Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Relle, Manfred ^a   Schwarting, Andreas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; HEAT SHOCK PROTEIN 70; HLA ANTIGEN CLASS 2; HLA DRB1 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 3; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; COMPLEMENT; HEAT SHOCK PROTEIN;

AUTOIMMUNITY; CYTOKINE PRODUCTION; ETHNICITY; GENE DOSAGE; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HEREDITY; HOMOZYGOSITY; HUMAN; LUPUS ERYTHEMATOSUS NEPHRITIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; DISEASE MODEL; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE;

ANIMALS; COMPLEMENT SYSTEM PROTEINS; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HEAT-SHOCK PROTEINS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863693357     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/584374     Document Type: Review

References (233)

1. Rahman A., Isenberg D. A., Systemic lupus erythematosus The New England Journal of Medicine 2008 358 9 929 939 (Pubitemid 351397092)
2. Merino R., Fossati L., Lacour M., Lemoine R., Higaki M., Izui S., H-2-1inked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice European Journal of Immunology 1992 22 2 295 299
3. Subramanian S., Tus K., Li Q. Z., Wang A., Tian X. H., Zhou J., Liang C., Bartov G., McDaniel L. D., Zhou X. J., Schultz R. A., Wakeland E. K., A Tlr7 translocation accelerates systemic autoimmunity in murine lupus Proceedings of the National Academy of Sciences of the United States of America 2006 103 26 9970 9975 (Pubitemid 43993607)
4. Pisitkun P., Deane J. A., Difilippantonio M. J., Tarasenko T., Satterthwaite A. B., Bolland S., Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication Science 2006 312 5780 1669 1672 (Pubitemid 43902669)
5. Chu J. L., Drappa J., Parnassa A., Elkon K. B., The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn The Journal of Experimental Medicine 1993 178 2 723 730 (Pubitemid 23218222)
6. Watanabe-Fukunaga R., Brannan C. I., Copeland N. G., Jenkins N. A., Nagata S., Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis Nature 1992 356 6367 314 317
7. Lynch D. H., Watson M. L., Alderson M. R., Baum P. R., Miller R. E., Tough T., Gibson M., Davis-Smith T., Smith C. A., Hunter K., Bhat D., Din W., Goodwin R. G., Seldin M. F., The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster Immunity 1994 1 2 131 136
8. Takahashi T., Tanaka M., Brannan C. I., Jenkins N. A., Copeland N. G., Suda T., Nagata S., Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand Cell 1994 76 6 969 976 (Pubitemid 24106378)
9. Andrews B., Eisenberg R. A., Theofilopoulos A. N., Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains The Journal of Experimental Medicine 1978 148 5 1198 1215 (Pubitemid 9053639)
10. Theofilopoulos A. N., Dixon F. J., Murine models of systemic lupus erythematosus Advances in Immunology 1985 37 269 390 (Pubitemid 15093080)
11. Cohen P. L., Eisenberg R. A., Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease Annual Review of Immunology 1991 9 243 269
12. Izui S., Iwamoto M., Fossati L., Merino R., Takahashi S., Ibnou-Zekri N., The Yaa gene model of systemic lupus erythematosus Immunological Reviews 1995 144 137 156
13. Nguyen C., Limaye N., Wakeland E. K., Susceptibility genes in the pathogenesis of murine lupus Arthritis Research 2002 4 supplement 3 S255 S263
14. Vyse T. J., Kotzin B. L., Genetic basis of systemic lupus erythematosus Current Opinion in Immunology 1996 8 6 843 851 (Pubitemid 27007651)
15. Santiago-Raber M. L., Laporte C., Reininger L., Izui S., Genetic basis of murine lupus Autoimmunity Reviews 2004 3 1 33 39 (Pubitemid 38197968)
16. Li L., Mohan C., Genetic basis of murine lupus nephritis Seminars in Nephrology 2007 27 1 12 21
17. Morel L., Genetics of SLE: evidence from mouse models Nature Reviews Rheumatology 2010 6 6 348 357
18. Ballestar E., Esteller M., Richardson B. C., The epigenetic face of systemic lupus erythematosus Journal of Immunology 2006 176 12 7143 7147 (Pubitemid 43849013)
19. Javierre B. M., Richardson B., A new epigenetic challenge: systemic lupus erythematosus Advances in Experimental Medicine and Biology 2011 711 117 136
20. Rioux J. D., Goyette P., Vyse T. J., Hammarstrm L., Fernando M. M. A., Green T., De Jager P. L., Foisy S., Wang J., De Bakker P. I. W., Leslie S., McVean G., Padyukov L., Alfredsson L., Annese V., Hafler D. A., Pan-Hammarstrm Q., Matell R., Sawcer S. J., Compston A. D., Cree B. A. C., Mirel D. B., Daly M. J., Behrens T. W., Klareskog L., Gregersen P. K., Oksenberg J. R., Hauser S. L., Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases Proceedings of the National Academy of Sciences of the United States of America 2009 106 44 18680 18685
21. Grumet F. C., Coukell A., Bodmer J. G., Bodmer W. F., McDevitt H. O., Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease The New England Journal of Medicine 1971 285 4 193 196
22. Harley J. B., Moser K. L., Gaffney P. M., Behrens T. W., The genetics of human systemic lupus erythematosus Current Opinion in Immunology 1998 10 6 690 696 (Pubitemid 28558585)
23. Criswell L. A., The genetic contribution to systemic lupus erythematosus Bulletin of the NYU Hospital for Joint Diseases 2008 66 3 176 183
24. Tan F. K., Arnett F. C., The genetics of lupus Current Opinion in Rheumatology 1998 10 5 399 408 (Pubitemid 28456959)
25. Walport M. J., Complement and systemic lupus erythematosus Arthritis Research 2002 4 supplement 3 S279 S293
26. Rozzo S. J., Vyse T. J., David C. S., Palmer E., Izui S., Kotzin B. L., Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice Journal of Immunology 1999 162 5 2623 2630 (Pubitemid 29309282)
27. Gorer P. A., The genetic and antigenic basis of tumour transplantation Journal of Pathology and Bacteriology 1937 44 691 697
28. Medawar P. B., Peter Alfred Gorer. 19071961 Biographical Memoirs of Fellows of the Royal Society 1961 7 95 109
29. Medawar P. B., The behaviour and fate of skin autografts and skin homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council Journal of Anatomy 1944 78, part 5 176 199
