
  • 15
    • 8744286786 scopus 로고    scopus 로고
    • Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7
    • Xu G, Zhong Y, Munir S, Yang BB, Tsang BK, Peng C. Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. J Clin Endocrinol Metab 2004;89:5523-34.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5523-5534
    • Xu, G.1    Zhong, Y.2    Munir, S.3    Yang, B.B.4    Tsang, B.K.5    Peng, C.6
  • 16
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-β superfamily
    • Attisano L, Wrana JL. Signal transduction by the TGF-β superfamily. Science 2002;296:1646-7.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 17
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-β-Smad signalling
    • ten Dijke P, Hill CS. New insights into TGF-β-Smad signalling. Trends Biochem Sci 2004;29:265-73.
    • (2004) Trends Biochem Sci , vol.29 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 18
    • 0029846430 scopus 로고    scopus 로고
    • A novel type I receptor serine/ threonine kinase predominantly expressed in the adult central nervous system
    • Rydén M, Imamura T, Jornvall H, et al. A novel type I receptor serine/ threonine kinase predominantly expressed in the adult central nervous system. J Biol Chem 1996;271:30603-9.
    • (1996) J Biol Chem , vol.271 , pp. 30603-30609
    • Rydén, M.1    Imamura, T.2    Jornvall, H.3
  • 19
    • 0030174277 scopus 로고    scopus 로고
    • Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF-β superfamily from rat brain
    • Tsuchida K, Sawchenko PE, Nishikawa SI, Vale WW. Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF-β superfamily from rat brain. Mol Cell Neurosci 1996;7:467-78.
    • (1996) Mol Cell Neurosci , vol.7 , pp. 467-478
    • Tsuchida, K.1    Sawchenko, P.E.2    Nishikawa, S.I.3    Vale, W.W.4
  • 20
    • 18444398034 scopus 로고    scopus 로고
    • cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)
    • Bondestam J, Huotari MA, Moren A, et al. cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). Cytogenet Cell Genet 2001;95:157-62.
    • (2001) Cytogenet Cell Genet , vol.95 , pp. 157-162
    • Bondestam, J.1    Huotari, M.A.2    Moren, A.3
  • 21
    • 0037407439 scopus 로고    scopus 로고
    • Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta
    • Roberts JR, Hu S, Qiu Q, et al. Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. Biol Reprod 2003;68:1719-26.
    • (2003) Biol Reprod , vol.68 , pp. 1719-1726
    • Roberts, J.R.1    Hu, S.2    Qiu, Q.3
  • 22
    • 0035425463 scopus 로고    scopus 로고
    • The orphan receptor ALK7 and the activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
    • Reissmann E, Jornvall H, Blokzijl A, et al. The orphan receptor ALK7 and the activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev 2001;15:2010-22.
    • (2001) Genes Dev , vol.15 , pp. 2010-2022
    • Reissmann, E.1    Jornvall, H.2    Blokzijl, A.3
  • 24
    • 0035895912 scopus 로고    scopus 로고
    • The orphan receptor serine/ threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line
    • Jörnvall H, Blokzijl A, ten Dijke P, Ibanez CF. The orphan receptor serine/ threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line. J Biol Chem 2001;276:5140-6.
    • (2001) J Biol Chem , vol.276 , pp. 5140-5146
    • Jörnvall, H.1    Blokzijl, A.2    Ten Dijke, P.3    Ibanez, C.F.4
  • 25
    • 3142618508 scopus 로고    scopus 로고
    • ALK7 induces apoptosis through activation of MAP kinases in a Smad3-dependent mechanism in hepatoma cells
    • Kim BC, Van Gelder H, Kim TA, et al. ALK7 induces apoptosis through activation of MAP kinases in a Smad3-dependent mechanism in hepatoma cells. J Biol Chem 2004;279:28458-65.