30. Starzl T. E., Peter Brian Medawar: father of transplantation Journal of the American College of Surgeons 1995 180 3 332 336
31. Snell G. D., Methods for the study of histocompatibility genes Journal of Genetics 1948 49 2 87 108
32. Snell G. D., Higgins G. F., Alleles at the histocompatibility-2 locus in the mouse as determined by tumor transplantation Genetics 1951 36 3 306 310
33. Klein J., George Snell's first foray into the unexplored territory of the major histocompatibility complex Genetics 2001 159 2 435 439 (Pubitemid 33035090)
34. Dausset J., Iso-leuko-antibodies Acta Haematologica 1958 20 14 156 166
35. Charron D. J., In memoriam: Jean Dausset (19162009) Tissue Antigens 2009 74 5 371 372
36. Payne R., Tripp M., Weigle J., Bodmer W., Bodmer J., A new leukocyte isoantigen system in man Cold Spring Harbor Symposia on Quantitative Biology 1964 29 285 295
37. Levine B. B., Ojeda A., Benacerraf B., Studies on artificial antigens. Iii. the genetic control of the immune response to hapten-poly-L-lysine conjugates in guinea pigs The Journal of Experimental Medicine 1963 118 953 957
38. Benacerraf B., McDevitt H. O., Histocompatibility-linked immune response genes Science 1972 175 4019 273 279
39. Ellman L., Green I., Martin W. J., Benacerraf B., Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs Proceedings of the National Academy of Sciences of the United States of America 1970 66 2 322 328
40. McDevitt H. O., Tyan M. L., Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus The Journal of Experimental Medicine 1968 128 1 1 11
41. Mcdevitt H. O., Chinitz A., Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type Science 1969 163 3872 1207 1208
42. Zinkernagel R. M., Doherty P. C., Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system Nature 1974 248 5450 701 702
43. Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D., Ankylosing spondylitis and HL-A 27 The Lancet 1973 1 7809 904 907
44. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M., High association of an HL-A antigen, W27, with ankylosing spondylitis The New England Journal of Medicine 1973 288 14 704 706
45. Klein J., Figueroa F., Klein D., H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17 Immunogenetics 1982 16 4 285 317 (Pubitemid 12001718)
46. Figueroa F., Tewarson S., Neufeld E., Klein J., H-2 haplotypes of strains DBR7, B10.NZW, NFS, BQ2, STU, TO1, and TO2 Immunogenetics 1982 15 4 431 436 (Pubitemid 12105372)
47. Beck S., Geraghty D., Inoko H., Rowen L., Complete sequence and gene map of a human major histocompatibility complex Nature 1999 401 6756 921 923
48. Stewart C. A., Horton R., Allock R. J. N., Ashurst J. L., Atrazhev A. M., Coggill P., Dunham I., Forbes S., Halls K., Howson J. M. M., Humphray S. J., Hunt S., Mungall A. J., Osoegawa K., Palmer S., Roberts A. N., Rogers J., Sims S., Wang Y., Wilming L. G., Elliot J. F., de Jong P. J., Sawcer S., Todd J. A., Trowsdale J., Beck S., Complete MHC haplotype sequencing for common disease gene mapping Genome Research 2004 14 6 1176 1187 (Pubitemid 38811554)
49. Horton R., Wilming L., Rand V., Lovering R. C., Bruford E. A., Khodiyar V. K., Lush M. J., Povey S., Talbot C. C., Wright M. W., Wain H. M., Trowsdale J., Ziegler A., Beck S., Gene map of the extended human MHC Nature Reviews Genetics 2004 5 12 889 899 (Pubitemid 39564252)
50. Dressel R., Walter L., Gnther E., Genomic and functional aspects of the rat MHC, the RT1 complex Immunological Reviews 2001 184 82 95 (Pubitemid 34123766)
51. Church D. M., Goodstadt L., Hillier L. W., Lineage-specific biology revealed by a finished genome assembly of the mouse PLoS Biology 2009 7 5
52. Lander E. S., Linton L. M., Birren B., Initial sequencing and analysis of the human genome Nature 2001 409 6822 860 921 (Pubitemid 32165345)
53. Waterston R. H., Lindblad-Toh K., Birney E., Initial sequencing and comparative analysis of the mouse genome Nature 2002 420 6915 520 562 (Pubitemid 35477048)
54. Trowsdale J., 'Both man and bird and beast': comparative organization of MHC genes Immunogenetics 1995 41 1 1 17 (Pubitemid 24373334)
55. Geraghty D. E., Koller B. H., Pei J., Hansen J. A., Examination of four HLA class I pseudogenes: common events in the evolution of HLA genes and pseudogenes Journal of Immunology 1992 149 6 1947 1956
56. Geraghty D. E., Koller B. H., Hansen J. A., Orr H. T., The HLA class I gene family includes at least six genes and twelve pseudogenes and gene fragments Journal of Immunology 1992 149 6 1934 1946
57. Beck S., Trowsdale J., The human major histocompatibility complex: lessons from the DNA sequence Annual Review of Genomics and Human Genetics 2000 1 2000 117 137
58. Ceppellini R., Curtoni E. S., Mattiuz R. L., Genetics of leukocyte antigens: a family study of segregation and linkage Histocompatibility Testing 1967 149 185
59. Xu T. J., Sun Y. N., Wang R. X., Allelic polymorphism, gene duplication and balancing selection of the MHC class II DAB gene of Cynoglossus semilaevis (Cynoglossidae) Genetics and Molecular Research 2011 10 1 53 64
60. Doherty P. C., Zinkernagel R. M., Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex Nature 1975 256 5512 50 52
61. Clarke B., Kirby D. R. S., Maintenance of histocompatibility polymorphisms Nature 1966 211 5052 999 1000
62. Bodmer W. F., Evolutionary significance of the HL-A system Nature 1972 237 5351 139 183
63. Takahata N., Nei M., Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci Genetics 1990 124 4 967 978 (Pubitemid 20146073)
64. Slade R. W., McCallum H. I., Overdominant vs. frequency-dependent selection at MHC loci Genetics 1992 132 3 861 862
65. De Boer R. J., Borghans J. A. M., Van Boven M., Kemir C., Weissing F. J., Heterozygote advantage fails to explain the high degree of polymorphism of the MHC Immunogenetics 2004 55 11 725 731 (Pubitemid 38316677)
66. Apanius V., Penn D., Slev P. R., Ruff L. R., Potts W. K., The nature of selection on the major histocompatibility complex Critical Reviews in Immunology 1997 17 2 179 224 (Pubitemid 27161351)
67. Zinkernagel R. M., Doherty P. C., Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis Nature 1974 251 5475 547 548
68. Wegner K. M., Kalbe M., Kurtz J., Reusch T. B. H., Milinski M., Parasite selection for immunogenetic optimality Science 2003 301 5638, article 1343
69. Sommer S., The importance of immune gene variability (MHC) in evolutionary ecology and conservation Frontiers in Zoology 2005 2, article 16
70. Reinertsen J. L., Klippel J. H., Johnson A. H., B-lymphocyte alloantigens associated with systemic lupus erythematosus The New England Journal of Medicine 1978 299 10 515 518 (Pubitemid 9053817)
71. Gibofsky A., Winchester R. J., Patarroyo M., Disease associations of the Ia like human alloantigens. Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus The Journal of Experimental Medicine 1978 148 6 1728 1732 (Pubitemid 9084047)
72. Scherak O., Smolen J. S., Mayr W. R., HLA-DRw3 and systemic lupus erythematosus Arthritis and Rheumatism 1980 23 8 954 957 (Pubitemid 10040130)
73. Fernando M. M. A., Stevens C. R., Walsh E. C., De Jager P. L., Goyette P., Plenge R. M., Vyse T. J., Rioux J. D., Defining the role of the MHC in autoimmunity: a review and pooled analysis PLoS Genetics 2008 4 4
74. Michel M., Johanet C., Meyer O., Francs C., Wittke F., Michel C., Arfi S., Tournier-Lasserve E., Piette J. C., Alamowitch S., Crassard I., Delrieu O., Duron F., Francs C., Heinzlef O., Johanet C., Marchelli F., Michel C., Michel M., Nahum L., Nunez S., Papeix C., Piette J. C., Roullet E., Tournier-Lasserve E., Wittke F., Familial lupus erythematosus: clinical and immunologic features of 125 multiplex families Medicine 2001 80 3 153 158 (Pubitemid 32466456)
75. Kaplan D., The onset of disease in twins and siblings with systemic lupus erythematosus Journal of Rheumatology 1984 11 5 648 652 (Pubitemid 15215052)
76. Arnett F. C., Reveille J. D., Wilson R. W., Systemic lupus erythematosus: current state of the genetic hypothesis Seminars in Arthritis and Rheumatism 1984 14 1 24 35 (Pubitemid 14031459)
77. Block S. R., Winfield J. B., Lockshin M. D., Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets American Journal of Medicine 1975 59 4 533 552
78. Deapen D., Escalante A., Weinrib L., Horwitz D., Bachman B., Roy-Burman P., Walker A., Mack T. M., A revised estimate of twin concordance in systemic lupus erythematosus Arthritis and Rheumatism 1992 35 3 311 318
79. Giles I., Isenberg D., Lupus in the familyanalysis of a cohort followed from 1978 to 1999 Lupus 2001 10 1 38 44 (Pubitemid 32416687)
80. Sestak A. L., Frnrohr B. G., Harley J. B., Merrill J. T., Namjou B., The genetics of systemic lupus erythematosus and implications for targeted therapy Annals of the Rheumatic Diseases 2011 70 supplement 1 i37 i43
81. Vyse T. J., Kotzin B. L., Genetic susceptibility to systemic lupus erythematosus Annual Review of Immunology 1998 16 261 292 (Pubitemid 28183366)
82. Moser K. L., Kelly J. A., Lessard C. J., Harley J. B., Recent insights into the genetic basis of systemic lupus erythematosus Genes and Immunity 2009 10 5 373 379
83. Agnello V., Complement deficiency states Medicine 1978 57 1 1 23 (Pubitemid 8237354)
84. Agnello V., Association of systemic lupus erythematosus and SLE syndromes with hereditary and acquired complement deficiency states Arthritis and Rheumatism 1978 21 5, supplement S146 S152
85. Sullivan K. E., Wisnieski J. J., Winkelstein J. A., Louie J., Sachs E., Choi R., Veksler E., Goldman D., Petri M., Serum complement determinations in patients with quiescent systemic lupus erythematosus Journal of Rheumatology 1996 23 12 2063 2067 (Pubitemid 27006752)
86. Smolen J. S., Klippel J. H., Penner E., HLA-DR antigens in systemic lupus erythematosus: association with specificity of autoantibody responses to nuclear antigens Annals of the Rheumatic Diseases 1987 46 6 457 462 (Pubitemid 17129918)
87. Tjernstrm F., Hellmer G., Nived O., Truedsson L., Sturfelt G., Synergetic effect between interleukin-1 receptor antagonist allele (IL1RN2) and MHC class II (DR17,DQ2) in determining susceptibility to systemic lupus erythematosus Lupus 1999 8 2 103 108 (Pubitemid 29103595)
88. Eroglu G. E., Kohler P. F., Familial systemic lupus erythematosus: the role of genetic and environmental factors Annals of the Rheumatic Diseases 2002 61 1 29 31 (Pubitemid 34074835)
89. Morel L., Genetics of Human Lupus Nephritis Seminars in Nephrology 2007 27 1 2 11
90. Deng Y., Tsao B. P., Genetic susceptibility to systemic lupus erythematosus in the genomic era Nature Reviews Rheumatology 2010 6 12 683 692
91. Han J.-W., Zheng H.-F., Cui Y., Sun L.-D., Ye D.-Q., Hu Z., Xu J.-H., Cai Z.-M., Huang W., Zhao G.-P., Xie H.-F., Fang H., Lu Q.-J., Xu J.-H., Li X.-P., Pan Y.-F., Deng D.-Q., Zeng F.-Q., Ye Z.-Z., Zhang X.-Y., Wang Q.-W., Hao F., Ma L., Zuo X.-B., Zhou F.-S., Du W.-H., Cheng Y.-L., Yang J.-Q., Shen S.-K., Li J., Sheng Y.-J., Zuo X.-X., Zhu W.-F., Gao F., Zhang P.-L., Guo Q., Li B., Gao M., Xiao F.-L., Quan C., Zhang C., Zhang Z., Zhu K.-J., Li Y., Hu D.-Y., Lu W.-S., Huang J.-L., Liu S.-X., Li H., Ren Y.-Q., Wang Z.-X., Yang C.-J., Wang P.-G., Zhou W.-M., Lv Y.-M., Zhang A.-P., Zhang S.-Q., Lin D., Li Y., Low H. Q., Shen M., Zhai Z.-F., Wang Y., Zhang F.-Y., Yang S., Liu J.-J., Zhang X.-J., Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus Nature Genetics 2009 41 11 1234 1237
92. Harley J. B., Alarcn-Riquelme M. E., Criswell L. A., Jacob C. O., Kimberly R. P., Moser K. L., Tsao B. P., Vyse T. J., Langefeld C. D., Nath S. K., Guthridge J. M., Cobb B. L., Mirel D. B., Marion M. C., Williams A. H., Divers J., Wang W., Frank S. G., Namjou B., Gabriel S. B., Lee A. T., Gregersen P. K., Behrens T. W., Taylor K. E., Fernando M., Zidovetzki R., Gaffney P. M., Edberg J. C., Rioux J. D., Ojwang J. O., James J. A., Merrill J. T., Gilkeson G. S., Seldin M. F., Yin H., Baechler E. C., Li Q. Z., Wakeland E. K., Bruner G. R., Kaufman K. M., Kelly J. A., Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nature Genetics 2008 40 2 204 210 (Pubitemid 351171405)