    • (2004) J Biol Chem , vol.279 , pp. 28458-28465
    • Kim, B.C.1    Van Gelder, H.2    Kim, T.A.3
  • 26
    • 3843110160 scopus 로고    scopus 로고
    • Nodal and activin receptor-like kinase (ALK) 7 inhibit proliferation and induce apoptosis in human trophoblast cells
    • Munir S, Xu G, Wu Y, Yang BB, Lala K, Peng C. Nodal and activin receptor-like kinase (ALK) 7 inhibit proliferation and induce apoptosis in human trophoblast cells. J Biol Chem 2004;279:31277-86.
    • (2004) J Biol Chem , vol.279 , pp. 31277-31286
    • Munir, S.1    Xu, G.2    Wu, Y.3    Yang, B.B.4    Lala, K.5    Peng, C.6
  • 27
    • 1542357606 scopus 로고    scopus 로고
    • Apoptosis pathways in cancer and cancer therapy
    • Debatin K-M. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 2004;53:153-9.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 153-159
    • Debatin, K.-M.1
  • 28
    • 0037633932 scopus 로고    scopus 로고
    • Apoptosis: Programmed cell death at a molecular level
    • Schultz DR, Harrington WJ, Jr. Apoptosis: programmed cell death at a molecular level. Semin Arthritis Rheum 2003;32:345-69.
    • (2003) Semin Arthritis Rheum , vol.32 , pp. 345-369
    • Schultz, D.R.1    Harrington Jr., W.J.2
  • 29
    • 0034905394 scopus 로고    scopus 로고
    • XIAP: Apoptotic brake and promising therapeutic target
    • Holcik M, Gibson H, Korneluk RG. XIAP: apoptotic brake and promising therapeutic target. Apoptosis 2001;6:253-61.
    • (2001) Apoptosis , vol.6 , pp. 253-261
    • Holcik, M.1    Gibson, H.2    Korneluk, R.G.3
  • 30
    • 7744224359 scopus 로고    scopus 로고
    • Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases
    • Breckenridge DG, Xue D. Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases. Curr Opin Cell Biol 2004;16:647-52.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 647-652
    • Breckenridge, D.G.1    Xue, D.2
  • 32
    • 0030900944 scopus 로고    scopus 로고
    • Mechanisms of apoptotic cell death
    • Rowan S, Fisher DE. Mechanisms of apoptotic cell death. Leukemia 1997; 11:457-65.
    • (1997) Leukemia , vol.11 , pp. 457-465
    • Rowan, S.1    Fisher, D.E.2
  • 33
    • 0033713002 scopus 로고    scopus 로고
    • Structure of Bax: Coregulation of dimer formation and intracellular localization
    • Suzuki M, Youle RJ, Tjandra N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 2000;103:645-54.
    • (2000) Cell , vol.103 , pp. 645-654
    • Suzuki, M.1    Youle, R.J.2    Tjandra, N.3
  • 34
    • 0034644508 scopus 로고    scopus 로고
    • Insights into programmed cell death through structural biology
    • Fesik AW. Insights into programmed cell death through structural biology. Cell 2000;103:273-82.
    • (2000) Cell , vol.103 , pp. 273-282
    • Fesik, A.W.1
  • 35
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997;275:1129-32.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3
  • 36
    • 0035266318 scopus 로고    scopus 로고
    • XIAP regulated Akt activity and caspase-3-depentent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cells
    • Asselin E, Mills GB, Tsang BK. XIAP regulated Akt activity and caspase-3-depentent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cells. Cancer Res 2001;61:1862-8.
    • (2001) Cancer Res , vol.61 , pp. 1862-1868
    • Asselin, E.1    Mills, G.B.2    Tsang, B.K.3
  • 37
    • 0032711511 scopus 로고    scopus 로고
    • Activation of caspase-8 in transforming growth factor-β-induced apoptosis of human hepatoma cells
    • Shima Y, Nakao K, Nakashima T, et al. Activation of caspase-8 in transforming growth factor-β-induced apoptosis of human hepatoma cells. Hepatology 1999;30:1215-22.