93. Hom G., Graham R. R., Modrek B., Taylor K. E., Ortmann W., Garnier S., Lee A. T., Chung S. A., Ferreira R. C., Pant P. V. K., Ballinger D. G., Kosoy R., Demirci F. Y., Kamboh M. I., Kao A. H., Tian C., Gunnarsson I., Bengtsson A. A., Rantap-Dahlqvist S., Petri M., Manzi S., Seldin M. F., Rnnblom L., Syvnen A. C., Criswell L. A., Gregersen P. K., Behrens T. W., Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX The New England Journal of Medicine 2008 358 9 900 909 (Pubitemid 351397089)
94. Graham R. R., Cotsapas C., Davies L., Hackett R., Lessard C. J., Leon J. M., Burtt N. P., Guiducci C., Parkin M., Gates C., Plenge R. M., Behrens T. W., Wither J. E., Rioux J. D., Fortin P. R., Cunninghame Graham D., Wong A. K., Vyse T. J., Daly M. J., Altshuler D., Moser K. L., Gaffney P. M., Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus Nature Genetics 2008 40 9 1059 1061
95. Barcellos L. F., May S. L., Ramsay P. P., Quach H. L., Lane J. A., Nititham J., Noble J. A., Taylor K. E., Quach D. L., Chung S. A., Kelly J. A., Moser K. L., Behrens T. W., Seldin M. F., Thomson G., Harley J. B., Gaffney P. M., Criswell L. A., High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions PLoS Genetics 2009 5 10
96. Budarf M. L., Goyette P., Boucher G., Lian J., Graham R. R., Claudio J. O., Hudson T., Gladman D., Clarke A. E., Pope J. E., Peschken C., Smith C. D., Hanly J., Rich E., Boire G., Barr S. G., Zummer M., Fortin P. R., Wither J., Rioux J. D., A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles Genes and Immunity 2011 12 1 51 58
97. Danchenko N., Satia J. A., Anthony M. S., Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden Lupus 2006 15 5 308 318 (Pubitemid 43828810)
98. Ruiz-Narvaez E. A., Fraser P. A., Palmer J. R., Cupples L. A., Reich D., Wang Y. A., Rioux J. D., Rosenberg L., MHC region and risk of systemic lupus erythematosus in African American women Human Genetics 2011 130 6 807 815
99. Ramos P. S., Criswell L. A., Moser K. L., A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap PLoS Genetics 2011 7 12
100. Waters S. T., Fu S. M., Gaskin F., Deshmukh U. S., Sung S. S. J., Kannapell C. C., Tung K. S. K., McEwen S. B., McDuffie M., NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci Clinical Immunology 2001 100 3 372 383
101. Wakeland E. K., Wandstrat A. E., Liu K., Morel L., Genetic dissection of systemic lupus erythematosus Current Opinion in Immunology 1999 11 6 701 707
102. Kono D. H., Theofilopoulos A. N., Genetics of SLE in mice Springer Seminars in Immunopathology 2006 28 2 83 96 (Pubitemid 46628478)
103. Xu Z., Morel L., Genetics of systemic lupus erythematosus: contributions of mouse models in the era of human genome-wide association studies Discovery Medicine 2010 10 50 71 78
104. Morel L., Perry D., Sang A., Yin Y., Zheng Y. Y., Murine models of systemic lupus erythematosus Journal of Biomedicine and Biotechnology 2011 2011 19
105. Wandstrat A., Wakeland E., The genetics of complex autoimmune diseases: non-MHC susceptibility genes Nature Immunology 2001 2 9 802 809
106. Sengupta M., Morel L., Lupus at the molecular level Protein Cell 2011 2 12 941 943
107. Morel L., Mohan C., Yu Y., Croker B. P., Tian N., Deng A., Wakeland E. K., Functional dissection of systemic lupus erythematosus using congenic mouse strains Journal of Immunology 1997 158 12 6019 6028 (Pubitemid 127484012)
108. Kono D. H., Burlingame R. W., Owens D. G., Kuramochi A., Balderas R. S., Balomenos D., Theofilopoulos A. N., Lupus susceptibility loci in New Zealand mice Proceedings of the National Academy of Sciences of the United States of America 1994 91 21 10168 10172 (Pubitemid 24311970)
109. Mohan C., Alas E., Morel L., Yang P., Wakeland E. K., Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnuclesomes The Journal of Clinical Investigation 1998 101 6 1362 1372 (Pubitemid 28145253)
110. Morel L., Rudofsky U. H., Longmate J. A., Schiffenbauer J., Wakeland E. K., Polygenic control of susceptibility to murine systemic lupus erythematosus Immunity 1994 1 3 219 229
111. Mohan C., Morel L., Yang P., Wakeland E. K., Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity Journal of Immunology 1997 159 1 454 465 (Pubitemid 127493732)
112. Rudofsky U. H., Evans B. D., Balaban S. L., Mottironi V. D., Gabrielsen A. E., Differences in expression of lupus nephritis in New Zealand Mixed H-2(z) homozygous inbred strains of mice derived from New Zealand Black and New Zealand White mice: origins and initial characterization Laboratory Investigation 1993 68 4 419 426 (Pubitemid 23136162)
113. Morel L., Blenman K. R., Croker B. P., Wakeland E. K., The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes Proceedings of the National Academy of Sciences of the United States of America 2001 98 4 1787 1792 (Pubitemid 32165576)
114. Xu Z., Cuda C. M., Croker B. P., Morel L., Nomura A., Fujita Y., Haji Y., Yamaguchi M., Tomino T., Watanabe T., Shimizu H., Okada M., The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in Fas-deficient mice Arthritis and Rheumatism 2011 63 3 764 774
115. Liu K., Li Q. Z., Yu Y., Liang C., Subramanian S., Zeng Z., Wang H. W., Xie C., Zhou X. J., Mohan C., Wakeland E. K., Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis Genes and Immunity 2007 8 8 634 645 (Pubitemid 350238433)
116. Cuda C. M., Zeumer L., Sobel E. S., Croker B. P., Morel L., Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells Genes and Immunity 2010 11 7 542 553
117. Xu Z., Duan B., Croker B. P., Wakeland E. K., Morel L., Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci Journal of Immunology 2005 175 2 936 943 (Pubitemid 41094977)
118. Li J., Liu Y., Xie C., Zhu J., Kreska D., Morel L., Mohan C., Deficiency of type I interferon contributes to Sle2-associated component lupus phenotypes Arthritis and Rheumatism 2005 52 10 3063 3072 (Pubitemid 41447087)
119. Chen Y., Cuda C., Morel L., Genetic determination of T cell help in loss of tolerance to nuclear antigens Journal of Immunology 2005 174 12 7692 7702 (Pubitemid 40806274)
120. Morel L., Croke B. P., Blenman K. R., Mohan C., Huang G., Gilkeson G., Wakeland E. K., Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains Proceedings of the National Academy of Sciences of the United States of America 2000 97 12 6670 6675 (Pubitemid 30412772)
121. Subramanian S., Yim Y. S., Liu K., Tus K., Zhou X. J., Wakeland E. K., Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 Mb Journal of Immunology 2005 175 2 1062 1072 (Pubitemid 41094992)
122. Morel L., Tian X. H., Croker B. P., Wakeland E. K., Epistatic modifiers of autoimmunity in a murine model of lupus nephritis Immunity 1999 11 2 131 139 (Pubitemid 29428806)
123. Vyse T. J., Rozzo S. J., Drake C. G., Appel V. B., Lemeur M., Izui S., Palmer E., Kotzin B. L., Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice Journal of Immunology 1998 160 6 2757 2766 (Pubitemid 28136729)
124. Jrgensen T. N., Gubbels M. R., Kotzin B. L., New insights into disease pathogenesis from mouse lupus genetics Current Opinion in Immunology 2004 16 6 787 793 (Pubitemid 39423670)
125. Mozes E., Lovchik J., Zinger H., Singer D. S., MHC class I expression regulates susceptibility to spontaneous autoimmune disease in (NZBxNZW)F1 mice Lupus 2005 14 4 308 314 (Pubitemid 40559176)
126. Vidal S., Kono D. H., Theofilopoulos A. N., Loci predisposing to autoimmunity in MRL-Fas(lpr) and C57BL/6-Fas(lpr) mice The Journal of Clinical Investigation 1998 101 3 696 702 (Pubitemid 28084255)
127. Price P., Witt C., Allcock R., Sayer D., Garlepp M., Kok C. C., French M., Mallal S., Christiansen F., The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases Immunological Reviews 1999 167 257 274 (Pubitemid 29178987)
128. Walport M. J., Black C. M., Batchelor J. R., The immunogenetics of SLE Clinics in Rheumatic Diseases 1982 8 1 3 21
129. Ulgiati D., Abraham L. J., Comparative analysis of the disease-associated complement C4 gene from the HLA-A1, B8, DR3 haplotype Experimental and Clinical Immunogenetics 1996 13 1 43 54 (Pubitemid 26257894)
130. Bishof N. A., Welch T. R., Beischel L. S., Carson D., Donnelly P. A., DP polymorphism in HLA-A1,-B8,-DR3 extended haplotypes associated with membranoproliferative glomerulonephritis and systemic lupus erythematosus Pediatric Nephrology 1993 7 3 243 246 (Pubitemid 23213979)
131. Griffing W. L., Moore S. B., Luthra H. S., Associations of antibodies to native DNA with HLA-DRw3. A possible major histocompatibility complex-linked human immune response gene The Journal of Experimental Medicine 1980 152 2, part 2 319s 325s
132. Singer D. S., Mozes E., Kirshner S., Kohn L. D., Role of MHC class I molecules in autoimmune disease Critical Reviews in Immunology 1997 17 5-6 463 468 (Pubitemid 27527395)
133. McPhee C. G., Sproule T. J., Shin D.-M., Bubier J. A., Schott W. H., Steinbuck M. P., Avenesyan L., Morse III H. C., Roopenian D. C., MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis Journal of Immunology 2011 187 9 4695 4704
134. Chan O. T. M., Paliwal V., McNiff J. M., Park S. H., Bendelac A., Shlomchik M. J., Deficiency in 2-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Faslpr mice: an example of disease regulation at the organ level Journal of Immunology 2001 167 5 2985 2990 (Pubitemid 32768936)
135. Mozes E., Kohn L. D., Hakim F., Singer D. S., Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus Science 1993 261 5117 91 93 (Pubitemid 23265383)
136. Christianson G. J., Blankenburg R. L., Duffy T. M., Panka D., Roths J. B., Marshak-Rothstein A., Roopenian D. C., 2-Microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice Journal of Immunology 1996 156 12 4932 4939 (Pubitemid 26174482)
137. Black C. M., Welsh K. I., Fielder A., HLA antigens and Bf allotypes in SLE: evidence for the association being with specific haplotypes Tissue Antigens 1982 19 2 115 120 (Pubitemid 12132702)
138. Celada A., Barras C., Benzonana G., Jeannet M., Increased frequency of HLA-DRw3 in systemic lupus erythematosus Tissue Antigens 1980 15 3 283 288 (Pubitemid 10130666)
139. Gladman D. D., Terasaki P. I., Park M. S., Iwaki Y., Louie S., Quismorio F. P., Barnett E. V., Liebling M. R., Increased frequency of HLA-DRW2 in SLE The Lancet 1979 2 8148, article 902
140. Scherak O., Smolen J. S., Mayr W. R., Prevalence of HLA-DRw2 not increased in systemic lupus erythematosus The New England Journal of Medicine 1979 301 11 612
141. Graham R. R., Ortmann W., Rodine P., Espe K., Langefeld C., Lange E., Williams A., Beck S., Kyogoku C., Moser K., Gaffney P., Gregersen P. K., Criswell L. A., Harley J. B., Behrens T. W., Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE European Journal of Human Genetics 2007 15 8 823 830 (Pubitemid 47109040)
142. Paisansinsup T., Deshmukh U. S., Chowdhary V. R., Luthra H. S., Fu S. M., David C. S., HLA class II influences the immune response and antibody diversification to Ro60/Sjgren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules Journal of Immunology 2002 168 11 5876 5884 (Pubitemid 34556176)
143. Jiang C., Deshmukh U. S., Gaskin F., Bagavant H., Hanson J., David C. S., Fu S. M., Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens Journal of Immunology 2010 184 2 1085 1091
144. Pisetsky D. S., Anti-DNA and autoantibodies Current Opinion in Rheumatology 2000 12 5 364 368
145. Franceschini F., Cavazzana I., Anti-Ro/SSA and La/SSB antibodies Autoimmunity 2005 38 1 55 63 (Pubitemid 40515004)
146. Heward J., Gough S. C. L., Genetic susceptibility to the development of autoimmune disease Clinical Science 1997 93 6 479 491 (Pubitemid 27517281)
147. Hamilton R. G., Harley J. B., Bias W. B., Roebber M., Reichlin M., Hochberg M. C., Arnett F. C., Two Ro (SS-A) autoantibody responses in systemic lupus erythematosus: correlation of HLA-DR/DQ specificities with quantitative expression of Ro (SS-A) autoantibody Arthritis and Rheumatism 1988 31 4 496 505
148. Vyse T. J., Drake C. G., Rozzo S. J., Roper E., Izui S., Kotzin B. L.,
149. Yoshida H., Kohno A., Ohta K., Genetic studies of autoimmunity in New Zealand mice. III. Associations among anti-DNA antibodies, NTA, and renal disease in (NZBxNZW)F1xNZW backcross Mice Journal of Immunology 1981 127 2 433 437 (Pubitemid 11054640)