    • (1999) Hepatology , vol.30 , pp. 1215-1222
    • Shima, Y.1    Nakao, K.2    Nakashima, T.3
  • 39
    • 2342561882 scopus 로고    scopus 로고
    • The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
    • Gottfried Y, Rotem A, Lotan R, Steller H, Larisch S. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO J 2004; 23:1627-35.
    • (2004) EMBO J , vol.23 , pp. 1627-1635
    • Gottfried, Y.1    Rotem, A.2    Lotan, R.3    Steller, H.4    Larisch, S.5
  • 40
    • 0033521529 scopus 로고    scopus 로고
    • XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TABI-1 in the BMP signaling pathway
    • Yamaguchi K, Nagai S, Ninomiya-Tsuji J, et al. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TABI-1 in the BMP signaling pathway. EMBO J 1999;18:179-87.
    • (1999) EMBO J , vol.18 , pp. 179-187
    • Yamaguchi, K.1    Nagai, S.2    Ninomiya-Tsuji, J.3
  • 41
    • 0035854738 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-β signaling
    • Reffey SB, Wurthner JU, Parks WT, Roberts AB, Duckett CS. X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-β signaling. J Biol Chem 2001;276:26542-9.
    • (2001) J Biol Chem , vol.276 , pp. 26542-26549
    • Reffey, S.B.1    Wurthner, J.U.2    Parks, W.T.3    Roberts, A.B.4    Duckett, C.S.5
  • 42
    • 1542335506 scopus 로고    scopus 로고
    • Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis
    • Lewis J, Burstein E, Reffey SB, Bratton SB, Roberts AB, Duckett CS. Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. J Biol Chem 2004;279:9023-9.
    • (2004) J Biol Chem , vol.279 , pp. 9023-9029
    • Lewis, J.1    Burstein, E.2    Reffey, S.B.3    Bratton, S.B.4    Roberts, A.B.5    Duckett, C.S.6
  • 43
    • 0032848011 scopus 로고    scopus 로고
    • Ovarian carcinoma cell cultures are resistant to TGF-β1-mediated growth inhibition despite expression of functional receptors
    • Yamada SD, Baldwin RL, Karlan BY. Ovarian carcinoma cell cultures are resistant to TGF-β1-mediated growth inhibition despite expression of functional receptors. Gynecol Oncol 1999;75:72-7.
    • (1999) Gynecol Oncol , vol.75 , pp. 72-77
    • Yamada, S.D.1    Baldwin, R.L.2    Karlan, B.Y.3
  • 44
    • 0030048782 scopus 로고    scopus 로고
    • Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: A potential role in autocrine growth regulation
    • Di Simone N, Crowley WF, Jr., Wang QF, Sluss PM, Schneyer AL. Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation. Endocrinology 1996;137:486-94.
    • (1996) Endocrinology , vol.137 , pp. 486-494
    • Di Simone, N.1    Crowley Jr., W.F.2    Wang, Q.F.3    Sluss, P.M.4    Schneyer, A.L.5
  • 45
    • 0035961978 scopus 로고    scopus 로고
    • Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE)
    • Choi KC, Kang SK, Nathwani PS, Cheng KW, Auersperg N, Leung PC. Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE). Mol Cell Endocrinol 2001;174:99-110.
    • (2001) Mol Cell Endocrinol , vol.174 , pp. 99-110
    • Choi, K.C.1    Kang, S.K.2    Nathwani, P.S.3    Cheng, K.W.4    Auersperg, N.5    Leung, P.C.6
  • 48
    • 0035860239 scopus 로고    scopus 로고
    • Expression of TGF-β signalling genes in the normal, premalignant, and malignant human trophoblast: Loss of Smad3 in choriocarcinoma cells
    • Xu G, Chakraborty C, Lala PK. Expression of TGF-β signalling genes in the normal, premalignant, and malignant human trophoblast: loss of Smad3 in choriocarcinoma cells. Biochem Biophys Res Commun 2001; 287:47-55.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 47-55
    • Xu, G.1    Chakraborty, C.2    Lala, P.K.3


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