150. Azizah M. R., Ainol S. S., Kuak S. H., Kong N. C. T., Normaznah Y., Rahim M. N., The association of the HLA class II antigens with clinical and autoantibody expression in Malaysian Chinese patients with systemic lupus erythematosus Asian Pacific Journal of Allergy and Immunology 2001 19 2 93 100 (Pubitemid 33034806)
151. Hartung K., Coldewey R., Krapf F., Lang B., Specker C., Schendel D., Schneider P., Seuchter S., Stangel W., Albert E., Deicher H., Baur M. P., Corvetta A., Frey J., Kalden R., Lakomek H. J., De Lange G. G., Muller R., Peter H. H., Hetero- and homozygosity of MHC class II gene products in systemic lupus erythematosus Tissue Antigens 1991 38 4 165 168
152. Mattos P., Santiago M. B., Association of antiphospholipid antibodies with valvulopathy in systemic lupus erythematosus: a systematic review Clinical Rheumatology 2011 30 2 165 171
153. Love P. E., Santoro S. A., Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance Annals of Internal Medicine 1990 112 9 682 698 (Pubitemid 20137178)
154. Ruiz-Irastorza G., Crowther M., Branch W., Khamashta M. A., Antiphospholipid syndrome The Lancet 2010 376 9751 1498 1509
155. Savi M., Ferraccioli G. F., Neri T. M., Zanelli P., Dall'Aglio P. P., Tincani A., Balestrieri G., Carella G., Cattaneo R., HLA-DR antigens and anticardiolipin antibodies in Northern Italian systemic lupus erythematosus patients Arthritis and Rheumatism 1988 31 12 1568 1570 (Pubitemid 19028426)
156. Azizah M. R., Ainol S. S., Kong N. C., Normaznah Y., Rahim M. N., HLA antigens in Malay patients with systemic lupus erythematosus: association with clinical and autoantibody expression The Korean Journal of Internal Medicine 2001 16 2 123 131
157. Truedsson L., Sturfelt G., Johansen P., Nived O., Thuresson B., Sharing of MHC haplotypes among patients with systemic lupus erythematosus from unrelated caucasian multicase families: disease association with the extended haplotype [HLA-B8,SCO1,DR17] Journal of Rheumatology 1995 22 10 1852 1861
158. Jnsen A., Bengtsson A. A., Sturfelt G., Truedsson L., Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility Arthritis Research and Therapy 2004 6 6 R557 R562
159. Skarsvag S., Nansen K. E., Hols A., Moen T., Distribution of HLA class II alleles among Scandinavian patients with systemic lupus erythematosus (SLE): an increased risk of SLE among non[DRB103,DQA10501,DQB10201] class II homozygotes? Tissue Antigens 1992 40 3 128 133
160. Yao Z., Kimura A., Hartung K., Haas P. J., Volgger A., Brunnler G., Bonisch J., Albert E. D., Baur M., Corvetta r A., Ehrfeld H., Frey J., Kalden J. R., Krapf F., Lang B., Lange G. G., Pirner K., Rittner C., Rother E., Polymorphism of the DQA1 promoter region (QAP) and DRB1, QAP, DQA1, DQB1 haplotypes in systemic lupus erythematosus Immunogenetics 1993 38 6 421 429 (Pubitemid 23290968)
161. Doherty D. G., Ireland R., Demaine A. G., Wang F., Veerapan K., Welsh K. I., Vergani D., Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in Southern Chinese Arthritis and Rheumatism 1992 35 6 641 646
162. Yao Z., Hartung K., Deicher H. G., Brunnler G., Bettinotti M. P., Keller E., Paul C., Gawron C., Mikschl S., Albert E., Baur M., Corvetta A., Frey J., Krapf F., Lang B., De Lange G. G., Pirner K., Rittner C., Rother R., Dna typing for HLA-DPB 1-alleles in German patients with systemic lupus erythematosus using the polymerase chain reaction and DIG-ddUTP-labelled oligonucleotide probes European Journal of Immunogenetics 1993 20 4 259 266 (Pubitemid 23244964)
163. Fouad F., Johny K., Kaaba S., Alkarmi T. O., Sharma P., Al-Harbi S., MHC in systemic lupus erythematosus: a study on a Kuwaiti population European Journal of Immunogenetics 1994 21 1 11 14 (Pubitemid 24042461)
164. Graham R. R., Ortmann W. A., Langefeld C. D., Jawaheer D., Selby S. A., Rodine P. R., Baechler E. C., Rohlf K. E., Shark K. B., Espe K. J., Green L. E., Nair R. P., Stuart P. E., Elder J. T., King R. A., Moser K. L., Gaffney P. M., Bugawan T. L., Erlich H. A., Rich S. S., Gregersen P. K., Behrens T. W., Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus American Journal of Human Genetics 2002 71 3 543 553 (Pubitemid 34970125)
165. Fernando M. M., Stevens C. R., Sabeti P. C., Walsh E. C., McWhinnie A. J., Shah A., Green T., Rioux J. D., Vyse T. J., Identification of two independent risk factors for lupus within the MHC in United Kingdom families PLoS Genetics 2007 3 11, article e192
166. Hartung K., Baur M. P., Coldewey R., Fricke M., Kalden J. R., Lakomek H. J., Peter H. H., Schendel D., Schneider P. M., Seuchter S. A., Stangel W., Deicher H. R. G., Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multicenter study The Journal of Clinical Investigation 1992 90 4 1346 1351
167. Halloran P. F., Urmson J., Ramassar V., Laskin C., Autenried P., Increased class I and class II MHC products and mRNA in kidneys of MRL-1pr/1pr mice3 during autoimmune nephritis and inhibition by cyclosporine Journal of Immunology 1988 141 7 2303 2312
168. Jevnikar A. M., Grusby M. J., Glimcher L. H., Prevention of nephritis in major histocompatibility complex class II- deficient MRL-lpr mice The Journal of Experimental Medicine 1994 179 4 1137 1143
169. Theofilopoulos A. N., Dixon F. J., Etiopathogenesis of murine SLE Immunological Reviews 1981 55 179 216 (Pubitemid 11157606)
170. Sekine H., Graham K. L., Zhao S., Elliott M. K., Ruiz P., Utz P. J., Gilkeson G. S., Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of systemic lupus erythematosus Journal of Immunology 2006 177 10 7423 7434 (Pubitemid 44715113)
171. Howie J. B., Helyer B. J., The immunology and pathology of NZB mice Advances in Immunology 1968 9 215 266
172. Hirose S., Nagasawa R., Sekikawa I., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB x NZW)F1 mice The Journal of Experimental Medicine 1983 158 1 228 233 (Pubitemid 13073523)
173. Hirose S., Ueda G., Noguchi K., Requirement of H-2 heterozygosity for autoimmunity in (NZB x NZW)F1 hybrid mice European Journal of Immunology 1986 16 12 1631 1633 (Pubitemid 17025708)
174. Zhang D., Fujio K., Jiang Y., Zhao J., Tada N., Sudo K., Tsurui H., Makamura K., Yamamoto K., Nishimura H., Shirai T., Hirose S., Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination Proceedings of the National Academy of Sciences of the United States of America 2004 101 38 13838 13843 (Pubitemid 39298494)
175. Hirose S., Kinoshita K., Nozawa S., Nishimura H., Shirai, Effects of major histocompatibility complex on autoimmune disease of H-2-congenic New Zealand mice International Immunology 1990 2 11 1091 1095 (Pubitemid 20376762)
176. Murphy E. D., Roths J. B., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation Arthritis and Rheumatism 1979 22 11 1188 1194 (Pubitemid 10163783)
177. Deane J. A., Pisitkun P., Barrett R. S., Feigenbaum L., Town T., Ward J., Flavell R. A., Bolland S., Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation Immunity 2007 27 5 801 810 (Pubitemid 350102256)
178. Kono D. H., Haraldsson M. K., Lawson B. R., Pollard K. M., Yi T. K., Du X., Arnold C. N., Baccala R., Silverman G. J., Beutler B. A., Theofilopoulos A. N., Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Proceedings of the National Academy of Sciences of the United States of America 2009 106 29 12061 12066
179. Kelley J., Johnson M. R., Alarcn G. S., Kimberly R. P., Edberg J. C., Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects Arthritis and Rheumatism 2007 56 10 3375 3378 (Pubitemid 47585432)
180. Shen N., Fu Q., Deng Y., Qian X., Zhao J., Kaufman K. M., Wu Y. L., Yu C. Y., Tang Y., Chen J. Y., Yang W., Wong M., Kawasaki A., Tsuchiya N., Sumida T., Kawaguchi Y., Howe H. S., Mok M. Y., Bang S. Y., Liu F. L., Chang D. M., Takasaki Y., Hashimoto H., Harley J. B., Guthridge J. M., Grossman J. M., Cantor R. M., Song Y. W., Bae S. C., Chen S., Hahn B. H., Lau Y. L., Tsao B. P., Sex-specific association of X-linked toll-like receptor 7 (TLR7) with male systemic lupus erythematosus Proceedings of the National Academy of Sciences of the United States of America 2010 107 36 15838 15843
181. Kawasaki A., Furukawa H., Kondo Y., Ito S., Hayashi T., Kusaoi M., Matsumoto I., Tohma S., Takasaki Y., Hashimoto H., Sumida T., Tsuchiya N., TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study Arthritis Research and Therapy 2011 13 2, article R41
182. Garca-Ortiz H., Velzquez-Cruz R., Espinosa-Rosales F., Jiménez-Morales S., Baca V., Orozco L., Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population Annals of the Rheumatic Diseases 2010 69 10 1861 1865
183. Zipfel P. F., Complement and immune defense: from innate immunity to human diseases Immunology Letters 2009 126 1-2 1 7
184. Zipfel P. F., Skerka C., Complement regulators and inhibitory proteins Nature Reviews Immunology 2009 9 10 729 740
185. Tansey M. G., Szymkowski D. E., The TNF superfamily in 2009: new pathways, new indications, and new drugs Drug Discovery Today 2009 14 23-24 1082 1088
186. Grewal I. S., Overview of TNF superfamily: a chest full of potential therapeutic targets Advances in Experimental Medicine and Biology 2009 647 1 7
187. Daugaard M., Rohde M., Jttel M., The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions FEBS Letters 2007 581 19 3702 3710 (Pubitemid 47081009)
188. Kudla G., Helwak A., Lipinski L., Gene conversion and GC-content evolution in mammalian Hsp70 Molecular Biology and Evolution 2004 21 7 1438 1444 (Pubitemid 38823746)
189. Sarma J. V., Ward P. A., The complement system Cell and Tissue Research 2011 343 1 227 235
190. Carroll M. V., Sim R. B., Complement in health and disease Advanced Drug Delivery Reviews 2011 63 12 965 975
191. Navratil J. S., Korb L. C., Ahearn J. M., Systemic lupus erythematosus and complement deficiency: clues to a novel role for the classical complement pathway in the maintenance of immune tolerance Immunopharmacology 1999 42 13 47 52 (Pubitemid 29322287)
192. Cook H. T., Botto M., Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus Nature Clinical Practice Rheumatology 2006 2 6 330 337 (Pubitemid 43842262)
193. Pickering M. C., Botto M., Taylor P. R., Lachmann P. J., Walport M. J., Systemic lupus erythematosus, complement deficiency, and apoptosis Advances in Immunology 2000 76 227 324
194. Morgan B. P., Walport M. J., Complement deficiency and disease Immunology Today 1991 12 9 301 306
195. Colten H. R., Molecular genetics of the major histocompatibility linked complement genes Springer Seminars in Immunopathology 1983 6 2-3 149 158 (Pubitemid 14239378)
196. Klble K., Reid K. B., Genetic deficiencies of the complement system and association with diseaseearly components International Reviews of Immunology 1993 10 1 17 36
197. Glass D., Raum D., Gibson D., Inherited deficiency of the second component of complement. Rheumatic disease associations The Journal of Clinical Investigation 1976 58 4 853 861
198. Fielder A. H. L., Walport M. J., Batchelor J. R., Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility BMJ 1983 286 6363 425 428 (Pubitemid 13143982)
199. Yu C. Y., Belt K. T., Giles C. M., Campbell R. D., Porter R. R., Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity The EMBO Journal 1986 5 11 2873 2881
200. Mauff G., Luther B., Schneider P. M., Rittner C., Stradmann-Bellinghausen B., Dawkins R., Moulds J. M., Reference typing report for complement component C4 Experimental and Clinical Immunogenetics 1998 15 4 249 260 (Pubitemid 29121672)
201. Yang Y., Chung E. K., Yee L. W., Savelli S. L., Nagaraja H. N., Zhou B., Hebert M., Jones K. N., Shu Y., Kitzmiller K., Blanchong C. A., McBride K. L., Higgins G. C., Rennebohm R. M., Rice R. R., Hackshaw K. V., Roubey R. A. S., Grossman J. M., Tsao B. P., Birmingham D. J., Rovin B. H., Hebert L. A., Yu C. Y., Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans American Journal of Human Genetics 2007 80 6 1037 1054 (Pubitemid 47579341)
202. Olsen M. L., Goldstein R., Arnett F. C., Duvic M., Pollack M., Reveille J. D., C4A gene deletion and HLA associations in black Americans with systemic lupus erythematosus Immunogenetics 1989 30 1 27 33 (Pubitemid 19182823)
203. Botto M., Fong K. Y., So A. K., Barlow R., Routier R., Morley B. J., Walport M. J., Homozygous hereditary C3 deficiency due to a partial gene deletion Proceedings of the National Academy of Sciences of the United States of America 1992 89 11 4957 4961
204. Davies K. A., Schifferli J. A., Walport M. J., Complement deficiency and immune complex disease Springer Seminars in Immunopathology 1994 15 4 397 416 (Pubitemid 24040808)
205. Moz L. E., Lauber K., Schiller M., Manfredi A. A., Herrmann M., The role of defective clearance of apoptotic cells in systemic autoimmunity Nature Reviews Rheumatology 2010 6 5 280 289
206. Carroll M. C., The role of complement in B cell activation and tolerance Advances in Immunology 2000 74 61 88
207. Lipsky P. E., Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity Nature Immunology 2001 2 9 764 766
208. Pattanakitsakul S. N., Zheng J. H., Natsuume-Sakai S., Takahashi M., Nonaka M., Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2(k) mice The Journal of Biological Chemistry 1992 267 11 7814 7820
209. Garlepp M. J., Hart D. A., Fritzler M. J., Regulation of plasma complement C4 and Factor B levels in murine systemic lupus erythematosus Journal of Clinical and Laboratory Immunology 1989 28 3 137 141 (Pubitemid 19147370)
210. Botto M., Dell'Agnola C., Bygrave A. E., Thompson E. M., Cook H. T., Petry F., Loos M., Pandolfi P. P., Walport M. J., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies Nature Genetics 1998 19 1 56 59 (Pubitemid 28242023)
211. Botto M., Links between complement deficiency and apoptosis Arthritis Research 2001 3 4 207 210 (Pubitemid 32621956)
212. Taylor P. R., Carugati A., Fadok V. A., Cook H. T., Andrews M., Carroll M. C., Savill J. S., Henson P. M., Botto M., Walport M. J., A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo The Journal of Experimental Medicine 2000 192 3 359 366 (Pubitemid 30629161)
213. Ritossa F., Discovery of the heat shock response Cell Stress and Chaperones 1996 1 2 97 98
214. Ripley B. J. M., Isenberg D. A., Latchman D. S., Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90 Journal of Autoimmunity 2001 17 4 341 346 (Pubitemid 34098418)
215. Walter L., Rauh F., Gunther E., Comparative analysis of the three major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat Immunogenetics 1994 40 5 325 330 (Pubitemid 24299321)
216. Favatier F., Bornman L., Hightower L. E., Gnther E., Polla B. S., Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance? Cell Stress and Chaperones 1997 2 3 141 155 (Pubitemid 27445574)
217. Jarjour W., Reed A. M., Gauthier J., Hunt S., Winfield J. B., The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans? Human Immunology 1996 45 1 59 63 (Pubitemid 26076040)
218. Hehlgans T., Pfeffer K., The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games Immunology 2005 115 1 1 20 (Pubitemid 40598088)
219. Cawthorn W. P., Sethi J. K., TNF- and adipocyte biology FEBS Letters 2008 582 1 117 131
220. Sugarman B. J., Aggarwal B. B., Hass P. E., Recombinant human tumor necrosis factor- : effects on proliferation of normal and transformed cells in vitro Science 1985 230 4728 943 945 (Pubitemid 16193990)
221. Beutler B., Cerami A., The biology of cachectin/TNFa primary mediator of the host response Annual Review of Immunology 1989 7 625 655 (Pubitemid 19138027)
222. Zembala M., Kowalczyk D., Pryjma J., Ruggiero I., Mytar B., Klysik J., Stec W. J., The role of tumor necrosis factor in the regulation of antigen presentation by human monocytes International Immunology 1990 2 4 337 342 (Pubitemid 20150940)
223. Wilson A. G., Di Giovine F. S., Blakemore A. I. F., Duff G. W., Single base polymorphism in the human Tumour Necrosis Factor alpha (TNF ) gene detectable by NcoI restriction of PCR product Human Molecular Genetics 1992 1 5, article 353
224. Wilson A. G., Gordon C., Di Giovine F. S., De Vries N., Van De Putte L. B. A., Emery P., Duff G. W., A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha European Journal of Immunology 1994 24 1 191 195 (Pubitemid 24014698)
225. Rudwaleit M., Tikly M., Khamashta M., Gibson K., Klinke J., Hughes G., Wordsworth P., Interethnic differences in the association of tumor necrosis factor promoter polymorphisms with systemic lupud erythematosus Journal of Rheumatology 1996 23 10 1725 1728 (Pubitemid 26342442)
226. Rood M. J., Van Krugten M. V., Zanelli E., Van Der Linden M. W., Keijsers V., Schreuder G. M. T., Verduyn W., Westendorp R. G. J., De Vries R. R. P., Breedveld F. C., Verweij C. L., Huizinga T. W. J., TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus Arthritis and Rheumatism 2000 43 1 129 134 (Pubitemid 30368221)
227. Schotte H., Willeke P., Tidow N., Domschke W., Assmann G., Gaubitz M., Schlter B., Extended haplotype analysis reveals an association of TNF polymorphisms with susceptibility to systemic lupus erythematosus beyond HLA-DR3 Scandinavian Journal of Rheumatology 2005 34 2 114 121 (Pubitemid 40703950)
228. Muller U., Jongeneel C. V., Nedospasov S. A., Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex Nature 1987 325 6101 265 267 (Pubitemid 17049888)
229. Jacob C. O., Hwang F., Lewis G. D., Stall A. M., Tumor necrosis factor alpha in murine systemic lupus erythematosus disease models: implications for genetic predisposition and immune regulation Cytokine 1991 3 6 551 561
230. Jacob C. O., McDevitt H. O., Tumour necrosis factor- in murine autoimmune lupus nephritis Nature 1988 331 6154 356 358 (Pubitemid 18042493)
231. Kontoyiannis D., Kollias G., Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor European Journal of Immunology 2000 30 7 2038 2047 (Pubitemid 30456200)
232. Artzt K., Barlow D., Dove W. F., Fischer-Lindahl K., Klein J., Lyon M. F., Silver L. M., Mouse chromosome 17 Mammalian Genome 1991 1 1 S280 S300
233. Endo T., Imanishi T., Gojobori T., Inoko H., Evolutionary significance of intra-genome duplications on human chromosomes Gene 1997 205 1-2 19 27 (Pubitemid 28029596)